Simulation Study

We perform simulation studies to visualize the ISRP estimates over time and the Histogram of the estimates. We simulated the growth trajectories for n = 100 individuals for 15 times points where each trajectory was generated from the multivariate normal distribution with the Von Bertalamffy mean function and variance-covariance matrix with Koopmans’ structure. Based on this data, we obtained an estimate of the parameters. The process was replicated 500 times to visualize the sampling distribution of the estimate of the parameters by using the histogram. In addition, even if the data were simulated from the other growth model, the normal approximation of the sampling distribution of the estimators remains unchanged.