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Research Area
Drug Discovery
Drug Discovery
신약 타겟 발굴 및 Validation
화합물 활용 High Throughput Screening
약효 평가 및 작용 기전 규명
In our laboratory, we are actively involved in drug discovery research.
Our focus is on identifying druggable targets through rigorous validation processes. Utilizing high throughput screening techniques with diverse chemical libraries, we identify promising hit compounds. Subsequently, we meticulously evaluate their pharmacological effects and elucidate their mechanisms of action.
To further advance our findings, we collaborate closely with chemists to develop novel compounds exhibiting favorable medicinal properties, thereby making them suitable for patent applications.
Development of ASO Therapeutics
Development of ASO Therapeutics
Anti-sense oligonucleotide 치료 가능 질환 발굴
ASO 시퀀스 설계 및 약효 평가
약물의 정량평가가 가능한 세포주 제작
핵산 단량체의 화학적 변형 최적화 연구
Our laboratory is dedicated to the discovery and development of antisense oligonucleotide (ASO) therapeutics. We systematically identify diseases that are amenable to ASO-based intervention by integrating genetic evidence, and disease mechanism studies. Through this approach, we prioritize targets where modulation of RNA expression or splicing is expected to deliver clear therapeutic benefit, with a particular focus on disorders that are difficult to address with conventional small molecules or antibodies.
Building on these insights, we design and optimize ASO sequences and rigorously evaluate their pharmacological activity. In parallel, we generate engineered cell lines that enable precise, reproducible, and high-throughput quantification of ASO efficacy, thereby providing standardized platforms for candidate selection and lead optimization.
Furthermore, our group focuses on the chemical optimization of modified nucleoside monomers used in ASO synthesis. Through this combined effort in target selection, sequence design, quantitative cell-based evaluation, and chemical optimization, our laboratory strives to advance next-generation nucleic acid therapeutics from concept to clinic-ready candidates.
Gene Editing/Therapy by CRISPR
Gene Editing/Therapy by CRISPR
유전자가위 작동 메커니즘을 활용한 유전자가위의 한계 극복 연구
신규 유전자 가위 제작
크리스퍼 활용 희귀질환 유전자 치료제 개발
Our laboratory is conducting research to enhance the efficiency of gene editing tools. We are investigating methods to improve gene correction through HDR (homology-directed repair) by leveraging the mechanism of gene editing tools. Based on these findings, we are developing novel and high-performance gene editing tools.
Additionally, we are also engaged in the exploration of gene editing targets for rare genetic disorders and the development of therapeutic approaches to treat them.
Disease Modeling
Disease Modeling
유전자가위 활용 유전 질환 모델 세포주 제작
오가노이드 활용 질환 모델 제작
실시간 분화 추척 세포주 제작 및 구축
약효 평가를 위한 세포주 제작 및 구축
Our laboratory is actively developing genetically edited cells for use in pharmacological evaluations. By performing gene editing in stem cells, cancer cells, and normal cells, we aim to develop suitable cells that possess biological relevance. Utilizing these engineered cells, we strive to obtain high-quality screening results.
Additionally, through gene editing techniques, we create genetic disease models or genetically engineered cells that express fluorescent proteins such as EGFP or mCherry, enabling their application in diverse pharmacological assays.
Moreover, we are developing cell lines that allow real-time, non-invasive monitoring of cellular homogeneity to ensure standardized and homogeneous pharmacological evaluations.
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