UNDERSTANDING HOW THE ENVIRONMENT AND GENES INFLUENCE THE PHYSIOLOGY OF THE BRAIN 

 

Welcome

What factors contribute to the failure of 90% of clinical drug developments? 

Why a significant number of approved drugs exhibit unwanted side effects? 

Why do both traditional and innovative therapeutic treatments result in varied effects among individuals? 

How can we enhance the efficacy of drug development and minimize adverse reactions?

For over 15 years, my research focus has revolved around probing into several of these critical questions. Specifically, I aim to unravel the intricate interplay between environmental influences and genetic predispositions to gain deeper insights into the complex brain circuit mechanisms governing behaviour in both health and illness.

Throughout my journey, I've honed expertise in employing and seamlessly integrating state-of-the-art methodologies to manipulate and monitor the activity of brain cells in rodent models. These techniques are coupled with behavioural assays designed to evaluate pertinent endophenotypes associated with a wide spectrum of psychiatric, neurodevelopmental, and neurodegenerative conditions.

Furthermore, the translational significance of my work in neuroscience is profound, as many of the behavioural paradigms utilized in rodents have direct relevance to human cognition and behaviour. This bridge between animal models and human conditions underscores the potential for impactful discoveries in translational neuroscience and drug development.

In tandem with my research pursuits, I remain deeply committed to fostering a culture of equity, diversity, and inclusion within my team. Drawing from my own experiences as an immigrant who has navigated through economic challenges, I am driven to ensure that everyone within my team feels valued and empowered to contribute their unique perspectives and talents.

 

ABOUT ME

I earned my Bachelor of Science degree in Biology from the University of Los Andes in Venezuela. Subsequently, I pursued both my Master's and PhD degrees in Cellular Biology and Neurochemistry at the same institution, working under the mentorship of Dr. Pedro Rada and Dr. Luis Hernandez. Their lab was a pioneering force in utilizing in vivo microdialysis techniques and analyzing brain dialysates at attomole concentrations in rodents engaged in behavioral tasks.

Following the completion of my doctoral studies, I embarked on a postdoctoral fellowship at the National Institute of Child Health and Human Development (USA), where I conducted research under the guidance of Dr. Andres Buonanno.

Currently, I serve as an Adjunct Professor in the Department of Anatomy and Cell Biology and hold the position of Research Associate at the Rodent Cognition Research and Innovation Core at Western University in Canada.

LEADERSHIP AND INCLUSIVENESS

As a first-generation neuroscientist and Canadian immigrant hailing from Latin America, I intimately understand the challenges posed by unconscious cultural biases and inequalities. I am committed to fostering an inclusive work environment where all individuals feel valued and encouraged to freely voice their opinions within a climate of trust and mutual respect.

Furthermore, I firmly believe in leading by example, prioritizing action over mere rhetoric. I dedicate myself to earning my position as a leader in every setting through diligence and dedication.

TEAM WORK

I recognize that my enthusiasm for science has been nurtured by inspiring mentors and collaborative teams that have encouraged me to reach beyond my limits. In envisioning my own team, I prioritize fostering a culture of trust and mutual support.

Yet, I am well aware that effectively leading a successful team requires more than just intention. As I step into a leadership role within the field, I have proactively equipped myself for the challenges ahead by undergoing professional training in project management, leadership, and motivational strategies.        

 

I enjoy teaching and promoting inclusiveness among my community.

Contact me at mskirzew@uwo.ca