In this study, we apply homeostatic RL to the Crafter, an open-ended environment in deep RL. We implemented homeostatic RL through motivation based on homeostasis for Health, Hunger, and Thirst, and Energy (Figure A). We constructed a policy consisting of a convolutional neural network (Resnet) and RNN, and used images and interoception as inputs (Figure B). We used Asynchronous PPO to optimize the training for 5B steps, and obtained an agent that could survive for up to 10,000 steps (right panel, red lines), the maximum number of steps for Crafter. We oberved that the agent could acquire various survival skills such as foraging and water collection, as well as attacking enemies and building shelters, in an integrated manner with the aim of maintaining homeostasis within the body.