• 신약 타겟 발굴 및 Validation

• 화합물 활용 High Throughput Screening

• 약효 평가 및 작용 기전 규명

In our laboratory, we are actively involved in drug discovery research. 

Our focus is on identifying druggable targets through rigorous validation processes. Utilizing high throughput screening techniques with diverse chemical libraries, we identify promising hit compounds. Subsequently, we meticulously evaluate their pharmacological effects and elucidate their mechanisms of action. 

To further advance our findings, we collaborate closely with chemists  to develop novel compounds exhibiting favorable medicinal properties, thereby making them suitable for patent applications.

• 유전자가위 작동 메커니즘을 활용한 유전자가위의 한계 극복 연구

• 신규 유전자 가위 제작

• 크리스퍼 활용 희귀질환 유전자 치료제 개발 

Our laboratory is conducting research to enhance the efficiency of gene editing tools. We are investigating methods to improve gene correction through HDR (homology-directed repair) by leveraging the mechanism of gene editing tools. Based on these findings, we are developing novel and high-performance gene editing tools. 

Additionally, we are also engaged in the exploration of gene editing targets for rare genetic disorders and the development of therapeutic approaches to treat them.

• 유전자가위 활용 유전 질환 모델 세포주 제작

• 오가노이드 활용 질환 모델 제작

• 실시간 분화 추척 세포주 제작 및 구축

• 약효 평가를 위한 세포주 제작 및 구축

Our laboratory is actively developing genetically edited cells for use in pharmacological evaluations. By performing gene editing in stem cells, cancer cells, and normal cells, we aim to develop suitable cells that possess biological relevance. Utilizing these engineered cells, we strive to obtain high-quality screening results. 

Additionally, through gene editing techniques, we create genetic disease models or genetically engineered cells that express fluorescent proteins such as EGFP or mCherry, enabling their application in diverse pharmacological assays. 

Moreover, we are developing cell lines that allow real-time, non-invasive monitoring of cellular homogeneity to ensure standardized and homogeneous pharmacological evaluations.