Publication
論文リスト (Publication List)
53. Jeesoo Choi, Anna Nawachi, Natsuki Saito, Yuta Kondo, Hiroyuki Morimoto*, Takashi Ohshima*
Evaluation of functional group compatibility and development of reaction-accelerating additives in ammonium salt-accelerated hydrazinolysis of amides
Front. Chem. 2024, accepted.
Published as a part of Recent Advances in Synthesizing and Utilizing Nitrogen-containing Heterocycles
52. Yuta Kondo, Hiroyuki Morimoto*, Takashi Ohshima*
Development of Novel Catalytic Direct Syntheses of N-Unsubstituted Ketimines and Their Applications to One-Pot Reactions
Synlett 2024, 35, 379–393. (invited account)
DOI: 10.1055/a-2131-3448
Published in 11th Singapore International Chemistry Conference (SICC-11)
51. Hiroyuki Morimoto*
Development of Unactivated Bond Cleavage Reactions Under Mild Conditions Based on Stabilization of Addition Intermediates
Yakugaku Zasshi, 2023, 143, 1005–1012. (invited review for incentive award; in Japanese)
50. Emna Mejri, Kosuke Higashida, Yuta Kondo, Anna Nawachi, Hiroyuki Morimoto, Takashi Ohshima, Masaya Sawamura*, Yohei Shimizu*
Visible-Light-Induced Aminochlorination of Alkenes
Org. Lett. 2023, 25, 4581–4585.
49. Natsuki Saito, Anna Nawachi, Yuta Kondo, Jeesoo Choi, Hiroyuki Morimoto*, Takashi Ohshima*
Functional Group Evaluation Kit for Digitalization of Information on the Functional Group Compatibility and Chemoselectivity of Organic Reactions
Bull. Chem. Soc. Jpn. 2023, 96, 465–474.
Selected as BCSJ Award Article and a Cover Picture
Press Release from Kyushu University and Kyutech
48. Koki Yamada, Yuta Kondo, Akihiko Kitamura, Tetsuya Kadota, Hiroyuki Morimoto*, Takashi Ohshima*
Organocatalytic Direct Enantioselective Hydrophosphonylation of N-Unsubstituted Ketimines for the Synthesis of α-Aminophosphonates
ACS Catal. 2023, 13, 3158–3163.
Selected as a Cover Picture
Press Release from Kyushu University
Highlighted by ChemStation (in Japanese)
Preprint published in ChemRxiv 2022.
47. Lu Lin, Shunsuke Kataoka, Kiichi Hirayama, Ryozo Shibuya, Kenji Watanabe, Hiroyuki Morimoto, Takashi Ohshima*
O- and N-Selective Electrophilic Activation of Allylic Alcohols and Amines in Pd-Catalyzed Direct Alkylation
Chem. Pharm. Bull. 2023, 71, 101–106.
DOI: 10.1248/cpb.c22-0074
Published in Current Topics - Transition Metal Catalysis Research in Pharmaceutical Organic Chemistry
46. Yuta Kondo, Yoshinobu Hirazawa, Tetsuya Kadota, Koki Yamada, Kazuhiro Morisaki, Hiroyuki Morimoto*, Takashi Ohshima*
One-Pot Catalytic Synthesis of α-Tetrasubstituted Amino Acid Derivatives via In Situ Generation of N-Unsubstituted Ketimines
Org. Lett. 2022, 24, 6594–6598.
45. Tsukasa Shimauchi, Takuro Numaga-Tomita, Yuri Kato, Hiroyuki Morimoto, Kosuke Sakata, Ryosuke Matsukane, Akiyuki Nishimura, Kazuhiro Nishiyama, Atsushi Shibuta, Yutoku Horiuchi, Hitoshi Kurose, Sang Geon Kim, Yasuteru Urano, Takashi Ohshima, Motohiro Nishida*
A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia
Cells 2022, 11, 2041. (19 pages)
44. Hiroyuki Morimoto*
Development of Greener Catalytic Synthetic Methods of Nitrogen-Containing Compounds Using N-Unprotected Ketimines
J. Synth. Org. Chem. Jpn. 2022, 80, 2–13. (in Japanese)
DOI: 10.5059/yukigoseikyokaishi.80.2
An article for Incentive Award in Synthetic Organic Chemistry, Japan
43. Tetsuya Kadota, Masanao Sawa, Yuta Kondo, Hiroyuki Morimoto* and Takashi Ohshima*
Catalytic Enantioselective Strecker Reaction of Isatin-Derived N-Unsubstituted Ketimines
Org Lett. 2021, 23, 4553–4558.
DOI: 10.1021/acs.orglett.1c01194
Selected as a Cover Picture
42. Hai-Long Xin, Bo Pang, Jeesso Choi, Walaa Akkad, Hiroyuki Morimoto* and Takashi Ohshima*
C–C Bond Cleavage of Unactivated 2-Acylimidazoles
J. Org. Chem. 2020, 85, 11592–11606.
Selected as a Featured Article
Highlighted by ChemistryViews
41. Kazuhiro Morisaki, Hiroyuki Morimoto* and Takashi Ohshima*
Recent Progress on Catalytic Addition Reactions to N-Unsubstituted Imines
ACS Catal. 2020, 10, 6924–6951. (Review)
40. Yuta Kondo, Hiroyuki Morimoto* and Takashi Ohshima*
Recent Progress towards the Use of Benzophenone Imines as an Ammonia Equivalent
Chem. Lett. 2020, 49, 497–504. (Highlight Review)
DOI: 10.1246/cl.200099
Highlighted as Inside Cover
39. Ryohei Yonesaki, Ibuki Kusagawa, Hiroyuki Morimoto*, Tamio Hayashi* and Takashi Ohshima*
Rhodium(I)/Chiral Diene-Catalyzed Enantioselective Addition of Boronic Acids to N-Unsubstituted Isatin-Derived Ketimines
Chem. Asian J. 2020, 15, 499–502.
Published in 100th Annual Meeting of the Chemical Society of Japan
Highlighted by ChemistryViews
38. Yuta Kondo, Tetsuya Kadota, Yoshinobu Hirazawa, Kazuhiro Morisaki, Hiroyuki Morimoto* and Takashi Ohshima*
Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines
Org. Lett. 2020, 22, 120–125.
37. Hiroyuki Morimoto*, Walaa Akkad, Toru Deguchi and Takashi Ohshima*
Mechanistic Studies of Nickel(II)-Catalyzed Direct Alcoholysis of 8-Aminoquinoline Amides
Heterocycles 2020, 101, 471–485.
Published in Kaoru Fuji's Special Issues
36. Takuya Yokoyama, Masaki Yukuhiro, Yuka Iwasaki, Chika Tanaka, Kazunari Sankoda, Risa Fujiwara, Atsushi Shibuta, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Kazumasa Yoshida, Nozomi Sugimoto, Hiroyuki Morimoto, Hidetaka Kosako, Takashi Ohshima* and Masatoshi Fujita*
Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10
Sci. Rep. 2019, 9, 16825. (13 pages)
35. Yuta Kondo, Kazuhiro Morisaki, Yoshinobu Hirazawa, Hiroyuki Morimoto* and Takashi Ohshima*
A Convenient Preparation Method for Benzophenone Imine Catalyzed by Tetrabutylammonium Fluoride
Org. Process Res. Dev. 2019, 23, 1718–1724.
Published in Honoring 25 Years of the Buchwald-Hartwig Amination
34. Megumi Noshita, Yuhei Shimizu, Hiroyuki Morimoto*, Shuji Akai, Yoshitaka Hamashima, Noriyuki Ohneda, Hiromichi Odajima and Takashi Ohshima*
Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process
Org. Process Res. Dev. 2019, 23, 588–594.
Published in Japanese Society for Process Chemistry
33. Masanao Sawa, Shotaro Miyazaki, Ryohei Yonesaki, Hiroyuki Morimoto* and Takashi Ohshima*
Catalytic Enantioselective Decarboxylative Mannich-Type Reaction of N-Unprotected Isatin-Derived Ketimines
Org. Lett. 2018, 20, 5393–5397.
32. Ryohei Yonesaki, Yuta Kondo, Walaa Akkad, Masanao Sawa, Kazuhiro Morisaki, Hiroyuki Morimoto* Takashi Ohshima*
3‐Mono‐Substituted BINOL Phosphoric Acids as Effective Organocatalysts in Direct Enantioselective Friedel‐Crafts‐Type Alkylation of N‐Unprotected α‐Ketiminoester
Chem. Eur. J. 2018, 24, 15211–15214.
Selected as a Hot Paper
31. Kazuhiro Morisaki, Hiroyuki Morimoto, Kazushi Mashima and Takashi Ohshima*
Development of Direct Enantioselective Alkynylation of α-Ketoester and α-Ketiminoesters Catalyzed by Phenylbis(oxazoline)Rh(III) Complexes
J. Synth. Org. Chem. Jpn. 2018, 76, 226–240. (in Japanese)
30. Kazuhiro Morisaki, Yuta Kondo, Masanao Sawa, Hiroyuki Morimoto* and Takashi Ohshima*
Synthesis of 1-Tetrasubstituted 2,2,2-Trifluoroethylamine Derivatives via Palladium-Catalyzed Allylation of sp3 C–H Bonds
Chem. Pharm. Bull. 2017, 65, 1089–1092.
29. Amrita Das, Kenji Watanabe*, Hiroyuki Morimoto and Takashi Ohshima*
Boronic Acid-Accelerated Three-Component Reaction for the Synthesis of α-Sulfanyl-Substituted Indole-3-Acetic Acids
Org Lett. 2017, 19, 5794–5797.
28. Masanao Sawa, Kazuhiro Morisaki, Yuta Kondo, Hiroyuki Morimoto* and Takashi Ohshima*
Direct Access to N-Unprotected α- and/or β-Tetrasubstituted Amino Acid Esters via Direct Catalytic Mannich-Type Reactions using N-Unprotected Trifluoromethyl Ketimines
Chem. Eur. J. 2017, 23, 17022–17028.
Selected as a Hot Paper and a Cover Picture
27. Kazuhiro Morisaki, Hiroyuki Morimoto* and Takashi Ohshima*
Direct access to N-unprotected tetrasubstituted propargylamines via direct catalytic alkynylation of N-unprotected trifluoromethyl ketimines
Chem. Commun. 2017, 53, 6319–6322.
DOI: 10.1039/C7CC02194A
Selected as a Inside back cover
Press Release from Kyushu University JPN / ENG
Highlighted by ChemStation (in Japanese)
26. Toru Deguchi, Hai-Long Xin, Hiroyuki Morimoto* and Takashi Ohshima*
Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides
ACS Catal. 2017, 7, 3157–3161.
25. Kazuhiro Morisaki, Hiroyuki Morimoto, Kazushi Mashima and Takashi Ohshima*
Direct Enantioselective Alkynylation of α-Ketoesters and α-Ketiminoesters Catalyzed by [Bis(oxazoline)phenyl]rhodium(III) Complexes
Heterocycles 2017, 95, 637–661. (review)
Published in Masakatsu Shibasaki's Special Issues
24. Megumi Noshita, Yuhei Shimizu, Hiroyuki Morimoto* and Takashi Ohshima*
Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas
Org Lett. 2016, 18, 6062–6065.
23. Kazuhiro Morisaki, Masanao Sawa, Ryohei Yonesaki, Hiroyuki Morimoto*, Kazushi Mashima and Takashi Ohshima*
Mechanistic Studies and Expansion of the Substrate Scope of Direct Enantioselective Alkynylation of α-Ketiminoesters Catalyzed by Adaptable (Phebox)Rh(III) Complexes
J. Am. Chem. Soc. 2016, 138, 6194–6203.
DOI: 10.1021/jacs.6b01590
Press Release from Kyushu University JPN / ENG
Highlighted by Chem-Station
22. Makoto Ohira, Yuka Iwasaki, Chika Tanaka, Michitaka Kuroki, Naoki Matsuo, Tatsuhiko Kitamura, Masaki Yukuhiro, Hiroyuki Morimoto, Nisha Pang, Bei Liu, Tohru Kiyono, Masahide Amemiya, Kozo Tanaka, Kazumasa Yoshida, Nozomi Sugimoto, Takashi Ohshima* and Masatoshi Fujita*
A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo
Biochim. Biophys. Acta Gen. Sub. 2015, 1850, 1676–1684.
21. Ming Zhang, Kenji Watanabe, Masafumi Tsukamoto, Ryozo Shibuya, Hiroyuki Morimoto and Takashi Ohshima*
A Short Scalable Route to (−)-α-Kainic Acid Using Pt-Catalyzed Direct Allylic Amination
Chem. Eur. J. 2015, 21, 3937–3941.
20. Yuhei Shimizu, Megumi Noshita, Yuri Mukai, Hiroyuki Morimoto* and Takashi Ohshima*
Cleavage of unactivated amide bonds by ammonium salt-accelerated hydrazinolysis
Chem. Commun. 2014, 50, 12623–12625.
DOI: 10.1039/C4CC02014F
Selected as a Back cover
19. Hiroyuki Morimoto*, Risa Fujiwara, Yuhei Shimizu, Kazuhiro Morisaki and Takashi Ohshima*
Lanthanum(III) Triflate Catalyzed Direct Amidation of Esters
Org. Lett. 2014, 16, 2018–2021.
DOI: 10.1021/ol500593v
18. Kazuhiro Morisaki, Masanao Sawa, Jun-ya Nomaguchi, Hiroyuki Morimoto, Yosuke Takeuchi, Kazushi Mashima* and Takashi Ohshima*
Rh-Catalyzed Direct Enantioselective Alkynylation of α-Ketiminoesters
Chem. Eur. J. 2013, 19, 8417–8420.
Highlighted by Synfacts 2013, 9, 0976.
17. Yuhei Shimizu, Hiroyuki Morimoto, Ming Zhang and Takashi Ohshima*
Microwave-Assisted Deacylation of Unactivated Amides Using Ammonium-Salt-Accelerated Transamidation
Angew. Chem., Int. Ed. 2012, 51, 8564–8567.
16. Gang Lu, Tatsuhiko Yoshino, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Stereodivergent Direct Catalytic Asymmetric Mannich-Type Reactions of α-Isothiocyanato Ester with Ketimines
Angew. Chem., Int. Ed. 2011, 50, 4382–4385.
Highlighted by Synfacts 2011, 0861.
15. Hiroyuki Morimoto, Tetsu Tsubogo, Nichole D. Litvinas and John F. Hartwig*
A Broadly Applicable Copper Reagent for Trifluoromethylations and Perfluoroalkylations of Aryl Iodides and Bromides
Angew. Chem., Int. Ed. 2011, 50, 3793–3798.
Cited by Wikipedia
The reagent (phen)CuCF3 is commercially available (CAS No. 1300746-79-5).
14. Takafumi Yukawa, Bianca Seelig, Yingjie Xu, Hiroyuki Morimoto, Shigeki Matsunaga*, Albrecht Berkessel* and Masakatsu Shibasaki*
Catalytic Asymmetric Aza-Morita−Baylis−Hillman Reaction of Methyl Acrylate: Role of a Bifunctional La(O-iPr)3/Linked-BINOL Complex
J. Am. Chem. Soc. 2010, 132, 11988–11992.
DOI: 10.1021/ja103294a
13. Tatsuhiko Yoshino, Hiroyuki Morimoto, Gang Lu, Shigeki Matsunaga* and Masakatsu Shibasaki*
Construction of Contiguous Tetrasubstituted Chiral Carbon Stereocenters via Direct Catalytic Asymmetric Aldol Reaction of α-Isothiocyanato Esters with Ketones
J. Am. Chem. Soc. 2009, 131, 17082–17083.
DOI: 10.1021/ja908571w
Highlighted by Synfacts 2010, 0321.
12. Keiichi Hara, Shin-ya Tosaki, Vijay Gnanadesikan, Hiroyuki Morimoto, Shinji Harada, Mari Sugita, Noriyuki Yamagiwa, Shigeki Matsunaga* and Masakatsu Shibasaki*
Mixed La-Li Heterobimetallic Complexes for Tertiary Nitroaldol Resolution
Tetrahedron 2009, 65, 5030–5036.
11. Hiroyuki Morimoto, Tatsuhiko Yoshino, Takafumi Yukawa, Gang Lu, Shigeki Matsunaga* and Masakatsu Shibasaki*
Lewis Base Assisted Brønsted Base Catalysis: Bidentate Phosphine Oxides as Activators and Modulators of Brønsted Basic Lanthanum-Aryloxides
Angew. Chem. Int. Ed. 2008, 47, 9125–9129.
Highlighted by Synfacts 2009, 0178.
10. Gang Lu, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Chiral γ-Amino Amide Synthesis by Heterobimetallic Lanthanum/Lithium/Pybox-Catalyzed Direct Asymmetric Mannich-Type Reactions of α-Keto Anilides
Angew. Chem. Int. Ed. 2008, 47, 6847–6850.
9. Zhihua Chen, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
A Bench-Stable Homodinuclear Ni2-Schiff Base Complex for Catalytic Asymmetric Synthesis of α-Tetrasubstituted anti-α,β-Diamino Acid Surrogates
J. Am. Chem. Soc. 2008, 130, 2170–2171.
DOI: 10.1021/ja710398q
Highlighted by Synfacts 2008, 0488.
8. Hiroyuki Morimoto, Gang Lu, Naohiro Aoyama, Shigeki Matsunaga* and Masakatsu Shibasaki*
Lanthanum Aryloxide/Pybox-Catalyzed Direct Asymmetric Mannich-Type Reactions Using a Trichloromethyl Ketone as a Propionate Equivalent Donor
J. Am. Chem. Soc. 2007, 129, 9588–9589.
DOI: 10.1021/ja073285p
7. So-Young Park, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Catalytic Asymmetric Michael Reactions of Malonate to α,β-Unsaturated N-Acylpyrroles Using a La(O-iPr)3/Ph-linked-BINOL Complex
Tetrahedron Lett. 2007, 48, 2815–2818.
DOI: 10.1016/j.tetlet.2007.02.112
Highlighted by Synfacts 2007, 0620.
6. Hiroyuki Kakei, Riichiro Tsuji, Takashi Ohshima, Hiroyuki Morimoto, Shigeki Matsunaga and Masakatsu Shibasaki*
Catalytic Asymmetric Epoxidation of α,β-Unsaturated Esters Using Chiral Yttrium-Biaryldiol Complexes
Chem. Asian J. 2007, 2, 257–264.
5. Zhihua Chen, Hiroyuki Morimoto, Shigeki Matsunaga* and Masakatsu Shibasaki*
Catalytic Asymmetric Epoxidation of α-Methyl α,β-Unsaturated Anilides as Ester Surrogates
Synlett 2006, 3529–3532.
Highlighted by Synfacts 2007, 0286.
4. Shin-ya Tosaki, Keiichi Hara, Vijay Gnanadesikan, Hiroyuki Morimoto, Shinji Harada, Mari Sugita, Noriyuki Yamagiwa, Shigeki Matsunaga* and Masakatsu Shibasaki*
Mixed La-Li Heterobimetallic Complexes for Tertiary Nitroaldol Resolution
J. Am. Chem. Soc. 2006, 128, 11776–11777.
DOI: 10.1021/ja064858l
Highlighted by Synfacts 2007, 0052.
3. Hiroyuki Morimoto, Sean H. Wiedemann, Akitake Yamaguchi, Shinji Harada, Zhihua Chen, Shigeki Matsunaga* and Masakatsu Shibasaki*
Trichloromethyl Ketones as Synthetically Versatile Donors: Application in Direct Catalytic Mannich-type Reactions and Stereoselective Synthesis of Azetidines
Angew. Chem., Int. Ed. 2006, 45, 3146–3150.
Selected as a Hot Paper
2. Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai, Shigeki Matsunaga* and Masakatsu Shibasaki*
Non-C2-Symmetric, Chirally Economical, and Readily Tunable Linked-BINOLs: Design and Application in Direct Catalytic Asymmetric Mannich-type Reaction
Angew. Chem., Int. Ed. 2005, 44, 3470–3474.
1. Shigeki Matsunaga, Takamasa Yoshida, Hiroyuki Morimoto, Naoya Kumagai and Masakatsu Shibasaki*
Direct Catalytic Asymmetric Mannich-type Reaction of Hydroxyketone Using a Et2Zn/linked-BINOL Complex: Synthesis of Either anti- or syn-β-Amino Alcohols
J. Am. Chem. Soc. 2004, 126, 8777–8785.
DOI: 10.1021/ja0482435
