Representative papers

Hariharan VN#, Shin M#, Chang CW#, O'Reilly D, Biscans A, Yamada K, Guo Z, Somasundaran M, Tang Q, Monopoli K, Krishnamurthy PM, Devi G, McHugh N, Cooper DA, Echeverria D, Cruz J, Chan IL, Liu P, Lim SY, McConnell J, Singh SP, Hildebrand S, Sousa J, Davis SM, Kennedy Z, Ferguson C, Godinho BMDC, Thillier Y, Caiazzi J, Ly S, Muhuri M, Kelly K, Humphries F, Cousineau A, Parsi KM, Li Q, Wang Y, Maehr R, Gao G, Korkin D, McDougall WM, Finberg RW, Fitzgerald KA, Wang JP, Watts JK, Khvorova A. Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.
Proc Natl Acad Sci U S A. 2023 Mar; 120(11):e2219523120. (#co-first authors)

 

Shin M, Chan IL, Cao Y, Gruntman AM, Lee J, Sousa J, Rodriguez TC, Echeverria D, Devi G, Debacker AJ, Moazami MP, Krishnamurthy PM, Rembetsy-Brown J, Kelly K, Yukselen O, Donnard E, Parsons TJ, Khvorova A, Sontheimer EJ, Maehr R, Garber M, Watts JK. Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts.
Nucleic Acids Research. 2022 Aug; 50(15):8418-8430.

 

 

Shin M, Meda Krishnamurthy P, Devi G, Watts JK. Quantification of Antisense Oligonucleotides by Splint Ligation and Quantitative Polymerase Chain Reaction.
Nucleic Acid Therapeutics. 2022 Feb; 32(1):66-73.

 

Tran H, Moazami MP, Yang H, McKenna-Yasek D, Douthwright CL, Pinto C, Metterville J, Shin M, Sanil N, Dooley C, Puri A, Weiss A, Wightman N, Gray-Edwards H, Marosfoi M, King RM, Kenderdine T, Fabris D, Bowser R, Watts JK, Brown RH Jr. Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide.
Nature Medicine. 2022 Jan; 28(1):117-124.

Complete list of published papers

Chen Z, Kwan SY, Mir A, Hazeltine M, Shin M, Liang SQ, Chan IL, Kelly K, Ghanta KS, Gaston N, Cao Y, Xie J, Gao G, Xue W, Sontheimer EJ, Watts JK. A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors.
The CRISPR journal. 2023 Dec;6(6):570-582.

Fakih HH, Tang Q, Summers A, Shin M, Buchwald JE, Gagnon R, Hariharan VN, Echeverria D, Cooper DA, Watts JK, Khvorova A, Sleiman HF. Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity.
Molecular therapy. Nucleic acids. 2023 Nov 17;34:102080.

Hariharan VN#, Shin M#, Chang CW#, O'Reilly D, Biscans A, Yamada K, Guo Z, Somasundaran M, Tang Q, Monopoli K, Krishnamurthy PM, Devi G, McHugh N, Cooper DA, Echeverria D, Cruz J, Chan IL, Liu P, Lim SY, McConnell J, Singh SP, Hildebrand S, Sousa J, Davis SM, Kennedy Z, Ferguson C, Godinho BMDC, Thillier Y, Caiazzi J, Ly S, Muhuri M, Kelly K, Humphries F, Cousineau A, Parsi KM, Li Q, Wang Y, Maehr R, Gao G, Korkin D, McDougall WM, Finberg RW, Fitzgerald KA, Wang JP, Watts JK, Khvorova A. Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.
Proc Natl Acad Sci U S A. 2023 Mar; 120(11):e2219523120. (#co-first authors)

 

Shin M, Chan IL, Cao Y, Gruntman AM, Lee J, Sousa J, Rodriguez TC, Echeverria D, Devi G, Debacker AJ, Moazami MP, Krishnamurthy PM, Rembetsy-Brown J, Kelly K, Yukselen O, Donnard E, Parsons TJ, Khvorova A, Sontheimer EJ, Maehr R, Garber M, Watts JK. Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts.
Nucleic Acids Research. 2022 Aug; 50(15):8418-8430.

 

Kim BS#, Shin M#, Kim KW, Ha KT, Bae SJ. NRF2 activation by 2-methoxycinnamaldehyde attenuates inflammatory responses in macrophages via enhancing autophagy flux.
BMB Reports. 2022 Aug; 55(8):407-412. (#co-first authors)

 

Hwang SJ, Ahn BJ, Shin MW, Song YS, Choi Y, Oh GT, Kim KW, Lee HJ. miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1.
Cell Death and Differentiation. 2022 Jun; 29(6):1199-1210.

 

Shin M, Meda Krishnamurthy P, Devi G, Watts JK. Quantification of Antisense Oligonucleotides by Splint Ligation and Quantitative Polymerase Chain Reaction.
Nucleic Acid Therapeutics. 2022 Feb; 32(1):66-73.

 

Tran H, Moazami MP, Yang H, McKenna-Yasek D, Douthwright CL, Pinto C, Metterville J, Shin M, Sanil N, Dooley C, Puri A, Weiss A, Wightman N, Gray-Edwards H, Marosfoi M, King RM, Kenderdine T, Fabris D, Bowser R, Watts JK, Brown RH Jr. Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide.
Nature Medicine. 2022 Jan; 28(1):117-124.

 

Bae SJ, Shin MW, Son T, Lee HS, Chae JS, Jeon S, Oh GT, Kim KW. Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts.
Experimental & Molecular Medicine. 2019 Jan; 51(1):1-16.

 

Le H, Ahn BJ, Lee HS, Shin A, Chae S, Lee SY, Shin MW, Lee EJ, Cha JH, Son T, Seo JH, Wee HJ, Lee HJ, Jang Y, Lo EH, Jeon S, Oh GT, Kim D, Kim KW. Disruption of Ninjurin1 Leads to Repetitive and Anxiety-Like Behaviors in Mice.
Molecular Neurobiology. 2017 Nov; 54(9):7353-7368.

 

Bae SJ, Shin MW, Kim RH, Shin D, Son T, Wee HJ, Kim KW. Ninjurin1 Assembles Into a Homomeric Protein Complex Maintained by N-linked Glycosylation.
Journal of Cellular Biochemistry. 2017 Aug; 118(8):2219-2230.

 

Shin MW, Bae SJ, Wee HJ, Lee HJ, Ahn BJ, Le H, Lee EJ, Kim RH, LEE HS, Seo JH, Park JH, Kim KW. Ninjurin1 regulates lipopolysaccharide-induced inflammation through direct binding.
International Journal of Oncology. 2016 Feb; 48(2):821-8.

 

Seo JH, Park JH, Lee EJ, Vo TT, Choi H, Jang JK, Wee HJ, Ahn BJ, Cha JH, Shin MW, Kim KW. Autoacetylation regulates differentially the roles of ARD1 variants in tumorigenesis.
International Journal of Oncology. 2015 Jan; 46(1):99-106.

 

Park JH, Seo JH, Wee HJ, Vo TT, Lee EJ, Choi H, Cha JH, Ahn BJ, Shin MW, Bae SJ, Kim KW. Nuclear translocation of hARD1 contributes to proper cell cycle progression.
PloS One. 2014 Aug; 9(8):e105185.

 

Ahn BJ, Le H, Shin MW, Bae SJ, Lee EJ, Lee SY, Yang JH, Wee HJ, Cha JH, Seo JH, Lee HS, Lee HJ, Arai K, Lo EH, Jeon S, Oh GT, Kim WJ, Ryu JK, Suh JK, Kim KW. Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics.
Journal of Biological Chemistry. 2014 Aug; 289(32):21926-36.

 

Ahn BJ, Le H, Shin MW, Bae SJ, Lee EJ, Wee HJ, Cha JH, Lee HJ, Lee HS, Kim JH, Kim CY, Seo JH, Lo EH, Jeon S, Lee MN, Oh GT, Yin GN, Ryu JK, Suh JK, Kim KW. Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice.
Journal of Biological Chemistry. 2014 Feb; 289(6):3328-38.

 

Ahn BJ, Le H, Shin MW, Bae SJ, Lee EJ, Wee HJ, Cha JH, Park JH, Lee HS, Lee HJ, Jung H, Park ZY, Park SH, Han BW, Seo JH, Lo EH, Kim KW. The N-terminal ectodomain of Ninjurin1 liberated by MMP9 has chemotactic activity.
Biochemical and Biophysical Research Communications. 2012 Nov; 428(4):438-44.

 

Lee HJ, Ahn BJ, Shin MW, Choi JH, Kim KW. Ninjurin1: a potential adhesion molecule and its role in inflammation and tissue remodeling.
Molecules and Cells. 2010 Mar; 29(3):223-7.

 

Lee HJ, Ahn BJ, Shin MW, Jeong JW, Kim JH, Kim KW. Ninjurin1 mediates macrophage-induced programmed cell death during early ocular development.
Cell Death and Differentiation. 2009 Oct; 16(10):1395-407.

 

Ahn BJ, Lee HJ, Shin MW, Choi JH, Jeong JW, Kim KW. Ninjurin1 is expressed in myeloid cells and mediates endothelium adhesion in the brains of EAE rats.
Biochemical and Biophysical Research Communications. 2009 Sep; 387(2):321-5.