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ABOUT
ABOUT
Our therapeutic projects involve developing new concepts for nucleic acid-based therapeutics, including using mirtrons for gene silencing, aptamers for binding intracellular targets and promoter decoys. We are keen to work with clinicians to develop nucleic acid-based therapeutics for their specific diseases, taking into account the limitations associated with each disease/target. There are also a number of projects brewing that are looking into where we think nucleic acid therapeutics will head to in the next decade, in anticipation of the maturation of the field.
Seow YiQi, PhD (Research Scientist - IMCB)(Deputy Director - IBB)seowy@ibb.a-star.edu.sgLinkedin Add Publications
I have a keen interest in genetic and molecular tinkering and is working to develop early gene therapy concepts that could be needed in the next 5-10 years. I have previously developed cytostatic DNA aptamers, targeted exosomes for gene delivery and synthetic mirtrons for gene knockdown.
Synthetic biologist and bioinformatician with interests in high-throughput assay development, lab automation, virology and cellular medicine.
Research fellow with expertise in protein biochemistry and structural biology. Through my doctoral and postdoctoral training, I have gained experience in molecular cloning, protein expression and purification, and structural biology techniques such as SAXS, cryo-EM and X-ray crystallography. I am invested in applying my skill set and experience to gain insights into protein function, protein-protein interactions and their role in biology.
I studied Chemistry as an undergraduate at the University of Cambridge as part of the A*STAR NSS (BS-PhD) scholarship. I subsequently enrolled in the Chemistry and Chemical Biology PhD program at Harvard University with Dr. David Liu. As a graduate student in the Liu lab, I developed the first mitochondrial base editor that enables precise installation and correction of point mutations in organelle DNA. Following my PhD, I joined MEL as a Research Fellow in 2022. I am interested in multidisciplinary projects that involve engineering and evolving proteins for gene editing, and possibly for agriculture and biomanufacturing.
I am a research fellow at the Molecular Engineering Lab (MEL) at IMCB, ASTAR. I have expertise/experience in applying microfluidic technologies for both chemical analysis (BSc) and synthesis (MRes, PhD). Some of my previous works involve the manipulation of water-in-oil micro-droplets for PCR (PhD), and also for nanoparticles synthesis (MRes). My recent interest (at MEL) is the development of a simple chip-free, centrifugation-based device for the generation of the micro-droplets and beads. I will be applying this development to conduct droplet-PCR and also to encapsulate microbes/cells in these generated micro-droplets for downstream applications and analyses. Besides droplets and microfluidics, I also have interest in POCT diagnostics. During the COVID period, I have the opportunity to develop a custom lyophilizable colorimetric RT-LAMP (Reverse Transcription Loop--Mediated Isothermal Amplification) mix for use in a COVID-19 POCT test kit. Besides COVID-19, I am also exploring to use this development for other infections/diseases of interest.
Highly motivated immunologist with more than 10 years of experience analyzing T cell functions, antibody responses and tissue macrophage characterization, developing in vitro assays using primary human and mouse samples as well as in vivo animal modelling. Excited to apply immunological skillsets to achieve translational goals. Flexibility to drive projects independently or collaborate in teams.
My current research interest revolves around the functions of tissue-resident macrophages in neuroimmunology and reproductive immunology.
I have been working in Molecular Engineering Lab (MEL) - Institute of Molecular and Cell Biology (IMCB) - Agency for Science, Technology and Research (A*Star) since it started in 2009. I have worked on various research projects, have experience in next-generation sequencing. I have also been a first aider and safety committee member for a minimum of 5 years. I have obtained certificates for A-PBA Biosafety Management, A-PBA Singapore Legislation (BATA & WHSA), Advanced and Specialist Diploma in Workplace Safety and Health, and Managing Work-At-Height.
I am a highly motivated, self-driven and eager to learn person who is systematic and well-organized. As independent of a worker I am who can work under pressure with minimum supervision, you can count on me being a team player as well. I possess excellent communication skills, strong work ethics and consider myself to be diligent, creative, focused and highly adaptable.
I am a highly motivated, self-driven and eager to learn person who is systematic and well-organized. As independent of a worker I am who can work under pressure with minimum supervision, you can count on me being a team player as well. I possess excellent communication skills, strong work ethics and consider myself to be diligent, creative, focused and highly adaptable.
Studied biological science at the Nanyang Technical University. Upon graduation, I am introduced to stem cell research in the private sector for a couple of years. Thereafter, went for an opening at Raffles Hospital as Laboratory Technologist. Following that moved on to be a research officer at Molecular Engineering Laboratory (MEL). I am presently still with MEL at the Institute of Molecular and Cell Biology (IMCB) with diverse backgrounds spanning immunology, microbiology, cell culture, molecular biology, single cell biology, gene editing, genomics and stem cells come together to work on multi-disciplinary projects.
Graduated from Nanyang Technological University (NTU) with a Bachelor's degree in Biological Sciences. Currently working on projects involving detection of circulating plasma transcripts.
I am a Research Officer of one year currently involved in a project working on the directed evolution of biosensors against drug targets in an automated liquid handling system. I have also previously studied the effects of macrophage depletion in meningeal lymphatics development in murine models.
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