Exposomics Research Laboratory 

Exposomics Research Laboratory (previously known as the Molecular Epidemiology Group) was established in 2004. Our group aims to explore potential biomarkers associated with various diseases and environmental toxicants, elucidate the underlying mechanisms, and ultimately develop clinical applications using mass spectrometry (MS) technologies.

In recent years, the research conducted by the Exposomics Research Laboratory has focused on two main areas: (i) the development of MS-based methods for the quantitative analysis of DNA modifications and exposure biomarkers induced by environmental toxicants, and (ii) the implementation of MS-based methods in epidemiological research and clinical practice. Lately, the focus of our work is to establish high-resolution mass spectrometry-omics platforms for the detection of the totality of DNA and RNA modifications (i.e., nucleic acid adductomics) as a screening and evaluation tool for environmental exposure, cancer risk, and precision medicine.

Recent research interests:

1. DNA adductomics/Nucleic acid adductomics

2. Carcinogens exposure derived from tobacco/areca nut and the associated DNA damages

3. Biomarkers for assessing nitrosative/oxidative stresses and the use in clinical practice

4. Carbonylomics