Meier-Stephenson Laboratory

Chronic viral infections, including hepatitis B virus (HBV), cause significant worldwide morbidity and mortality. These viruses infect and manipulate host cells in ways that are incompletely understood.

Our group uses structural information from viral and host protein interactions to find unique ways of understanding and targeting viral diseases. The approach incorporates computational, biophysical and molecular virology techniques. While the main initial focus is on HBV, the platform will be expanded to explore similar questions in other viruses.

Keywords:

viral-host protein interactions, viral pathogenesis, hepatitis B virus, hepatitis C virus, polyomaviruses, G-quadruplexes, computational chemistry, biophysics, biochemistry, cell culture, virology, medicinal chemistry, drug design, drug development