"Novel carbonylomics with stable isotope-coded derivatization for non-targeted analysis of reactive carbonyl species i in cooking oil" is published

Research

OVERVIEW

DNA adductomics/Nucleic acid adductomics

Adductome-Wide Association Studies (AWAS) may be used to explore the environmental causes of cancer.

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Selected Publications

Mu-Rong Chao*, Yuan-Jhe Chang#, Marcus S. Cooke, Chiung-Wen Hu#. Multi-adductomics: Advancing mass spectrometry techniques for comprehensive exposome characterization.

TrAC Trends in Analytical Chemistry, 2024, 180, 117900.

Chiung-Wen Hu#, Yuan-Jhe Chang#, Wei-Hung Chang, Marcus S. Cooke, Yet-Ran Chen, Mu-Rong Chao*. A Novel Adductomics Workflow Incorporating FeatureHunter Software: Rapid Detection of Nucleic Acid Modifications for Studying the Exposome.

Environmental Science & Technology, 2024 58 (1), 75-89

Marcus S Cooke#, Yuan-Jhe Chang#, Yet-Ran Chen, Chiung-Wen Hu*, Mu-Rong Chao*. Nucleic acid adductomics – The next generation of adductomics towards assessing environmental health risks.

Science of The Total Environment, 2023, 856, 159192.

Yuan-Jhe Chang, Marcus S. Cooke, Yet-Ran Chen, Shun-Fa Yang, Pei-Shan Li, Chiung-Wen Hu*, Mu-Rong Chao*. Is high resolution a strict requirement for mass spectrometry-based cellular DNA adductomics?

Chemosphere, 2021, 274, 129991.

Chiung-Wen Hu#, Yuan-Jhe Chang#, Marcus S. Cooke, Mu-Rong Chao*. DNA crosslinkomics: A tool for the comprehensive assessment of interstrand crosslinks using high resolution mass spectrometry.

Analytical Chemistry, 2019, 91, 15193-15203. (an NIEHS Extramural Paper of the Month, Jan 2020).

Yuan-Jhe Chang, Marcus S. Cooke, Chiung-Wen Hu*, Mu-Rong Chao*. Novel approach to integrated DNA adductomics for the assessment of in vitro and in vivo environmental exposures.

Archives of Toxicology, 2018, 92, 2665-2680.

Marcus S. Cooke#, Chiung-Wen Hu#, Yuan-Jhe Chang, Mu-Rong Chao*. Urinary DNA adductomics – A novel approach for exposomics.

Environment International, 2018, 121, 1033-1038.

Carcinogens exposure derived from tobacco/areca nut and the associated DNA damages

Distribution and transformation of alkaloids in oral cavity.

Cigarette smoke/chronic inflammation induced oxidative and alkylating stresses.

Selected Publications

Yuan-Jhe Chang, Rajendra Bose Muthukumaran, Jian-Lian Chen, Hsin-Yi. Chang, Yu-Cheng Hung, Chiung-Wen Hu*, Mu-Rong Chao*. Simultaneous determination of areca nut- and tobacco-specific alkaloids in saliva by LC-MS/MS: distribution and transformation of alkaloids in oral cavity.

Journal of Hazardous Materials, 2022, 426, 128116.

Ying-Ming Shih, Yuan-Jhe Chang, Marcus S Cooke, Chih-Hong Pan, Ching-Hsuan Hu, Mu-Rong Chao*, Chiung-Wen Hu*. Alkylating and oxidative stresses in smoking and non-smoking patients with COPD: Implications for lung carcinogenesis.

Free Radical Biology and Medicine, 2021, 164, 99-106.

Chiung-Wen Hu#, Marcus S. Cooke#, Yuan-Jhe Chang, Mu-Rong Chao*. Direct-acting DNA ethylating agents associated with tobacco use primarily originate from the tobacco itself, not combustion.

Journal of Hazardous Materials, 2018, 358, 397-404.

Mu-Rong Chao, Marcus S. Cooke, Chung-Yih Kuo, Chih-Hong Pan, Hung-Hsin Liu, Hao-Jan Yang, Szu-Chieh Chen, Yi-Chen Chiang, Chiung-Wen Hu*. Children are particularly vulnerable to environmental tobacco smoke exposure: Evidence from biomarkers of tobacco-specific nitrosamines, and oxidative stress.

Environment International, 2018, 120, 238-245.

Biomarkers for assessing nitrosative/oxidative stresses and the use in clinical practice

The nitrite/nitrate ratio is a better method for UTIs diagnosis than nitrite alone.

Selected Publications

Mu-Rong Chao#, Yuan-Jhe Chang, Ying-Ming Shih#, Jian-Lian Chen, Cheng-Chieh Yen, Chiung-Wen Hu*. Elevated nitrite/nitrate ratio as a potential biomarker for the differential diagnosis of pleural effusions.

Antioxidants, 2022, 11, 1327.

Mu-Rong Chao#, Mark D Evans, Chiung-Wen Hu#, Yunhee Ji, Peter Møller, Pavel Rossner, Marcus S. Cooke*. Biomarkers of nucleic acid oxidation - A summary state-of-the-art.

Redox Biology, 2021, 42, 101872.

Chiung-Wen Hu#, Yuan-Jhe Chang#, Cheng-Chieh Yen, Jian-Lian Chen, Rajendra Bose Muthukumaran, Mu-Rong Chao*. 15N-labelled nitrite/nitrate tracer analysis by LC-MS/MS: Urinary and fecal excretion of nitrite/nitrate following oral administration to mice.

Free Radical Biology and Medicine, 2019, 143, 193-202.

Ying-Ming Shih, Marcus S. Cooke, Chih-Hong Pan, Mu-Rong Chao*, Chiung-Wen Hu*. Clinical relevance of guanine-derived urinary biomarkers of oxidative stress, determined by LC-MS/MS.

Redox Biology, 2019, 20, 556-565.

Chiung-Wen Hu#, Yuan-Jhe Chang#, Jian-Lian Chen, Yu-Wen Hsu, Mu-Rong Chao*. Sensitive detection of 8-nitroguanine in DNA by chemical derivatization coupled with online solid-phase extraction LC-MS/MS.

Molecules, 2018, 23, 605.

Chiung-Wen Hu, Ying-Ming Shih, Hung-Hsin Liu, Yi-Chen Chiang, Chih-Ming Chen, Mu-Rong Chao*. Elevated urinary levels of carcinogenic

N-nitrosamines in patients with urinary tract infections measured by isotope dilution online SPE LC-MS/MS.

Journal of Hazardous Materials, 2016, 310, 207-216.

Mu-Rong Chao, Ying-Ming Shih, Yu-Wen Hsu, Hung-Hsin Liu, Yuan-Jhe Chang, Bo-Huei Lin, Chiung-Wen Hu*. Urinary nitrite/nitrate ratio measured by isotope-dilution LC-MS/MS as a tool to screen for urinary tract infections.

Free Radical Biology and Medicine, 2016, 93, 77-83.

Carbonylomics

Novel carbonylomics workflow for comprehensive screening of reactive carbonyl species.

Selected Publications

Chiung-Wen Hu, Yuan-Jhe Chang, Yi-Jhen Wang, Yet-Ran Chen , Marcus S. Cooke , Mu-Rong Chao . Novel carbonylomics with stable isotope-coded derivatization for non-targeted analysis of reactive carbonyl species in cooking oils.

Journal of Hazardous Materials, 2025, 494, 138435

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