mtDNA transfer from senescent cancer cells to MDSCs promotes immunosuppression.
Cañadas I, Murayama T, Galluzzi L. Trends Cancer. 2025 Aug;11(8):716-718. doi: 10.1016/j.trecan.2025.06.010. Epub 2025 Jul 2. PubMed PMID: 40610348.
Loss of p53 Induces Tolerance to Viral Mimicry as a Mechanism of Immune Evasion in Early Tumorigenesis.
Murayama T, Cañadas I. Cancer Discov. 2025 Apr 2;15(4):670-672. doi: 10.1158/2159-8290.CD-25-0104. PubMed PMID: 40170538.
RNA sensing induced by chromosome missegregation augments anti-tumor immunity.
Sasaki N, Homme M, Murayama T, Osaki T, Tenma T, An T, Takegami Y, Tani T, Gedeon PC, Kobayashi Y, Cañadas I, Barbie DA, Yao R, Kitajima S. Mol Cell. 2025 Feb 20;85(4):770-786.e7. doi: 10.1016/j.molcel.2024.11.025. Epub 2024 Dec 19. PubMed PMID: 39706184; PubMed Central PMCID: PMC11888943.
Targeting TREX1 Induces Innate Immune Response in Drug-Resistant Small-Cell Lung Cancer.
Murayama T, Mahadevan NR, Meador CB, Ivanova EV, Pan Y, Knelson EH, Tani T, Nakayama J, Ma X, Thai TC, Hung YP, Kim W, Watanabe H, Cai KQ, Hata AN, Paweletz CP, Barbie DA, Cañadas I. Cancer Res Commun. 2024 Sep 1;4(9):2399-2414. doi: 10.1158/2767-9764.CRC-24-0360. PubMed PMID: 39177280; PubMed Central PMCID: PMC11391691.
Murayama T, Nakayama J, Jiang X, Miyata K, Morris AD, Cai KQ, Prasad RM, Ma X, Efimov A, Belani N, Gerstein ER, Tan Y, Zhou Y, Kim W, Maruyama R, Campbell KS, Chen L, Yang Y, Balachandran S, Cañadas I. Cancer Discov. 2024 Mar 1;14(3):468-491. doi: 10.1158/2159-8290.CD-23-0486. PubMed PMID: 38189443; PubMed Central PMCID: PMC10905673.
*Highlighted in In the Spotlight in Cancer Discovery.
Takeuchi Y*, Kimura N*, Murayama T*, Machida Y, Iejima D, Nishimura T, Terashima M, Wang Y, Li M, Sakamoto R, Yamamoto M, Itano N, Inoue Y, Ito M, Yoshida N, Inoue JI, Akashi K, Saya H, Fujita K, Kuroda M, Kitabayashi I, Voon D, Suzuki T, Tojo A, Gotoh N. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43). doi: 10.1073/pnas.2103658118. PubMed PMID: 34663724; PubMed Central PMCID: PMC8639355. *co-first
Hirano M, Imai Y, Kaito Y, Murayama T, Sato K, Ishida T, Yamamoto J, Ito T, Futami M, Ri M, Yasui H, Denda T, Tanaka Y, Ota Y, Nojima M, Kamikubo Y, Gotoh N, Iida S, Handa H, Tojo A. J Exp Clin Cancer Res. 2021 Mar 23;40(1):110. doi: 10.1186/s13046-021-01909-7. PubMed PMID: 33757580; PubMed Central PMCID: PMC7989023.
Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity.
Mahadevan NR, Knelson EH, Wolff JO, Vajdi A, Saigí M, Campisi M, Hong D, Thai TC, Piel B, Han S, Reinhold BB, Duke-Cohan JS, Poitras MJ, Taus LJ, Lizotte PH, Portell A, Quadros V, Santucci AD, Murayama T, Cañadas I, Kitajima S, Akitsu A, Fridrikh M, Watanabe H, Reardon B, Gokhale PC, Paweletz CP, Awad MM, Van Allen EM, Lako A, Wang XT, Chen B, Hong F, Sholl LM, Tolstorukov MY, Pfaff K, Jänne PA, Gjini E, Edwards R, Rodig S, Reinherz EL, Oser MG, Barbie DA. Cancer Discov. 2021 Aug;11(8):1952-1969. doi: 10.1158/2159-8290.CD-20-0913. Epub 2021 Mar 11. PubMed PMID: 33707236; PubMed Central PMCID: PMC8338750.
MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells.
Murayama T*, Takeuchi Y*, Yamawaki K, Natsume T, Li M, Marcela RN, Nishimura T, Kogure Y, Nakata A, Tominaga K, Sasahara A, Yano M, Ishikawa S, Ohta T, Ikeda K, Horie-Inoue K, Inoue S, Seki M, Suzuki Y, Sugano S, Enomoto T, Tanabe M, Tada KI, Kanemaki MT, Okamoto K, Tojo A, Gotoh N. Cancer Sci. 2021 Mar;112(3):1209-1224. doi: 10.1111/cas.14776. Epub 2021 Jan 22. PubMed PMID: 33340428; PubMed Central PMCID: PMC7935783. *co-first
Murayama T, Gotoh N. Cancer Drug Resist. 2019;2(3):457-470. doi: 10.20517/cdr.2019.36. eCollection 2019. Review. PubMed PMID: 35582573; PubMed Central PMCID: PMC8992527.
Patient-Derived Xenograft Models of Breast Cancer and Their Application.
Murayama T, Gotoh N. Cells. 2019 Jun 20;8(6). doi: 10.3390/cells8060621. Review. PubMed PMID: 31226846; PubMed Central PMCID: PMC6628218.
Tominaga K, Minato H, Murayama T, Sasahara A, Nishimura T, Kiyokawa E, Kanauchi H, Shimizu S, Sato A, Nishioka K, Tsuji EI, Yano M, Ogawa T, Ishii H, Mori M, Akashi K, Okamoto K, Tanabe M, Tada KI, Tojo A, Gotoh N. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):625-630. doi: 10.1073/pnas.1806851116. Epub 2018 Dec 26. PubMed PMID: 30587593; PubMed Central PMCID: PMC6329980.
Nishimura T, Nakata A, Chen X, Nishi K, Meguro-Horike M, Sasaki S, Kita K, Horike SI, Saitoh K, Kato K, Igarashi K, Murayama T, Kohno S, Takahashi C, Mukaida N, Yano S, Soga T, Tojo A, Gotoh N. Oncogene. 2019 Apr;38(14):2464-2481. doi: 10.1038/s41388-018-0589-1. Epub 2018 Dec 7. PubMed PMID: 30532069; PubMed Central PMCID: PMC6484769.
Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells.
Tominaga K, Shimamura T, Kimura N, Murayama T, Matsubara D, Kanauchi H, Niida A, Shimizu S, Nishioka K, Tsuji EI, Yano M, Sugano S, Shimono Y, Ishii H, Saya H, Mori M, Akashi K, Tada KI, Ogawa T, Tojo A, Miyano S, Gotoh N. Oncogene. 2017 Mar 2;36(9):1276-1286. doi: 10.1038/onc.2016.293. Epub 2016 Aug 22. PubMed PMID: 27546618; PubMed Central PMCID: PMC5340799.
Murayama T*, Nakaoku T*, Enari M, Nishimura T, Tominaga K, Nakata A, Tojo A, Sugano S, Kohno T, Gotoh N. Cancer Res. 2016 Feb 15;76(4):974-83. doi: 10.1158/0008-5472.CAN-15-2135. Epub 2016 Feb 2. PubMed PMID: 26837769. *co-first