Md Joynal Abedin, PhD

Neuroscientist with expertise in neurological disease modeling, combining in vitro, in vivo, and computational approaches to study Alzheimer’s disease, epilepsy, and glioblastoma. Skilled in neuroimaging, electrophysiology, optogenetics, and high-throughput drug screening. Proven track record in translational neuroscience research at MGH/Harvard with a focus on therapeutic development and neural circuit analysis.

Technical Skills

In-situ & In-vitro

3D Organoids Culture, hIPSC Cultures, Organotypic Hippocampal Slice Culture, Dissociated Neuronal Culture (2D/3D), Cultures in Microfluidic Devices.

In-vivo

Animal Breeding and Genotyping, Cranial Windows + Dura Removal, Miniscope Installation, EEG-EMG Telemetry Device Implantation, Optic Cannula Installation, Dosing (IV, IP, IM, SubQ & Retro-orbital Injections), AAV Viral Injections, Cardiac Perfusion, Vibratome/Microtome/Cryostat Sectioning.

In-silico

Mathematical and Statistical Modeling of Biological Systems.

Advanced Imaging, Electrophysiology, and Molecular Techniques

Bright Field, Phase Contrast & DIC Imaging. Fluorescent Imaging. Confocal & Multiphoton Microscopy. Calcium Imaging, Micro-electrode Array (MEA), Patch-Clamp, VSD Imaging, EEG-EMG, Optogenetics (In-vivo, In-vitro), High-throughput Drug Screening, Immunohistochemistry, Tissue Clearing, Automated Assay Platforms, ELISA, Western Blot.

Software Skills

Imaris, ImageJ, SPSS, MATLAB, Python, R, LabVIEW, GraphPad Prism, Autocad (2D/3D), Photoshop.

Work Experience

Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), Boson, MA, USA January 2023 - present

Post-doctoral Research Fellow

Role description: Performed in vivo stereotaxic surgeries; Led studies on synaptic and calcium signaling dysfunction in Alzheimer’s models using patch-clamp, multiphoton imaging, and in vivo recordings; applied advanced signal processing to identify biomarkers and therapeutic targets; mentored a team of researchers.

Lehigh University September 2017 - December 2022

Research Assistant, Neural Engineering Lab

Role description: Developed and characterized advanced in vitro models, including 3D organoids and organotypic slices, to study glioblastoma and epilepsy. Applied electrophysiology, calcium imaging, and machine learning to identify novel therapeutic strategies.

Education

PhD in Bioengineering

Lehigh University, Bethlehem, PA, USA

Neural Engineering Lab

Thesis: In vitro tissue models for neurological disorders

Bachelor in Electrical & Electronic Engineering

Bangladesh University of Engineering and Technology (BUET)

Dhaka, Bangladesh

Focus: Biomedical signal processing.

Awards

• BrightFocus Foundation Alzheimer’s Disease Research Grant

• Mightex Travel Award

• Graduate Teaching & Research Assistantship, Gottshall Fellowship, Lehigh University

Graduate Courseworks

• Cell Biology

• Neuronal Modeling and Computation

• Mathematical Methods in Engineering

• Neural Engineering

• Introduction to Biophotonics and Optical Biomedical Imaging

• Central Nervous System and Behavior

• Neuropharmacology

• Neurobiology of Sensory Systems

• Bioengineering Statistics

Research Funds

• BrightFocus Foundation Alzheimer’s Disease Research Grant (Principle Investigator)

• National Institute of Health (NIH)

• National Institute of Aging (NIA)

• National Institute of Neurological Disorders and Stroke (NINDS)

• National Science Foundation (NSF)

• Air Force Oﬃce of Scientific Research (AFOSR)

Editorial Contributions

• Peer reviewer of frontiers of aging neuroscience

• Conference reviewer of mentoring institute of University of New Mexico