Publications

<学術誌論文>

1.   Yamagishi, M., Miyata, K., Kamatani, T., Kabata, H., Baba, Rie., Tanaka, Y., Suzuki, N., Matsusaka, M., Motomura, Y., Kiniwa, T., Koga, S., Goda, K., Ohara, O., Funatsu, T., Fukunaga, K., Moro, K., Uematsu, S., Shirasaki, Y. Quantitative live-cell imaging of secretion activity reveals dynamic immune responses, iScience 27(6), (2024)

2.   Otaki, N., Motomura, Y., Terooatea, T., Thomas Kelly, S., Mochizuki, M., Takeno, N., Koyasu, S., Tamamitsu, M., Sugihara, F., Kikuta, J., Kitamura, H., Shiraishi, Y., Miyanohara, J., Nagano, Y., Saita, Y., Ogura, T., Asano, K., Minoda, A., Moro, K. Activation of ILC2s through constitutive IFNγ signaling reduction leads to spontaneous pulmonary fibrosis. Nature communications 14, 8120, (2023)

3.   Tanaka, Y., Yamagishi, M., Motomura, Y., Kamatani, T., Oguchi, Y., Suzuki, N., Kiniwa, T., Kabata, H., Irie, M., Tsunoda, T., Miya, F., Goda, K., Ohara, O., Funatsu, T., Fukunaga, K., Moro, K., Uemura, S., Shirasaki, Y. Time-dependent cell-state selection identifies transiently expressed genes regulating ILC2 activation. Communications biology 6, 915, (2023)

4.   Imanishi, T., Unno, M., Yoneda, N., Motomura, Y., Mochizuki, M., Sasaki, T., Pasparakis, M., and Saito, T. RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8. Science advances 9, eadd6097, (2023)

5.   Naito M., Nakanishi., Y, Motomura, Y., Takamatsu, H., Koyama, S., Nishide, M., Naito, Y., Izumi, M., Mizuno, Y., Yamaguchi, Y., Nojima, S., Okuzaki, D., Kumanogoh, A. Semaphorin 6D-expressing mesenchymal cells regulate IL-10 production by ILC2s in the lung. Life Sci Alliance 5(11):e202201486, (2022)

6.   Hikichi, Y., Motomura, Y*., Takeuchi, O., Moro, K*. Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin. J Exp Med 218, (2021) *Co-coresponding

7.   Momiuchi, Y#., Motomura, Y#., Suga, E., Mizuno, H., Kikuta, J., Morimoto, A., Mochizuki, M., Otaki, N., Ishii, M., Moro, K. Group 2 innate lymphoid cells in bone marrow regulate osteoclastogenesis in a reciprocal manner via RANKL, GM-CSF and IL-13. Int Immunol 33: 573-85, (2021)  #Equally contribution

8.   Matsuyama, T., Machida, K., Motomura, Y., Takagi, K., Doutake, Y., Tanoue-Hamu, A., Kondo, K., Mizuno, K., Moro, K., and Inoue, H*.  Long-acting muscarinic antagonist regulates group 2 innate lymphoid cell-dependent airway eosinophilic inflammation. Allergy 76(9):2785-2796, (2021)

9.   Sudo, T., Motomura, Y., Okuzaki, D., Hasegawa, T., Yokota, T., Kikuta, J., Ao, T., Mizuno, H., Matsui, T., Motooka, D., Yoshizawa, R., Nagasawa, T., Kanakura, Y., Moro, K., and Ishii, M*.  Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions. The Journal of experimental medicine 218, (2021)

10.  Nakatsuka, Y., Yaku, A., Handa, T., Vandenbon, A., Hikichi, Y., Motomura, Y., Sato, A., Yoshinaga, M., Tanizawa, K., Watanabe, K., Hirai, T., Chin, K., Suzuki, Y., Uehara, T., Mino, T., Tsujimura, T., Moro, K., and Takeuchi, O*. Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by Regnase-1. Eur Respir J. 57(3):2000018, (2020)

11.  Satoh-Takayama, N*., Kato, T., Motomura, Y., Kageyama, T., Taguchi-Atarashi, N., Kinoshita-Daitoku, R., Kuroda, E., Di Santo, J.P., Mimuro, H., Moro, K., and Ohno, H*. Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA. Immunity 52, 635-649.e634, (2020)

12.  Miyajima, Y., Ealey, K.N., Motomura, Y., Mochizuki, M., Takeno, N., Yanagita, M., Economides, A.N., Nakayama, M., Koseki, H., and Moro, K*. Effects of BMP7 produced by group 2 innate lymphoid cells on adipogenesis. International immunology 32, 407-419, (2020)

13.  Wagner, M*., Ealey, K.N., Tetsu, H., Kiniwa, T., Motomura, Y., Moro, K., and Koyasu, S*. Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s. Cell Rep 30, 2743-2757.e2745, (2020).

14.  Jiang, X., Kumar, A., Motomura, Y., Liu, T., Zhou, Y., Moro, K., Zhang, K.Y.J*., and Yang, Q*. A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors. J Med Chem 63, 987-1001, (2020)

15.  Hosokawa, H*., Romero-Wolf, M., Yang, Q., Motomura, Y., Levanon, D., Groner, Y., Moro, K., Tanaka, T., and Rothenberg, E.V*. Cell type-specific actions of Bcl11b in early T-lineage and group 2 innate lymphoid cells. The Journal of experimental medicine 217, (2020)

16.  Motomura, Y., Kobayashi, T., and Moro, K*. The Neuropeptide CGRP Induces Bipolar Syndrome in Group 2 Innate Lymphoid Cells. Immunity 51, 598-600, (2019)

17.  Miyai, T., Takano, J., Endo, T.A., Kawakami, E., Agata, Y., Motomura, Y., Kubo, M., Kashima, Y., Suzuki, Y., Kawamoto, H., and Ikawa, T*. Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells. Genes Dev 32, 112-126, (2018)

18.  Nagashima, H., Okuyama, Y., Fujita, T., Takeda, T., Motomura, Y., Moro, K., Hidaka, T., Omori, K., Sakurai, T., Machiyama, T., Ndhlovu, LC., Riccardi, C., So, T., and Ishii N*. GITR cosignal in ILC2s controls allergic lung inflammation. The Journal of allergy and clinical immunology 141, 1939-1943.e1938, (2018)

19.  Nakano, N*., Nishiyama, C., Yagita, H., Hara, M., Motomura, Y., Kubo, M., Okumura, K., and Ogawa, H*. Notch signaling enhances FcεRI-mediated cytokine production by mast cells through direct and indirect mechanisms. Journal of immunology 194, 4535-4544, (2015)

20.  Xu, W., Domingues, R.G., Fonseca-Pereira, D., Ferreira, M., Ribeiro, H., Lopez-Lastra, S., Motomura, Y., Moreira-Santos, L., Bihl, F., Braud, V., Kee, B., Brady, H., Coles, MC., Vosshenrich, C., Kubo, M., Di Santo, JP., and Veiga-Fernandes*. NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors. Cell Rep 10, 2043-2054, (2015)

21.  Motomura, Y., Morita, H., Moro, K., Nakae, S., Artis, D., Endo, T.A., Kuroki, Y., Ohara, O., Koyasu, S., and Kubo, M*. Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation. Immunity 40, 758-771, (2014)

22.  Furusawa, J., Moro, K*., Motomura, Y., Okamoto, K., Zhu, J., Takayanagi, H., Kubo, M., and Koyasu, S*. Critical role of p38 and GATA3 in natural helper cell function. Journal of immunology 191, 1818-1826, (2013)

23.  Kubo, M*., and Motomura, Y. Transcriptional regulation of the anti-inflammatory cytokine IL-10 in acquired immune cells. Frontiers in immunology 3, 275, (2012)

24.  Uto-Konomi, A., Miyauchi, K., Ozaki, N., Motomura, Y., Suzuki, Y., Yoshimura, A., Suzuki, S., Cua, D., and Kubo, M*.  Dysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokines. PloS one 7, e40343, (2012)

25.  Harada, Y., Tanaka, S., Motomura, Y., Harada, Y., Ohno, S., Ohno, S., Yanagi, Y., Inoue, H., and Kubo, M*. The 3' enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells. Immunity 36, 188-200, (2012)

26.  Watarai, H*., Sekine-Kondo, E., Shigeura, T., Motomura, Y., Yasuda, T., Satoh, R., Yoshida, H., Kubo, M., Kawamoto, H., Koseki, H., and Taniguchi, M. Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines. PLoS Biol 10, e1001255, (2012)

27.  Motomura, Y., Kitamura, H., Hijikata, A., Matsunaga, Y., Matsumoto, K., Inoue, H., Atarashi, K., Hori, S., Watarai, H., Zhu, J., Taniguchi, M., and Kubo, M*.The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nature immunology 12, 450-459, (2011)

28.  Tanaka, S#., Motomura, Y#., Suzuki, Y., Yagi, R., Inoue, H., Miyatake, S., and Kubo, M*. The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. Nature immunology 12, 77-85, (2011) #Equally contribution

29.  Yagi, R., Tanaka, S., Motomura, Y., and Kubo, M. Regulation of the Il4 gene is independently controlled by proximal and distal 3' enhancers in mast cells and basophils. Mol Cell Biol 27, 8087-8097, (2007)

＜著書＞

       Kabata H, Motomura Y, Kiniwa T, Kobayashi T, Moro K. ILCs and Allergy. Adv Exp Med Biol 1365: 75-95, (2022)