Understanding how metastasizing cells successfully adapt to the changing environments they encounter after leaving the primary tumor.

Host immune response to parasite infection with a particular focus on type 2 immunity.

Fundamental biology of innate immune cells, particularly monocytes and macrophages.

Roles for the microbiota and dietary factors in the control of immunity and protection to pathogens.

Early life immune development and mechanisms underlying tolerance to the microbiota.

Identifying the molecular and cellular factors that influence tumor sensitivity and resistance to immune surveillance.

Molecular mechanisms determining the role of the lysosome and other membrane-bound organelle interactions with biomolecular condensates.

How the developing brain establishes immune protection and how childhood brain tumours exploit these same mechanisms to evade detection.

Unraveling the complex interplay between cells that sense potential threats and effector cells that are responsible for restoring homeostasis.

Understanding what brings dormant tumour cells in and out of dormancy, and how can dormant DTCs be targeted.

Decoding the molecular language of immune recognition to advance cancer immunotherapy and understand autoimmunity.

Hedgehog signalling in T lymphocytes in the context of cancer.

Using biochemistry, biophysics and in vivo biology to study chemokines, the glycocalyx and inflammatory disease.

Understanding how the immune system fights fungal infections.

Mechanisms of MS, neuroinflammation, regenerative inflammation, inflammasomes in tissue damage and repair.

How neuroimmune circuits regulate barrier tissue function in both homeostasis and disease.

Understanding how the salivary glands are built in the first place and how they are damaged during radiotherapy.

Immunological memory, specifically on memory T cells as essential mediators of protective immunity.

Roles of neutrophils and autoantibodies in the pathology of Arthritis.

Interactions between the microbial community of the gastrointestinal track and the central nervous system.

How T cells regulate B cells and contribute to the development of autoimmunity. 

B cell immunity to Mucosal Antigens.

Ontogeny and differentiation of macrophages and dendritic cells.

Understanding the origins of cancer, both in children and adults.

Understanding host interactions that enable the immune system to mount a response against cancer.

Understanding how age-driven metabolic and epigenetic changes drive tumor progression and metastasis formation. 

Understanding how DCs develop from hematopoietic stem cells and control the activation T lymphocytes.

How the tuberculosis bacteria manage to outsmart our body’s defences and survive inside human cells.

Understanding the mechanisms of inflammation occurring in a diseased brain.

Understanding the functional diversity of dendritic cells and macrophages in tumor immunity and immunotherapy.

Understanding the pathways ILCs use to regulate inflammation at mucosal barrier tissue sites.

The role of tissue immune niches in regulating organ homeostasis, inflammation, and cancer.

Mechanisms of how innate immune cells contribute to physiology and pathology.

Interactions between the immune system and whole body and cellular metabolism in the context of health and obesity.

Understanding the mechanisms that underpin robust responses to vaccination and infection.

Understanding mucosal immunity in the bladder in the context of infection, cancer, and immunotherapy.

How adaptive immune responses are shaped within tissues, with a particular focus on the liver, in the context of chronic infection and cancer.

The mechanisms of how dendritic cells control lymphocyte responses.

CD4 T cell responses in barrier tissues, with a specific focus on the formation and impact of CD4 T cells that support antibody production by B cells.

Molecular physiology of phagocytic cells in health and disease.

Investigating ways to generate robust immune responses to infectious diseases across the lifespan.

Studying the spatio-temporal dynamics of immune cells.

Understanding how M. tuberculosis changes the lung environment to render human macrophages more susceptible to HIV-1 infection.

Studying T lymphocyte development, both under steady state, physiological conditions, as well as in leukemia.

Studying how the intestine generates protective responses against invading pathogens while absorbing beneficial molecules.

Effects of stroke on systemic immune function and how this contributes to complications of stroke recovery, including infection, gastrointestinal dysfunction and fatigue.

Fundamental differences between naïve and memory T cells and investigate the interactions between immune cells and local stromal cells following viral infection.

Biology of dendritic cells in the intestine, and on how these cells respond to infectious or inflammatory stimuli.

How conventional dendritic cells (cDCs) act as central sensors: decoding signals from the bone marrow to configure immunity across tissues.

Antibody-producing B lymphocytes and how their education by the mucosal microenvironment shapes antibody responses.

The regulation of immunity and pathogenesis in tuberculosis (TB).

Understanding how different cell types cooperate to achieve healthy tissue function and coordinate the response to injury and inflammation.

Studying innate immune mechanisms in a physiological context and applies its discoveries to engineer innovative immunotherapies

Understanding the specific adaptations made by CD4 and CD8 T cells to their local environment in health and disease within the human liver.

How interactions with gut microbes and metabolites affect resistance to infection, T cell responses and the gut-brain axis of neuronal function.

Investigating immunity and neuro-immune modulation in infection and cancer.

We want to uncover the injury signals and molecular mechanisms that activate neural stem cells and control regenerative neurogenesis.

Mechanisms that underlie the regulation of inflammation and the homeostatic control of immune function.

Discover how cancers suppress T cell responses to evade destruction and resist immunotherapy.

Understanding how the T-cell-mediated immune response is initiated.

Understanding the contribution of the different tumour cell populations and genetic alterations to cancer progression and response to therapy.

We study circadian rhythms in the immune response at the intersection of immunology, biochemistry and physiology.

Understanding of host microbe interactions, considering its translational impact towards the treatment of global infectious diseases.

Cellular and molecular interactions within the tumor microenvironment, with a focus on gamma-delta (γδ) T cells.

Dissecting the functional properties of dendritic cell subsets.

Understanding global principles of gene regulation and protein interactions, with application to immunology.

Understanding of the differentiation and the re-activation of Trm to ultimately develop approaches to wield these memory T cells for therapy of cancer patients.

Investigating the regulation of B lymphocyte activation and differentiation and the process of antibody affinity maturation.

Understanding sensory and communication pathways that determine immune cell fate and disease progression.

Using nanotechnology and single-molecule imaging to understand and cure neurodegenerative diseases.

Understanding the underlying mechanisms that mediate cancer-inhibitory versus tumour-promoting inflammation.

Whole-organism, cellular and molecular aspects of immune responses during viral infections.