Publications

Link to National Library of Medicine "My Bibliography":

https://www.ncbi.nlm.nih.gov/myncbi/kyle.mccommis.1/bibliography/public/

Current Preprints:

Weiss RC, Pyles KD, Cho K, Brennan M, Fisher JS, Patti GJ, McCommis KS. Loss of mitochondrial pyruvate transport initiates cardiac glycogen accumulation and heart failure. bioRxiv 2024 bioRxiv

Hadfield CM, Walker JK, Dastvan R, Arnatt C, McCommis KS. Computational structural prediction and chemical inhibition of the human mitochondrial pyruvate carrier protein heterodimer complex. bioRxiv 2024 bioRxiv

Handlin LJ, Macchi NL, Dumaire N, Salih L, McCommis KS, Moutal A, Dai G. Disruption of ordered membrane domains as a mechanism underlying neuropathic pain. bioRxiv 2023 bioRxiv

Li J, Kumar S, Miachin K, Bean NL, Halawi O, Lee S, Park J, Pierre TH, Hor JH, Ng SY, Wallace KJ, Rindtorff N, Miller TM, Niehoff ML, Farr SA, Kletzien RF, Colca JR, Tanis SP, Chen Y, Griffett K, McCommis KS, Finck BN, Peterson TR. A dual MTOR/NAD+ acting gerotherapy. bioRxiv 2023 bioRxiv

Publications:

2024:

Mostafa ME, Agongo J, Grady SF, Pyles KD, McCommis KS, Arnatt CK, Ford DA, Edwards JL. Double cyclization tandem mass for identification of phosphatidylcholines using isobaric six-plex capillary nLC-MS/MS. J am Soc Mass Spectrom. 2024;In press. J Am Soc Mass Spectrom PubMed

Piening A, Ebert E, Gottlieb C, Khojandi N, Kuehm LM, Hoft SG, Pyles KD, McCommis KS, DiPaolo RJ, Ferris ST, Alspach E, Teague RM. Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk. Nat Commun. 2024;15:2835. Nat Commun PubMed

Williams MJ, Halabi CM, Patel HM, Joseph Z, McCommis KS, Weinheimer CJ, Kovocs A, Lima F, Finck BN, Malluche H, Hruska KA. In chronic kidney disease altered cardiac metabolism precedes cardiac hypertrophy. Am J Physiol Renal Physiol. 2024;326:F751-F767. AJP Renal Phys PubMed

2023:

Weiss RC, Menezes TN, McCommis KS. Metabolic drivers and rescuers of heart failure. MO Medicine. 2023;120:5:354-358. MO Medicine PubMed

Yiew NKH, Vazquez JH, Martino MR, Kennon-McGill S, Price JR, Allard FD, Yee EU, Layman AJ, James LP, McCommis KS, Finck BN, McGill MR. Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult. Mol Metab. 2023;101808. Mol Metab PubMed

Giannoukakis N, McCommis KS. Editorial: Diabetes and non-alcoholic fatty liver disease: points of physiological and mechanistic intersection and current co-therapeutic approaches. Front Endocrinol. 2023;14:1253604. Front Endocrinol PubMed

Mukherjee S, Chakraborty M, Msengi EN, Haubner J, Zhang J, Jellinek MJ, Carlson HL, Pyles KD, Ulmasov B, Lutkewitte AJ, Carpenter D, McCommis KS, Ford DA, Finck BN, Neuschwander-Tetri BA, Chakraborty A. Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo. Mol Metab. 2023;101767. Mol Metab PubMed

Cancado de Faria R, Shashkova EV, Flaveny C, Baldan A, McCommis KS, Gonzalo S. STAT1 drives the interferon-like response and aging hallmarks in progeria. AgingBio. 2023;1:1-15. AgingBio PubMed

Sharpe MC, Pyles KD, Hallcox T, Kamm DR, Piechowski M, Fisk B, Albert CJ, Carpenter DH, Ulmasov B, Ford DA, Neuschwander-Tetri BA, McCommis KS. Enhancing hepatic MBOAT7 in mice with nonalcoholic steatohepatitis. Gastro Hep Advances. 2023;2:558-572 . Gastro Hep Advances PubMed

McCommis KS, Finck BN. The hepatic mitochondrial pyruvate carrier as a regulator of systemic metabolism and a therapeutic target for treating metabolic disease. Biomolecules. 2023;13:261. Biomolecules PubMed

Ferguson D, Eichler SJ, Yiew NKH, Colca JR, Cho K, Patti GJ, Shew TM, Lutkewitte AJ, Mukherjee S, McCommis KS, Niemi NM, Finck BN. Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism. Mol Metab. 2023;101694. Mol Metab PubMed

Shakya S, Pyles KD, Albert CJ, Patel RP, McCommis KS, Ford DA. Myeloperoxidase-derived hypochloroous acid targets human airway epithelial plasmalogens liberating protein modifying electrophilic 2-chlorofatty aldehydes. Redox Biol. 2023;59:102557. Redox Biol PubMed

2022:

Martino MR, Gutierrez-Aguilar M, Yiew NKH, Lutkewitte AJ, Singer JM, McCommis KS, Ferguson D, Liss KHH, Yoshino J, Rankemeyer MK, Smith GI, Cho K, Fletcher JA, Klein S, Patti GJ, Burgess SC, Finck BN. Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids. Cell Rep. 2022;39:110733. Cell Rep PubMed

Kamm DR, McCommis KS. Hepatic stellate cells in physiology and pathology. J Physiol. 2022; 600:1825-1837. J Physiol PubMed

Yuan L, McCommis KS, Neuschwander-Tetri BA. Two faces of pioglitazone: sorting out the roles of its PPARg binding versus mitochondrial pyruvate carrier inhibition is not so simple. Hepatol Comms. 2022;6:3003-3005. Hepatol Comms PubMed

Brahma MK, Wends AR, McCommis KS. Rebuttal from Manoja K. Brahma, Adam R. Wende, and Kyle S. McCommis: Ketone bodies are not an important metabolic fuel for the heart. J Physiol. 2022;600:1011-1012. J Physiol PubMed

Brahma MK, Wends AR, McCommis KS. Ketone bodies are not an important metabolic fuel for the heart. J Physiol. 2022;600:1005-1007. J Physiol PubMed

Hegazy L, Gill LE, Pyles KD, Kaiho C, Kchouk S, Finck BN, McCommis KS, Elgendy B. Identification of novel mitochondrial pyruvate carrier inhibitors by homology modeling and pharmacophore-based virtual screening. Biomedicines. 2022;10:365. Biomedicines PubMed

2021:

Hodges WT, Jarasvaraparn C, Ferguson D, Griffett K, Gill LE, Chen Y, Ilagan MXG, Hegazy L, Elgendy B, Cho K, Patti GJ, McCommis KS, Finck BN. Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice. J Biol Chem. 2021;298:101554. J Biol Chem PubMed

Mukherjee S, Chakraborty M, Ulmasov B, McCommis KS, Zhang J, Carpenter DH, Msengi EN, Haubner J, Guo C, Pike DP, Ghoshal S, Ford DA, Neuschwander-Tetri BA, Chakraborty A. Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis. Mol Metab. 2021;54:101364. Mol Metab PubMed

Mandala P, Chen WJ, Armstrong A, Malhotra MR, Chavalmane S, McCommis KS, Chen A, Carpenter D, Biswas P, Gnana-Prakasam JP. PPARa agonist fenofibrate attenuates iron induced liver injury in mice by modulating the Sirt3 and b-Catenin signaling. Am J Physiol Gastrointest Liver Physiol. 2021;321:G262-G269. Am J Physiol Gastrionest Liver Physiol PubMed

Kamm DK, Pyles KP, Sharpe MC, Healy L, Colca JR, McCommis KS. MSDC-0602K, A novel insulin sensitizer improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide. J Biol Chem. 2021;296:100807. J Biol Chem PubMed

Chambers KT, Cooper MA, Swearingen AR, Brookheart RT, Schweitzer GG, Weinheimer CJ, Kovacs A, Koves TR, Muoio DM, McCommis KS, Finck BN. Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations. JCI Insight. 2021;6:134340. JCI Insight PubMed

McCommis KS, Butler AA. Importance of keeping time in the liver. Endocrinology. 2021;162:bqaa230. Endocrinology PubMed

Kuehm LM, Khojandi N, Piening A, Klevorn LE, Geraud SC, McLaughlin NR, Griffett K, Burris TP, Pyles KD, Nelson AM, Preuss ML, Bockerstett KA, Donlin MJ, McCommis KS, DiPaolo RJ, Teague RM. Fructose promotes cytoprotection in melanoma tumors and resistance to immunotherapy. Cancer Immunol Res. 2021;9:227-238. Cancer Immunol Res PubMed

Liss KHH, Ek SE, Lutkewitte AJ, Pietka TA, He M, Skaria P, Tycksen E, Ferguson D, Blanc V, Graham MJ, Hall AM, McGill MR, McCommis KS, Finck BN. Monoacylglycerol acyltransferase 1 knockdown exacerbates hepatic ischemia-reperfusion injury in mice with hepatic steatosis. Liver Transpl. 2021;27:116-133. Liver Transpl PubMed

2020:

McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, King MT, Veech RJ, DeBosch BJ, Muoio DM, Gross RJ, Finck BN. Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. Nat Metab. 2020;2:1232-1247. Nat Metab PubMed

Banerjee S, Ghoshal S, Stevens JR, McCommis KS, Gao S, Castro-Sepulveda M, Mizgier ML, Girardet C, Kumar KG, Galgani JE, Niehoff M, Farr SA, Zhang J, Butler AA. Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction. J Biol Chem. 2020;295:13753-13768. J Biol Chem PubMed

Gansemer ER, McCommis KS, Martino M, Qaadir King-McAlpin A, Potthoff MJ, Finck BN, Taylor EB, Rutkowski DT. NAPDH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis. iScience. 2020;23(5):e101116. iScience PubMed

2019:

Gao S, Ghoshal S, Zhang L, Stevens JR, McCommis KS, Finck BN, Lopaschuk GD, Butler AA. The Peptide Hormone Adropin Regulates Signal Transduction Pathways Controlling Hepatic Glucose Metabolism in a Mouse Model of Diet-Induced Obesity. J Biol Chem. 2019;294(36):13366-13377. J Biol Chem PubMed

McCommis KS, Finck BN. Treating Hepatic Steatosis and Fibrosis by Modulating Mitochondrial Pyruvate Metabolism. Cell Mol Gastroenterol Hepatol. 2019;7(2):275-284. Cell Mol Gastroenterol Hepatol PubMed

Lutkewitte AJ, McCommis KS, Schweitzer GG, Chambers KT, Graham MJ, Wang L, Patti GJ, Hall AM, Finck BN. Hepatic Monoacylglycerol Acyltransferase 1 Is Induced by Prolonged Food Deprivation to Modulate the Hepatic Fasting Response. J Lipid Res. 2019;60(3):528-538. J Lipid Res PubMed

Schweitzer GG, Collier SL, Chen Z, McCommis KS, Pittman SK, Yoshino J, Matkovich SJ, Hsu FF, Chrast R, Eaton JM, Harris TE, Weihl CC, Finck BN. Loss of Lipin 1-Mediated Phosphatidic Acid Phosphohydrolase Activity in Muscle Leads to Skeletal Myopathy in Mice. FASEB J. 2019;33(1):652-667. FASEB J PubMed

2018:

Liss KHH, McCommis KS, Chambers KT, Pietka TA, Schweitzer GG, Park SL, Nalbantoglu I, Weinheimer CJ, Hall AM, Finck BN. The Impact of Diet-Induced Hepatic Steatosis in a Murine Model of Hepatic Ischemia/Reperfusion Injury. Liver Transpl. 2018;24(7):908-921. Liver Transpl PubMed

Chen Y, McCommis KS, Ferguson D, Hall AM, Harris CA, Finck BN. Inhibition of the Mitochondrial Pyruvate Carrier by Tolyfluanid. Endocrinology. 2018;159(2):609-621. Endocrinology PubMed

McCommis KS, Colca JR, Finck BN. Reply (Letter to Editor). Hepatology. 2018;67(5):2055-2056. Hepatology PubMed

2017:

Colca JR, McDonald WG, McCommis KS, Finck BN. Treating Fatty Liver Disease by Modulating Mitochondrial Pyruvate Metabolism. Hepatol Commun. 2017;1(3):193-197. Hepatol Commun PubMed

Vigueira PA, McCommis KS, Hodges WT, Schweitzer GG, Cole SL, Oonthonpan L, Taylor EB, McDonald WG, Kletzien RF, Colca JR, Finck BN. The Beneficial Metabolic Effects of Insulin Sensitizers Are Not Attenuated by Mitochondrial Pyruvate Carrier 2 Hypomorphism. Exp Physiol. 2017;102(8):985-999. Exp Physiol PubMed

McCommis KS, Hodges WT, Brunt EM, Nalbantoglu I, McDonald WG, Holley C, Fujiwara H, Schaffer JE, Colca JR, Finck BN. Targeting the Mitochondrial Pyruvate Carrier Attenuates Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis. Hepatology. 2017;65(5):1543-1556. Hepatology PubMed

2016:

McCommis KS, Hodges WT, Bricker DK, Wisidagama DR, Compan V, Remedi MS, Thummel CS, Finck BN. An Ancestral role for the Mitochondrial Pyruvate Carrier in Glucose-Stimulated Insulin Secretion. Mol Metab. 2016;5(8):602-614. Mol Metab PubMed

Lam WY, Becker AM, Kennerly KM, Wong R, Curtis JD, Llufrio EM, McCommis KS, Fahrmann J, Pizzato HA, Nunley RM, Lee J, Wolfgang MJ, Patti GJ, Finck BN, Pearce EL, Bhattacharya D. Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells. Immunity. 2016;45(1):60-73. Immunity PubMed

2015:

McCommis KS, Chen Z, Fu X, McDonald WG, Colca JR, Kletzien RF, Burgess SC, Finck BN. Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling. Cell Metab. 2015;22(4):682-694. Cell Metab PubMed

McCommis KS, Finck BN. Mitochondrial Pyruvate Transport: A Historical Perspective and Future Research Directions. Biochem J. 2015;466(3):443-454. Biochem J PubMed

Schweitzer GG, Chen Z, Gan C, McCommis KS, Soufi N, Chrast R, Mitra MS, Yang K, Gross RW, Finck BN. Liver-Specific Loss of Lipin-1-Mediated Phosphatidic Acid Phosphatase Activity Does Not Mitigate Intrahepatic TG Accumulation in Mice. J Lipid Res. 2015;56(4):848-858. J Lipid Res PubMed

2014:

Heimstra JA, Gutierrez-Aguilar M, Marshall KD, McCommis KS, Zgoda PJ, Cruz-Rivera N, Jenkins NT, Krenz M, Domeier TL, Baines CP, Emter CA. A New Twist on an Old Idea Part 2: Cyclosporine Preserves Normal Mitochondrial but Not Cardiomyocyte Function in Mini-Swine with Compensated Heart Failure. Physiol Rep. 2014;2(6):e12050. Physiol Rep PubMed

Vigueira PA, McCommis KS, Schweitzer GG, Remedi MS, Chambers KT, Fu X, McDonald WG, Cole SL, Colca JR, Kletzien RF, Burgess SC, Finck BN. Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion. Cell Rep. 2014;7(6):2042-2053. Cell Rep PubMed

Hall AM, Soufi N, Chambers KT, Chen Z, Schweitzer GG, McCommis KS, Erion DM, Graham MJ, Su X, Finck BN. Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice. Diabetes. 2014;63(7):2284-2296. Diabetes PubMed

2013:

McCommis KS, Douglas DL, Krenz M, Baines CP. Cardiac-Specific Hexokinase 2 Overexpression Attenuates Hypertrophy by Increasing Pentose Phosphate Pathway Flux. J Am Heart Assoc. 2013;2(6):e000355. J Am Heart Assoc PubMed

2012:

McCommis KS, Baines CP. The Role of VDAC in Cell Death: Friend or Foe? Biochim Biophys Acta. 2012;1818(6):1444-1450. Biochim Biophys Acta PubMed

McCommis KS, Baines CP. The balance of glucose metabolism and cell death: uncovering protective and lethal effects of Hexokinase-2. Bioenergetics. 2012;1:2. Bioenergetics

2011:

McCommis KS, McGee AM, Laughlin MH, Bowles DK, Baines CP. Hypercholesterolemia Increases Mitochondrial Oxidative Stress and Enhances the MPT Response in the Porcine Myocardium: Beneficial Effects of Chronic Exercise. Am J Physiol Regul Integr Comp Physiol. 2011;301(5):R1250-1258. Am J Physiol Regul Integr Comp Physiol PubMed

McCommis KS, O'Connor R, Abendschein DR, Muccigrosso D, Gropler RJ, Zheng J. T(2) Preparation Method for Measuring Hyperemic Myocardial O(2) Consumption: In Vivo Validation by Positron Emission Tomography. J Magn Reson Imaging. 2011;33(2):320-327. J Magn Reson Imaging PubMed

2010:

McCommis KS, O'Connor R, Lesniak D, Lyons M, Woodard PK, Gropler RJ, Zheng J. Quantification of Global Myocardial Oxygenation in Humans: Initial Experience. J Cardiovasc Magn Reson. 2010;12(1):34. J Cardiovasc Magn Reson PubMed

McCommis KS, Koktzoglou I, Zhang H, Goldstein TA, Northrup BE, Li D, Gropler RJ, Zheng J. Improvement of Hyperemic Myocardial Oxygen Extraction Fraction Estimation by a Diffusion-Prepared Sequence. Magn Reson Med. 2010;63(6):1675-1682. Magn Reson Med PubMed

McCommis KS, He X, Abendschein DR, Gupte PM, Gropler RJ, Zheng J. Cardiac 17O MRI: Toward Direct Quantification of Myocardial Oxygen Consumption. Magn Reson Med. 2010;63(6):1442-1447. Magn Reson Med PubMed

McCommis KS, Goldstein TA, Abendschein DR, Misselwitz B, Pilgram T, Gropler RJ, Zheng J. Roles of Myocardial Blood Volume and Flow in Coronary Artery Disease: An Experimental MRI Study at Rest and During Hyperemia. Eur Radiol. 2010;20(8):2005-2012. Eur Radiol PubMed

Liu Y, Abendschein DR, Woodard GE, Rossin R, McCommis KS, Zheng J, Welch MJ, Woodard PK. Molecular Imaging of Atherosclerotic Plaque With (64)Cu-Labeled Natriuretic Peptide and PET. J Nucl Med. 2010;51(1):85-91. J Nucl Med PubMed

McCommis KS, Goldstein TA, Abendschein DR, Herrero P, Misselwitz B, Gropler RJ, Zheng J. Quantification of Regional Myocardial Oxygenation by Magnetic Resonance Imaging: Validation with Positron Emission Tomography. Circ Cardiovasc Imaging. 2010;3(1):41-46. Circ Cardiovasc Imaging PubMed

2009:

McCommis KS, Zhang H, Goldstein TA, Misselwitz B, Abendschein DR, Gropler RJ, Zheng J. Myocardial Blood Volume Is Associated With Myocardial Oxygen Consumption: An Experimental Study with Cardiac Magnetic Resonance in a Canine Model. JACC Cardiovasc Imaging. 2009;2(11):1313-1320. JACC Cardiovasc Imaging PubMed

Zheng J, Abendschein DR, Okamoto RJ, Yang D, McCommis KS, Misselwitz B, Gropler RJ, Tang D. MRI-Based Biomechanical Imaging: Initial Study on Early Plaque Progression and Vessel Remodeling. Magn Reson Med. 2009;27(10):1309-1318. Magn Reson Med PubMed

2008:

Northrup BE, McCommis KS, Zhang H, Ray S, Woodard PK, Gropler RJ, Zheng J. Resting Myocardial Perfusion Quantification with CMR Arterial Spin Labeling at 1.5T and 3.0T. J Cardiovasc Magn Reson. 2008;10(1):53. J Cardiovasc Magn Reson PubMed

McCommis KS, Zhang H, Herrero P, Gropler RJ, Zheng J. Feasibility Study of Myocardial Perfusion and Oxygenation by Noncontrast MRI: Comparison with PET Study in a Canine Model. Magn Reson Imaging. 2008;26(1):11-19. Magn Reson Imaging PubMed

2007:

McCommis KS, Goldstein TA, Zhang H, Misselwitz B, Gropler RJ, Zheng J. Quantification of Myocardial Blood Volume During Dipyridamole and Dobutamine Stress: A Perfusion CMR Study. J Cardiovasc Magn Reson. 2007;9(5):785-792. J Cardiovasc Magn Reson PubMed

Book, Magazine, & White-Paper Publications:

McCommis KS. Targeting Insulin Resistance for the Treatment of NASH. Cayman Currents. Issue 31, Winter 2019. Cayman Currents

Abstract Presentations:

Weiss RC, Gill LE, Kamm DR, Pyles KD, Pherson M, Cho KY, Patti GJ, McCommis KS. Deletion of the mitochondrial pyruvate carrier enhances glycolysis and mTOR activation which drives cardiac hypertrophy and failure. Society for Heart and Vascular Metabolism Meeting, September, 2021; Virtual due to COVID-19.

Ferguson D, Yiew NKH, McCommis KS, Colca JR, Finck BN. Mechanisms of metabolic cross talk between mitochondrial pyruvate carrier inhibition and branched-chain amino acid catabolism in hepatocytes. American Diabetes Association Scientific Sessions, June, 2021; Virtual due to COVID-19.

Pyles KD, Kamm DR, Colca JR, McCommis KS. The new insulin sensitizer MSDC-0602K synergizes with the GLP1 receptor agonist Liraglutide. American Diabetes Association Scientific Sessions, June, 2020; Virtual meeting due to COVID-19.

McCommis KS, Hodges WT, Chen Y, Finck BN. Mitochondrial Pyruvate Carrier Inhibitors to Treat Nonalcoholic Fatty Liver Disease. The AASLD Liver Meeting, November, 2019; Boston, MA.

McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Muoio DM, Crawford PA, Finck BN. Heart failure caused by defective mitochondrial pyruvate metabolism is prevented and reversed with a ketogenic diet. NHLBI Mitochondrial Biology Symposium, September, 2019; Bethesda, MD.

Banerjee S, Ghoshal S, McCommis KS, Niehoff M, Chakraborty M, Chakraborty A, Farr SA, Finck BN, Butler AA. Glucagon Signaling dynamics are altered in liver-specific adropin knockout mice. The Obesity Society Annual Meeting, November, 2019; Las Vegas, NV.

Colca JR, McCommis KS, Finck BN. MSDC-0602K targets the mitochondrial pyruvate carrier to treat nonalcoholic steatohepatitis. European Association for the Study of the Liver International Liver Conference, April, 2019; Vienna, Austria.

Hodges WT, McCommis KS, Finck BN. Novel mitochondrial pyruvate carrier modulators to treat non-alcoholic steatohepatitis and insulin resistance. European Association for the Study of the Liver International Liver Conference, April, 2019; Vienna, Austria.

Hodges WT, McCommis KS, Chen Y, Chambers KT, Finck BN. Mitochondrial pyruvate carrier modulators to treat nonalcoholic steatohepatitis. Keystone Symposia: A4 Integrated Pathways of Disease in NASH and NAFLD, January, 2019; Santa Fe, NM.

McCommis KS, Chen Y, Carpenter D, Finck BN. Characterization of a novel insulin-sensitizer to treat diabetes and nonalcoholic steatohepatitis. Keystone Symposia: A4 Integrated Pathways of Disease in NASH and NAFLD, January, 2019; Santa Fe, NM.

Finck BN, Matkovich SJ, Colca JR, McCommis KS. The novel insulin-sensitizer MSDC-0602K alters plasma microRNAs in a mouse model of NASH. The AASLD Liver Meeting, November, 2018; San Francisco, CA.

Chen Y, Chambers KT, McDonald WG, Finck BN, McCommis KS. Identification and characterization of a novel insulin-sensitizer to treat diabetes and nonalcoholic steatohepatitis. American Diabetes Association Scientific Sessions, June, 2018; Orlando, FL.

McCommis KS, Hodges WT, Chen Y, Chambers KT, Finck BN. Identification of mitochondrial pyruvate carrier modulators to treat diabetes. American Diabetes Association Scientific Sessions, June, 2018; Orlando, FL.

Lutkewitte AJ, McCommis KS, Chambers KT, Graham MJ, Hall AM, Finck BN. Mogat1 is a fasting-induced PPARα target gene that plays a role in coordinating the hepatic response to food deprivation. Experimental Biology, April, 2018; San Diego, CA.

McCommis KS, McDonald WG, Colca JR, Finck BN. Targeting mitochondrial pyruvate metabolism to ameliorate hepatic fibrosis in a mouse model of NASH. Midwest Liver Symposium, April, 2018; Kansas City, KS.

Martino M, Gutierrez-Aguilar M, McCommis KS, Schneider B, McGill MR, Finck BN. Mitochondrial ALT2 plays a role in physiologic and pathologic hepatic gluconeogenesis. Midwest Liver Symposium, April, 2018; Kansas City, KS.

Hodges WT, Chen Y, McCommis KS, Finck BN. Identification of mitochondrial pyruvate carrier modulators to treat diabetes and NAFLD. Keystone Symposia: J3 Organ Crosstalk in Obesity and NAFLD, January, 2018; Keystone, CO.

McCommis KS, Koves TR, Ilkayeva OR, Kovacs A, Weinheimer CJ, Muoio DM, Crawford PA, Finck BN. Ketogenic diet prevents and reverses heart failure caused by defective mitochondrial pyruvate metabolism. Keystone Symposia: A1 Heart Failure: Crossing the Translational Divide, January, 2018; Keystone, CO.

McCommis KS, McDonald WG, Colca JR, Finck BN. Acute mitochondrial pyruvate carrier-dependent and independent effects of MSDC-0602 in hepatocytes on insulin sensitivity and NASH endpoints in mice. The AASLD Liver Meeting, November, 2017; Washington D.C.

Liss KHH, McCommis KS, Chambers KT, Hall AM, Finck BN. The impact of diet-induced hepatic steatosis in a murine model of hepatic ischemia-reperfusion injury. The AASLD Liver Meeting, November, 2017; Washington D.C.

Ghoshal S, Stevens JE, McCommis KS, Finck BN, Butler AA. Adropin modulates hepatic gluconeogenesis through inhibition of glucagon action. The Obesity Society Annual Meeting, October, 2017; Washington, D.C.

Lutkewitte AJ, Hall AM, McCommis KS, Finck BN. The impact of Mogat1 deficiency in the hepatic response to fasting. Gordon Research Conference: Molecular & Cellular Biology of Lipids. August, 2017; Waterville Valley, NH.

McCommis KS, Gierasch CM, Kovacs A, Weinheimer CJ, Koves TR, Muoio DM, Finck BN. Cardiac deletion of the mitochondrial pyruvate carrier results in dilated cardiomyopathy with preservation of fatty acid catabolism. American Heart Association Basic Cardiovascular Sciences Conference, July 11, 2017; Portland, OR.

Gutierrez-Aguilar M, McCommis KS, McGill MR, Schneider B, Finck BN. Mitochondrial transaminase GPT2 regulates hepatic gluconeogenesis and contributes to hyperglycemia in diabetic mice. Keystone Symposia: J3 Diabetes, January 23, 2017; Keystone, CO.

McCommis KS, McDonald WG, Colca JR, Finck BN. Targeting mitochondrial pyruvate metabolism to ameliorate hepatic fibrosis in a mouse model of NASH. NASH-TAG Meeting, January, 2017; Park City, UT.

McCommis KS, McDonald WG, Colca JR, Finck BN. Targeting mitochondrial pyruvate metabolism to ameliorate hepatic fibrosis in a mouse model of NASH. The AASLD Liver Meeting, November, 2016; Boston.

McCommis KS, McDonald WG, Colca JR, Brunt E, Schaeffer JE, Finck BN. Modulating mitochondrial pyruvate carrier activity decreases hepatic fibrosis in a mouse model of NASH. American Diabetes Association Scientific Sessions, June, 2016; New Orleans.

Lam W, Becker A, Kennerly K, Wong R, Payne E, Curtis J, McCommis KS, Fahrmann J, Nunley R, Wolfgang M, Patti G, Finck BN, Pearce E, Bhattacharya D. Plasma cell mitochondrial pyruvate import controls the duration of humoral immunity. American Association of Immunologists Annual Meeting, May 16, 2016; Seattle.

McCommis KS, Chen Z, Fu X, McDonald WG, Colca JR, Kletzien RF, Burgess SC, Finck BN. The mitochondrial pyruvate carrier regulates hepatic gluconeogenesis. American Diabetes Association Scientific Sessions, June, 2015; Boston.

McCommis KS, Hodges W, McDonald WG, Colca JR, Kletzien RF, Remedi M, Finck BN. Mice with β-cell-specific knockout of mitochondrial pyruvate carrier 2 exhibit defects in glucose-stimulated insulin secretion. American Diabetes Association Scientific Sessions, June 2015; Boston.

McDonald WG, Chen Z, McCommis KS, Cole SL, Wheeler J, Brightwell-Conrad A, Holewa D, Wolfe C, Coulter K, Kilkuskie P, Tomasselli A, Finck BN, Kletzien R, Colca JR. Novel insulin sensitizers regulate pyruvate metabolism via a direct interaction with the mitochondrial pyruvate carrier. American Diabetes Association Scientific Sessions, June 2015; Boston.

McCommis KS, Chen Z, Fu X, McDonald WG, Colca JR, Kletzein RL, Burgess SC, Finck BN. The mitochondrial pyruvate carrier regulates hepatic gluconeogenesis. Keystone Symposia: X8 Liver Metabolism and Nonalcoholic Fatty Liver Disease, March 22, 2015; Whistler, B.C., Canada.

Schweitzer GG, Chen Z, Gan C, McCommis KS, Soufi N, Chrast R, Mitra MS, Yang K, Gross RW, Finck BN. Liver-specific loss of lipin 1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic triglyceride accumulation in mice. Keystone Symposia: X8 Liver Metabolism and Nonalcoholic Fatty Liver Disease, March 22, 2015; Whistler, B.C., Canada.

McCommis KS, Chen Z, McDonald WG, Colca JR, Kletzein RL, Fu X, Burgess SC, Finck BN. Regulation of hepatic gluconeogenesis by the mitochondrial pyruvate carrier. Keystone Symposia: Diabetes and Metabolic Dysfunction, January 27, 2015; Santa Fe.

Soufi N, Schweitzer GG, Chen Z, Gan C, McCommis KS, Finck BN. Effects of liver-specific loss of lipin 1-mediated phosphatidate phosphohydrolase activity. The Liver Meeting, November 7, 2014; Boston.

McCommis KS, Vigueira PA, Schweitzer GG, Remedi MS, Fu X, McDonald WG, Cole SL, Colca JR, Kletzien RF, Burgess SC, Finck BN. Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion. American Diabetes Association Scientific Sessions, June 2014; San Francisco.

Hiemstra JA, Gutierrez-Aguilar M, McCommis KS, Marshall KD, Cobb MS, Gibson AK, Baines CP, Domeier TL, Emter CA. Chronic cyclosporine treatment preserves mitochondrial energetics but does not improve cardiomyocyte contractile function or calcium handling in a translational mini-swine model of heart failure with preserved ejection fraction. American Heart Association Scientific Sessions, November, 2013; Dallas.

McCommis KS, Baines CP. Hexokinase-2-mediated protection against death is dependent upon voltage-dependent anion channels 2 & 3. American Heart Association Scientific Sessions, November 5, 2012; Los Angeles.

McGee AM, McCommis KS, Laughlin MH, Bowles DK, Baines CP. Exercise training prevents hypercholesterolemia-induced cardiac mitochondrial dysfunction. American Heart Association Basic Cardiovascular Sciences Conference, July 20, 2011; New Orleans.

McCommis KS, Baines CP. VDAC2 and 3, but not VDAC1 are required for HK2-mediated protection against cell death. American Heart Association Basic Cardiovascular Sciences Conference, July 18, 2011; New Orleans.

McCommis KS, Liu Y, Abendschein DR, Woodard GE, Rossin R, Gropler RJ, Zheng J, Welch MJ, Woodard PK. Extracellular matrix deposition and natriuretic peptide receptor-C expression in restenosis after angioplasty: a MRI and PET imaging study in rabbits. North American Society for Cardiovascular Imaging, October 4, 2009; Orlando.

McCommis KS, O’Conner R, Lesniak D, Gropler RJ, Woodard PK, Zheng J. In vivo MRI methods for estimation of myocardial oxygenation: initial experience. North American Society for Cardiovascular Imaging, October 4, 2009; Orlando.

Liu Y, Rossin R, Abendschein DR, Woodard GE, Zheng J, McCommis KS, Woodard PK, Welch MJ. Assessment of Natriuretic Petpide Clearance Receptor with Positron Emission Tomography in Cardiovascular Disease Models. Computers in Cardiology, September 2009; Park City.

Liu Y, Rossin R, Abendschein DR, Zheng J, McCommis KS, Woodard GE, Woodard PK, Welch MJ. Molecular imaging of atherosclerosis plaque with 64Cu-labeled natriuretic peptide and positron emission tomography. Society of Nuclear Medicine Multimodality Cardiovascular Molecular Imaging Symposium; J Nucl Med; 2009;50:658; May 2009; Bethesda.

McCommis KS, Goldstein TA, Abendschein DR, Misselwitz B, Gropler RJ, Zheng J. Measurements of myocardial perfusion and metabolism with MR: validation study with PET in a canine model. Proceedings of the International Society of Magnetic Resonance in Medicine; p. 151; #704, April 23, 2009; Honolulu.

McCommis KS, He X, Abendschein DR, Gupte PM, Gropler RJ, Zheng J. New methods for the quantification of myocardial oxygen consumption with 17O MRI. Proceedings of the International Society of Magnetic Resonance in Medicine; p. 151; #706, April 23, 2009; Honolulu.

Skrok J, Shehata M, Sibley C, Goldstein TA, McCommis KS, Zheng J, Lima JA, Bluemke DA, Hassoun P, Vogel-Claussen J. Patients with pulmonary arterial hypertension have a lower left ventricular myocardial perfusion reserve on cardiac MR adenosine stress perfusion imaging compared to aged matched healthy controls. Proceedings of the International Society of Magnetic Resonance in Medicine; p. 264; #1768, April 23, 2009; Honolulu.

McCommis KS, Lesniak D, Goldstein TA, Woodard PK, Gropler RJ, Zheng J. Quantification of myocardial oxygen consumption rate: initial experience in humans. Proceedings of the International Society of Magnetic Resonance in Medicine; p. 441; #3777, April 22, 2009; Honolulu.

McCommis KS, O’Conner R, Abendschein DR, Misselwitz B, Gropler RJ, Zheng J. T2 preparation methods for the quantification of myocardial oxygenation at rest and during hyperemia. Proceedings of the International Society of Magnetic Resonance in Medicine; p. 441; #3778, April 22, 2009; Honolulu.

Liu Y, Rossin R, Abendschein DR, Zheng J, McCommis KS, Woodard GE, Woodard PK, Welch MJ. Molecular imaging of atherosclerotic plaque with 64Cu-labeled natriuretic peptide and positron emission tomography. Symposium on Multimodality Cardiovascular Molecular Imaging; April, 2009; NIH, Bethesda.

Zheng J, Abendschein DR, Okamoto RJ, Yang D, McCommis KS, Gropler RJ, Tang D. Low plaque tensile stress may be a driving force to plaque regression: contrast enhanced MRI study in a porcine model of atherosclerosis. American Heart Association Scientific Sessions; November, 2008; New Orleans.

McCommis KS, Zhang H, Gropler RJ, Zheng J. MR Quantification of Regional Myocardial Oxygen Consumption Rate. Proceedings of the International Society of Magnetic Resonance in Medicine; p. 9; #50; May 5, 2008; Toronto.

McCommis KS, Koktzoglou I, Zhang H, Li D, Gropler RJ, Zheng J. Diffusion-weighting imaging improves the quantification of myocardial oxygenation when arrhythmias are present. Proceedings of the International Society of Magnetic Resonance in Medicine; p. 192; #1017; May 5, 2008; Toronto.

Zheng J, Abendschein DR, Okamoto RJ, Yang D, McCommis KS, Misselwitz B, Gropler RJ, Tang D. MRI-based biomechanical imaging: Role of hemodynamic forces on the early plaque remodeling. Proceedings of the International Society of Magnetic Resonance in Medicine; p. 465; #2847; May 5, 2008; Toronto.

McCommis KS, Rossin R, Abendschein DR, Ochoa B, Woodard GE, Welch MJ, Woodard PK, Zheng J. Detection of atherosclerotic plaque progression: Correlation of contrast MRI with PET using 64Cu-labeled Natriuretic peptide. Proceedings of the International Society of Magnetic Resonance in Medicine; p. 99; #519; May 7, 2008; Toronto.

McCommis KS, Northrup BE, Zhang H, Gropler RJ, Zheng J. Regional OEF Determination with the BOLD Effect in Normal and Stenotic Canines. Proceedings of the International Society of Magnetic Resonance in Medicine; p. 110; #583; May 7, 2008; Toronto.

Northrup BE, He X, McCommis KS, Zheng J. Myocardial T1rho mapping at 3T using a novel spin-locking technique. Proceedings of the International Society of Magnetic Resonance in Medicine; p. 482; #2961; May 7, 2008; Toronto.

McCommis KS, Goldstein TA, Gropler RJ, Zheng J. Detection of coronary artery disease with both myocardial blood flow and volume: A MRI study in a canine model. Proceedings of the International Society of Magnetic Resonance in Medicine; p. 190; #1005; May 8, 2008; Toronto.

McCommis KS, Gropler RJ, Zheng J. Detection of changes in myocardial blood flow and volume: A CMR study in a canine model of coronary artery stenosis. Society of Cardiovascular Magnetic Resonance Annual Meeting; p. 12; Feb. 1, 2008; Los Angeles.

McCommis KS, Gropler RJ, Zheng J. Determination of myocardial OEF by CMR in stenotic dogs. Society of Cardiovascular Magnetic Resonance Annual Meeting; p. 16; Feb. 1, 2008; Los Angeles.

McCommis KS, Koktzoglou I, Zhang H, Li D, Gropler RJ, Zheng J. Black-blood myocardial T2 and oxygenation using a diffusion-weighted prepared sequence. Society of Cardiovascular Magnetic Resonance Annual Meeting; Feb. 1, 2008; Los Angeles.

Zhang J, Abendschein DR, Okamoto RJ, Yang D, McCommis KS, Misselwitz B, Gropler RJ, Tang D. Role of hemodynamic forces on the plague development: Non-invasive assessment with MRI methods. Society of Cardiovascular Magnetic Resonance Annual Meeting; Feb. 2, 2008; Los Angeles.

McCommis KS, Gropler RJ, Zheng J. Alternation of myocardial oxygen consumption during hyperemia: Detection with CMR. Society of Cardiovascular Magnetic Resonance Annual Meeting; p. 25; Feb. 2, 2008; Los Angeles.

Dentler WL, McCommis KS. Remodeling of anterograde IFT complexes in Chlamydomonas fla10.1 and the role of IFT in flagellar disassembly. American Society for Cell Biology Annual Meeting; Dec. 3, 2007; Washington D.C.

McCommis KS, Zhang H, Scott SW, Herrero P, Gropler RJ, Zheng J. Non-contrast measurement of myocardial perfusion and oxygenation by MRI: Comparison with PET in an acute coronary stenotic canine model. Proceedings of the International Society of Magnetic Resonance in Medicine; May 8, 2006; Seattle.

Goldstein TA, McCommis KS, Zhang H, Misselwitz B, Zheng J. Transmural myocardial blood volume during dipyridamole and dobutamine stress: correlation between MRI and radioactive measurements. North American Society for Cardiovascular Imaging; Oct. 9, 2006; Las Vegas.