Objective Staging of Axillary Nodes

An objective nodal staging system for breast cancer patients undergoing neoadjuvant systemic treatment

Background: In this study, we aimed to develop an objective staging system to determine the degree of nodal metastasis in breast cancer patients undergoing neoadjuvant systemic treatment (NST).

Methods: We reviewed the pre-treatment computed tomography (CT) images of 393 breast cancer patients who received NST. The association between the patterns of the enlarged regional lymph nodes and treatment outcome was analyzed.

Results: In the development cohort of 261 patients, 89 (34.1%) patients experienced tumor recurrence whom had significantly higher number of enlarged lymph nodes on the pre-treatment CT compared to patients with no recurrence. When patients were classified according to the numbers and locations of enlarged lymph nodes on pre-treatment CT, the number of lymph nodes larger than 1cm was most significantly associated with tumor recurrence. The accuracy of the CT-based nodal staging system was validated in an independent cohort of 132 patients. The presence of the enlarged supraclavicular nodes was associated with worse outcome, but the effect seemed to originate from the accompanied extensive axillary nodal burden. The prognostic effect of the objectively measured axillary nodal metastasis was more pronounced in hormone receptor negative tumors.

Conclusions: We have developed and validated an objective method of nodal staging in breast cancer patients who undergo NST based on the number of the enlarged axillary lymph nodes. Our system can improve the current subjective approach using physical examination alone.

BMC Cancer http://rdcu.be/s9rg PMID: 28569197