🧑🔬 Translational Cancer Biologist
🧑🔬 Translational Cancer Biologist
🧬 DNA repair and telomere biology enthusiast
🧬 DNA repair and telomere biology enthusiast
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My research journey
My research journey
My research career has focused on understanding cancer biology better and applying this knowledge to improve clinical disease management. My Ph.D. training was focussed on DNA replication and repair pathways that ensure the accurate transmission of genetic information. Subsequently, I studied DNA repair pathways specifically at the chromosome ends – called telomeres – to understand how disrupting telomere integrity enables normal cells to achieve replicative immortality and transform into tumor cells. My current research is focussed on applying my knowledge of DNA repair pathways to understand why clinical resistance to specific chemotherapies is observed in advanced metastatic breast cancer.
Research Experience
Research Experience
March 2021 - present
Post-doctoral Training Fellow
The Institute of Cancer Research, London, UK
- Led an interdisciplinary project profiling longitudinal clinical samples from advanced BRCA1/2 mutated breast cancer patients to identify drivers of PARP-inhibitor (PARPi) resistance.
- Identified BRCA1/2-reversion mutations as the predominant mechanism of resistance to PARPi and novel mechanisms of acquiring these reversions in advanced BRCA1/2 mutated breast cancer.
- Characterizing novel candidate genes that confer resistance to PARPi in BRCA2-mutated breast cancer.
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August 2017- December 2020
Post-doctoral Training Fellow
Catholic University of Louvain, Brussels, BE
- Identified a non-canonical function of the telomerase RNA subunit hTR, in mediating telomere dysfunction, in human cancers that use the ALT pathway of telomere maintenance.
- Identified a novel role for RNA binding protein NHP2 in regulating DNA double strand break repair.
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August 2011- May 2017
Graduate Research Assistant
University of Minnesota Twin Cities, Minneapolis, MN, USA
Identified novel roles of the Fanconi Anemia (FA) pathway in maintenance of genome stability.
Demonstrated a non-canonical mode of function of the FA pathway in replication stress response distinct from previously established role in DNA inter-strand crosslink repair.
Identified and functionally characterized a novel role for FA protein FANCD2 in chromatin remodeling during replication stress response via interaction with the protein ATRX.
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