協同主持人
邱馨瑩 博士
單位: 高雄長庚醫院醫學研發部基因體暨蛋白質體核心實驗室
職稱: 副研究員
電子信箱: phoenixchiou@gmail.com
現職
高雄長庚醫院醫學研究發展部基因體暨蛋白質體核心實驗室 副研究員
國立暨南國際大學應用化學系 兼任助理教授
學歷
國防醫學院生命科學研究所 博士 (指導教授:李小媛教授)
陽明大學醫學生物技術暨檢驗學系暨研究所 碩士 (指導教授:黃奇英教授)
中興大學生命科學系 學士 (指導教授:葛其梅教授)
經歷
市立小港醫院教學研究中心(委託財團法人高雄醫學大學經營) 醫學助理研究員
高雄醫學大學附院內分泌新陳代謝內科 醫學助理研究員
三軍總醫院神經外科部 博士後研究員 (洪東源教授實驗室)
研究領域
神經退化性疾病
代謝症候群
環境汙染物與呼吸道疾病
腫瘤生物學
專題計畫
科技部
110年度新進人員研究計畫(個別型) 2021.8.1-2024.7.31 (主持人)
109年度新進人員研究計畫(個別型) 2020.8.1-2023.7.31 (共同主持人)
108年度新進人員研究計畫(個別型) 2019.5.1-2020.10.31 (共同主持人)
107年度一般研究計畫(個別型) 2018.8.1-2021.7.31 (共同主持人)
106年度一般研究計畫(個別型) 2017.8.1-2018.7.31 (共同主持人)
小港醫院
110年度研究計畫(個別型) 2022.1.1-2022.12.31 (主持人)
高醫大附院
110年度研究計畫(個別型) 2017.1.1-2017.12.31 (主持人)
期刊論文
Chen HC, Chiou HY Clair, Tsai ML, Chen SC, Lin MH, Chuang TC, Hung CH, and Kuo CH. Effects of Montelukast on Arsenic-Induced Epithelial-Mesenchymal Transition and the Role of Reactive Oxygen Species Production in Human Bronchial Epithelial Cells. Frontiers in Pharmacology, 2022, 13:877125, PHARMACOLOGY & PHARMACY 2020 IF=5.811, R/C=40/276 (14.49% )
Lee MJ, Lin PC, Lin MH, Chiou HY Clair, Wang K, and Huang CW. Kinetic Alterations in Resurgent Sodium Currents of Mutant Na v 1.4 Channel in Two Patients Affected by Paramyotonia Congenita. Biology, 11(4): 613, BIOLOGY, 2020 IF=5.079, R/C=16/93 (17.2%)
Chiu KJ, Chiou HY Clair, Huang CH, Lu PC, Kuo HR, Wang JW, and Lin MH. Natural Compounds Targeting Cancer-Associated Fibroblasts against Digestive System Tumor Progression: Therapeutic Insights Biomedicines, 2022, 10 (3): 713, PHARMACOLOGY & PHARMACY, 2020 IF=6.081, R/C=32/275 (11.6%)
Chiou HY Clair, Huang SH, Hung CH, Tsai SM, Kuo HR, Huang YR, Wang JW, Chen SC, Kuo CH, Wu DC, Huang SK, Hsu SH and Lin MH*(2021, Aug) Hyperbaric Oxygen Therapy Alleviates the Autoimmune Encephalomyelitis via the Reduction of IL-17a and GM-CSF Production of Autoreactive T Cells as Well as Boosting the Immunosuppressive IL-10 in the Central Nervous System Tissue Lesions Biomedicines 2021, 9(8), 943 (PHARMACOLOGY & PHARMACY, 2020 IF=6.081, R/C=32/275 (11.6%)
Li CH, Chiou HY Clair (equal contribution to first author), Lin MH, Kuo CH, Lin YC*, Hung CH*, Kuo CH*(2021 Aug) Immunological Map in COVID-19 Journal of Microbiology, Immunology and Infection 2021;54(4):547-556. INFECTIOUS DISEASE, 2020 IF=4.399, RANK=28/92 (30.4%)
Wang LT, Lin MH, Liu KY, Chiou SS, Wang SN, Chai CY, Tseng LW, Chiou HY Clair, Wang HC, Yokoyama KK, Hsu SH*, Huang SK (2021,Apr) Wntless is essential in controlling dendritic cell homeostasis via Wnt signaling independent mechanism. Autophagy 14;1-16 (CELL BIOLOGY, 2020 IF=16.016, RANK=14/195 (7.2%)
Chiu TH, Tsai HJ, Chiou HY Clair, Wu PY, Huang JC, Chen SC (2021,Jan). A high triglyceride-glucose index is associated with left ventricular dysfunction and atherosclerosis. Int. J. Med.Sci. 18(5): 1051-1057. MEDICINE, GENERAL & INTERNAL, 2020 IF=3.738, R/C=44/169 (26%)
Chiu TH, Huang YC, Chiu H, Wu PY, Chiou HY Clair, Huang JC, Chen SC (2020, Dec). Comparison of Various Obesity-Related Indices for Identification of Metabolic Syndrome: A Population-Based Study from Taiwan Biobank. Diagnostics, 10(12), 1081.MEDICINE, GENERAL & INTERNAL, 2019 IF=3.110, R/C=47/164 (28.65%).
Chiou HY Clair, Jiang HJ, Yang SF, Kuo KK, Lin PC, Hsiao PJ* (2020, Apr) Stemness regulation of the adrenal mixed corticomedullary tumorigenesis-a case-control study Neoplasia 2020, 22(7), 263. ONCOLOGY, 2019 IF=5.696, RANK=48/244 (19.7%)
Liu SY, Ma YL, Hsu WL, Chiou HY Clair, Lee Eminy HY* (2019, Jun). PIAS1 Ser‐503 phosphorylation mediated Elk 1 SUMOylation promotes neuronal survival in APP/PS1 mice. British Journal of Pharmacology 2019;176(11):1793-1810. PHARMACOLOGY & PHARMACY, 2018 IF=6.583, RANK=14/267 (5.2%)
Chiou HY Clair, Lin MW, Hsiao PJ, Chen CL, Chiao S, Chen YC, Lin TY, Wu DC, Lin MH* (2019, Mar). Dulaglutide modulates the development of tissue-infiltrating Th1/Th17 cells and the pathogenicity of encephalitogenic Th1 cells in the central nervous system. Int. J. Mol. Sci. 2019, 20(7), 1584 BIOCHEMISTRY & MOLECULAR BIOLOGY, 2018 IF=4.183, RANK =78/299 (26%)
Lee MY, Huang JC, Chen SC, Chiou HY Clair and Wu PY* (2018, Dec). Association of HbA1C Variability and Renal Progression in Patients with Type 2 Diabetes with Chronic Kidney Disease Stages 3–4. Int. J. of Mol. Sci., 19(12), 4116. CHEMISTRY, MULTIDISCIPLINARY 2017 IF=3.687, RANK=52/171 (30.4%)
Jiang HJ, Wu CW, Chiang FY, Chiou HY Clair, Chen IJ, Hsiao PJ* (2018, Mar). Reliable sonographic features for nodal thyroglobulin to diagnose recurrent lymph node metastasis from papillary thyroid carcinoma. Clinical Otolaryngology, 43(4):1065-1072. OTORHNOLARYNGOLOGY 2017 IF=2.696, RANK=7/41 (17%).
Hsiao PJ, Chiou HY Clair, Jiang HJ, Lee MY, Hsieh TJ, Kuo KK* (2017, Aug). Pioglitazone Enhances Cytosolic Lipolysis, β-oxidation and Autophagy to Ameliorate Hepatic Steatosis. Scientific Reports, 7(1):9030. MULTIDISPLINARY SCIENCES 2016 IF=4.259, RANK=10/64 (15.6%)
Feng SW, Y Chen, Tsai WC, Chiou HY Clair, Wu ST, Huang LC, Lin C, Hsieh CC, Yang YJ, Hueng DY* (2016, Jun). Overexpression of TELO2 decreases survival in human high-grade gliomas. Oncotarget, 7(29): 46056-46066. ONCOLOGY 2015 IF=5.008, RANK=36/213 (16.9%)
Hueng DY*, Tsai WC, Chiou HY Clair, Feng SW, Lin C, Li YF, Huang LC, Lin MH (2015, Jul). DDX3X Biomarker Correlates with Poor Survival in Human Gliomas. Int. J. of Mol. Sci., 16(7), p.15578-91. CHEMISTRY, MULTIDISCIPLINARY, 2014 IF=2.862, RANK=46/157 (29.3%)
Chiou HY Clair, Lai WK, Huang LC, Huang SM , Chueh SH, Ma HI and Hueng DY* (2015, Apr). Valproic acid promotes radiosensitization in meningioma stem-like cells. Oncotarget, 6(12).p.9959-9969. ONCOLOGY 2014 IF=6.359, RANK=21/211 (10%)
Chiou HY Clair, Liu SY, Lin CH, Lee Eminy HY* (2014, Jun). Hes-1 SUMOylation by protein inhibitor of activated STAT1 enhances the suppressing effect of Hes-1 on GADD45α expression to increase cell survival. Journal of Biomedical Science, 21(1):53. MEDICINE, RESEARCH & EXPERIMENTAL 2013 IF=2.736, RANK=49/124 (39.5%)
Lin MH, Yeh LT, Chen SJ, Chiou HY Clair, Chu CC, Yen LB, Lin KI, Chang DM, Sytwu HK* (2014, Feb). T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in nonobese diabetic mice by increasing Th1 and Th17 cells. Clinical Immunology, 151(2):101-113. IMMUNOLOGY 2013 IF=3.992, RANK=40/144 (27.8%)
Lin MH, Chou FC, Yeh LT, Fu SH, Chiou HY Clair, Lin KI, Chang DM, Sytwu HK* (2013, Jan). B lymphocyte-induced maturation protein 1 (BLIMP-1) attenuates autoimmune diabetes in NOD mice by suppressing Th1 and Th17 cells. Diabetologia, 56(1):136-146. ENDOCRINOLOGY & METABOLISM 2012 IF=6.487, RANK=10/143 (9.4%)
Chen TC, Lee SA, Hong TM, Shih JY, Lai JM, Chiou HY Clair, Yang SC, Chan CH, Kao CY, Yang PC, Huang CY* (2009 Nov). From midbody protein-protein interaction network construction to novel regulators in cytokinesis J Proteome Res. 2009;8(11):4943-53.