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Assistant Professor
University of South Carolina
Department of Mathematics
Welcome to my website
Welcome to my website
My name is Mitchel Colebank, and I am an Assistant Professor in the Department of Mathematics at the University of South Carolina, Columbia. I am also an affiliate faculty in the Department of Biomedical Engineering.
Postdoctoral researchers, graduate students, undergraduate students, and high schoolers are encouraged to visit the "The Team" page for information about joining the group.
RECENT NEWS
RECENT NEWS
May 2025: Happy to announce that I have been selected as an NIAID-funded R25AI164581 (R25) Big Data Health Science Fellow for the 2025 - 2026 academic year! I will be matched with a mentoring team and receive curriculum-based professional development training for research in big-data and data science research this coming year. Looking forward to using this opportunity to expand my skill set in computation and machine learning!
RECENT NEWS
RECENT NEWS
March 2025: I am pleased to announce that a set of two special issues on "Uncertainty quantification for healthcare and biological systems" have been published in Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. I was one of four guest editors forming the special issue, and contributed (with co-authors Mihaela Paun and Dirk Husmeier) a comparative study of Gaussian processes and polynomial chaos expansions. I also helped co-author (with Louise Kimpton, Mihaela Paun, and Victoria Volodina) an overview and opinion piece on the challenges and opportunities in uncertainty quantification for problems in biology and physiology.
You can find the articles here.
OLDER NEWS
OLDER NEWS
January 2025: The article "Guidelines for assessing ventricular pressure-volume relationships in rodents" was published in the American Journal of Physiology, Heart and Circulatory Physiology. This text (on which Colebank was a co-author) provides a set of guidelines for measuring pressure-volume loops in rodents for experimental purposes. The article can be found here.
November 2024: Group members Aidan Anthony, Josh Prioleau, and Elena Webb have all received notices of undergraduate research funding through the USC Office for Undergraduate Research (OUR). We are very proud of all these students for putting together successful funding applications. Congratulations Aidan, Josh, and Elena!
October 2024: Our recent publication in the American Journal of Physiology - Heart and Circulatory Physiology, has been spotlighted by the AJP Heart and Circ podcast! You can find the interview between Drs. Jeff Saucermann, Naomi Chesler, and myself here.
July/August 2024: I'm pleased that the last two papers from my postdoctoral work have been published! The first is our uncertainty quantification study "Efficient uncertainty quantification in a spatially multiscale model of pulmonary arterial and venous hemodynamics," which has been published open access in Biomechanics and Modeling in Mechanobiology. We show how polynomial chaos expansions can propagate uncertainty across spatial scales in a pulmonary hemodynamics model.
Another major paper is our "Guidelines for mechanistic modeling and analysis in cardiovascular research," which was published in the American Journal of Physiology, Heart and Circulatory Physiology. This article provides a roadmap for mechanistic modeling (for both non-computational and computational readers) in cardiovascular research. In particular, we highlight ideas in model development, model calibration, model validation, and uncertainty quantification. Be on the look out for a podcast interview with the journal this fall/winter!
February 2024: I am excited to announce that I have accepted a faculty offer at the University of South Carolina (USC) in the Department of Mathematics! I will start my faculty position in August, 2024. I'm looking forward to this next chapter in my research career, and to starting my own group of computational scientists!
October 2023: My new preprint is now available on arXiv! In this study, we quantify uncertainty in a two-sided model of the pulmonary arterial and venous tree using polynomial chaos expansions. Specifically, we show how uncertainties in the structured tree model and proximal and distal stiffness affect pressure-flow relationships. We also provide uncertainty bounds for mechanotransduction stimuli, like wall shear stress and cyclic stretch, and quantify uncertainty around the predictions provided from the structured tree model and the distal vasculature.
https://arxiv.org/abs/2309.04057
April 27th, 2023: We had an incredible turnout at the 2023 Cardiac Physiome Workshop! Hosted together with Edwards Lifesciences, our organizing committee at the CIRC put together a 3.5 day conference focused on cardiovascular function, modeling, and innovation. We were pleased to host four plenary speakers, over 130 participants, and scientists from over 12 countries. Thank you to everyone who participated, and funding from UCI and the National Science Foundation. Looking forward to the next meeting in Freiburg, Germany!
Website: https://www.cardiacphysiome.org/
April 22, 2023: I was thankful to be an attendee and presenter at the Lorentz Center workshop on "Uncertainty Quantification for Healthcare and Biological Systems" in Leiden, the Netherlands! I presented preliminary work on using polynomial chaos expansions as a surrogate model for pulmonary arteriovenous dynamics. We had an outstanding slate of presenters and workshop time to address concepts related to UQ, simulation in healthcare, and the future of digital twins.
March 1, 2023: Very excited that the final project from my Ph.D. (co-first authored with the now Dr. Amanda Colunga at NC State University) was published in the Journal of the Royal Society Interface! Our work combined hemodynamic data from nine pulmonary hypertension (PH) patients with a closed-loop, lumped parameter model of all four heart chambers and the systemic and pulmonary circulations. Happy that this paper is finally published!
November 5, 2022: Happy to see that Alyssa Taylor-LaPole (Ph.D. candidate, NC State) had her first manuscript published! Our work used a one-dimensional hemodynamics model to simulate systemic arterial function in two pediatric patients: one with hypoplastic left heart syndrome and another with double outlet right ventricle anatomy. Great job, Alyssa!
January 17, 2023: Happy to be a co-author on Dr. Ryan Pewowaruk's paper on smooth muscle tone and its (potential) therapeutic target for decreasing arterial stiffness. A relatively simple model of vasoactive tone within a physiology pressure-area relationship shows that smooth muscle stiffness is less than that of the collagen, suggesting it may decrease effective arterial stiffness. Great work, Ryan!
September 20, 2022: My first manuscript from my postdoc has been published! The study investigates different in-vivo experimental designs using a multiscale computational model of murine cardiovascular dynamics. Results show that data from both the RV and LV are required to reduce uncertainty and infer model parameters uniquely. Happy to publish this work with Dr. Chesler!
June 20 2022: Very pleased that our review "Aerosol Transport Modeling: The Key Link Between Lung Infections of Individuals and Populations," was published in Frontiers in Physiology! This was a great joint effort by our pulmonary/lung subgroup of the NIH Interagency Modeling and Analysis Group (IMAG) Multiscale Modeling group on Viral Pandemics group. Great work to all the authors, especially Dr. Chantal Darquenne at UCSD for keeping us organizing and getting this to submission!
Paper: https://doi.org/10.3389/fphys.2022.923945
IMAG Page: https://www.imagwiki.nibib.nih.gov/working-groups/multiscale-modeling-and-viral-pandemics
FALL 2021 NEWS
I am happy to announce that I have been awarded an NIH TL-1 fellowship through UCI's Institute for Clinical and Translational Research (ICTS). My project will utilize in-silico, in-vitro, and in-vivo experiments to deduce the mechanobiology of pulmonary vascular remodeling. Funding for this project will begin March 2022.
Questions?
Questions?
Contact [mjcolebank (at) sc (dot) edu] to get more information on my research and outreach interests
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