English Version
PI: MING-HONG LIN, PhD
Affiliation:
1. Department of Microbiology and Immunology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan
2. Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan
Current Position: Associate Professor (2022/2-present)
Office: MR313, 3rd Floor, Medical Research Building
Laboratory: MR307, 3rd Floor, Medical Research Building
TEL: +886-7-312-1101 ext. 2150 #11 (Office) or #20 (Lab)
Mail Address: No.100, Shih-Chuan 1st Road, Sanmin Dist., Kaohsiung City,80708, Taiwan
Education
National Sun Yat-Sen University, Taiwan BS 1999 Biology Sciences
National Tsing Hua University, Taiwan MS 2001 Life Sciences
National Defense Medical Center, TAIWAN PhD 2012 Immunology
National Defense Medical Center, TAIWAN Postdoctoral Fellow 2015 Immunology
National Defense Medical Center, TAIWAN Postdoctoral SCHOLAR 2016 Immunology
POSITION HELD
2022/2-present Full-time associate professor, Department of Microbiology and Immunology, School of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan
2016/2-2022/1 Full-time assistant professor, Department of Microbiology and Immunology, School of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan
2019/8-present Joint-appointment investigator, Center for Cancer Research, Kaohsiung Medical University, Taiwan
2017/1-present Adjunct investigator, Department of Medical Research, Kaohsiung Medical University Hospital, Taiwan
2016/8-present Joint-appointment assistant professor, M.Sc. Program in Tropical Medicine, College of Medicine, Kaohsiung Medical University, Taiwan
2015/8-2016/1 Postdoctoral Research Scholar, Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taiwan
2013/8 – 2016/1 Adjunct Assistant Professor, Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taiwan
PUBLICATION
C.-W Wang#, H.-Y.C. Chiou#, S.-C. Chen, D.-W. Wu, H.-H. Lin, H.-C. Chen, W.-T. Liao, M.-H. Lin*, C.-H. Hung* and C.-H. Kuo*; Arsenic exposure and lung fibrotic changes-evidence from a longitudinal cohort study and experimental models. Frontiers in Immunology 2023 Jul (Accepted) (2022 JCR, IF=7.3; R/C=35/161, IMMUNOLOGY - SCIE)
L.-T. Wang, S.-N. Wang, S.-S. Chiou, J.-P. Tsai, C.-Y. Chai, L.-W. Tseng, J.-C. Lee, M.-H. Lin, S.-K. Huang and S.-H. Hsu*; HCV core protein–ISX axis promotes chronic liver disease progression via metabolic remodeling and immune suppression. Adv Sci (Weinh) 2023 Jun 14;e2300644. doi: 10.1002/advs.202300644; Co-Author (2022 JCR, IF=15.1; R/C=24/342, MATERIALS SCIENCE, MULTIDISCIPLINARY-SCIE) PubMed
S.-H. Cheng, H.-Y.C. Chiou, J.-W. Wang, M.-H. Lin*; Reciprocal regulation of cancer-associated fibroblasts and tumor microenvironment in gastrointestinal cancer: implications for cancer dormancy; Cancers 2023, 15(9), 2513; https://doi.org/10.3390/cancers15092513; Corresponding author (2022 JCR, IF=5.2; R/C=72/241, ONCOLOGY-SCIE) PubMed
H.-Y.C. Chiou, C.-W. Wang, S.-C. Chen, M.-L. Tsai, M.-H. Lin*, C.-H. Hung*, C.-H. Kuo*; Copper Exposure Induces Epithelial-Mesenchymal Transition-Related Fibrotic Change via Autophagy and Increase Risk of Lung Fibrosis in Human; Antioxidants 2023; 12(2):532. https://doi.org/10.3390/antiox12020532; Corresponding author (2022 JCR, IF=7.0; R/C=6/60, CHEMISTRY, MEDICINAL-SCIE) PubMed
C.-H. Lin, S.-C. Li, M.-H. Lin, C.-J. Ho, Y.-T. Lu, Y. Lin, P.-H. Lin, K.-W. Tsai, M.-H Tsai; S100A6 Participates in Initiation of Autoimmune Encephalitis And Is Under Epigenetic Control; Brain and Behavior 2023 Feb 7;e2897. doi: 10.1002/brb3.2897. Online ahead of print; Co-author (2022 JCR, IF=3.1; R/C=15/52, BEHAVIORAL SCIENCES-SCIE) PubMed
M.-H. Lin, P.-C. Cheng, P.-J. Hsiao, S.-C. Chen, C.-H. Hung, C.-H. Kuo, S.-K. Huang, and H.-Y.C. Chiou*; The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in diet-induced obese mice through modulation of microglial M2 polarization and downregulation of SR-A4; International Immunopharmacology 2023 Feb;115:109653. doi: 10.1016/j.intimp.2022.109653. Epub 2022 Dec 30; First author (2022 JCR, IF=5.6; R/C=45/277, PHARMACOLOGY&PHARMACY-SCIE) PubMed
M.-K. Tsai, M.-L. Tsai, Z.-H. Wen, W.-T. Liao, Y.-C. Lin, H.-Y.C. Chiou, M.-H. Lin, C.-H. Hung*; Suppressive Effects of 4-(phenylsulfanyl) butan-2-one on CCL-1 Production via Histone Acetylation in Monocytes; Current Issues in Molecular Biology 2022 Oct; 44(10): 4616–4625; Co-Author (2021 JCR IF=2.976, R/C=216/296, BIOCHEMISTRY & MOLECULAR BIOLOGY-SCIE) PubMed
J.-W. Wang, P.-I. Hsu, M.-H. Lin, J. Y. Kao, F.-W. Tsay, I.-T. Wu, C.-B. Shie, D.-C. Wu*; The efficacy of culture-guided versus empirical therapy with high-dose proton pump inhibitor as third-line treatment of Helicobacter pylori infection－A real-world clinical experience; Journal of Gastroenterology and Hepatology 2022 Oct;37(10):1928-1934. doi: 10.1111/jgh.15942. Epub 2022 Jul 20.; Co-Author (2021 JCR IF=4.369, R/C=43/93, GASTROENTEROLOGY & HEPATOLOGY-SCIE) PubMed
L.-T. Wang, K.-Y. Liu, S.-N. Wang, M.-H. Lin, Y.-M. Liao, P.-C. Lin, S.-K. Huang, S.-H. Hsu, S.-S. Chiou; Aryl hydrocarbon receptor–kynurenine axis promotes oncogenic activity in BCP-ALL; Cell Biology and Toxicology 2022 Jun 10. doi: 10.1007/s10565-022-09734-0; Co-Author (2021 JCR IF=6.819, R/C=9/94, TOXICOLOGY-SCIE) PubMed
Y.-W. Liu, S.-H. Fu, M.-W. Chien, C.-Y. Hsu, M.-H. Lin, J.-L. Dong, J.-H.R. Lu, Y.-J. Lee, P.-Y. Chen, C.-H. Wang, H.-K. Sytwu*; Blimp-1 moulds the epigenetic architecture of IL-21-mediated autoimmune diseases through an autoregulatory circuit; JCI INSIGHT 2022 Jun 8;7(11):e151614. doi: 10.1172/jci.insight.151614; Co-Author (2021 JCR IF=9.533, R/C=19/139, MEDICINE, RESEARCH & EXPERIMENTAL-SCIE) PubMed
M.-J. Lee†, P.-C. Lin†, M.-H. Lin, H.-Y.C. Chiou, K. Wang, C.-W. Huang*; Kinetic alternations in resurgent sodium currents of mutant Nav1.4 channel in two patients affected by paramyotonia congenita; BIOLOGY-Basel 2022 APRIL, 11(4), 613, doi.org/10.3390/biology11040613; Co-Author (2021 JCR IF=5.168, R/C=21/94, BIOLOGY-SCIE) PubMed
H.-C. Chen, H.-Y.C. Chiou, M.-L. Tsai, S.-C. Chen, M.-H. Lin, T.-C. Chuang, C.-H. Hung, C.-H. Kuo; Effects of Montelukast on Arsenic-Induced Epithelial-Mesenchymal Transition and the Role of Reactive Oxygen Species Production in Human Bronchial Epithelial Cells; Frontiers in Pharmacology 2022 Apr 19;13:877125. doi: 10.3389/fphar.2022.877125. eCollection 2022; Co-Author (2021 JCR IF=5.988, R/C=50/279, PHARMACOLOGY&PHARMACY-SCIE) PubMed
K.-J. Chiu†, H.-Y. C. Chiou†, C.-H. Huang, P.-C. Lu, H.-R. Kuo, J.-W. Wang*, M.-H. Lin*; Natural compounds targeting cancer-associated fibroblasts against digestive system tumor progression: Therapeutic insights; BIOMEDICINES 2022 Mar, 10(3), 713, doi.org/10.3390/biomedicines10030713; Corresponding Author (2021 JCR IF=4.757, R/C=86/279, PHARMACOLOGY&PHARMACY-SCIE) PubMed
L.-T Wang†, M.-H. Lin†, K.-Y. Liu, S.-S Chiou, S.-N. Wang, C.-Y. Chai, L.-W. Tseng, H.-Y. C. Chiou, H.-C. Wang, K. K. Yokoyama, S.-H. Hsu*, S.-K. Huang*; Wntless is essential in controlling dendritic cell homeostasis via Wnt signaling-independent mechanism; Autophagy 2021 Dec; 17(12), 4202-4217; DOI: 10.1080/15548627.2021.1907516; First Author (2021 JCR, IF=13.391; R/C=22/194, CELL BIOLOGY-SCIE) PubMed
T.-Y. Huang*, S.-S. Yang, C.-L. Liao, M.-H. Lin, H.-H. Lin, J.-C. Lin, P.-J. Chen, Y.-L. Shih, W.-K. Chang, T.-Y. Hsieh; SPAK Deficiency Attenuates Chemotherapy-Induced Intestinal Mucositis; Frontiers in Oncology 2021 Nov, 11:733555, doi.org/10.3389/fonc.2021.733555; Co-Author (2021 JCR IF=5.738, R/C=78/245, ONCOLOGY-SCIE) PubMed
H.-Y. C. Chiou, S.-H. Huang, C.-H. Hung, S.-M. Tsai, H.-R. Kuo, Y.-R. Huang, J.-W. Wang, S.-C. Chen, C.-H. Kuo, D.-C. Wu, S.-K. Huang, S.-H. Hsu, M.-H. Lin*; Hyperbaric oxygen therapy alleviates the autoimmune encephalomyelitis via the reduction of IL-17A and GM-CSF production of autoreactive T cells as well as boosting the immunosuppressive IL-10 in the central nervous system tissue lesions; BIOMEDICINES 2021 Aug, 9 (8), 943; Corresponding Author (2021 JCR IF=4.757, R/C=86/279, PHARMACOLOGY & PHARMACY-SCIE) PubMed
C.-H. Li, H.-Y. C. Chiou, M.-H. Lin, C.-H. Kuo, Y.-C. Lin, Y.-C. Lin*, C.-H. Hung*, C.-H. Kuo* Immunological map in COVID-19; Journal of Microbiology Immunology and Infection 2021 Aug;54(4):547-556. doi: 10.1016/j.jmii.2021.04.006 (Review); Co-Author (2021 JCR, IF=10.273; R/C=15/94, INFECTIOUS DISEASES-SCIE) PubMed
M.-H Tsai, C.-H Lin, K.-W. Tsai, M.-H Lin, C.-J Ho, Y.-T Lu, K.-P Weng, Y. Lin, P.-H Lin, S.-C Li* S100A6 promotes B lymphocytes penetration through blood-brain barrier in autoimmune encephalitis; Frontiers in Genetics 2019 November, 10 (29), 1188-1196; Co-Author (2021 JCR, IF=4.772; R/C=55/191, GENETICS&HEREDITY-SCIE) PubMed
M.-H Lin, K.-M. Lee, C.-Y. Hsu, S.-Y. Peng, C.-N. Lin, C.-C. Chen, C.-K. Fan, P.-C. Cheng* Immunopathological effects of Agaricus blazei Murill polysaccharides against Schistosoma mansoni infection by Th1 and NK1 cells differentiation; International Immunopharmacology 2019 Jun, 73, 502-514; First Author (2021 JCR, IF=5.714; R/C=56/279, PHARMACOLOGY&PHARMACY-SCIE) PubMed
H.-Y.C. Chiou, M.-W. Lin, P.-J. Hsiao, C.-L. Chen, S. Chiao, T.-Y. Lin, Y.-C. Chen, D.-C. Wu, M.-H. Lin* Dulaglutide modulates the development of tissue-infiltrating Th1/Th17 cells and the pathogenicity of encephalitogenic Th1 cells in the Central Nervous System; International Journal of Molecular Sciences 2019 Mar, 20(7), 1584; Corresponding Author (2021 JCR, IF=6.206; R/C=69/296, BIOCHEMISTRY&MOLECULAR BIOLOGY-SCIE) PubMed
P.-C. Wu, W.-L Hsu, C.-L. Chen, C.-F Lam, Y.-B. Huang, C.-C. Huang, M.-H. Lin*, M.-W. Lin*; Morphine Induces Fibroblast Activation through Up-regulation of Connexin 43 Expression: Implication of Fibrosis in Wound Healing; International Journal of Medical Sciences 2018 Jun; 15(9):875-882. Corresponding Author (2021 JCR, IF=3.642; R/C=64/172, MEDICINE, GENERAL & INTERNAL-SCIE) PubMed
C.-L. Chung, S.-W. Wang, R. Martin, H.-J. Knölker, Y.-C. Kao, M.-H Lin, J.-J. Chen, Y.-B. Huang, D.-C. Wu, C.-L. Chen; Pentachloropseudilin inhibits transforming growth factor-β (TGF-β) activity by accelerating cell-surface type II TGF-β receptor turnover in target cells. Chembiochem. 2018 Apr, 19, 1-15. Co-Author (2021 JCR, IF=3.461; R/C = 36/63, CHEMISTRY, MEDICINAL-SCIE) PubMed
L.-L. Chang, W.-H. Hsu, M.-C. Kao, C.-C. Chou, C.-C. Lin, C.-J. Liu, B.-C. Weng, F.-C. Kuo, C.-H. Kuo, M.-H. Lin, C.-J. Wang, C.-H. Lin, D.-C. Wu*, S.-K. Huang*; Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases; Scientific Reports 2018 Feb 28;8(1):3821. Co-Author (2021 JCR, IF=4.996; R/C=19/73, MULTIDISCIPLINARY SCIENCES-SCIE) PubMed
M.-W. Chien, M.-H. Lin, S.-H. Huang, S.-H. Fu, C.-Y. Hsu, B.L. Yen, J.-T. Chen, D.-M. Chang and H.-K. Sytwu; Glucosamine modulates T cell differentiation through downregulating N-linked glycosylation of CD25. J Biol. Chem. 2015 Dec 4;290(49):29329-44. Co-Author (2021 JCR, IF=5.486; R/C=94/296, BIOCHEMISTRY & MOLECULAR BIOLOGY-SCIE) PubMed
W.-B Wang, M.-L Yen, K.-J Liu, P.-J Hsu, M.-H Lin, P.-M. Chen, P.-R. Sudhir, C.-H. Chen, C.-H Chen, H.-K. Sytwu, B.L. Yen; IL-25 mediates transcriptional control of PD-L1 via STAT3 in multipotent human mesenchymal stromal cells (hMSCs) to suppress Th17 responses. Stem Cell Reports 2015 September, Vol. 5: 1-13. Co-Author (2021 JCR, IF=7.294; R/C=8/29, CELL & TISSUE ENGINEERING-SCIE) PubMed
D.-Y Hueng, W.-C. Tsai, H.-Y. C. Chiou, S.-W. Feng, Y.-F. Li, L.-C. Huang, M.-H. Lin DDX3X biomarker correlates with poor survival in human gliomas International Journal of Molecular Sciences 2015 July, 16, 15578-15591. Co-Author (2021 JCR, IF=6.206; R/C=69/296, BIOCHEMISTRY&MOLECULAR BIOLOGY-SCIE) PubMed
S.-H. Fu, M.-H. Lin, L.-T. Yeh, Y.-L. Wang, M.-W. Chien, S.-H. Lin, D.-M. Chang and H.-K. Sytwu; Targeting tumor necrosis factor receptor 1 assembly reverses Th17-mediated colitis through boosting a Th2 response. GUT 2015 May, 64 (5): 765-775. Co-Author (2021 JCR, IF=31.84; R/C = 4/93, GASTROENTEROLOGY & HEPATOLOGY-SCIE) PubMed
C.-H. Li, M.-H. Lin, S.-H. Chu, P.-H. Tu, C.-C. Fang, C.-H. Yen, P.-I. Liang, J.-C. Huang, Y.-C. Su, H.-K. Sytwu and Y.-M. A. Chen; Role of Glycine N-methyltransferase in the Regulation of T Cell Responses in Experimental Autoimmune Encephalomyelitis. Molecular Medicine 2014 December, 20 (1): 684-696. Co-Author (2021 JCR, IF=6.4; R/C=66/296, BIOCHEMISTRY&MOLECULAR BIOLOGY-SCIE) PubMed
M.-H. Lin, L.-T. Yeh, S.-J. Chen, H.-Y.C. Chiou, C.-C. Chu, B.L. Yen, K.-I. Lin, D.-M. Chang and H.-K. Sytwu; T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in non-obese diabetic mice by increasing Th1 and Th17 cells. Clinical Immunology 2014 Apr; 151(2):101-13. First Author (2021 JCR, IF=10.19; R/C=28/161, IMMUNOLOGY-SCIE) PubMed
F.-C. Chou, C.-C. Kuo, Y.-L. Wang, M.-H. Lin, B.L. Yen, D.-M. Chang and H.-K. Sytwu; Overexpression of Galectin-9 in Islets Prolongs Grafts Survival via Downregulation of Th1 Responses. Cell Transplantation 2013 Nov; 22(11):2135-45. Co-Author (2021 JCR, IF=4.139; R/C=9/24, TRANSPLANTATION-SCIE) PubMed
L.-T. Yeh, S.-C. Miaw, M.-H. Lin, F.-C. Chou, S.-J. Shieh, Y.-P. Chuang, S.-H. Lin, D.-M. Chang and H.-K. Sytwu; Different Modulation of Ptpn22 in Effector and Regulatory T Cells Leads to Attenuation of Autoimmune Diabetes in Transgenic Nonobese Diabetic Mice. Journal of Immunology 2013 Jul 15; 191(2):594-607. Co-Author (2021 JCR, IF=5.446; R/C=65/161, IMMUNOLOGY-SCIE) PubMed
M.-H. Lin, F.-C. Chou, L.-T. Yeh, S.-H. Fu, H.-Y.C. Chiou, K.-I. Lin, D.-M. Chang and H.-K. Sytwu; B lymphocyte-induced maturation protein 1 (BLIMP-1) attenuates autoimmune diabetes in NOD mice by suppressing Th1 and Th17 cells. Diabetologia 2013 Jan; 56(1):136-46. First Author (2021 JCR, IF=10.46; R/C=11/146, ENDOCRINOLOGY & METABOLISM-SCIE) PubMed
D.-W. Tzeng, M.-H. Lin, B.-Y. Chen, Y.-C. Chen, Y.-C. Chang and W.-Y. Chow; Molecular and functional studies of tilapia (Oreochromis mossambicus) NMDA receptor NR1 subunits. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 2007 Mar; 146 (3):402-11. Co-Author (2021 JCR, IF=2.495; R/C=34/176, ZOOLOGY-SCIE) PubMed
A.-C. Tien, M.-H. Lin, L.-J. Su, Y.-R. Hong, T.-S. Cheng, Y.-C. Lee, W.-J. Lin, I.-H. Still and C.-Y. Huang; Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. Mol Cell Proteomics. 2004 Jan; 3(1):93-104. Co-Author (2021 JCR, IF=7.381; R/C=7/79, BIOCHEMICAL RESEARCH METHODS-SCIE) PubMed