Publications

Molecules
Volume 26 (13); 2021

Anticancer Activity of 2-O-caffeoyl Alphitolic Acid Extracted from the Lichen, Usnea barbata 2017-KL-10

Chae HJ, Kim GJ, Deshar B, Kim HJ, Shin MJ, Kwon H, Youn UJ, Nam JW, Kim SH, Choi H, Suh SS.

In this study, we demonstrated that 2OCAA, a secondary metabolite from Usnea barbata 2017-KL-10, a Chilean lichen, exhibited potential anticancer activities on HCT116 cell lines. The anticancer activities included effective inhibition of cell growth, induction of apoptosis through the modulation of apoptosis-associated genes, and suppression of migration and invasion. To the best of our knowledge, this study is the first to analyze the role of 2OCAA in the colorectal cancer cell line (HCT116). On the basis of the results from these studies, more specific functions of the anticancer activities of 2OCAA in other cell lines or in vivo are required for clinical trials. Taken together, our findings indicate that 2OCAA is a potential therapeutic candidate for inhibiting colorectal cancer.

Keywords: colorectal cancer; 2-O-caffeoyl alphitolic acid; lichen; Usnea barbata; apoptosis; HCT116

New anti-adipogenic triterpenoid saponins from the aerial parts of Glinus oppositifolius (Click)

Kim-Hoa Phi, Min-Ha Park, Seulah Lee, Man Hyung Koo, Sung Suk Suh, Ui Joung Youn

Biomedicine & Pharmacotherapy 176 (2024) 116851

MiR-29 and MiR-140 regulate TRAIL-induced drug tolerance in lung cancer (Click)

Suyeon Kima, Ki Wook Leea, Yongjin Yoob , Sang Hee Parka , Ji Won Leea , Suhyun Jeonc , Shaginyan Illiaa , Pooja Joshid , Hyun Woo Parka , Han-En Loa , Jimin Seoa , Yeonwoo Kima , Min Changa , Tae Jin Leee , Jong Bae Seoc , Sung-Hak Kimf , Carlo M. Croced , Inki Kimg , Sung-Suk Suh and Young-Jun Jeona

ANIMAL CELLS AND SYSTEMS 2024, VOL. 28, NO. 1, 184–197

Stellera chamaejasme L. extract inhibits adipocyte differentiation through activation of the extracellular signal-regulated kinase pathway. (Click)

Jaegoo Yeon, Eunbin Kim, Badamtsetseg Bazarragchaa , Soo-Yong Kim , Jin Young Huh , Hyuntae Park , Sung-Suk Suh, Jong Bae Seo

PLoS ONE 19(3): e0300520.

CREB5 promotes the proliferation and self-renewal ability of glioma stem cells. (Click)

Hyun-Jin Kim, Hye-Min Jeon, Don Carlo Batara, Seongsoo Lee, Suk Jun Lee, Jinlong Yin, Sang-Ik Park, Minha Park, Jong Bae Seo, Jinik Hwang, Young Joon Oh, Sung-Suk Suh and Sung-Hak Kim

Cell Death Discovery (2024) 10:103

Methanol extract of Elsholtzia fruticosa promotes 3T3-L1 preadipocyte differentiation. (Click)

Deumaya Shrestha , Eunbin Kim , Krishna K. Shrestha , Sung-Suk Suh, Sung-Hak Kim and Jong Bae Seo

J Anim Sci Technol 2024;66(1):204-218

SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation. (Click)

Jin Eom, Juhyun Choi, Sung-Suk Suh, and Jong Bae Seo

Mol. Cells 2022; 45(12): 963-975

7β-22 Dihydroxyhopane, Isolated from the Sub-Antarctic Lichen, Inhibits the Viability and Stemness in Glioma Stem Like Cells. (Click)

Sung-Suk Suh, Kim HJ, Park J, Shin MJ, Koo MH , Lee SJ, Jeon YJ, Lee S, Youn UJ, Kim SH

OncoTargets and Therapy 2022:15 November 2022

Lucidumol A, Purified Directly from Ganoderma lucidum, Exhibits Anticancer Effect and Cellular Inflammatory Response in Colorectal Cancer (Click)

Min-Ji Shin, Hae-Jung Chae, Ji Won Lee, Man Hyung Koo, Hyun-Jin Kim, Jong Bae Seo, Shagin yanIllia, Sang Hee Park, Han En Lo, Sung-Hak Kim, Ui Joung Youn, Young-Jun Jeonhes and Sung-Suk Suh

Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2022

Characterization of bacterial community structure in two alcyonacean soft corals (Litophyton sp. and Sinularia sp.) from Chuuk, Micronesia. (Click)

Joon Sang Park, Jeonghoon Han, Sung-Suk Suh, Hyun-Jung Kim, Taek-Kyun Lee, Seung Won Jung

Coral Reefs 41, 563–574 (2022).

Inhibitory Effects of Acetyloctadecadienediynoic Acid Isolated from Leaves of Dendropanax morbiferus on Viability and Self-Renewal Activity of Glioma Stem-Like Cells (Click)

Hyun-Jin Kim, Young Shin Park, Jihee Kim, Jae-Hak Moon, Seongsoo Lee, Sung-Suk Suh, Hang Yeon Jeong, Jeong-Yong Cho, and Sung-Hak Kim

Journal of Medicinal Food. 2022 Oct.963-970.

Bioactive Terphenyls Isolated from the Antarctic Lichen Stereocaulon alpinum. (Click)

Kim-Hoa Phi, Min-Ji Shin, Seulah Lee, Jae Eun So, Ji Hee Kim, Sung-Suk Suh, Man Hyung Koo, Seung Chul Shin, Jin-Hyoung Kim, Jun Hyuck Lee and Ui Joung Youn

Molecules. 2022 Apr 6;27(7):2363.

Bioactive secondary metabolites isolated from the Antarctic lichen Himantormia lugubris (Click)

Youn UJ, Koo MH, Shin MJ, Kim MJ, Lee S, So JE, Kim JH, Lee JH, Suh SS.

Chem Biodivers. 2022 Aug 17; Accepted Author Manuscript.

Stereocalpin B, a New Cyclic Depsipeptide from the Antarctic Lichen Ramalina terebrata (Click)

Lee S, Jeong SY, Nguyen DL, So JE, Kim KH, Kim JH, Han SJ, Suh SS, Lee JH, Youn UJ.

Metabolites. 2022 Feb 3;12(2):141.

Antiinflammatory lanostane triterpenoids from Ganoderma lucidum (Click)

Koo MH, Chae HJ, Lee JH, Suh SS, Youn UJ.

Nat Prod Res. 2021 Dec 24:1-8.

Anticancer Activity of 2- O-caffeoyl Alphitolic Acid Extracted from the Lichen, Usnea barbata 2017-KL-10 (Click)

Chae HJ, Kim GJ, Deshar B, Kim HJ, Shin MJ, Kwon H, Youn UJ, Nam JW, Kim SH, Choi H, Suh SS.

Molecules. 2021 Jun 28;26(13):3937.

Dynamic bacterial community response to Akashiwo sanguinea (Dinophyceae) bloom in indoor marine microcosms. (Click)

Jung SW, Kang J, Park JS, Joo HM, Suh SS, Kang D, Lee TK, Kim HJ.

Sci Rep. 2021 Mar 26;11(1):6983.

Antarctic Freshwater Microalga, Micractinium simplicissimum, Suppresses Inflammation. (Click)

Chae HJ, Seo JB, Kim SH, Youn EJ, Kim S, Suh SS.

J Nanosci Nanotechnol. 2021 Jul 1;21(7):4098-4103.

Methanol Extract of Mongolian Iris bungei Maxim. Stimulates 3T3-L1 Adipocyte Differentiation. (Click)

Yeon J, Suh SS, Youn UJ, Bazarragchaa B, Enebish G, Seo JB.

J Nanosci Nanotechnol. 2021 Jul 1;21(7):3943-3949.

Anti-Viral microRNAs Profiling in Infectious Salmon Anemia Virus (ISAV)-Infected Atlantic Salmon Kidney (ASK) Cells. (Click)

Suh SS.

J Nanosci Nanotechnol. 2021 Jul 1;21(7):3673-3678.

Fhit induces the reciprocal suppressions between Lin28/Let-7 and miR-17/92miR. (Click)

Chae HJ, Seo JB, Kim SH, Jeon YJ, Suh SS.

Int J Med Sci. 2021 Jan 1;18(3):706-714.

Pleiotropic tumor suppressor functions of WWOX antagonize metastasis. (Click)

Khawaled S, Nigita G, Distefano R, Oster S, Suh SS, Smith Y, Khalaileh A, Peng Y, Croce CM, Geiger T, Seewaldt VL, Aqeilan RI.

Signal Transduct Target Ther. 2020 Apr 17;5(1):43.

The Comprehensive Roles of ATRANORIN, A Secondary Metabolite from the Antarctic Lichen Stereocaulon caespitosum, in HCC Tumorigenesis. (Click)

Jeon YJ, Kim S, Kim JH, Youn UJ, Suh SS.

Molecules. 2019 Apr 10;24(7):1414.

Antarctic freshwater microalga, Chloromonas reticulata, suppresses inflammation and carcinogenesis. (Click)

Suh SS, Hong JM, Kim EJ, Jung SW, Chae H, Kim JE, Kim JH, Kim IC, Kim S.

Int J Med Sci. 2019 Jan 1;16(2):189-197.

WWOX Inhibits Metastasis of Triple-Negative Breast Cancer Cells via Modulation of miRNAs. (Click)

Khawaled S, Suh SS, Abdeen SK, Monin J, Distefano R, Nigita G, Croce CM, Aqeilan RI.

Cancer Res. 2019 Apr 15;79(8):1784-1798.

miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCL (Click)

Jeon YJ, Kim T, Park D, Nuovo GJ, Rhee S, Joshi P, Lee BK, Jeong J, Suh SS, Grotzke JE, Kim SH, Song J, Sim H, Kim Y, Peng Y, Jeong Y, Garofalo M, Zanesi N, Kim J, Liang G, Nakano I, Cresswell P, Nana-Sinkam P, Cui R, Croce CM.

Nat Commun. 2018 Nov 30;9(1):5110.

Anti-inflammation and Anti-Cancer Activity of Ethanol Extract of Antarctic Freshwater Microalga, Micractinium sp.(Click)

Suh SS, Hong JM, Kim EJ, Jung SW, Kim SM, Kim JE, Kim IC, Kim S.

Int J Med Sci. 2018 Jun 12;15(9):929-936.

Anti-Cancer Activity of Lobaric Acid and Lobarstin Extracted from the Antarctic Lichen Stereocaulon alpnum. (Click)

Hong JM, Suh SS, Kim TK, Kim JE, Han SJ, Youn UJ, Yim JH, Kim IC.

Molecules. 2018 Mar 14;23(3):658.

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