PUBLICATIONS
Site-selective Chlorination of Pyrrolic Heterocycles by Flavin Dependent Enzyme PrnC. Guangrong Peh, Terence Tay, Lee Ling Tan, Elaine Tiong, Yi Ling Goh, Suming Ye, Fu Lin, Cheryl Jia Xin Tan, Yong Zi Tan, Joel Wong, Huimin Zhao, Fong Tian Wong, Ee Lui Ang, Yee Hwee Lim. Chemrxiv. pdf link Cost-effective hybrid long-short read assembly delineates alternative GC-rich Streptomyces chassis for natural product discovery. Elena Heng, Lee Ling Tan, Dillon WP Tay, Yee Hwee Lim, Lay-Kien Yang, Deborah CS Seow, Chung Yan Leong, Veronica Ng, Siew Bee Ng, Yoganathan Kanagasundaram, Fong Tian Wong, Lokanand Koduru. bioRxiv, 2022.12. 05.519232. pdf link Fabrication of immunomodulatory interface layers for medical implants through additive manufacturing. Dionis Si Ying Yew, Peter See, Cyrus W Beh. Materials Today: Proceedings, Volume 70, 2022, Pages 643-648. pdf link Vascularization strategies for bioprinting. Theresa Seah, Wan Ling Wong, Cyrus Beh. Materials Today: Proceedings, Volume 70, 2022, Pages 638-642. pdf link Developing a bioprintable epidermis. Ruth Jinfen Chai, Wan Ling Wong, Cyrus Weijie Beh. Materials Today: Proceedings, Volume 70, 2022, Pages 72-77. pdf link BNT162B2 COVID-19 mRNA vaccination did not promote substantial anti-syncytin-1 antibody production nor mRNA transfer to breast milk in an exploratory pilot study. Citra NZ Mattar, Winston Koh, Yiqi Seow, Shawn Hoon, Aparna Venkatesh, Pradip Dashraath, Li Min Lim, Judith Ong, Rachel Lee, Nuryanti Johana, Julie SL Yeo, David Chong, Lay Kok Tan, Jerry KY Chan, Mahesh Choolani, Paul Anantharajah Tambyah. Annals of the Academy of Medicine, Singapore. 2022 May;51(5):309-312. doi: 10.47102/annals-acadmedsg.2021447. pdf link Towards a rapid-turnaround low-depth unbiased metagenomics sequencing workflow on the Illumina platforms. Lian Chye, Winston Koh, Si En Poh, Chun Kiat Lee, Hon Man, Tim Chan, Gabriel Yan, Kiat Whye Kong, Lalita Lau, Wai Yip, Thomas Lee, Clark Cheng, Shawn Hoon, Yiqi Seow. medRxiv, 2023.01. 02.22283504. : https://doi.org/10.1101/2023.01.02.22283504 (4 Jan 2023). pdf link Enhancing armeniaspirols production through multi-level engineering of a native Streptomyces producer. Fong Tian Wong, Elena Heng, Yi Wee Lim, Chung Yan Leong, Veronica WP Ng, Siew Bee Ng, Yee Hwee Lim. Authorea Preprints, 2023 (Jan 18). DOI: 10.22541/au.167406305.55486888/v1. pdf link CRISPR/Cas-Mediated Genome Editing of Streptomyces. Lee Ling Tan, Elena Heng, Nadiah Zulkarnain, Wan-Chi Hsiao, Fong Tian Wong, Mingzi M. Zhang. Recombineering pp 207–225. Part of the Methods in Molecular Biology book series (MIMB,volume 2479) BNT162B2 COVID-19 mRNA vaccination did not promote substantial anti-syncytin-1 antibody production nor mRNA transfer to breast milk in an exploratory pilot study. Citra NZ Mattar, Winston Koh, Yiqi Seow, Shawn Hoon, Aparna Venkatesh, Pradip Dashraath, Li Min Lim, Judith Ong, Rachel Lee, Nuryanti Johana, Julie SL Yeo, David Chong, Lay-Kok Tan, Jerry KY Chan, Mahesh Choolani, Paul Anantharajah Tambyah. Ann Acad Med Singap 2022;51:309-12 . https://doi.org/10.47102/annals-acadmedsg.2021447. pdf link Functional imaging and targeted drug delivery in mice and patient tumors with a cell nucleoluslocalizing and tumor-targeting peptide. Renwei Jing , Qian Wang , Lu Chen , Guangtao Li , Ruibin Li , Leijie Zhang , Hongbing Zhang , Bingfeng Zuo , Yiqi Seow , Xin Qiao , Jingyuan Xu , Jun Chen Tianjin Med , Tianqiang Song , HaiFang Yin. Research Square, posted 21 April, 2022. DOI: https://doi.org/10.21203/rs.3.rs-1567587/v1. pdf link Cardio-respiratory and phenotypic rescue of dystrophin/utrophin-deficient mice by combination therapy. Caorui Lin, Gang Han , Lulu Jia , Yiwen Zhao , Jun Song , Ning Ran , Toshifumi Yokota , Yiqi Seow , HaiFang Yin . EMBO Reports (2022)23:e53955. https://doi.org/10.15252/embr.202153955 .
The Biosynthetic Landscape of Triceptides Reveals Radical SAM Enzymes That Catalyze Cyclophane Formation on Tyr- and His-Containing Motifs. Ryosuke Sugiyama, Angelica Faith L. Suarez, Yohei Morishita, Thi Quynh Ngoc Nguyen, Yi Wei Tooh, Muhammad Nur Hadi Bin Roslan, Justin Lo Choy, Qi Su Wei Yang Goh, Gregory Adrian Gunawan, Fong Tian Wong and Brandon I. Morinaka. J. Am. Chem. Soc. 2022 https://doi.org/10.1021/jacs.2c00521
Universal immunotherapeutic strategy for hepatocellular carcinoma with exosome vaccines that engage adaptive and innate immune responses. Bingfeng Zuo, Yang Zhang, Kangjie Zhao , Li Wu , Han Qi , Rong Yang , Xianjun Gao , Mengyuan Geng , Yingjie Wu, Renwei Jing , Qibing Zhou , Yiqi Seow and HaiFang Yin . Journal of Hematology & Oncology . (2022) 15:46 https://doi.org/10.1186/s13045-022-01266-8 . pdf link
Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans. Xin-Zi Emily Tang , Shu Xuan Tan, Shawn Hoon and Gene W. Yeo . Nature Medicine (2022). doi: https://doi.org/10.1038/s41591-022-01848-6. pdf link
Cephalopod-Mimetic Tunable Photonic Coatings Assembled from Quasi-Monodispersed Reflectin Protein Nanoparticles. Jun Jie Loke, Shawn Hoon, Ali Miserez. ACS Appl. Mater. Interfaces 2022, 14, 18, 21436–21452. https://doi.org/10.1021/acsami.2c01999. Expression of Staphylococcus aureus virulence factors in atopic dermatitis. Poh SE, Koh WLC, Derek Lim SY, Wang ECE, Yew YW, Common JEA, Oon HH, Li H. JID Innovations (2022), doi: https://doi.org/10.1016/j.xjidi.2022.100130.pdf link
Secretory Proteases of the Human Skin Microbiome. Wisely Chua, Si En Poh, Hao Li. ASM Journals, Infection and Immunity, Vol. 90, No. 1DOI:https://doi.org/10.1128/IAI.00397-21. pdf link MapCell: Learning a Comparative Cell Type Distance Metric With Siamese Neural Nets With Applications Toward Cell-Type Identification Across Experimental Datasets. Winston Koh & Shawn Hoon. Front. Cell Dev. Biol., 02 November 2021 | https://doi.org/10.3389/fcell.2021.767897 pdf link Application of Cas12j for Streptomyces editing and cluster activation. Lee Ling Tan, Elena Heng, Nadiah Zulkarnain, Chung Yan Leong, Veronica Ng, Lay Kien Yang, Deborah Chwee San Seow, Guangrong Peh, Yee Hwee Lim, Koduru Lokanand, Yoganathan Kanagasundaram, Siew Bee Ng, Fong Tian Wong. BioRxiv doi: https://doi.org/10.1101/2021.10.28.465406. pdf link Broad spectrum antimicrobial PDMS-based biomaterial for catheter fabrication. Arunmozhiarasi Armugam , Siew Ping Teong , Diane S. W. Lim , Shook Pui Chan , Guangshun Yi , Dionis S. Yew , Cyrus W. Beh and Yugen Zhang. Biomaterials Research (2021) 25:33 https://doi.org/10.1186/s40824-021-00235-5 . pdf link Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles. Dhanu Gupta, Oscar P.B Wiklander , André Görgens, Mariana Conceição , Giulia Corso , Xiuming Liang , Yiqi Seow , Sriram Balusu , Ulrika Feldin , Beklem Bostancioglu , Rim Jawad , Doste R Mamand , Yi Xin Fiona Lee , Justin Hean , Imre Mäger , Thomas C. Roberts , Manuela Gustafsson , Dara K Mohammad, Helena Sork , Alexandra Backlund, Edvard Smith , Matthew J.A. Wood, Roosmarijn E. Vandenbroucke , Joel Z. Nordin, and Samir EL Andaloussi. Nature Biochemical Engineering 5, 1084–1098 (2021)
Addressing anti-syncytin antibody levels, and fertility and breastfeeding concerns, following BNT162B2 COVID-19 mRNA vaccination. Citra NZ Mattar, Winston Koh, Yiqi Seow, Shawn Hoon, Aparna Venkatesh, Pradip Dashraath, Li Min Lim, Judith Ong, Rachel Lee, Nuryanti Johana, Julie SL Yeo, David Chong, Lay-Kok Tan, Jerry Chan, Mahesh Choolani, Paul Anantharajah Tambyah. MedRxiv May 25, 2021. doi: https://doi.org/10.1101/2021.05.23.21257686. pdf link
A fluid-supported 3D hydrogel bioprinting method. Cyrus W. Beh, Dionis S. Yew, Ruth J. Chai, Sau Yin Chin, Yiqi Seow, Shawn S. Hoon. Biomaterials, Volume 276, September 2021, 121034 .https://doi.org/10.1016/j.biomaterials.2021.121034. pdf link Non-Invasive Characterization of the Pancreas During Bariatric Surgery via Circulating Pancreatic Specific Cell-free Messenger RNA. Kong Kiat Whye, E ShyongTai, Asim Shabbir, Chin Meng Khoo, Winston Koh. Front Genet. 2021 Oct 11;12:742496. doi: 10.3389/fgene.2021.742496. eCollection 2021. pdf link CRISPR-Cas strategies for natural product discovery and engineering in actinomycetes. Elena Heng , Lee Ling Tan, Mingzi M. Zhang , Fong Tian Wong. Process Biochemistry Volume 102, March 2021, Pages 261-268. pdf link Clinical performance of Roche cobas 6800, Luminex ARIES, MiRXES Fortitude Kit 2.1, Altona RealStar, and Applied Biosystems TaqPath for SARS‐CoV‐2 detection in nasopharyngeal swabs. Chun Kiat Lee , Jason Wei Ming Tham , Siyu Png , Chean Nee Chai , Shu Chi Ng , Eunice Jia Min Tan , Li Jie Ng , Rui Ping Chua , Musa Sani , Yiqi Seow , Gabriel Yan , Julian Tang . 14 March 2021. https://doi.org/10.1002/jmv.26940 . pdf link
The Biosynthetic Landscape of Triceptides Reveals Radical SAM Enzymes That Catalyze Cyclophane Formation on Tyr- and His-Containing Motifs. Ryosuke Sugiyama, Angelica Faith L. Suarez, Yohei Morishita, Thi Quynh Ngoc Nguyen, Yi Wei Tooh, Muhammad Nur Hadi Bin Roslan, Justin Lo Choy, Qi Su Wei Yang Goh, Gregory Adrian Gunawan, Fong Tian Wong and Brandon I. Morinaka. J. Am. Chem. Soc. 2022 https://doi.org/10.1021/jacs.2c00521
Universal immunotherapeutic strategy for hepatocellular carcinoma with exosome vaccines that engage adaptive and innate immune responses. Bingfeng Zuo, Yang Zhang, Kangjie Zhao , Li Wu , Han Qi , Rong Yang , Xianjun Gao , Mengyuan Geng , Yingjie Wu, Renwei Jing , Qibing Zhou , Yiqi Seow and HaiFang Yin . Journal of Hematology & Oncology . (2022) 15:46 https://doi.org/10.1186/s13045-022-01266-8 . pdf link
Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans. Xin-Zi Emily Tang , Shu Xuan Tan, Shawn Hoon and Gene W. Yeo . Nature Medicine (2022). doi: https://doi.org/10.1038/s41591-022-01848-6. pdf link
Cephalopod-Mimetic Tunable Photonic Coatings Assembled from Quasi-Monodispersed Reflectin Protein Nanoparticles. Jun Jie Loke, Shawn Hoon, Ali Miserez. ACS Appl. Mater. Interfaces 2022, 14, 18, 21436–21452. https://doi.org/10.1021/acsami.2c01999. Expression of Staphylococcus aureus virulence factors in atopic dermatitis. Poh SE, Koh WLC, Derek Lim SY, Wang ECE, Yew YW, Common JEA, Oon HH, Li H. JID Innovations (2022), doi: https://doi.org/10.1016/j.xjidi.2022.100130.pdf link
Secretory Proteases of the Human Skin Microbiome. Wisely Chua, Si En Poh, Hao Li. ASM Journals, Infection and Immunity, Vol. 90, No. 1DOI:https://doi.org/10.1128/IAI.00397-21. pdf link MapCell: Learning a Comparative Cell Type Distance Metric With Siamese Neural Nets With Applications Toward Cell-Type Identification Across Experimental Datasets. Winston Koh & Shawn Hoon. Front. Cell Dev. Biol., 02 November 2021 | https://doi.org/10.3389/fcell.2021.767897 pdf link Application of Cas12j for Streptomyces editing and cluster activation. Lee Ling Tan, Elena Heng, Nadiah Zulkarnain, Chung Yan Leong, Veronica Ng, Lay Kien Yang, Deborah Chwee San Seow, Guangrong Peh, Yee Hwee Lim, Koduru Lokanand, Yoganathan Kanagasundaram, Siew Bee Ng, Fong Tian Wong. BioRxiv doi: https://doi.org/10.1101/2021.10.28.465406. pdf link Broad spectrum antimicrobial PDMS-based biomaterial for catheter fabrication. Arunmozhiarasi Armugam , Siew Ping Teong , Diane S. W. Lim , Shook Pui Chan , Guangshun Yi , Dionis S. Yew , Cyrus W. Beh and Yugen Zhang. Biomaterials Research (2021) 25:33 https://doi.org/10.1186/s40824-021-00235-5 . pdf link Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles. Dhanu Gupta, Oscar P.B Wiklander , André Görgens, Mariana Conceição , Giulia Corso , Xiuming Liang , Yiqi Seow , Sriram Balusu , Ulrika Feldin , Beklem Bostancioglu , Rim Jawad , Doste R Mamand , Yi Xin Fiona Lee , Justin Hean , Imre Mäger , Thomas C. Roberts , Manuela Gustafsson , Dara K Mohammad, Helena Sork , Alexandra Backlund, Edvard Smith , Matthew J.A. Wood, Roosmarijn E. Vandenbroucke , Joel Z. Nordin, and Samir EL Andaloussi. Nature Biochemical Engineering 5, 1084–1098 (2021)
Addressing anti-syncytin antibody levels, and fertility and breastfeeding concerns, following BNT162B2 COVID-19 mRNA vaccination. Citra NZ Mattar, Winston Koh, Yiqi Seow, Shawn Hoon, Aparna Venkatesh, Pradip Dashraath, Li Min Lim, Judith Ong, Rachel Lee, Nuryanti Johana, Julie SL Yeo, David Chong, Lay-Kok Tan, Jerry Chan, Mahesh Choolani, Paul Anantharajah Tambyah. MedRxiv May 25, 2021. doi: https://doi.org/10.1101/2021.05.23.21257686. pdf link