Production Scientifique

1- Exploration et exploitation de la diversité génétique

Khiralla, A., Eltahir, L., Tzanova, T., Schohn, H., Deschaumes, S., Hehn, A., Tein, A., Yagi, S., Laurain-Mattar, D. (2016) Promising cytotoxic and antibacterial potentialities of endophytic fungi associated with medicinal plants from Sudan. (Sous presse dans FEMS Microbiology Letters)

Bouarroudj, K., Tamendjari, A., Larbat, R. (2016). Quality, composition and antioxidant activity of Algerian wild olive (Olea europaea L. subsp. Oleaster) oil. Industrial crops and products, 83, 484-491. DOI: 10.1016/j.indcrop.2015.12.081

Rottloff, S., Miguel, S., Biteau, F., Nisse, E., Hammann, P., Kuhn, L., Chicher, J., Bazile, V., Gaume, L., Mignard, B., Hehn, A., Bourgaud, F. (2016). Proteome analysis of digestive fluids in Nepenthese pitchers. Annals of Botany, 117 (3): 479-495. DOI: 10.1093/aob/mcw001

Dueholm, B., Krieger, C., Drew, D., Olry, A., Kamo, T., Taboureau, O., Weitzel, C., Bourgaud, F., Hehn, A., Simonsen, H. T. (2015). Evolution of substrate recognition sites (SRSs) in cytochromes P450 from Apiaceae exemplified by the CYP71AJ subfamily. BMC evolutionary biology, 15. DOI : 10.1186/s12862-015-0396-z

Dugrand, A., Olry, A., Hehn, A., Costantino, G., Ollitrault, P., Froelicher, Y., Bourgaud, F. (2015). The Distribution of Coumarins and Furanocoumarins in Citrus Species Closely. Matches Citrus Phylogeny and Reflects the Organization of Biosynthetic Pathways. Plos One Volume: 10, Issue: 11 Article Number: e0142757 . DOI: 10.1371/journal.pone.0142757

Durand-Hulak, M., Dugrand, A., Duval, T., Bidel, L., Jay-Allemand, C., Froelicher, Y., Bourgaud, F., Fanciullino, A.-L. (2015). Mapping the genetic and tissular diversity of 64 phenolic compounds in Citrus species using a UPLC-MS approach. Annals of Botany, 115 (5), 861-877. DOI : 10.1093/aob/mcv012

Larbat, R., Paris, C., Le Bot, J., Adamowicz, S. (2014). Phenolic characterization and variability in leaves, stems and roots of Micro-Tom and patio tomatoes, in response to nitrogen limitation. Plant Science, 224, 62-73. DOI : 10.1016/j.plantsci.2014.04.010

Biteau, F., Nisse, E., Miguel, S., Hannewald, P., Bazile, V., Gaume, L., Mignard, B., Hehn, A., Bourgaud, F. (2013). A simple SDS-PAGE protein pattern from pitcher secretions as a new tool to distinguish Nepenthes species (Nepenthaceae). American Journal of Botany, 100 (12), 2478-2484. DOI : 10.3732/ajb.1300145

Chougui, N., Tamendjari, A., Hamidj, W., Hallal, S., Barras, A., Richard, T., Larbat, R. (2013). Oil composition and characterisation of phenolic compounds of Opuntia ficus-indica seeds. Food Chemistry, 139 (1-4), 796 - 803. DOI : 10.1016/j.foodchem.2013.01.054

Dugrand, A., Olry, A., Duval, T., Hehn, A., Froelicher, Y., Bourgaud, F. (2013). Coumarin and furanocoumarin quantitation in citrus peel via ultraperformance liquid chromatography coupled with mass spectrometry (UPLC-MS). Journal of Agricultural and Food Chemistry, 61 (45), 10677-84. DOI : 10.1021/jf402763t

Biteau, F., Nisse, E., Hehn, A., Miguel, S., Hannewald, P., Bourgaud, F. (2012). A rapid and efficient method for isolating high quality DNA from leaves of carnivorous plants from the Drosera genus. Molecular Biotechnology, 51 (3), 247-253. DOI : 10.1007/s12033-011-9462-y

KOALA M., HEMA A., PALE E., SPINA R., DUPIRE F., CHRETIEN F.,SEREME A., NACRO M., CHAPLEUR Y., LAURAIN-MATTAR D. Farine de la Patate Douce à Chair Orange caractérisation des caroténoïdes et conservation. J. Soc. Ouest-Afr. Chim., 2014, 038, 42- 49. KHIRALLA A., SPINA R., YAGI S., MOHAMED I. and LAURAIN-MATTAR D. Endophytic fungi: occurrence, classification, function and natural products. In: Endophytic Fungi: Diversity, Characterization and Biocontrol, Evelyn Hughes ed., Nova Science Publishers, Hauppauge NY, USA, 2017, 1-35.

RIVIERE, C., NGUYEN THI HONG, V., NGUYEN HOAI, N., DEJAEGHER, B., TISTAERT, C., PHAN VAN, K., VANDER HEYDEN, Y., CHAU VAN, M., QUETIN-LECLERCQ, J. N-methyl-5-carboxamide-2-pyridone from Mallotus barbatus: A chemosystematic marker of the Euphorbiaceae genus Mallotus. Biochem. Syst. Ecol., 2012, 44, 212- 215 (IF = 1,2).

RIVIERE, C., PAWLUS, A.D., MERILLON, J.M. Natural stilbenoids: distribution in the plant kingdom and chemotaxonomic interest in Vitaceae. Nat. Prod. Rep., 2012, 29, 1317-1333 (IF = 10,2).

PAWLUS, A.D., SAHLI, R., BISSON, J., RIVIERE, C., DELAUNAY, J.C., RICHARD, T., GOMEZ, E., BORDENAVE, L., WAFFO-TEGUO, P., MERILLON, J.M. Stilbenoid Profiles of Canes from Vitis and Muscadinia Species. J. Agr. Food Chem., 2013, 61, 501-511 (IF = 3,3).

ROUAIGUIA-BOUAKKAZA, S., AMIRA-GUEBAILIA, H., RIVIERE, C., DELAUNAY, J.C., WAFFO-TEGUO, P., MERILLON, J.M. Identification and quantification of furanocoumarins in stem bark and woody part of eight Algerian varieties of Ficus carica L. by RP-HPLC-DAD and RP-HPLC-DAD-MS. Nat. Prod. Commun., 2013, 4, 485- 486 (IF = 1,0).

Van, N.T.H., C. Rivière, P.Q. Long, T.A. Vien, P. Van Kiem, & C. Van Minh, Flavonoids, megastigmanes and other constituents from Ardisia incarnata. Biochemical Systematics and Ecology, 2015. 61: p. 413-416.

Landoulsi, A., V. Roumy, N. Duhal, F. Harzallah Skhiri, C. Rivière, S. Sahpaz, C. Neut, J. Benhamida, & T. Hennebelle, Chemical Composition and Antimicrobial Activity of the Essential Oil from Aerial Parts and Roots of Eryngium barrelieri Boiss. and Eryngium glomeratum Lamk. from Tunisia. Chemistry & Biodiversity, 2016: p. n/a-n/a.

ANDRELLO M, BIZOUX J-P, BARBET-MASSIN M, GAUDEUL M, NICOLÈ F, TILL-BOTTRAUD I (2012) Effects of management regimes and extreme climatic events on plant population viability in Eryngium alpinum. Biological Conservation 147: 99-106

ANDRELLO M, NICOLÈ F, TILL-BOTTRAUD I, GAGGIOTTI OE (2012) Effect of stage-specific vital rates on population growth rates and effective population sizes in an endangered iteroparous plant. Conservation Biology 26: 208-217

CONORD C, GUREVITCH J, FADY B (2012) Large-scale longitudinal gradients of genetic diversity: A meta-analysis across six phyla in the mediterranean basin. Ecology and Evolution 2: 2600-2614

NICOLÈ F, GUITTON Y, COURTOIS EA, MOJA S, LEGENDRE L, HOSSAERT-MCKEY M (2012) Mseasy: Unsupervised and untargeted gc-ms data processing. Bioinformatics 28: 2278-2280

DAVISON R, NICOLE F, JACQUEMYN H, TULJAPURKAR S (2013) Contributions of covariance: Decomposing the components of stochastic population growth in Cypripedium calceolus. The American naturalist 181: 410-420

BLEROT B, BAUDINO S, PRUNIER C, DEMARNE F, TOULEMONDE B, CAISSARD J-C (2016) Botany, agronomy and biotechnology of pelargonium used for essential oil production. Phytochemistry Reviews 15: 935-960

CAISSARD JC, BAUDINO S (2016) Letters to the twenty-first century botanist: “What is a flower?” (4) the flower as a scent factory. Botany Letters 163: 355-358

MOJA S, GUITTON Y, NICOLÈ F, LEGENDRE L, PASQUIER B, UPSON T, JULLIEN F (2016) Genome size and plastid trnk-matk markers give new insights into the evolutionary history of the genus Lavandula L. Plant Biosystems 150: 1216-1224

RENAULT H., DE MAROTHY M.T.I., JONASSON G., LARA P., NELSON D.R., NILSSON I.M., ANDRÉ F., VON HEIJNE G., WERCK-REICHHART D. (2017) Evolution in seed plants of a CYP73 cytochrome P450 enzyme with atypical membrane topology. Mol. Biol. Evol., doi.org/10.1093/molbev/msx160

RENAULT H., ALBER A., HORST N.A., BASILIO LOPES A., FICH E.A., KRIEGSHAUSER L., WIEDEMANN G., ULLMANN P., HERRGOTT L., ERHARDT M., PINEAU E., EHLTING J., SCHMIT M., ROSE J.K.C., RESKI R., WERCK-REICHHART D. (2017) A phenol-enriched cuticle biopolymer is ancestral to lignin evolution in land plants. Nat. Commun., 8 :14713.

LIU Z., BOACHON B., LUGAN R., TAVARES R., ERHARDT M., MUTTERER J., DEMAIS V., PATEYRON S., BRUNAUD V., OHNISHI T., PENCIK A., ACHARD P., GONG F., HEDDEN P., WERCK-REICHHART D., RENAULT H. (2015) A conserved cytochrome P450 evolved in seed plants regulates flower maturation. Mol. Plant, 8:1751-1765.

VILLETTE C, BERNA A, COMPAGNON V, SCHALLER H (2015) Plant sterol diversity in pollen from angiosperms. Lipids 50:749-760.

HEITZLER P (2014) The mystery of recurrent blooming finally revealed in roses. (2014). Newsletter of the WFRS Heritage Rose Group, 11: 8-11.

HEITZLER P (2015) Rosa persica and its descendants. (2015). Newsletter of the WFRS Heritage Rose Group, 12: 14-18.

HEITZLER P (2016) New important insights on rose fragrance. (2016). Rosa Mundi, In Press.

VAN DEENEN N, BACHMANN AL, SCHMIDT T, SCHALLER H, SAND J, PRÜFER D, SCHULZE GRONOVER C (2012) Molecular cloning of mevalonate pathway genes from Taraxacum brevicorniculatum and functional characterisation of the key enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Mol Biol Rep 39:4337-4349.

FARHAN UL HAQUE M, NADALIG T, BRINGEL F, SCHALLER H, VUILLEUMIER S (2013) Fluorescence-based bacterial bioreporter for specific detection of methyl halide emissions in the environment. Appl Environ Microbiol. 79:6561-6567

QUERO A., MOLINIE R., BRANCOURT D., REMY M.J., MESNARD F. (2016) Sesquiterpene composition of Cinnamosma fragrans: A Malagasy endemic plant used in traditional medicine. Comptes Rendus Chimie, In Press : In Press.

BOUGOFFA-SADAOUI K., GONTIER E., TELLIEZ M.S., LEQUART-PILLON M., OUADID-AHIDOUCH H., MAIZA-BENABDESSELAM F. (2015) Caractérisation des alcaloïdes isoquinoléique de Fumaria agraria et évaluation de leur potentiel antiprolifératif vis-à-vis des cellules cancéreuses mammaires. Phytothérapie, septembre : 1-8.

HAMANISHI E.T., BARCHET G.L.H., DAUWE R., MANSFIELD S.D., CAMPBELL M. (2015) Poplar trees reconfigure the transcriptome and metabolome in response to drought in a genotype- and time-of-day-dependent manner. BMC Genomics, 16 : 329

KHODHOROVA N.V., SHAVARDA A.L., LEQUART-PILLON M., LABERCHE J.C., VOITSEKHOVSKAJA O.V., BOITEL-CONTI M. (2013) Biosynthesis of benzylisoquinoline alkaloids in Corydalis bracteata : Compartmentation and seasonal dynamics. Phytochemistry, 92 : 60-70.

ILC T, HALTER D, MIESCH L, LAUVOISARD F, KRIEGSHAUSER L, ILG A, BALTENWECK R, HUGUENEY P, WERCK-REICHHART D, DUCHENE E, NAVROT N (2017) Wine aroma: A cytochrome P450 generates the precursor of the key odorant wine lactone in grape. New Phytologist, 213(1), 264-274.

PENSEC F, SZAKIEL A, PACZKOWSKI C, WOZNIAK A, GRABARCZYK M, BERTSCH C, FISCHER MJC, CHONG J (2015) Characterization of triterpenoid profiles and triterpene synthase expression in the leaves of eight Vitis vinifera cultivars grown in the Upper Rhine Valley. Journal of Plant Research, 129(3), 499-512.

KOECHLER S, BERTIN PN, PLEWNIAK F, BALTENWECK R, CASIOT C, HEIPIEPER HJ, BOUCHEZ O, ARSENE-PLOETZE F, HUGUENEY P, HALTER D (2016) Arsenite response in Coccomyxa sp. Carn explored by transcriptomic and non-targeted metabolomic approaches. Environmental Microbiology, 18(4), 1289-1300.

DUAN D, HALTER D, BALTENWECK R, TISCH C, TROSTER V, KORTEKAMP A, HUGUENEY P, NICK P, 2015. Genetic diversity of stilbene metabolism in Vitis sylvestris. Journal of Experimental Botany, 66, 3243–3257. doi:10.1093/jxb/erv137

GUILLAUMIE S, ILG A, RETY S, BRETTE M, TROSSAT-MAGNIN C, DECROOCQ S, LEON C, KEIME C, YE T, BALTENWECK-GUYOT R, CLAUDEL P, BORDENAVE L, VANBRABANT S, DUCHENE E, DELROT S, DARRIET P, HUGUENEY P, GOMES E (2013) Genetic Analysis of the Biosynthesis of 2-Methoxy-3-Isobutylpyrazine, a Major Grape-Derived Aroma Compound Impacting Wine Quality. Plant Physiology, 162, 604–615.

STEYER D, ERNY C, CLAUDEL P, RIVEILL G, KARST F, LEGRAS JL (2013) Genetic analysis of geraniol metabolism during fermentation. Food Microbiology, 33, 228–234.

STEYER D, AMBROSET C, BRION C, CLAUDEL P, DELOBEL P, SANCHEZ I, ERNY C, BLONDIN B, KARST F, LEGRAS JL (2012) QTL mapping of the production of wine aroma compounds by yeast. BMC Genomics, 13, 573.

DOUSSOT J, MATHIEU V, COLAS C, MOLINIÉ R, CORBIN C, MONTGUILLON J, MORENO Y BANULS L, RENOUARD S, LAMBLIN F, DUPRÉ P, MAUNIT B, KISS R, HANO C, LAINÉ E (2017) Investigation of the lignans content in extracts from Linum, Callitris and Juniperus species in relation to their antiproliferative activities. Planta Medica 83(6):574-581 (IF=2.34)

Ansel JL, Moretti C, Raharivelomanana P, Hano C (2016) Cosmetopoeia. CR Chimie 19 : 1033-1034 (IF=1.88)

RENOUARD S, CORBIN C, COLAS C, FIDEL T, LOPEZ T, LECLERC E, HENDRAWATI O, FALGUIERES A, DOUSSOT J, FERROUD C, MAUNIT B, LAINE E, HANO C (2015) Aerial Parts of Callitris Species as a Rich Source of Deoxypodophyllotoxin. Industrial Crops and Products 63 53–57 (IF=3.02)

RAYMOND O, GOUZY J, JUST J, BADOUIN H, VERDENAUD M, LEMAINQUE A, VERGNE P, MOJA S et al. (2018) The Rosa genome provides new insights into the domestication of modern roses. Nature Genetics 50, 772-777

2- Compréhension des voies de biosynthèse & ingénierie

COQUERET V., LE BOT J., LARBAT R., DESNEUX N., ROBIN C., ADAMOWICZ S., 2017. Nitrogen nutrition of tomato alters leafminer dietary intake dynamics. Journal of Insect Physiology (sous presse). 10.1016/j.jinsphys.2017.04.002

Larbat, R., Robin, C., Lillo, C., Drengstig, T., Ruoff, P. (2016). Modeling the diversion of primary carbon flux into secondary metabolism under variable nitrate and light/dark conditions. Journal of Theorical Biology • Doi: 10.1016/j.jtbi.2016.05.008

Soler, M., Plasencia, A., Lepikson-Neto, J., Leal Oliveira Camargo, E., Dupas, A., Ladouce, N., Pesquet, E., Mounet, F., Larbat, R., Grima-Pettenati, J. (2016) The woody-preferential gene EgMYB88 regulates the biosynthesis of phenylpropanoid-derived compounds in wood. Frontiers in Plant Science DOI: 10.3389/fpls.2016.01422

Royer, M., Larbat, R., Le Bot, J., Adamowicz, S., Nicot, P.C., Robin, C. (2016). Tomato response traits to pathogenic Pseudomonas species. Does nitrogen limitation matter? Plant Science, 244, 57-67.. DOI: 10.1016/j.plantsci.2015.12.008

Larbat, R., Adamowicz, S., Robin, C., Han, P., Desneux, N., Le Bot, J. (2016). Interrelated responses of tomato plants and the leaf miner Tuta absoluta to nitrogen supply. Plant Biology, 18, 495-504. DOI: 10.1111/plb.12425

Miguel, S., Biteau, F., Mignard, B., Marais, A., Candresse, T., Theil, S., Bourgaud F., Hehn, A. (2016). Beet western yellows virus infection in carnivorous plants from the Nepenthes mirabilis species. (Sous presse dans Archives of Virology). DOI: 10.1007/s00705-016-2891

Munakata, R., Olry, A., Karamat, F., Courdavault, V., Sugiyama, A., Date, Y., Krieger, C., Prisca, S., Foureau, E., Papon, N., Grosjean, J., Yazaki, K., Bourgaud, F., Hehn, A. (2016). Molecular evolution of parsnip membrane-bound prenyltransferases for linear and/or angular furanocoumarin biosynthesis. New Phytologist (sous presse) DOI:10.1111/nph.13899

Soler, M., Plasencia, A., Larbat, R., Pouzet, C., Jauneau, A., Rivas, S., Pesquet, E., Lapierre, C., Truchet, I., Grima-Pettenati, J. (2016). The Eucalyptus linker histone variant EgH1.3 cooperates with the transcription factor EgMYB1 to control wood formation. New Phytologist 213: 287-299 DOI: 10.1111/nph.14129

Eljounaidi, K., Comino, C., Moglia, A., Cankar, K., Genre, A., Hehn, A., Bourgaud, F., Beekwilder, J., Lanteri, S. (2015). Accumulation of cynaropicrin in globe artichoke and localization of enzymes involved in its biosynthesis. Plant Science, 239, 128-136. DOI : 10.1016/j.plantsci.2015.07.020

Eljounaidi, K., Cankar, K., Comino, C., Moglia, A., Hehn, A., Bourgaud, F., Bouwmeester, H., Menin, B., Lanteri, S., Beekwilder, J. (2014). Cytochrome P450s from Cynara cardunculus L. CYP71AV9 and CYP71BL5, catalyze distinct hydroxylations in the sesquiterpene lactone biosynthetic pathway. Plant Science, 223, 59-68. DOI : 10.1016/j.plantsci.2014.03.007

Höfer, R., Boachon, B., Renault, H., Gavira, C., Miesch, L., Iglesias, J., Ginglinger, J. F., Allouche, L., Miesch, M., Grec, S., Larbat, R., Werck-Reichhart, D. (2014). Dual function of the cytochrome P450 CYP76 family from Arabidopsis thaliana in the metabolism of monoterpenols and phenylurea herbicides. Plant Physiology, 166 (3), 1149-1161. DOI : 10.1104/pp.114.244814

Karamat, F., Olry, A., Munakata, R., Koeduka, T., Sugiyama, A., Paris, C., Hehn, A., Bourgaud, F., Yazaki, K. (2014). A coumarin-specific prenyltransferase catalyzes the crucial biosynthetic reaction for furanocoumarin formation in parsley. Plant Journal, 77 (4), 627-638. DOI : 10.1111/tpj.12409

Munakata, R., Inoue, T., Koeduka, T., Karamat, F., Olry, A., Sugiyama, A., Takanashi, K., Dugrand, A., Froelicher, Y., Tanaka, R., Uto, Y., Hori, H., Azuma, J.-I., Hehn, A., Bourgaud, F., Yazaki, K. (2014). Molecular cloning and characterization of a geranyl diphosphate-specific aromatic penyltransferase from lemon. Plant Physiology, 166 (1), 80 - 90. DOI : 10.1104/pp.114.246892

Siwinska, J., Kadzinski, L., Banasiuk, R., Gwizdek-Wisniewska, A., Olry, A., Banecki, B., Lojkowska, E., Ihnatowicz, A. (2014). Identification of QTLs affecting scopolin and scopoletin biosynthesis in Arabidopsis thaliana. BMC Plant Biology, 14. DOI : 10.1186/s12870-014-0280-9

Royer, M., Larbat, R., Le Bot, J., Adamowicz, S., Robin, C. (2013). Is the C:N ratio a reliable indicator of C allocation to primary and defence-related metabolisms in tomato? Phytochemistry, 88, 25 - 33.DOI : 10.1016/j.phytochem.2012.12.003

Karamat, F., Olry, A., Doerper, S., Vialart, G., Ullmann, P., Werck-Reichhart, D., Bourgaud, F., Hehn, A. (2012). CYP98A22, a phenolic ester 3 '-hydroxylase specialized in the synthesis of chlorogenic acid, as a new tool for enhancing the furanocoumarin concentration in Ruta graveolens. BMC Plant Biology, 12. DOI : 10.1186/1471-2229-12-152

Vialart, G., Hehn, A., Olry, A., Ito, K., Krieger, C., Larbat, R., Paris, C., Shimizu, B.-I., Sugimoto, Y., Mizutani, M., Bourgaud, F. (2012). A 2-oxoglutarate-dependent dioxygenase from Ruta graveolens L. exhibits p-coumaroyl CoA 2'-hydroxylase activity (C2'H): a missing step in the synthesis of umbelliferone in plants. Plant Journal, 70 (3), 460-470.DOI : 10.1111/j.1365-313X.2011.04879.x

Larbat, R., Le Bot, J., Bourgaud, F., Robin, C., Adamowicz, S. (2012). Organ-specific responses of tomato growth and phenolic metabolism to nitrate limitation. Plant Biology, 14 (5), 760 - 769. DOI : 10.1111/j.1438-8677.2012.00564.x

Larbat, R., Olsen, K. M., Slimestad, R., Lovdal, T., Benard, C., Verheul, M., Bourgaud, F., Robin, C., Lillo, C. (2012). Influence of repeated short-term nitrogen limitations on leaf phenolics metabolism in tomato. Phytochemistry, 77, 119 - 128. DOI : 10.1016/j.phytochem.2012.02.004

Benard, C., Bourgaud, F., Gautier, H. (2011). Temporary Nitrogen Deprivation on Tomato Leaf Phenolics. International Journal of Molecular Sciences, 12, (11), 7971-7981.

CAISSARD JC, OLIVIER T, DELBECQUE C, PALLE S, GARRY PP, AUDRAN A, VALOT N, MOJA S, NICOLE F, MAGNARD JL, LEGRAND S, BAUDINO S, JULLIEN F. (2012) Extracellular localization of the diterpene sclareol in clary sage (Salvia sclarea L., Lamiaceae). PLoS One 7(10):e48253.

CANIARD A, ZERBE P, LEGRAND S, COHADE A, VALOT N, MAGNARD JL, BOHLMANN J, LEGENDRE L. 2012. Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture. BMC Plant Biology 26;12:119.

Delporte, M., G. Legrand, J.-L. Hilbert, & D. Gagneul, Selection and validation of reference genes for quantitative real-time PCR analysis of gene expression in Cichorium intybus. Frontiers in Plant Science,

Legrand, G., M. Delporte, C. Khelifi, A. Harant, C. Vuylsteker, M. Mörchen, P. Hance, J.-L. Hilbert, & D. Gagneul, Identification and characterization of five BAHD acyltransferases involved in hydroxycinnamoyl ester metabolism in chicory. Frontiers in Plant Science, 2016. 7: p. 741.

Carciochi R.A., L. Galván D’Alessandro., P. Vandriessche, S. Chollet, Effect of germination and fermentation process on the antioxidant compounds of quinoa seeds. Plant Foods for Human Nutrition, 2016.

Carciochi, R.A., D. Galván, L. Alessandro, & G.D. Manrique, Effect of roasting conditions on the antioxidant compounds of quinoa seeds. International Journal of Food Science & Technology, 2016. 51(4): p. 1018-1025.

AMINI, A., ANDREU, F., GLEVAREC, G., RIDEAU, M. & CRECHE, J. (2012). Down-regulation of the CrHPT1 histidine phosphotransfer protein prevents cytokinin-mediated up-regulation of CrDXR, and CrG10H transcript levels in periwinkle cell cultures. Mol Biol Rep 39, 8491–6.

AL BALKHI, M. H., SCHILTZ, S., LESUR, D., LANOUE, A., WADOUACHI, A. & BOITEL-CONTI, M. (2012). Norlittorine and norhyoscyamine identified as products of littorine and hyoscyamine metabolism by (13)C-labeling in Datura innoxia hairy roots. Phytochemistry 74, 105–14.

GEU-FLORES, F., SHERDEN, N. H., COURDAVAULT, V., BURLAT, V., GLENN, W. S., WU, C., NIMS, E., CUI, Y. & O’CONNOR, S. E. (2012). An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis. Nature 492, 138–42.

GUIRIMAND, G., SIMKIN, A. J., PAPON, N., BESSEAU, S., BURLAT, V., ST-PIERRE, B., GIGLIOLI-GUIVARC’H, N., CLASTRE, M. & COURDAVAULT, V. (2012). Cycloheximide as a tool to investigate protein import in peroxisomes: a case study of the subcellular localization of isoprenoid biosynthetic enzymes. J Plant Physiol 169, 825–9.

GINIS, O., COURDAVAULT, V., MELIN, C., LANOUE, A., GIGLIOLI-GUIVARC’H, N., ST-PIERRE, B., COURTOIS, M. & OUDIN, A. (2012a). Molecular cloning and functional characterization of Catharanthus roseus hydroxymethylbutenyl 4-diphosphate synthase gene promoter from the methyl erythritol phosphate pathway. Mol Biol Rep 39, 5433–47.

GINIS, O., OUDIN, A., GUIRIMAND, G., CHEBBI, M., COURDAVAULT, V., GLÉVAREC, G., PAPON, N., CRÈCHE, J. & COURTOIS, M. (2012b). A type-B response regulator drives the expression of the hydroxymethylbutenyl diphosphate synthase gene in periwinkle. J Plant Physiol 169, 1571-4.

GUIRIMAND, G., GUIHUR, A., PHILLIPS, M. A., OUDIN, A., GLÉVAREC, G., MELIN, C., PAPON, N., CLASTRE, M., ST-PIERRE, B., RODRÍGUEZ-CONCEPCIÓN, M., BURLAT, V. & COURDAVAULT, V. (2012b). A single gene encodes isopentenyl diphosphate isomerase isoforms targeted to plastids, mitochondria and peroxisomes in Catharanthus roseus. Plant Mol Biol 79, 443–59.

GUIRIMAND, G., GUIHUR, A., PHILLIPS, M.A., OUDIN, A., GLÉVAREC, G., MAHROUG, S., MELIN, C., PAPON, N., CLASTRE, M., GIGLIOLI-GUIVARC'H, N., ST-PIERRE, B., RODRÍGUEZ-CONCEPCIÓN, M., BURLAT, V. & COURDAVAULT, V.(2012c). Triple subcellular targeting of isopentenyl diphosphate isomerases encoded by a single gene. Plant Signaling & Behavior 7,1495-7.

THABET, I., GUIRIMAND, G., GUIHUR, A., LANOUE, A., COURDAVAULT, V., PAPON, N., BOUZID, S., GIGLIOLI-GUIVARC’H, N., SIMKIN, A. J. & CLASTRE, M. (2012). Characterization and subcellular localization of geranylgeranyl diphosphate synthase from Catharanthus roseus. Mol Biol Rep 39, 3235–43.

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HEITZ T., WIDEMANN E., LUGAN R., MIESCH L., ULLMANN P., DESAUBRY L., HOLDER E., GRAUSEM B., KANDEL S., MIESCH M., WERCK-REICHART D., PINOT F. (2012) Cytochromes P450 CYP94C1 and CYP94B3 catalyze two successive oxidation steps of plant hormone Jasmonoyl-isoleucine for catabolic turnover. J. Biol. Chem., 287:6296–6306.

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SONAWANE PD, POLLIER J, PANDA S, SZYMANSKI J, MASSALHA H, YONA M, UNGER T, MALITSKY S, ARENDT P, PAUWELS L, ALMEKIAS-SIEGL E, ROGACHEV I, MEIR S, CÁRDENAS PD, MASRI A, PETRIKOV M, SCHALLER H, SCHAFFER AA, KAMBLE A, GIRI AP, GOOSSENS A, AHARONI A (2016) Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism. Nat Plants 3:16205-16217.

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HARTMANN M, HEMMERLIN A, GAS-PASCUAL E, GERBER E, TRITSCH D, ROHMER M, BACH TJ (2013) The effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cells. Faculty of 1000, F1000Res doi: 10.12688/f1000research.2-170.v2.

HEMMERLIN A, TRITSCH D, HAMMANN P, ROHMER M, BACH TJ (2013) Profiling of defense responses in Escherichia coli treated with fosmidomycin. Biochimie 99:54-62 (doi: 10.1016/j.biochi.2013.11.008)

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HUCHELMANN A, GASTALDO C, TRITSCH D, ROHMER M, BACH TJ, HEMMERLIN A (2013) metabolic regulation of protein isoprenylation in tobacco. febs j 280: 513-513.

HUCHELMANN A, CASTALDO C, VEINANTE M, ZENG Y, HEINTZ D, TRITSCH D, SCHALLER H, ROHMER M, BACH TJ, HEMMERLIN A (2014) S-Carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation. Plant Physiol 164(2):935-950.

GAS-PASCUAL E, BERNA A, BACH TJ, SCHALLER H (2014) Plant oxidosqualene metabolism: cycloartenol synthase-dependent sterol biosynthesis in Nicotiana benthamiana. PLoS One 2014 Oct 24; 9(10):e109156. doi: 10.1371/journal.pone.0109156. eCollection 2014.

GAS-PASCUAL E, SIMONOVIK B, SCHALLER H, BACH TJ (2015) Inhibition of cycloartenol synthase (CAS) function in tobacco BY-2 cells. Lipids 50: 761-772 (DOI 10.1007/s11745-015-4036-6).

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NAKAMOTO M, SCHMIT AC, HEINTZ D, SCHALLER H , OHTA D (2015) Diversification of sterol methyltransferase enzymes in plants and a role for β-sitosterol in oriented cell plate formation and polarized grow Plant J 84:860-874.

HEMMERLIN A, HARWOOD JL, BACH TJ (2012) A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis? Prog Lipid Res 51(2): 95-148.

LIAO P, WANG H, HEMMERLIN A, NAGEGOWDA DA, BACH TJ, WANG M, CHYE ML (2014) Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway. Plant Cell Rep 33:1005–1022 (doi 10.1007/s00299-014-1592-9)

BACH TJ, ROHMER M (eds) Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches; Springer New York, Heidelberg, Dordrecht, London 2013, 505 p.; Preface: p. V – VII.

WENTZINGER L, GERBER E, BACH TJ, HARTMANN M-A (2013) Occurrence of two acetoacetyl-coenzyme A thiolases with distinct expression patterns and subcellular localization in tobacco. In: Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches; Bach TJ & Rohmer M, eds; Springer New York, Chapter 24, pp 347-365.

HEMMERLIN A (2013) Post-translational events and modifications regulating plant enzymes involved in isoprenoid precursor biosynthesis. Plant Sci 203-204: 41-54.

MOREAU RA, BACH TJ, NES WD, PARISH EJ, MOSER JK, NYSTRÖM L (2015) 2014 G.J. Schroepfer Jr. Memorial AOCS Sterol Symposium: Recent Advances in Sterol Research, (Editorial). Lipids 50:719–720 (DOI 10.1007/s11745-015-4051-7.

BRODERSEN P, SAKVARELIDZE-ACHARD L, SCHALLER H, KHAFIF M, SCHOTT G, BENDAHMANE A, VOINNET O (2012) Isoprenoid biosynthesis is required for miRNA function and affects membrane association of AGO1 in Arabidopsis. Proc Natl Acad Sci USA 109: 1778-1783.

POST J, VAN DEENEN N, FRICKE J, KOWALSKI N, WURBS D, SCHALLER H, EISENREICH W, HUBER C, TWYRMAN RM, PRÜFER D, GRONOVER CS (2012) Laticifer-specific cis-prenyltransferase silencing affects the rubber, triterpene, and inulin content of Taraxacum brevicorniculatum. Plant Physiol 158:1406-1417.

WANG H, NAGEGOWDA DA, RAWAT R, BOUVIER-NAVÉ P, GUO D, BACH TJ, CHYE M-L (2012) Overexpression of Brassica juncea wild-type and mutant HMG-CoA synthase 1 in Arabidopsis up-regulates genes in sterol biosynthesis and enhances sterol production and stress tolerance. Plant Biotech J 10:31-42.

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LIAO P, WANG H, WANG M, HSIAO A-S, BACH TJ, CHYE M-L (2014) Transgenic tobacco overexpressing Brassica juncea HMG-CoA synthase 1 shows increased plant growth, pod size and seed yield. PLoS One 9(5):e98264. doi: 10.1371/journal.pone.0098264.

DE GHELLINCK A, SCHALLER H, LAUX V, HAERTLEIN M, SFERRAZZA M, MARÉCHAL E, WACKLIN H, JOUHET J, FRAGNETO G (2014) Production and Analysis of Perdeuterated Lipids from Pichia pastoris Cells. PLoS One 9(4):e92999

XING S, VAN DEENEN N, MAGLIANO P, FRAHM L, FORESTIER E, NAWRATH C, SCHALLER H, GRONOVER CS, PRÜFER D, POIRIER Y (2014) ATP citrate lyase activity is post-translationally regulated by sink strength and impacts the wax, cutin and rubber biosynthetic pathways. Plant J 79:270-8

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ABOURAICHA E., EL ALAOUI-TALIBI Z., TADLAOUI-OUAFI A., EL BOUTACHFAITI R., PETIT E., DOUIRA A., COURTOIS B., COURTOIS J., El MODAFAR C. (2016) Glucuronan and oligoglucuronans isolated from green algae activate natural defense responses in apple fruit and reduce postharvest blue and gray mold decay. Journal of Applied Phycology, DOI information: 10.1007/s10811-016-0926-0.

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QUERO A., MOLINIE R., MATHIRON D., THIOMBIANO B., FONTAINE J.-X., BRANCOURT D., VAN WUYTSWINKEL O., PETIT E., DEMAILLY H., MONGELARD G., PILARD S., THOMASSET B., MESNARD F. (2016) Metabolite profiling of developing Camelina sativa seed Metabolomics, 12 : 186

QUERO A., MOLINIE R., BRANCOURT D., REMY M.J., MESNARD F. (2016) Sesquiterpene composition of Cinnamosma fragrans: A Malagasy endemic plant used in traditional medicine. Comptes Rendus Chimie, 19 : 1056-1061.

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ROULARD R., PETIT E., MESNARD F., RHAZI L. (2016) Molecular investigations of flaxseed mucilage polysaccharides. International Journal of Biological Macromolecules, 86 : 840-847

ABOURAICHA E., EL ALAOUI-TALIBI Z., EL BOUTACHFAITI R., PETIT E., COURTOIS J., COURTOIS B., EL MODAFAR C. (2015) Induction of natural defense and protection against Penicillium expansum and Botrytis cinerea in apple fruit in response to bioelicitors isolated from green algae. Scientia Horticulturae, 181 : 121-128.

BOUAL Z., PIERRE G., DELATTRE C., BENAOUN F., PETIT E., GARDARIN C., MICHAUD P., DIDIOULDELHADJ M. (2015) Mediterranean semi-aridplant Astragalus armatusas a source of bioactive galactomannan. Bioactive Carbohydrates and Dietary Fibre, 5 : 10-18.

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DELATTRE C., PIERRE G., GARDARIN C., TRAIKIA M., EL BOUTACHFAITI R., ISOGAI A., MICHAUD P. (2015) Antioxidant activities of a polyglucuronic acid sodium salt obtained from TEMPO-mediated oxidation of xanthan. Carbohydrate Polymers, 116 : 34-41.

NGUYEN T.K.O., JAMALI A., LANOUE A., GONTIER E., DAUWE R. (2015) Unravelling the architecture and dynamics of tropane alkaloid biosynthesis using metabolite correlation networks . Phytochemistry, 116 : 94-103.

PAWLICKI-JULLIAN N., LEQUART-PILLON M., CONG L.H., LESUR D., CAILLEU D., MESNARD F., LABERCHE J.C., GONTIER E., BOITEL-CONTI M. (2015) Arylnaphtalene and aryltetralin-type lignans in hairy root cultures of Linum perenne, and the stereochemistry of 6-methoxypodophyllotoxin and one diastereoisomer by high performance liquid chromatography/mass spectrometry and NMR spectrometry. Phytochemical analysis, 26 : 310-319.

RENOUARD S., TRIBALAT M.A., LAMBLIN F., MONGELARD G., FLINIAUX O., CORBIN C., MAROSEVIC D., PILARD S., DEMAILLY H., GUTIERREZ L., HANO C., MESNARD F., LAINE E (2014) RNAi-mediated pinoresinol lariciresinol reductase gene silencing in flax (Linum usitatissimum L.) seed coat: Consequences on lignans and neolignans accumulation. Journal of Plant Physiology, 171 : 1372-1377

FANG J., RAMSAY A., PAETZ C., TATSIS E.C., RENOUARD S., HANO C., GRAND E., FLINIAUX O., ROSCHER A., MESNARD F., SCHNEIDER B. (2013) Concentration kinetics of secoisolariciresinol diglucoside and its biosynthetic precursor coniferin in developing flaxseed. Phytochemical analysis, 24 : 41-46.

CAILLOT S., RAT S., TAVERNIER M.L., MICHAUD P., KOVENSKY J., WADOUACHI A., CLEMENT C., BAILLIEUL F., PETIT E. (2012) Native and sulfated oligoglucuronans as elicitors of defence-related responses inducing protection against Botrytis cinerea of Vitis vinifera. Carbohydrate Polymers, 87 : 1728-1736.

EL MODAFAR, C., ELGADDA M., EL BOUTACHFAITI R., ABOURAICHA E., ZEHHAR N., PETIT E., EL ALAOUI-TALIBI Z., COURTOIS B., COURTOIS J. (2012) Induction of natural defence accompanied by salicylic acid-dependant systemic acquired resistance in tomato seedlings in response to bioelicitors isolated from green algae. Scientia Horticulturae, 138 : 55-63.

AL BALKHI M.H., SCHILTZ S., LESUR D., LANOUE A., WADOUACHI A., BOITEL-CONTI M. (2012) Norlittorine and norhyoscyamine identified as products of littorine and hyoscyamine metabolism by (13) C-labeling in Datura innoxia hairy roots. Phytochemistry, 74 : 105-114.

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MAGNARD JL, ROCCIA A, CAISSARD JC, VERGNE P, SUN P, HECQUET R, DUBOIS A, HIBRAND-SAINT OYANT L, JULLIEN F, NICOLE F, RAYMOND O, HUGUET S, BALTENWECK R, MEYER S, CLAUDEL P, JEAUFFRE J, ROHMER M, FOUCHER F, HUGUENEY P, BENDAHMANE M, BAUDINO S (2015) Biosynthesis of monoterpene scent compounds in roses. Science, 349: 81-83.

FISCHER MJC, RUSTENHOLZ C, LEH-LOUIS V, PERRIERE G (2015) Molecular and functional evolution of the fungal diterpene synthase genes. BMC Microbiology, 15:221.

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GINGLINGER JF, BOACHON B, HÖFER R, PAETZ C, KÖLLNER TG, MIESCH L, LUGAN R, BALTENWECK R, MUTTERER J, ULLMANN P, BERAN F, CLAUDEL P, VERSTAPPEN F, FISCHER MJC, KARST F., BOUWMEESTER H, MIESCH M, SCHNEIDER B, GERSHENZON J, EHLTING J, WERCK-REICHHART D (2013) Gene Coexpression Analysis Reveals Complex Metabolism of the Monoterpene Alcohol Linalool in Arabidopsis Flowers. Plant Cell, 25, 4640–4657.

BOUBAKRI H, POUTARAUD A, WAHAB MA, CLAYEUX C, BALTENWECK-GUYOT R, STEYER D, MARCIC C, MLIKI A, SOUSTRE-GACOUGNOLLE I (2013). Thiamine modulates metabolism of the phenylpropanoid pathway leading to enhanced resistance to Plasmopara viticola in grapevine. BMC Plant Biology, 13(31).

SIMKIN AJ, MIETTINEN K, CLAUDEL P, BURLAT V, GUIRIMAND G, COURDAVAULT V, PAPON N, MEYER S, GODET S, ST-PIERRE B, GIGLIOLI-GUIVARC'H N, FISCHER MJ, MEMELINK J, CLASTRE M. (2013) Characterization of the plastidial geraniol synthase from Madagascar periwinkle which initiates the monoterpenoid branch of the alkaloid pathway in internal phloem associated parenchyma. Phytochemistry, 85:36-43.

PARAGE C, TAVARES R, RETY S, BALTENWECK-GUYOT R, POUTARAUD A, RENAULT L, HEINTZ D, LUGAN R, MARAIS GAB, AUBOURG S, HUGUENEY P (2012) Structural, Functional, and Evolutionary Analysis of the Unusually Large Stilbene Synthase Gene Family in Grapevine. Plant Physiology, 160, 1407–1419.

CORBIN C, DROUET S, MATELJAK I, MARKULIN L, DECOURTIL C, RENOUARD S, LOPEZ T, DOUSSOT J, LAMBLIN F, AUGUIN D, LAINÉ E, FUSS E, HANO C. (2017) Functional characterization of the pinoresinol-lariciresinol reductase-2 gene reveals its roles in yatein biosynthesis and flax defense response. Planta. doi: 10.1007 (IF=3.59)

ANJUM S, ABBASI BH, DOUSSOT J, FAVRE-RÉGUILLON A, HANO C (2017) Effects of photoperiod regimes and ultraviolet- C radiations on biosynthesis of industrially important lignans and neolignans in cell cultures of Linum usitatissimum L. (Flax) Journal of Photochemistry and Photobiology B: 167:216-227 (IF=3.04)

RENOUARD S, HANO C, OUAGNE P, DOUSSOT J, BLONDEAU JP, LAINÉ E (2017) Cellulose coating and chelation of antibacterial compounds for the protection of flax yarns against natural soil degradation Polymer Degradation and Stability 138, 12-17 (IF=3.72)

RAMSAY A, FLINIAUX O, QUÉRO A, MOLINIE R, DEMAILLY H, HANO C, PAETZ C, ROSCHER A, GRAND E, KOVENSKY J, SCHNEIDER B, MESNARD F (2017) Kinetics of the incorporation of the main phenolic compounds into the lignan macromolecule during flaxseed development Food Chem 217:1-8. (IF=4.53)

FANG J, RAMSAY A, RENOUARD S, HANO C, LAMBLIN F, CHABBERT B, MESNARD F, SCHNEIDER B (2016) Laser microdissection and spatiotemporal pinoresinol-lariciresinol reductase gene expression assign the cell layer-specific accumulation of secoisolaricirésinol diglucoside in flaxseed coats. Frontiers in Plant Science. 7:1743. doi: 10.3389 (IF=4.30)

CONG LH, DAUWE R, LEQUART M, VINCHON S, RENOUARD S, FLINIAUX O, COLAS C, CORBIN C, DOUSSOT J, HANO C, LAMBLIN F, MOLINIE R, PILARD S, JULLIAN N, BOITEL M, GONTIER E, MESNARD F, LABERCHE J-C (2015) Kinetics of glucosylated and non-glucosylated aryltetralin lignans in Linum hairy root cultures Phytochemistry 115:70-8 (IF=3.57)

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RENOUARD S, HANO C, OUAGNE P, BLONDEAU JP, LAINE E (2014) Protection of flax fiber based yarns against natural soil degradation by chitosan. Material Letters 137 269-273 (IF=2.29)

RENOUARD S, TRIBALAT M-A, LAMBLIN F, MONGELARD G, FLINIAUX O, CORBIN C, MAROSEVIC D, PILARD S, DEMAILLY H, GUTIERREZ L, HANO C, MESNARD F, LAINE E (2014) RNAi-mediated pinoresinol lariciresinol reductase gene silencing in flax (Linum usitatissimum L.) seed coat: consequences on lignans and neolignans accumulation. J Plant Physiol 171(15), 1372-1377 (IF=3.07)

CORBIN C, MAROSEVIC D, BAILLY M, LOPEZ T, RENOUARD S, DOUSSOT J, DUTILLEUL C, AUGUIN D, GIGLIOLI-GUIVARC'H N, LAINÉ E, LAMBLIN F, HANO C (2013) Roles of protein farnesylation events in the ABA-mediated regulation of the Pinoresinol-Lariciresinol Reductase 1 (LuPLR1) gene expression and lignan biosynthesis in flax (Linum usitatissimum L.). Plant Physiol Biochem. 72:96-111 (IF5=3.023)

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JEANDET P, COUROT E, CLEMENT C, RICORD S; CROUZET J, AZIZ A, CORDELIER S (2017) Molecular Engineering of Phytoalexins in Plants: Benefits and Limitations for Food and Agriculture, Journal of Agricultural and Food Chemistry, 65 (13), 2643-2644

TISSERANT LP, AZIZ A, JULLIAN N, JEANDET P, CLÉMENT C, COUROT E, BOITEL-CONTI M (2016) Enhanced stilbene production and excretion in Vitis vinifera cv Pinot noir hairy root cultures, Molecules, special issue Phytoalexins, 21(12), 1703; doi:10.3390/molecules21121703

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JEANDET P, CLÉMENT C, COUROT E, CORDELIER S (2013) Modulation of phytoalexin biosynthesis in engineered plants for disease resistance, International Journal of Molecular Sciences, Special Issue: Molecular research in Plant secondary Metabolism, 14, 14136-14170; doi:10.3390/ijms 140714136

JEANDET P, VASSEROT Y, CHASTANG T, COUROT E (2013) Engineering microbial cells for the biosynthesis of natural compounds of pharmaceutical significance, BioMed Research International, vol. 2013, Article ID 780145, 13 pages, doi:10.1155/2013/780145

JEANDET P, DELAUNOIS B, AZIZ A, DONNEZ D, VASSEROT Y, CORDELIER S, COUROT E (2012) Metabolic engineering of yeast and plants for the production of the biologically active stilbene, resveratrol; Journal of Biomedicine and Biotechnology, Article ID 579089, 14 pages,doi:10.1155/2012/579089

YAN H, BAUDINO S, CAISSARD JC, NICOLE F, ZHANG H, TANG K, LI S, LU S (2018) Functional characterization of the eugenol synthase gene (RcEGS1) in rose. Plant Physiology and Biochemistry 129, 21-26

BLEROT B, MARTINELLI L, PRUNIER C, SAINT MARCOUX D, LGRAND S, BONY A, SARRABERE L, GROS F, BOYER N, CAISSARD JC, BAUDINO S, JULLIEN F (2018) Functional analysis of four terpene synthases in rose-scented pelargonium cultivars (Pelargonium x hybridum) and evolution of scent in the Pelargonium genus. Frontiers in Plant Science 9, e1435

ROCCIA A, HIBRAND SAINT OYANT L, CAVEL E, CAISSARD JC, MACHENAUD J, THOUROUDE T, JEAUFFRE J, BONY A, DUBOIS A, VERGNE P, SZECSI J, FOUCHER F, BENDAHMANE M, BAUDINO S (2019) Biosynthesis of 2-phenylethanol in rose petals is linked to the expression of one allele of RhPAAS. Plant Physiology 179, 1064-1079

3- Bioréacteurs végétaux & procédés d’extraction

Chery, C., Hehn, A., Mrabet, N., Oussalah, A., Jeannesson, E., Besseau, C., Alberto, J.-M., Gross, I., Josse, T., Gerard, P., Gueant-Rodriguez, R. M., Freund, J.-N., Devignes, J., Bourgaud, F., Peyrin-Biroulet, L., Feillet, F., Gueant, J.L. (2013). Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant. Biochimie, 95 (5), 995 - 1001. DOI : 10.1016/j.biochi.2013.01.022

Neunzig, I., Widjaja, M., Peters, F. T., Maurer, H. H., Hehn, A., Bourgaud, F., Bureik, M. (2013). Coexpression of CPR from various origins enhances biotransformation activity of human CYPs in S. pombe. Applied biochemistry and biotechnology, 170 (7), 1751-1766. DOI : 10.1007/s12010-013-0303-2

PTAK A., SIMLAT M., KWIECIEN M. and LAURAIN-MATTAR D.Leucojum aestivum plants propagated in in vitro bioreactor culture and on solid media containing cytokinins. Engineering in Life Sciences, 2013, 13, N°3, 261-270.

SALIBA S., PTAK A. and LAURAIN-MATTAR D. 4’-O-Methylnorbelladine feeding enhances galanthamine and lycorine production by Leucojum aestivum L. shoot cultures. Engineering in Life Sciences, 2015, 15(6), 640-645.

SALIBA S., PTAK A., BOISBRUN M., SPINA R., DUPIRE F. and LAURAIN-MATTAR D. Stimulating effect of both 4'-O-methylnorbelladine feeding and temporary immersion conditions on galanthamine and lycorine production by Leucojum aestivum L. bulblets. Engineering in Life Sciences, 2016, 16, 731-739.

PTAK A., MORAŃSKA E., SALIBA S., ZIELIŃSKI A., SIMLAT M. and LAURAIN-MATTAR D.

Elicitation of galanthamine and lycorine biosynthesis by Leucojum aestivum L. and L. aestivum ‘Gravety Giant’ plants cultured in bioreactor RITA^®. Plant Cell, Tissue Organ Cult, 2017, 128, 335-345.

LAURAIN-MATTAR D and PTAK A. Amaryllidaceae Alkaloid Accumulation by Plant in vitro Systems. In: Bioprocessing of Plant in vitro Systems, Atanas Pavlov and Thomas Bley ed, Springer, Heidelberg, Germany, 2016, 1-22.

BAHRI M., HANCE P., GREC S., QUILLET M-C., TROTIN F., HILBERT J-L., HENDRIKS T. (2012) A novel protocol for the analysis of hydroxycinnamic acids in leaf tissue of chicory (Cichorium intybus L., Asteraceae). The Scientific World Journal Volume 2012 (2012) Article ID 142983, 8 pages.

ACEVEDO DE LA CRUZ, A., HILBERT, G., RIVIERE, C., MENGIN, V., OLLAT, N., BORDENAVE, L., DECROOCQ, S., DELAUNAY, J.-C., DELROT, S., MERILLON, J.-M., MONTI, J.-P., GOMES, E., RICHARD, T. Anthocyanin identification and composition of wild Vitis spp. accessions by using LC-MS and LC-NMR. Anal. Chim. Acta, 2012, 732, 145-152.

DIAS A.L., ROZET E., CHATAIGNÉ G., OLIVEIRA A.C., RABELO C.A., HUBERT P., ROGEZ H. and QUETIN-LECLERCQ J. (2012) A rapid validated UHPLC-PDA method for anthocyanins quantification from Euterpe oleracea fruits. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci., 907, 108-116.

BOUDESOCQUE L., KAPEL R., PARIS C., DHULSTER P., MARC I. and RENAULT J.-H. (2012) Concentration and selective fractionation of an antihypertensive peptide from an alfalfa white proteins hydrolysate by mixed ion-exchange centrifugal partition chromatography. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci., 905, 23-30.

GALVAN D’ALESSANDRO L., KRIAA K., NIKOV I. and DIMITROV K. (2012) Ultrasound assisted extraction of polyphenols from black chokeberry. Sep. Purif. Technol., 93, 42-47.

RAKOTONIRIANA E.F., CHATAIGNÉ G., RAOELISON G., RABEMANANTSOA C., MUNAUT F., EL JAZIRI M., URVEG-RATSIMAMANGA S., MARCHAND-BRYNAERT J., CORBISIER A.M., DECLERCK S. and QUETIN-LECLERCQ J. (2012) Characterization of an endophytic whorl-forming Streptomyces from Catharanthus roseus stems producing polyene macrolide antibiotic. Can. J. Microbiol., 58, 617-627.

Willeman, H., P. Hance, A. Fertin, N. Voedts, N. Duhal, J.-F. Goossens, & J.-L. Hilbert, A method for the simultaneous determination of chlorogenic acid and sesquiterpene lactone content in industrial chicory root foodstuffs. The Scientific World Journal, 2014. 2014.

Ehtash, M., M.-C. Fournier-Salaün, K. Dimitrov, P. Salaün, & A. Saboni, Phenol removal from queous media by pertraction using vegetable oil as a liquid membrane. Chemical Engineering Journal, 2014. 250: p. 42-47

D’Alessandro, L.G., K. Dimitrov, P. Vauchel, & I. Nikov, Kinetics of ultrasound assisted extraction of anthocyanins from Aronia melanocarpa (black chokeberry) wastes. Chemical Engineering Research and Design, 2014. 92(10): p. 1818-1826.

Carciochi, R.A., G.D. Manrique, & K. Dimitrov, Optimization of antioxidant phenolic compounds extraction from quinoa (Chenopodium quinoa) seeds. Journal of food science and technology, 2015. 52(7): p. 4396-4404.

Vauchel, P., L.G. D’Alessandro, P. Dhulster, I. Nikov, & K. Dimitrov, Pilot scale demonstration of integrated extraction–adsorption eco-process for selective recovery of antioxidants from berries wastes. Journal of Food Engineering, 2015. 158: p. 1-7.

Hadrich, B., K. Dimitrov, & K. Kriaa, Modelling Investigation and Parameters Study of Polyphenols Extraction from Carob (Ceratonia siliqua L.) Using Experimental Factorial Design. Journal of Food Processing and Preservation, 2016.

Pradal, D., P. Vauchel, S. Decossin, P. Dhulster, & K. Dimitrov, Kinetics of ultrasound-assisted extraction of antioxidant polyphenols from food by-products: Extraction and energy consumption optimization. Ultrasonics sonochemistry, 2016. 32: p. 137-146.

ETSE, K. D., AÏDAM, A. V., MELIN, C., BLANC, N., OUDIN, A., COURDAVAULT, V., CRECHE, J. & LANOUE, A. (2014). Optimized genetic transformation of Zanthoxylum zanthoxyloides by Agrobacterium rhizogenes and the production of chelerythrine and skimmiamine in hairy root cultures. Eng Life Sci 14, 95–99.

BROWN, S., CLASTRE, M., COURDAVAULT, V. & O’CONNOR, S.E. (2015) De novo production of the plant derived alkaloid strictosidine in yeast. Proceedings of the National Academy of Sciences of the United States of America 12, 3205-3210.

FLINIAUX O., CORBIN C., RAMSAY A., RENOUARD S., BEEJMOHUN V., DOUSSOT J., FALGUIERES A., FERROUD C., LAMBLIN F., LAINE E., ROSCHER A., GRAND E., MESNARD F., HANO C. (2014) Microwave-assisted extraction of herbacetin diglucoside from flax (Linum usitatissimum L.) seed cakes and its quantification using an RP-HPLC-UV system. Molecules, 19 : 3025-3037.

KOSIERADZKA K., LE FAOUDER P., MOLINIE R., GENTIL E., LEBRETON J., ROBINS R.J. (2014) Tropane alkaloid metabolism by Pseudomonas AT3 cell cultures: Interchange between the nortropine and norpseudotropine catabolic pathways. Phytochemistry Letters, 10 : lx-lxviii.

HANO C., RENOUARD S., MOLINIE R., CORBIN C., BARAKZOY E., DOUSSOT J., LAMBLIN F., LAINE E. (2013) Flaxseed (Linum usitatissimum L.) extract as well as (+)-secoisolariciresinol diglucoside and its mammalian derivatives are potent inhibitors of alpha-amylase activity. Bioorganic & Medicinal Chemistry Letters, 23 : 3007-3012.

AL BALKHI M.H., MOHAMMAD M.A., TISSERANT L.P., BOITEL-CONTI M. (2016) Development of a liquid-liquid extraction method of resveratrol from cell culture media using solubility parameters. Separation and purification technology, 170 : 138–145.

HA L.T., PAWLICKI-JULLIAN N., LEQUART-PILLON M., BOITEL-CONTI M., XO H.D., GONTIER E. (2016) Hairy root cultures of Panax vietnamensis, a promising approach for the production of ocotillol-type ginsenosides. Plant Cell, Tissue and Organ Culture, 126 : 93-103.

NGUYEN T.K.O., DAUWE R., BOURGAUD F., GONTIER E. (2013) From bioreactor to entire plants: development of production systems for secondary metabolites. Advances in Botanical Research, 68 : 205-232.

TISSERANT L.P., AZIZ A., JULLIAN N., JEANDET P., CLÉMENT C., COUROT E., BOITEL-CONTI M. (2016) Enhanced stilbene production and excretion in Vitis vinifera cv Pinot Noir hairy root cultures, Molecules, 21(12), 1703 IF2016=2.45

TISSERANT L.P., HUBERT J., LEQUART M., BORIE N., MAURIN N., PILARD S., JEANDET P., AZIZ A., RENAULT J.H, NUZILLARD J.M., CLÉMENT C., BOITEL-CONTI M. and COUROT E., (2016) Chemical profiling of major stilbenes of pharmaceutical significance produced by elicited Vitis vinifera cv Pinot Noir hairy roots J. Nat. Prod., 79 (11), pp 2846–2855 IF2016=3.79

MAI N.T.P., BOITEL-CONTI M., GUERINEAU F. (2016) Arabidopsis thaliana hairy roots for the production of heterologous proteins. Plant Cell, Tissue and Organ Culture, 127 : 489-496.

HUET Y., ELE EKOUNA J.P., CARON A., MEZREB K., BOITEL-CONTI M., GUERINEAU F. (2014) Production and secretion of a heterologous protein by turnip hairy roots with superiority over tobacco hairy roots. Biotechnology Letters, 36 : 181-190.

JEANDET P, CLÉMENT C, TISSERANT LP, CROUZET J, COUROT E (2016) Use of grapevine cell cultures for the production of phytostilbenes of cosmetic interest, Comptes Rendus Chimie, 19, 9, 1062-1070

JEANDET P, CLÉMENT C, COUROT E (2014) Resveratrol production at large scale using plant cell suspensions, Engineering in Life Sciences, 14, 622-632

CORBIN C, FIDEL T, LECLERC E, BARAKZOY E, SAGOT N, FALGUIÉRE A, RENOUARD S, BLONDEAU JP, FERROUD C, DOUSSOT J, LAINÉ E, HANO C (2015) Development and validation of an efficient ultrasound assisted extraction of phenolic compounds from flax (Linum usitatissimum L.) seeds. Ultrasonic sonochemistry 26 176-185 (IF=4.4)

FLINIAUX O, CORBIN C, RAMSAY A, RENOUARD S, BEEJMOHUN V, DOUSSOT J, FALGUIERES A, FERROUD C, LAMBLIN F, LAINE E, ROSCHER A, GRAND E, MESNARD F, HANO C (2014) Microwave-assisted extraction of herbacetin diglucoside from flax (Linum usitatissimum L.) seed cakes and its quantification using an RP-HPLC-UV system. Molecules 19, 3025-3037 (IF=2.68)

RENOUARD S, HANO C, DOUSSOT J, BLONDEAU JP, LAINE E (2014) Characterization of ultrasonic impact on coir, flax and hemp fibers. Material Letters 129, 137-141(IF=2.29)

RENOUARD S, CORBIN C, LOPEZ T, LAMBLIN F, LAINE E, HANO C (2012) Isolation of nuclear proteins from flax (Linum usitatissimum L.) seed coats for gene expression regulation studies. BMC Research Notes 5: 15 (IF=1.324)

4- Activités biologiques et applications

Nabet, N., Boudries, H., Chougui, N., Loupassaki, S., Souagui, S., Burló, F., Hernández, F., Carbonell-Barrachina, A.A., Madani, K., Larbat, R. (2016) Determination of biological activities and secondary compound composition from Crithmum maritimum aerial parts. International Journal of Food Properties DOI:10.1080/10942912.2016.1222541

Saad, R., Kobaissi, A., Robin, C., Echevarria, G., Benizri, E. (2016). Nitrogen fixation and growth of Lens culinaris evaluated on Nickel-contaminated soils: a pre-requisite for optimization of agromining. Environmental and Experimental Botany, sous presse

Chougui, N., Djerroud, N., Naraoui, F., Hadjal, S., Aliane, K., Zeroual, B., Larbat, R. (2015). Physicochemical properties and storage stability of margarine containing Opuntia ficus-indica peel extract as antioxidant. Food Chemistry, 173, 382-390. DOI : 10.1016/j.foodchem.2014.10.025

Chaouche, T. M., Haddouchi, F., Atik-Bekara, F., Ksouri, R., Azzi, R., Boucherit, Z., Tefiani, C., Larbat, R. (2015). Antioxidant, haemolytic activities and HPLC-DAD-ESI-MSn characterization of phenolic compounds from root bark of Juniperus oxycedrus subsp. Oxycedrus. Industrial Crops and Products, 64, 182-187. DOI : 10.1016/j.indcrop.2014.10.051

Barnier, C., Ouvrard, S., Robin, C., Morel, J.L. (2014). Desorption kinetics of PAHs from aged industrial soils for availability assessment. Science of the Total Environment, 470-471, 639-645. DOI : 10.1016/j.scitotenv.2013.10.032

Yagi, S., Drouart, N., Bourgaud, F., Henry, M., Chapleur, Y., Laurain-Mattar, D. (2013). Antioxidant and antiglycation properties of Hydnora johannis roots. South African Journal of Botany, 84, 124-127.

KHIRALLA A., MOHAMED I., THOMAS J., MIGNARD B., SPINA R., YAGI S. and LAURAIN-MATTAR D. A pilot study of antioxidant potential of endophytic fungi from some Sudanese medicinal plants. Asian Pacific Journal of Tropical Medicine, 2015, 8(9), 701-704.

KHIRALLA A., MOHAMED I., TZANOVA T., SCHOHN H., SLEZACK-DESCHAUME S., HEHN A., ANDRÉ P.; CARRE G., SPINA R., LOBSTEIN A., YAGI S., LAURAIN-MATTAR D. Endophytic fungi associated with Sudanese medicinal plants show cytotoxic and antibiotic potential. FEMS Microbiology Letters 04/2016; 363(11):fnw089. DOI: 10.1093/femsle/fnw089.

FADL ALMOULAH N., VOYNIKOV Y., GEVRENOVA R., SCHOHN H.,TZANOVA T., YAGI S., THOMAS J., MIGNARD B., AZIM A. AHMED A., A. EL SIDDIG M., SPINA R., LAURAIN-MATTAR D. Antibacterial, antiproliferative and antioxidant activity of leaf extracts of selected Solanaceae species^.South African Journal of Botany, 2017, 112, 368-374.

YAGI S., CHRETIEN F., DUVAL R.E., FONTANAY S., MALDINI M., PIACENTE S., HENRY M., CHAPLEUR Y. and LAURAIN-MATTAR D. Antibacterial activity, cytotoxicity and chemical constituents of Hydnora johannis roots. South African Journal of Botany, 2012, 78, 228-234.

HAID, S., NOVODOMSKÁ, A., GENTZSCH, J., GRETHE, C., GEUENICH, S., BANKWITZ, D., CHHATWAL, P., JANNACK, B., HENNEBELLE, T., BAILLEUL, F., KEPPLER, O.T., PÖNISCH, M., BARTENSCHLAGER, R., HERNANDEZ, C., LEMASSON, M., ROSENBERG, A., WONG-STAAL, F., DAVIOUD-CHARVET, E., PIETSCHMANN, T. A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes. Gastroenterology, 2012, 143, 213-222

MOREL, S., KERZAON, I., ROUMY, V., AZAROUAL, N., SAHPAZ, S., JOSEPH, H., BAILLEUL, F., HENNEBELLE, T. A new cernuane-type alkaloid from Lycopodium cernuum. Biochem. Syst. Ecol., 2012, 45, 188- 190 (IF = 1,2).

TISTAERT C., CHATAIGNE G., DEJAEGHER B., RIVIERE C., NGUYEN HOAI N., CHAU VAN M., QUETIN- LECLERCQ J., VANDER HEYDEN Y. Multivariate data analysis to evaluate the fingerprint peaks responsible for the cytotoxic activity of Mallotus species. J.Chromatogr. B, 2012, 910, 103-113 (IF = 2,5).

TISTAERT, C., DEJAEGHER, B., CHATAIGNE, G., RIVIERE, C., NGUYEN HOAI, N., CHAU VAN, M., QUETIN- LECLERCQ, J., VANDER HEYDEN, Y. Potential antioxidant compounds in Mallotus species fingerprints. Part II : Fingerprint alignment, data analysis and peak identification. Anal. Chim. Acta, 2012, 721, 35-43 (IF = 4,4).

ELASAAD, K., ALKHATIB, R., HENNEBELLE, T., NORBERG, B., WOUTERS, J. Determination of the absolute configuration of aegelinol by crystallization of its inclusion complex with β-cyclodextrin. Crystals, 2012, 2, 1441- 1454.

BIABIANY, M., ROUMY, V., M., HENNEBELLE, T., FRANÇOIS, N., SENDID, B., POTTIER, M., ALIOUAT, E.M., ROUAUD, I., LOHEZIC-LE DEVEHAT, F., JOSEPH, H., BOURGEOIS, P., SAHPAZ, S., BAILLEUL, F. Antifungal activity of 10 Guadeloupean plants on mycoses. Phytother. Res., 2012, on line : doi : 10.1002/ptr.4906 (IF = 2,1).

ACEVEDO DE LA CRUZ A., HILBERT G., MENGIN V., RIVIERE C., OLLAT N., VITRAC C., BORDENAVE L., DECROOCQ S., DELAUNAY J.C., MÉRILLON J.M., MONTI J.P., GOMES E., RICHARD T., 2013. Anthocyanin phytochemical profiles and antioxidant activities of Vitis candicans and Vitis doaniana. Phytochem. Analysis, 2013, acceptée pour publication.

AUGER, F., MARTIN, F., PETRAULT, O., SAMAILLIE, J., HENNEBELLE, T., BAILLEUL, F., STAELS, B., BORDET, R., DURIEZ, P. Dietary Curcuminoids Significantly Improve the Lipid and Glucid Metabolic Disorders Associated to Risperidone in Mice. J. Psychopharmacol., 2013.

ABEDINI, A., ROUMY, V., MAHIEUX, S., BIABIANY, M., STANDAERT-VITSE, A., RIVIERE, C., SAHPAZ, S., BAILLEUL, F., NEUT, C., HENNEBELLE, T. Rosmarinic acid and its methyl ester as antimicrobial components of the hydro-methanolic extract of Hyptis atrorubens Poit. (Lamiaceae). Evid.-Based Complement. Altern Med., 2013

ABEDINI, A., ROUMY, V., MAHIEUX, S., LHAFIDI, S., GOHARI, A.R., FARIMANI, M.M., RIVIERE, C., SAHPAZ, S., BAILLEUL, F., NEUT, C., HENNEBELLE, T. Screening of some Iranian medicinal plant extracts for antimicrobial activity. J. Ethnopharmacol., 2013

MUSTAPHA, N., I. BOUHLEL, F. CHAABANE, I.M. BZÉOUICH, K. GHEDIRA, T. HENNEBELLE, AND L. CHEKIR-GHEDIRA, Aqueous extract of Crataegus azarolus protects against DNA damage in human lymphoblast Cell K562 and enhances antioxidant activity. Applied biochemistry and biotechnology, 2014. 172(4): p. 2266-2275.

Bahri-Sahloul, R., R. Ben Fredj, N. Boughalleb, J. Shriaa, S. Saguem, J.-L. Hilbert, F. Trotin, S. Ammar, S. Bouzid, & F. Harzallah-Skhiri, Phenolic composition and antioxidant and antimicrobial activities of extracts obtained from Crataegus azarolus L. var. aronia (Willd.) Batt. ovaries calli. Journal of Botany, 2014. 2014

Abedini, A., V. Roumy, S. Mahieux, A. Gohari, M. Farimani, C. Rivière, J. Samaillie, S. Sahpaz, F. Bailleul, & C. Neut, Antimicrobial activity of selected Iranian medicinal plants against a broad spectrum of pathogenic and drug multiresistant micro‐organisms. Letters in applied microbiology, 2014. 59(4): p. 412-421.

Boutefnouchet, S., P. Champy, T. Hennebelle, & A. Maciuk, Comments on EFSA's opinion about the health claim" improvement of bowel function" for hydroxyanthracenic derivatives. Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, 2014. 21(7): p. 928-931.

Mahamodo, S., C. Rivière, C. Neut, A. Abedini, H. Ranarivelo, N. Duhal, V. Roumy, T. Hennebelle, S. Sahpaz, & A. Lemoine, Antimicrobial prenylated benzoylphloroglucinol derivatives and xanthones from the leaves of Garcinia goudotiana. Phytochemistry, 2014. 102: p. 162-168.

Rivière, C., S. Krisa, L. Péchamat, M. Nassra, J.-C. Delaunay, A. Marchal, A. Badoc, P. Waffo-Téguo, & J.-M. Mérillon, Polyphenols from the stems of Morus alba and their inhibitory activity against nitric oxide production by lipopolysaccharide-activated microglia. Fitoterapia, 2014. 97: p. 253-260.

Symoneaux, R., A. Baron, N. Marnet, R. Bauduin, & S. Chollet, Impact of apple procyanidins on sensory perception in model cider (part 1): Polymerisation degree and concentration. LWT-Food Science and Technology, 2014. 57(1): p. 22-27.

Symoneaux, R., S. Chollet, R. Bauduin, J. Le Quéré, & A. Baron, Impact of apple procyanidins on sensory perception in model cider (part 2): Degree of polymerization and interactions with the matrix components. LWT-Food Science and Technology, 2014. 57(1): p. 28-34

Beka, R.G., F. Krier, M. Botquin, V.D. Guiama, P. Donn, D.G. Libouga, C.M. Mbofung, K. Dimitrov, M.-C. Slomianny, & D. Guillochon, Characterisation of a milk-clotting extract from Balanites aegyptiaca fruit pulp. International Dairy Journal, 2014. 34(1): p. 25-31.

Carciochi, R., G. Manrique, and K. Dimitrov, Changes in phenolic composition and antioxidant activity during germination of quinoa seeds (Chenopodium quinoa Willd.). International Food Research Journal, 2014. 21(2): 767-773. 2015

Roumy, V., A.-L. Gutierrez-Choquevilca, J.P.L. Mesia, L. Ruiz, J.C.R. Macedo, A. Abedini, A. Landoulsi, J. Samaillie, T. Hennebelle, & C. Rivière, In vitro antimicrobial activity of traditional plant used in mestizo shamanism from the Peruvian amazon in case of infectious diseases. Pharmacognosy magazine, 2015. 11(Suppl 4): p. S625.

Mustapha, N., I.M. Bzéouich, K. Ghedira, T. Hennebelle, & L. Chekir-Ghedira, Compounds isolated from the aerial part of Crataegus azarolus inhibit growth of B16F10 melanoma cells and exert a potent inhibition of the melanin synthesis. Biomedicine & Pharmacotherapy, 2015. 69: p. 139-144.

MUSTAPHA, N., A. PINON, Y. LIMAMI, A. SIMON, K. GHEDIRA, T. HENNEBELLE, AND L. CHEKIR‐GHEDIRA, Crataegus azarolus Leaves Induce Antiproliferative Activity, Cell Cycle Arrest, and Apoptosis in Human HT‐29 and HCT‐116 Colorectal Cancer Cells. Journal of cellular biochemistry, 2015.

Calland, N., M.-E. Sahuc, S. Belouzard, V. Pène, P. Bonnafous, A.A. Mesalam, G. Deloison, V. Descamps, S. Sahpaz, and C. Wychowski, Polyphenols inhibit hepatitis C virus entry by a new mechanism of action. Journal of virology, 2015. 89(19): p. 10053-10063.

Mustapha, N., I. Mokdad-Bzéouich, M. Maatouk, K. Ghedira, T. Hennebelle, & L. Chekir-Ghedira, Antitumoral, antioxidant, and antimelanogenesis potencies of Hawthorn, a potential natural agent in the treatment of melanoma. Melanoma research, 2016. 26(3): p. 211-222.

Mustapha, N., I. Mokdad-Bzéouich, A. Sassi, B. Abed, K. Ghedira, T. Hennebelle, & L. Chekir-Ghedira, Immunomodulatory potencies of isolated compounds from Crataegus azarolus through their antioxidant activities. Tumor Biology, 2016: p. 1-14.

Sahli, R., Riviere, C., Siah, A., Samaillie, J., Hennebelle, T., Roumy, V., Ksouri, R., Halama, P. & Sahpaz, S. Biocontrol activity of effusol from Juncus maritimus extremophile plant against the wheat pathogen Zymoseptoria tritici. Environmental Science and Pollution Research. 2017 In press

HOUILLE, B., PAPON, N., BOUDESOCQUE, L., BOURDEAUD, E., BESSEAU, S., COURDAVAULT, V., ENGUEHARD-GUEIFFIER, C., DELANOUE, G., GUERIN, L., BOUCHARA, J.-P., CLASTRE, M., GIGLIOLI-GUIVARC’H, N., GUILLARD, J. & LANOUE, A. (2014). Antifungal Activity of Resveratrol Derivatives against Candida Species. J Nat Prod 77, 1658–62.

GAUCHER, M., DUGE DE BERNONVILLE, T., GUYOT, S., DAT, J. F. & BRISSET, M.-N. (2013). Same ammo, different weapons: enzymatic extracts from two apple genotypes with contrasted susceptibilities to fire blight (Erwinia amylovora) differentially convert phloridzin and phloretin in vitro. Plant Physiol Biochem 72, 178–89.

BOUCLE, S., MELIN, C., CLASTRE, M. & GUILLARD, J. (2015) Design, synthesis and evaluation of new marine alkaloid-derived pentacyclic structures with anti-tumoral potency. Mar Drugs 13, 655-65.

EL BOUZIDI L, ABBAD A, HASSANI L, FATTARSI K, LEACH D, MARKOUK M, LEGENDRE L, BEKKOUCHE K (2012) Essential oil composition and antimicrobial activity of wild and cultivated moroccan Achillea ageratum l.: A rare and threatened medicinal species. Chemistry & Biodiversity 9: 598-605

LAVILLE R, CASTEL C, FATTARSI K, ROY C, LEGENDRE L, DELBECQUE C, GARRY P-P, AUDRAN A, FERNANDEZ X (2013) Low sclareol by-product of clary sage concrete: Chemical analysis of a waste product of the perfume industry. Flavour and Fragrance Journal 28: 93-101

FOUAD R, JENNAN S, MOJA S, AMRI I, JAMOUSSI B, GRECHE H (2014) Chemical composition and herbicidal effects of essential oils of rosmarinus officinalis, lavandula angustifolia l., citrus aurantium l. And origanum majoranal. Cultivated in morocco. International Journal of Indigenous Medicinal Plants 47: 1546-1553

OUEDRHIRI W, BOUHDID S, BALOUIRI M, LALAMI A, MOJA S, CHAHDI F, GRECHE H (2015) Chemical composition of citrus aurantium l. Leaves and zest essential oils, their antioxidant, antibacterial single and combined effects. Jounal of chemical and pharmaceutical research 7: 78-84

OUEDRHIRI W, BALOUIRI M, HARKI EH, MOJA S, GRECHE H (2017) Synergistic antimicrobial activity of two binary combinations of marjoram, lavender, and wild thyme essential oils. International Journal of Food Properties: 1-10

OUEDRHIRI W, BALOUIRI M, BOUHDID S, HARKI EH, MOJA S, GRECHE H (2017) Antioxidant and antibacterial activities of Pelargonium asperum and Ormenis mixta essential oils and their synergistic antibacterial effect. Environmental Science and Pollution research, in press.

HARTMANN M, GAS-PASCUAL E, HEMMERLIN A, ROHMER M AND BACH TJ (2015) Development of an image-based screening system for inhibitors of the plastidial MEP pathway and of protein geranylgeranylation. Faculty of 1000, Version 2 (doi: 10.12688/f1000research.5923.2) (eCollection2015).

TAIEB A., B'CHIR F., MOLINIE R., NAVA-SAUCEDO J.E., NAKHILI J., FLINIAUX M.A., HADJ ALI B.B., SAGUEM S. (2012) Relationships between clozapine and norclozapine plasma concentrations, clozapine dose, and clinical response in Tunisian patients with schizophrenia-treatment resistance. Open Journal of Psychiatry, 2 : 262-268.

HANO C, CORBIN C, DROUET S, QUÉRO A, ROMBAUT N, SAVOIRE R, MOLINIÉ R, THOMASSET B, MESNARD F, LAINÉ E (2017) The lignan (+)-secoisolariciresinol extracted from flax hulls is an effective protectant of linseed oil and its emulsion against oxidative damage European Journal of Lipid Science and Technology 119: 1600219. (IF=2.15)

ANJUM S, ABBASI BH, HANO C (2017) Trends in accumulation of pharmacologically important antioxidant-secondary metabolites in callus cultures of Linum usitatissimum L. Plant Cell, Tissue and Organ Culture 129, 73-87 (IF=2.00)

ABBASI BH, ANJUM S, HANO C (2017) Differential effects of in vitro cultures of Linum usitatissimum L. (Flax) on biosynthesis, stability, antibacterial and antileishmanial activities of zinc oxide nanoparticles: a mechanistic approach. RSC Advances 7: 15931-15943 (IF=3.11).

SUMAIRA, KHAN T, ABBASI BH, AFRIDI S, TANVEER F, ULLAH I, BASHIRA S, HANO C (2017) Melatonin-enhanced biosynthesis of antimicrobial AgNPs by improving the phytochemical reducing potential of a callus culture of Ocimum basilicum L. var. thyrsiflora. RSC Advances 7: 38699-38713 (IF=3.11).

BOURGEOIS C, LECLERC E, CORBIN C, DOUSSOT J, SERRANO V, VANNIER JR, SEIGNEURET JM, AUGUIN D, PICHON C, LESELLIER E, LAINÉ E, HANO C (2016) Nettle (Urtica dioica L.) as a natural source of antioxidant and anti-aging phytochemicals for cosmetic applications. CR Chimie 19 :1090-1100 (IF=1.88)

LOPEZ T, CORBIN C, FALGUIERES A, DOUSSOT J, MONTGUILLON J, HAGÈGE D, HANO C, LAINÉ E (2016) Secondary metabolite accumulation, antibacterial and antioxidant properties of in vitro propagated Clidemia hirta L. extracts are influenced by the basal culture medium CR Chimie 19 : 1171-1176 (IF=1.88)

HANO C, RENOUARD S, MOLINIÉ R, CORBIN C, BARAKZOY E, DOUSSOT J, LAMBLIN F, LAINÉ E (2013) Flaxseed (Linum usitatissimum L.) extract as well as (+)-secoisolariciresinol diglucoside and its mammalian derivatives are potent inhibitors of alpha-amylase activity. Bioorganic & Medicinal Chemistry Letters 23 (10):3007-3012 (IF5=2.539)

NIVELLE L, HUBERT J, COUROT E, JEANDET P, AZIZ A, NUZILLARD JM, RENAULT JH, CLÉMENT C, MARTINY L, DELMAS D, TARPIN M (2017) Anti-Cancer Activity of Resveratrol and Derivatives Produced by Grapevine Cell Suspensions in a 14 L Stirred Bioreactor, Molecules, special issue Improvements for Resveratrol Efficacy, 22(3), 474; doi:10.3390/molecules22030474

5- Brevets:

Bourgaud, F., Hehn, A., Olry, A., Munakata, R., Yazaki, K., Mizutani, M. (2015). new method for inhibiting production of furanocoumarins in plants. USPTO, 62/120,492.

Menin, B., Duriot, L., Hehn, A., Bourgaud, F. (2012). "Enzymes de bioconversion de l’acide chrologénique en au moins un acide di-, tri- ou tétra-caféoylquinique" Numéro de demande PCT/EP(2013)/061119

GONTIER E., CLEMENT A., BOURGAUD F., GUCKERT A. (2013) Method for producing metabolites from plants cultivated in soil-less medium. Brevet JP5276759(B2) ― 2013-08-28.

GONTIER E., CLEMENT A., BOURGAUD F., GUCKERT A. (2013) Method for producing metabolites from plants cultivated in soil-less medium. Brevet JP5276759(B2) ― 2013-08-28.

BOITEL-CONTI M., HUET Y., GUERINEAU F., ELE EKOUNA J.P (2014) Methods for producing recombinant proteins from plant hairy roots, PCT/EP2011/056786. World Patent

GUERINEAU F., BOITEL-CONTI M., ELE EKOUNA J.P., (2015) Procédé de production de protéines d’intérêt à partir d’une structure végétale.Brevet France n° 15/ 01002

Concession à RLT SAS (2011) d’une licence d’exploitation exclusive mondiale sur les brevets EP 10305478.0. et F 15/01002

HUGUENEY P, DUCHENE E, MERDINOGLU D (2012) International patent WO201252171 A1, Génoplante-Valor : « 1-deoxy-D-xylulose 5-phosphate synthase alleles responsible for enhanced terpene biosynthesis ». Licence exclusive acquise en 2014 par la société DEINOVE (Alternext Paris : ALDEI).

6- Création de Start-up:

Plant Advanced Technologies

Root Lines Technology