Publications

PUBLICATIONS

2024

McIntyre CA, Grimont A, Park J, Meng T, Sisso WJ, Seier K, Jang GH, Walch H, Aveson VG, Falvo DJ, Fall WB, Chan CW, Wenger A, Ecker BL, Pulvirenti A, Gelfer R, Zafra MP, Schultz N, Park W, O’Reilly EM, Houlihan SL, Alonso A, Hissong E, Church GM, Mason CE, Siolas D, Notta F, Gonen M, Dow LE, Jarnagin Park J, Chandwani. Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancer. Cancer Cell, 2024, 42(9):1614-1629.e5. doi: 10.1016/j.ccell.2024.08.002

Katti A*, Vega-Pérez A*, Foronda M, Zimmerman J, Zafra MP, Granowsky E, Goswami S, Gardner EE, Diaz BJ, Simon JM, Wuest A, Luan W, Calvo Fernandez MT, Kadina AP, Walker 2nd JA, Holden K, Lowe SW, Sánchez Rivera FJ, Dow LE. Generation of precision preclinical cancer models using regulated in vivo base editing. Nature Biotechnology, 2024, 42(3):437-447. doi: 10.1038/s41587-023-01900-x. 

2023

Blair LM, Juan MJ, Sebastian L, Tran VyB, Nie W, Wall GD, Mehmet G, Lai IK, Apilado EA, Grenot G, Amar D, Foggetti G, Carmo MC, Ugur Z, Deng D, Chenchik A, Zafra MP, Dow LE, Politi K, MacQuitty JJ, Petrov DA, Winslow MM, Rosen NJ, Winters IP. Oncogenic context shapes the fitness landscape of tumor suppression. Nature Communications, 2023, 14(1), pp. 6422. doi: 10.1038/s41467-023-42156-y.

2021

Zafra MP, Dow LE. Revealing ARID1A Function in Gastric Cancer from the Bottom Up. Cancer Discovery, 2021, 11(6), 1327-1329. doi: 10.1158/2159-8290.CD-21-0271.

2020

Zafra MP#, Parsons MJ, Kim J, Alonso-Curbelo D, Goswami S, Schatoff EM, Han T, Katti A, Calvo Fernandez MT, Wilkinson JE, Piskounova E, Dow LE#. An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants. Cancer Discovery, 2020, 10(11), 1654-1671. doi: 10.1158/2159-8290.CD-20-0442.

Teng H; Goswami S, Hu Y, Tang F, Zafra MP. Murphy C, Cao Z, Poirier JT, Khurana E, Elemento O, Hechtman JF, Ganesh, K, Yaeger R, Dow LE. Lineage reversion drives WNT independence in intestinal cancer. Cancer Discovery, 2020, 10-10, 1590-1609. doi: 10.1158/2159-8290.CD-19-1536.

Nogués A, Gallardo-Vara E, Zafra MP, Mate P, Marijuan JL, Alonso A, Botella LM, Prieto MI. Endoglin (CD105) and VEGF as potential angiogenic and dissemination markers for colorectal cancer. World J Surg Oncol, 2020, 18(1):99. doi: 10.1186/s12957-020-01871-2.

Billon P, Nambiar TS, Hayward SB, Zafra MP, Schatoff EM, Oshima K, Dunbar A, Breinig M, Park YC, Ryu HS, Tschaharganeh, Levine RL, Baer R, Ferrando A, Dow LE, Ciccia A. Detection of marker-free precision editing and Genetic variation through the capture of genomic signatures.  Cell Reports, 2020, 30(10):3280-3295. doi: 10.1016/j.celrep.2020.02.068.

Katti A, Foronda M, Zimmerman J, Diaz B, Zafra MP, Goswami S, Dow LE. Go: a functional reporter system to identify and enrich base editing activity. Nucleic Acids Research, 2020, 48(6):2841-2852. doi: 10.1093/nar/gkaa124.

Annunziato S, Lutz C, Henneman L, Bhin J, Wong K, Siteur B, Gerwen B, Korte-Grimmerink R, Zafra MP, Schatoff EM, Drenth AP, Van der Burg E, Eijkman T, Mukherjee S, Boroviak K, Fa Wessels L, Van de Ven M, Huijbers IJ, Adams DJ, Dow LE, Jonkers J. In situ CRISPR-Cas9 base editing for the development of genetically engineered mouse models of breast cancer. EMBO Journal, 2020, 39(5): e102169. doi: 10.15252/embj.2019102169.

2019

Song CQ, Jiang T, Richter M, Rhym LH, Koblan LW, Zafra MP, Schatoff EM, Doman JL, Cao Y, Dow LE, Zhu LJ, Anderson DG, Liu DR, Yin H, Xue W.  Adenine base editing  in  an  adult  mouse model of tyrosinemia. Nature Biomedical Engineering, 2019, 4-1, pp.125-130. doi: 10.1038/s41551-019-0357-8.

Schatoff EM, Goswami S, Zafra MP, Foronda M, Shusterman M, Leach BI, Katti A, Diaz BJ, Dow LE. Distinct Colorectal Cancer-Associated APC mutations dictate response to Tankyrase inhibition. Cancer Discovery, 2019, 9(10):1358-1371. doi: 10.1158/2159-8290.CD-19-0289.

Schatoff EM, Zafra MP, Dow LE. Base editing the mammalian genome. Methods, 2019, 164-165:100-108. doi: 10.1016/j.ymeth.2019.02.022.

2018

Zafra MP*, Schatoff EM*, Katti A, Foronda M, Breinig M, Schweitzer AY, Simon A, Han T, Goswami S,Montgomery E, Thibado J, Kastenhuber ER, Sánchez-Rivera FJ, Shi J, Vakoc CR, Lowe SW, Tschaharganeh DF, Dow LE. (*Co-first authors). Optimized base editors enable efficient editing in cells, organoids and mice. Nature Biotechnology, 2018, 36(9):888-893. doi: 10.1038/nbt.4194.

2017

Han T, Schatoff EM, Murphy C, Zafra MP, Wilkinson JE, Elemento O, Dow LE. R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine. Nature Communications, 2017, 8:15945. doi: 10.1038/ncomms15945.

Albiñana V, Zafra MP, Colau J, Zarrabeitia R, Recio-Poveda L, Olavarrieta L, Peréz-Pérez J, Botella LM. Mutation affecting the proximal promoter of Endoglin as the origin of hereditary hemorrhagic telangiectasia type 1. BMC Med Genet, 2017, 18(1):20. doi: 10.1186/s12881-017-0380-0.

Jara-Gutiérrez P, Zafra MP, Sanz V, Del Pozo V, Fernandez-Nieto M. Asthma due to Swiss Chard: Identification of a New Allergen. J Investig Allergol Clin Immunol, 2017, 27(1): 67-68. doi: 10.18176/jiaci.0120.

2016

Zafra MP, Dow LE. Somatic genome editing goes viral. Trends Mol Med, 2016, 22(10):831-833. doi: 10.1016/j.molmed.2016.08.004.

2015

Zafra MP, Cañas JA, Mazzeo C, Gámez C, Sanz V, Fernández-Nieto M, Quirce S, Barranco P, Ruiz-Hornillos J, Sastre J, del Pozo V. SOCS3 silencing attenuates eosinophil functions in asthma patients. Int J Mol Sci, 2015, 16(3):5434-51. doi: 10.3390/ijms16035434.

Mazzeo C, Cañas JA, Zafra MP, Rojas Marco A, Fernández-Nieto M, Sanz V, Mittelbrunn M, Izquierdo M, Baixaulli F, Sastre J, Del Pozo V. Exosome secretion by eosinophils: A possible role in asthma pathogenesis. Journal of Allergy and Clinical Immunology, 2015, 135(6):1603-13.

Gámez C, Zafra MP, Sanz V, Mazzeo C, Ibáñez MD, Sastre J, del Pozo V. Simulated gastrointestinal digestion reduces the allergic reactivity of shrimp extract proteins and tropomyosin. Food Chem, 2015, 173:475-81. doi: 10.1016/j.foodchem.2014.10.063.

Manso L, Valbuena T, Padial MA, Reche M, Zafra MP, Del Pozo V, Pascual CY. Allergy to short-acting b2-agonists in a COPD patient: Is an immunological mechanism involved? Allergol Immunopathol (Madr), 2015, 43(3):329-30. doi: 10.1016/j.aller.2014.04.003.

Pre-2015

Gámez C, Zafra M, Boquete M, Sanz V, Mazzeo C, Ibáñez MD, Sánchez-García S, Sastre J, del Pozo V. New shrimp IgE-binding proteins involved in mite-seafood cross-reactivity. Mol Nutr Food Res, 2014, 58(9):1915-25. doi: 10.1002/mnfr.201400122.

Zafra MP, Mazzeo C, Gámez C, Rodriguez Marco A, de Zulueta A, Sanz V, Bilbao I, Ruiz-Cabello J, Zubeldia JM, del Pozo V. Gene silencing of SOCS3 by siRNA intranasal delivery inhibits asthma phenotype in mice. PLoS One, 2014, 9(3):e91996. doi: 10.1371/journal.pone.0091996.

Arochena L, Zafra MP, Fariña MC, Del Pozo V, Fernández-Nieto M. Acute generalized exanthematic pustulosis due to ibuprofen. Ann Allergy Asthma Immunol, 2013, 110(5):386-7. doi: 10.1016/j.anai.2013.01.020.

Zafra MP, Cancelliere N, Rodríguez del Río P, Ruiz-García M, Estévez L, Andregnette V, Sánchez-García S, Fiandor A, Collantes E, Sastre J, Quirce S, Ibáñez MD, del Pozo V. Misregulation of suppressors of cytokine signaling in eosinophilic esophagitis. 2013, 48(8):910-20. doi: 10.1007/s00535-012-0723-8.

López E, Zafra MP, Sastre B, Gámez C, Fernández-Nieto M, Sastre J, Lahoz C, Quirce S, Del Pozo V. Suppressors of cytokine signaling 3 expression in eosinophils: regulation by PGE2 and Th2 cytokines. Clin Dev Immunol, 2011:917015.  doi: 10.1155/2011/917015.

López E, Zafra MP, Sastre B, Gámez C, Lahoz C, del Pozo V. Gene expression profiling in lungs of chronic asthmatic mice treated with galectin-3: downregulation of inflammatory and regulatory genes. Mediators Inflamm, 2011, 823279. doi: 10.1155/2011/823279.

Acosta YY, Zafra MP, Ojeda G, Bernardone IS, Dianzani U, Portolés P, Rojo JM. Biased binding of class IA phosphatidyl inositol 3-kinase subunits to inducible costimulatory (CD278). Cell Mol Life Sci, 2011, 68(18):3065-79. doi: 10.1007/s00018-010-0606-1.