9:00 a.m.
Marco Viceconti Istituto Ortopedico Rizzoli e Alma Mater Studiorum Università di Bologna - DIN UNIBO
The role of mathematics in in silico medicine
The term in silico medicine is used to indicate, in analogy with the terms in vitro and in vivo, the investigation of living organisms using computer modelling and simulation (silico comes from the silicon of the computer chips). The most common applications are the so-called digital twins in healthcare (DTH), subject-specific computer models, usually built from prior knowledge about biophysics and human pathophysiology, designed to predict clinically relevant quantities which are difficult or impossible to measure. My own research focuses on the use of digital twins of neuro-musculoskeletal pathologies. Applied math plays a very important role in this field. To substantiate this statement, we present four applications where advanced applied math methods became game changers in our research: parallel finite element analysis in bone tissue mechanobiology, modelling suboptimal neuromuscular control, quantum-computable predictor-corrector motor controllers, and surrogate modelling of large-scale in silico trials of treatment to reduce hip fractures.
10:15 a.m.
Cristiana Corsi
Modelling stroke risk in atrial fibrillation: a patient specific approach
In the era of precision medicine, it is essential to design new therapeutic approaches that take individual variability into account. After a brief review of the main concepts related to precision medicine, I will present the case study of stroke risk in atrial fibrillation, in which the use of mathematical modelling could directly improve the knowledge of the disease, optimize its treatment, and identify new prognostic models.
10:35 a.m.
Giovanna Citti
Brain models & Neural Network architectures
Modellazione di meccanismi neurali e cognitivi mediante strumenti di analisi geometrica e PDEs.
10:55 a.m.
Maria Carla Tesi
Mathematics for brain diseases: modelling aspects
We will see how to model brain pathologies, such as Alzehimer’s disease or τ-pathies, through a system of reaction-diffusion type differential equations on a network.
11:15 a.m.
Germana Landi
Mathematics for brain diseases: numerical aspects
We will see how to identify relevant biological parameters characterizing mathematical models for brain pathologies by using clinical data.
11:35 a.m
Alberto Dellacasa Bellingegni Emanuele Gruppioni INAIL
TBA
11:55 a.m.
Francesco Edoardo Vaccari DIBINEM UNIBO
Modern neuroscience: from physiology to models and back again
Brain research requires transversal skills ranging from biology and physiology during experiments and data collection, while data analysis and interpretation are based on the application of more or less complex mathematical models. The presentation will provide examples of how different fields of knowledge interact to produce new scientific results.
12:15 p.m.
Marco Bontempi IOR
Mathematics at Rizzoli: Mathematical Adventures in Orthopedics
It may sound strange, but mathematics is a fundamental part of orthopedic research.
Research in this field requires expertise in biology, health, mathematics, physics, and chemistry.
We will explore the experiences of three mathematicians who had the courage and curiosity to venture into this unfamiliar field. This will serve as a starting point to discover the opportunities and demands in this fascinating medical field, which is fundamental to public health.