Research Experience

Prof. Dipti Sareen has 22 years of research experience in discovery and characterization of novel enzymes and antimicrobial peptides,  gene knockout,  as evident from her publications, a granted U.S. Patent, and a patent filed in India. She has expertise in protein /peptide analysis by different biophysical and biochemical techniques.

The UG and PG courses being taught by her are Enzymes and Bioenergetics, Advanced Enzymology and Molecular Cell Biology.

Citation Indices :

Publications: 25          Patents: 02(Granted) & 01 (Filed)                  Book Chapter: 02     

Citations: 1287               h-index: 14                                                                   i10-index: 15

Positions held: 

Nov. 2020 - Till today.  Professor, Department of Biochemistry, Panjab University, Chandigarh, India.

Nov. 2017 - Nov. 2020.   Associate Professor, Department of Biochemistry, Panjab University, Chandigarh, India.

Nov. 2014 - Nov. 2017.  Assistant Professor (Stage-3), Department of Biochemistry, Panjab University, Chandigarh, India.

Nov. 2009 - Nov. 2014.  Assistant Professor (Stage-2), Department of Biochemistry, Panjab University, Chandigarh, India.

Nov. 2005 - Nov. 2009.  Assistant Professor (Stage-1), Department of Biochemistry, Panjab University, Chandigarh, India

2004 - 2005. DST Young Scientist, CSIR-Regional Research Laboratory, Bhopal, India.

2001 - 2002. Postdoctoral Research Fellow, Department of Chemistry & Biochemistry, University of California, San Diego, U.S.A. 

1997 - 2001. Ph.D. from CSIR-IMTECH, Chandigarh.

Publications

Book Chapter

• Priya Saini and Dipti Sareen (2019) "Epoxide hydrolase for green synthesis of chiral drugs",  in Nanoscience and Biotechnology for Environmental Applications , part of Environmental Chemistry for a Sustainable World book series (ECSW, volume 22)  Springer Link http://www.springer.com/series/11480   pp. 141-198. 

• Shweta Kishen, Mangal Singh and Dipti Sareen (2021) Lantibiotics: Strengthening our armor against AMR pathogens. Accepted as Chapter- 28, Volume 4: Biomedical Research, Medicine and Disease_9781032115498, CRC, Springer.

Research Articles:

Non-antibiotic pharmaceuticals are toxic against Escherichia coli with no evolution of cross-resistance to antibiotics.

RJ Hall, AE Snaith, SJ Element, RA Moran, H Smith, Cummins EA...and Alan McNally, npj Antimicrobials and Resistance 2 (1), 11, 2024.

Value Addition to Agro-Industrial Waste Through Pectin Extraction: Chemometric Categorization, Density Functional Theory Analysis, Rheology Investigation, Optimization Using Response Surface Methodology and Prospective Applications Through Hydrogel Preparation 

H Rana, J Rana, D Sareen, S Goswami, Journal of Polymers and the Environment, 1-23, 2024

Nanocellulose-Based Ecofriendly Nanocomposite for Effective wastewater Remediation: A study on its process optimization, improved swelling, adsorption, and thermal and Thermal and Mechanical Behavior

H Rana, Anamika, D Sareen, S Goswami, ACS omega 9 (8), 8904-8922, February 13, 2024. 

Phylogeny-guided genome mining of roseocin family lantibiotics to generate improved variants of roseocin  Chaudhary, S., Kishen, S., Singh, M., Jassal, S., Pathania, R., Bisht, K., & Sareen, D. AMB Express, 13, 1, 1-20, 2023.

Thiopeptides encoding biosynthetic gene clusters mined from bacterial genomes.  Aggarwal, E., Chauhan, S. & Sareen, D. Journal of Biosciences, 46, 36, 2021. 

New developments in RiPP discovery, enzymology and engineering M. Montalbán-López ....D Sareen et al., -Natural Product Reports, 2021. 

Bioinformatics approach to understand nature’s unified mechanism of stereo-divergent synthesis of isoprenoid skeletons. P Bhaskar, D Sareen - World Journal of Microbiology and Biotechnology, 2020.

Roseocin, a novel two-component lantibiotic from an Actinomycete M Singh, S Chaudhary , Sareen D - Molecular Microbiology, 2020.

Electrochemical determination of M. tuberculosis antigen based on Poly (3, 4-ethylenedioxythiophene) and functionalized carbon nanotubes hybrid platform  H Thakur, N Kaur, D Sareen, N Prabhakar - Talanta, 2017.

Aptamer based voltammetric biosensor for the detection of Mycobacterium tuberculosis antigen MPT64. H Thakur, N Kaur, P Sabherwal, D Sareen… - Microchimica Acta, 2017.

Bioresolution of racemic phenyl glycidyl ether by a putative recombinant epoxide hydrolase from Streptomyces griseus NBRC 13350. P Saini, N Kumar, SI Wani, S Sharma, SS Chimni… - World Journal of Microbiology and Biotechnology, 2017.

An overview on the enhancement of enantioselectivity and stability of microbial epoxide hydrolases. P Saini, D Sareen - Molecular biotechnology, 2017.

Non-ribosomal peptide synthetases: Identifying the cryptic gene clusters and decoding the natural product. M Singh, S Chaudhary, D Sareen - Journal of biosciences, 2017.

Trigger factor assisted folding of the recombinant epoxide hydrolases identified from C. pelagibacter and S. nassauensis. P Saini, SI Wani, R Kumar, R Chhabra, SS Chimni… - Protein expression and purification, 2014.

Novel LanT associated lantibiotic clusters identified by genome database mining. M Singh, D Sareen - PLoS One, 2014.

Cloning and characterization of an epoxide hydrolase from Cupriavidus metallidurans-CH34 R Kumar, SI Wani, NS Chauhan, R Sharma, D Sareen - Protein expression and purification, 2011.

Prospecting for efficient enantioselective epoxide hydrolases. D Sareen, R Kumar - NISCAIR-CSIR , 2011.

A coupled spectrophotometric assay for l-cysteine: 1-d-myo-inosityl 2-amino-2-deoxy-α-d-glucopyranoside ligase and its application for inhibitor screening. GL Newton, P Ta, D Sareen, RC Fahey - Analytical biochemistry, 2006.

Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman. D Sareen, GL Newton, RC Fahey, NA Buchmeier - Journal of bacteriology, 2003.

ATP-dependent L-cysteine: 1D-myo-inosityl 2-amino-2-deoxy-α-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases. Dipti Sareen, M Steffek, GL Newton, RC Fahey - Biochemistry, 2002.

Chaperone-assisted overexpression of an active D-carbamoylase from Agrobacterium tumefaciens AM 10. D Sareen, R Sharma, RM Vohra - Protein expression and purification, 2001.

Two-Step Purification of D (−)-Specific Carbamoylase from Agrobacterium tumefaciens AM 10. D Sareen, R Sharma, HS Nandanwar, RM Vohra - Protein expression and purification, 2001.

Awards/Honors

July 17th, 2020. Special Recommendation by the Grand Jury in Grand Finale  presentations of the CARB-X/ C-CAMP AMR Quest 2020 over the lab Innovation " Roseocin: A novel Two-component lantibiotic to combat AMR" and sucessfully completed the 3-month (August-October) C-CAMP AMR Accelerator program.

2020. Outstanding Oral presentation award  at the International Conference ICONICA 2020 - A Global Summit on "Next-Gen Paradigms in Health Care", held at Panjab University, Chandigarh, India on the topic entitled  "Roseocin: A novel antimicrobial Two-component Lantibiotic" [13-14 Februray, 2020].

2018. Best Oral presentation award on the topic "Lantibiotics as novel antimicrobial agents: Bioproduction and Action".-  International Conference on "Translational research in Life sciences under the aegis of CRIKC & DST-CPR at Panjab University, Chandigarh [6-7 July,2018].

2017. Shortlisted among 21 scientists in India to attend the Antimicrobial Resistance (AMR) Sandpit Event,  against the submitted EoI (Expression of Interest), conducted by Department of Biotechnology, New Delhi & United Kingdom Research Council held at The Taj, Damdama, Haryana [7th to 10th November, 2017].

2016. Received the International Travel Award to give an Oral talk on "Novel lantibiotic encoding cluster Identified by genome mining" in the IVth International Conference on Antimicrobial Research (ICAR 2016) at Formatex Research Center, Torremolinos, Malaga, Spain [29th  June to 1st  July, 2016].

2013. Best poster award in the session “Bioinformatics and Genome analysis” for the poster entitled “In- silico discovery of novel epoxide hydrolases”, presented in an International Conference on Health, Environment and Industrial Biotechnology - Bio Sangam, at MNNIT, Allahabad, India.

2013. Honoured by Panjab University Teacher’s Association (PUTA) in recognition of Scientific achievements on Teacher’s day.

2012. Received the Award of Honour for Scientific Innovation on IPR day [26th April, 2012].

2011. Received the International Travel Award to present a poster on "Biocatalysis of epoxides by novel recombinant Epoxide hydrolases identified by genome analysis" in 10th International Symposium on Biocatalysis and Biotransformations -“Biotrans 2011 Sicilia” on October 2-6, 2011  at Giardini Naxos, Sicily, Italy.

2000. Best poster award at the Annual conference of Association of Microbiologists of India, MIROBIOTECH 2000 held at Birla Institute of Science and Technology, Jaipur, India.

1997. CSIR-NET, and GATE qualified.

Editorial Activities

Review Editor for ACS Chemical Biology, ACS Infectious Diseases, Evolutionary and Genomic Microbiology, Process Biochemistry, International Journal of Biological Macromolecules, Frontiers in Microbiology, Indian Journal of Microbiology.