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Research Theme 2
Vessel-on-a-chip platforms are sophisticated in vitro models designed to recapitulate the complex structural and functional characteristics of human vasculature. By integrating microfluidics with tissue engineering, we provide a controllable environment to study vascular physiology and pathology in high resolution.
Physiological Recapitulation of Human Vessels: We develop advanced microfluidic systems that mimic 3D angiogenic sprouting, vessel perfusion, and the blood-brain barrier (BBB). These platforms allow us to overcome the limitations of conventional 2D cultures and animal models by providing human-relevant physiological contexts.
Next-Generation Therapeutic Screening: Our research utilizes these "Organs-on-chips" to evaluate the efficacy of diverse therapeutic modalities, including drug delivery systems and immune cell therapies. By monitoring the real-time "Cancer-Vessel-Immune" interactions within the chip, we aim to accelerate the development of precision medicine and personalized treatment strategies.
Research Projects
Modeling Vascular Pathophysiology
Blood-Tumor Barrier (BTB)-on-a-Chip
Modeling Vascular Pathophysiology
Blood-Tumor Barrier (BTB)-on-a-Chip
Immune-on-a-Chip
1) Investigating the Immunosurveillance of LV
2) Screening Cell-based Immunotherapies
Immune-on-a-Chip
1) Investigating the Immunosurveillance of LV
2) Screening Cell-based Immunotherapies
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