Selected publications

Articles submitted for peer-review, arXiv publications and abstracts/presentations are not included here.

List includes UAB SOM team and Lab head publications prior to UAB.

* Click on image to access PDF file *


Journal Publications

Zhang, M., Li, F., Marquez-Lago, T.T., Leier, A., Fan, C., Kwoh, C.K. Chou, K-C., Song, J., Jia, C. (2019)

MULTiPLy: a novel multi-layer predictor for discovering general and specific types of promoters

Bioinformatics btz016



Bachus, H., Kaur, K., Papilllon, A.M., Marquez-Lago, T.T., Yu, Z., Ballesteros-Tato, A., Matalon, S. and Beatriz Leon (2019)

Impaired Tumor-Necrosis-Factor-alpha-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants

Immunity 50:1-16



Wang, J., Li, J., Yang, B., Xie, R., Marquez-Lago, T.T., Leier, A., Hayashida, M., Akutsu, T., Zhang, J., Chou, K-C, Selkrig, J., Zhou, T., Song, J. and Trevor Lithgow (2018)

Bastion3: a two-layer ensemble predictor of type III secreted effectors

Bioinformatics



Chen, Z., Liu, X., Li, F., Li, C., Marquez-Lago, T.T., Leier, A., Akutsu, T., Smith, I., Webb, G.I., Li, L., Chou, K-C and Jiangning Song (2018)

Large-scale comparative assessment of computational predictors for lysine post-translational modification sites

Briefings in Bioinformatics



Zhang, Y., Xie, R., Wang, J., Leier, A., Marquez-Lago, T.T., Akutsu, T., Webb, G.I., Chou, K-C and Jiangning Song (2018)

Computational analysis and prediction of lysine malonylation sites by exploiting informative features in an integrative machine-learning framework

Briefings in Bioinformatics



Li, F., Wang, Y., Li, C., Marquez-Lago, T.T., Leier, A., Rawlings, N.D., Haffari, G., Revote, J., Akutsu, T., Chou, K.C., Purcell, A.W., Pike, R.N., Webb, G.I., Smith, A.I., Lithgow, T., Daly, R.J., Whisstock, J.C. and Jiangning Song (2018)

Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods

Briefings in Bioinformatics



Li, F., Li, C., Marquez-Lago, T.T., Leier, A., Akutsu, T., Purcell, A.W., Lithgow, T., Daly, R.J., Song, J. and Kuo-Chen Chou (2018)

Quokka: a comprehensive tool for rapid and accurate prediction of kinase family-specific phosphorylation sites in the human proteome

Bioinformatics 34(24): 4223-4231



Wang, J., Yang, B., Leier, A., Marquez-Lago, T., Hayashida, M., Rocker, A., Zhang, Y., Akutsu, T., Chou, K-C, Strugnell, R.A., Song, J. and Trevor Lithgow (2018)

Bastion6: a bioinformatics approach for accurate prediction of type VI secreted effectors

Bioinformatics bty155



Chen, Z.*, Zhao, P.*, Li, F., Leier, A., Marquez-Lago, T., Wang, Y., Webb, G.I., Daly, R.J., Chou, K-C, Song, J. (2018)

iFeature: a python package and web server for features extraction and selection from protein and peptide sequences

Bioinformatics bty 140

*Co-first authors


Wang, J.*, Yang, B.*, An, Y.*, Marquez-Lago, T., Leier, A., Wilksch, J., Hong, Q., Zhang, Y., Hayashida, M., Akutsu, T., Webb, G.I., Strugnell, R.A., Song, J., Lithgow, T. (2017)

Systematic analysis and prediction of type IV secreted effector proteins by machine learning approaches

Briefings in Bioinformatics. bbx164

*Co-first authors



Song, J., Li, F., Leier, A., Marquez-Lago, T.T., Akutsu, T., Haffari, G., Chou, K.C., Webb, G.I., Pike, R.N. (2017)

PROSPERous: high-throughput prediction of substrate cleavage sites for 90 proteases with improved accuracy.

Bioinformatics 34(4): 684–687




Botta, D., Fuller, M.J., Marquez-Lago, T.T., Bachus, H., Bradley, J.E., Weinmann, A.S., Zajac, A.J., Randall, T.D., Lund, F.E., Leon, B., Ballesteros-Tato A. (2017)

Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection.

Nature Immunology 18, 1249-1260




Song, J., Wang, H., Wang, J., Leier, A., Marquez-Lago, T., Yang, B., Zhang, Z., Akutsu, T., Webb, G., Daly R. (2017)

PhosphoPredict: A bioinformatics tool for prediction of human kinase-specific phosphorylation substrates and sites by integrating heterogeneous feature selection.

Scientific Reports 7:6862




Wang, Y., Song, J., Marquez-Lago, T., Leier, A., Li, C., Lithgow, T., Webb, G., Shen H. (2017)

Knowledge-transfer learning for prediction of matrix metalloprotease substrate-cleavage sites.

Scientific Reports 7:5755



Buono, R.A. , Leier, A. , Paez-Valencia, J., Pennington, J.G., Goodman, K., Miller, N., Ahlquist, P., Marquez-Lago, T. and Otegui M. (2017)

ESCRT-mediated vesicle concatenation in plant endosomes.

J. Cell Biol. Vol 216, No. 7

** Article featured in JCB Research Highlights

Faculty of 1000 rated: Link




Wang, J., Yang B., Revote J., Leier, A., Marquez-Lago, T., Webb, G.I., Song, J., Chou K-C. and Lithgow, T. (2017)

POSSUM: a bioinformatics toolkit for generating numerical sequence feature descriptors based on PSSM profiles.

Bioinformatics Vol 33, Issue 17, Pages 2756–2758




You, C., Marquez-Lago, T., Richter, C.P, Wilmes, S., Moraga, I., Garcia, K.C., Leier, A. and Piehler, J. (2016)

Receptor dimer stabilization by hierarchical plasma membrane microcompartmets regulates cytokine signaling.

Science Advances Vol. 2, No. 12, e1600452



Zhou, A., Liu, Y., Chang, Z., Wang, H., Leier, A., Marquez-Lago, T., Ma, Y., Li, J. and Song, J. (2016)

Structure-based engineering of a pectate lyase with improved specific activity for ramie degumming.

Applied Microbiology and Biotechnology Vol. 101, Issue 7, pp 2919



An, Y., Wang, J., Li, C., Leier, A., Marquez-Lago, T., Wilksch, J., Zhang, Y., Webb, G.I., Song, J. and Lithgow, T. (2016)

Comprehensive assessment and performance improvement of effector protein predictors for bacterial secretion systems III, IV and VI.

Briefings in Bioinformatics bbw100:1-14



Denton, J., Ghosh, A. and Marquez-Lago, T. (2015)

Asymmetrical inheritance of plasmids depends on dynamic cellular geometry and volume exclusion effects.

PLoS ONE 10(10):e0139443




Ghosh, A. and Marquez-Lago, T. (2015)

Simulating Stochastic Reaction-Diffusion Systems on and within Moving Boundaries.

PLoS ONE 10(7):e0133401



Leier, A. and Marquez-Lago, T. (2015)

Delay chemical master equation: direct and closed-form solutions.

Proc. Royal Society A 471:20150049




Ghosh, A., Leier, A. and Marquez-Lago, T. (2015)

The Spatial Chemical Langevin Equation and Reaction Diffusion Master Equations: moments and qualitative solutions.

Theoretical Biology and Medical Modelling 12:5




Sanchez-Garduno, F., Miramontes, P. and Marquez-Lago, T. (2014)

Role reversal in a predator-prey interaction.

Royal Society Open Science 1: 140186




Lopez-Caamal, F. and Marquez-Lago, T. (2014)

Order Reduction of the Chemical Master Equation via Balanced Realisation.

PLoS ONE 9(8): e103521



Zavala, E. and Marquez-Lago, T. (2014)

The Long and Viscous Road: Uncovering Nuclear Diffusion Barriers in Closed Mitosis.

PLoS Computational Biology 10(7): e1003725




Lopez-Caamal, F. and Marquez-Lago, T. (2014)

Exact Probability Distributions of Selected Species in Stochastic Chemical Reaction Networks.

Bull. Math. Biol. 76:2334




Leier, A., Barrio, M. and Marquez-Lago, T. (2014)

Exact model reduction with delays: closed-form distributions and extensions to fully bi-directional monomolecular reactions.

J. Royal Society Interface 11: 20140108




Marquez-Lago, T. and Padilla, P. (2014)

A selection criterion for patterns in reaction-diffusion systems.

Theoretical Biology and Medical Modelling 11:7



Zavala, E. and Marquez-Lago, T. (2014)

Delays Induce Novel Stochastic Effects in Negative Feedback Gene Circuits.

Biophysical J. Vol. 106, Issue 2: 467-478




Barrio, M.*, Leier, A.*, and Marquez-Lago, T.* (2013)

Reduction of chemical reaction networks through delay distributions.

J. Chem. Phys. 138, 104114

* All authors contributed equally




Boettcher, B. *, Marquez-Lago, T. *, Bayer, M., Weiss, E., Barral, Y. (2012)

Nuclear envelope morphology constrains diffusion and promotes asymmetric protein segregation in closed mitosis.

J. Cell Biol. Vol. 197, Number 7: 921-937

** Article featured in JCB Research Highlights

Article included in JCB's most-read list

Faculty of 1000 rated: Link

* Co-first authors


Marquez-Lago, T., Leier, A., and Burrage, K. (2012)

Anomalous diffusion and multifractional Brownian motion: simulating molecular crowding and physical obstacles in Systems Biology.

IET Systems Biology 6(4):134-142

** Article appearing in special issue (Modelling Noise in Biochemical Reaction Networks)




Hatzikirou, H., Chauviere, A., Bauer, A., Leier, A., Lewis, M., Macklin, P., Marquez-Lago, T., Bearer, E., Cristini, V. (2012)

Integrative Physical Oncology.

WIREs Systems Biology and Medicine Vol. 4, Issue 1, Pages 1-14




Leier, A., and Marquez-Lago, T. (2011)

Correction factors for boundary diffusion and bimolecular reactions in reaction-diffusion master equations.

J. Chem. Phys. 135, 134109

** Article selected for JCP focus in Biochemical Physics, Volume 5, Issue 10: Link




Marquez-Lago, T. and Leier, A. (2011)

Stochastic adaptation and fold-change detection: from single-cell to population behavior.

BMC Systems Biology 5:22



Lang, M., Marquez-Lago, T., Stelling, J., and Waldherr, S. (2011)

Autonomous synchronization of chemically coupled synthetic oscillators.

Bull. Math. Biol. Vol. 73, Number 11: 2678



Marquez-Lago, T., Allen, D.M. and Thewalt, J. (2010)

A novel approach to modelling water transport and drug diffusion through the stratum corneum.

Theoretical Biology and Medical Modelling 7:33



Marquez-Lago, T., and Stelling, J. (2010)

Counter-intuitive stochastic behavior of simple gene circuits with negative feedbacks.

Biophysical J. 98(9):1742-1750

** Article commented in Nature (News and Views): PDF link




Marquez-Lago, T., Leier, A., and Burrage, K. (2010)

Probability distributed time delays: integrating spatial effects into temporal models.

BMC Systems Biology 4:19



Tigges, M., Marquez-Lago, T., Stelling, J. and Fussenegger, M. (2009)

A tunable synthetic mammalian oscillator.

Nature 457: 309-312

** Article featured in Nature (News and Views): PDF link

Nature podcast: 15 January 2009. Link

Nature webfocus (Synthetic systems biology). Link

Faculty of 1000 rated: Link




Leier, A., Marquez-Lago, T., Burrage, K. (2008)

Generalized binomial tau-leap method for biochemical processes incorporating both delay and intrinsic noise.

J. Chem. Phys. 128, 205107

** Article selected for JCP focus in Biochemical Physics, Volume 2, Issue 5: Link




Leier, A., Marquez-Lago, T., Burrage, K., Burrage, P. (2008)

Modelling intrinsic noise and delays in chemical kinetics of coupled autoregulated oscillating cells.

J. Mult. Comp. Eng. Vol. 6, Issue 1: 77-86



Marquez-Lago, T., Burrage, K. (2007)

Binomial tau-leap spatial stochastic simulation algorithm for applications in chemical kinetics.

J. Chem. Phys. 127, 104101

** Article selected for JCP focus in Biochemical Physics, Volume 1, Issue 9: Link






Book Chapters


Burrage, K., Burrage, P., Leier, A. and Marquez-Lago, T.T. (2017)

A review of stochastic and delay simulation approaches in both time and space in Computational Cell Biology. In Stochastic Dynamical Systems in Cellular Biology: Multiscale modeling, asymptotics and numerical methods (Springer). Holcman, D. (Ed.) > In press


Burrage, K., Burrage, P., Leier, A., Marquez-Lago, T.T. and Nicolau, D.V. (2011)

Stochastic simulation for spatial modelling of dynamic processes in a living cell. In Design and Analysis of Bio-molecular Circuits (Springer Verlag). Koeppl, H., Setti, G. di Bernardo, M. and Densmore, D. (Eds.) > PDF link


Marquez-Lago, T.T. and Marchisio M.A. (2010)

Synthetic Biology: dynamic modeling and construction of cell systems. In Dynamic Process Modelling (Wiley-VCH). Banga, J., Georgiadis, M. and Pistikopoulos, S. (Eds.) > PDF link


Barrio, M., Burrage, K., Burrage, P., Leier, A. and Marquez-Lago, T. (2009)

Computational Approaches for Modeling Intrinsic Noise and Delays in Genetic Regulatory Networks. In Computational Methodologies in Gene Regulatory Networks. Das, S., Caragea, D., Hsu, W. H. and Welch, S. M. (Eds.). > PDF link


Lopez-Aguilar, F., Marquez-Lago, T. (2007)

El colapso de un altepetl. Trayectoria de Itzmiquilpan despues de la conquista. In Antropologia Fractal. Lopez Aguilar, F., Brambila Paz, F. (Eds.), pp. 141-164.CIMAT and Sociedad Matematica Mexicana (first edition), Insituto Nacional de Antropologia e Historia (second edition).



Conference Proceedings

Burrage, K., Burrage, P., Leier, A., Marquez-Lago, T. (2008)

Stochastic delay models for molecular clocks and somite formation. Proc. SPIE. Complex Systems II, 68020Z, Vol. 6802 > PDF link


Leslie, K.K., Marquez-Lago, T., Slepoy, A., Plimpton, S., Oliver, J., and Steinberg, S. (2005)

ChemCell mathematical modeling defines a biologically relevant lower limit of progesterone receptors in endometrial cancer. Reproductive Sciences, Vol. 12: pp. 22A - 82A.


Bohun, S. et al. (2001)

Modelling InSb Czochralski Growth. Proc. 5th PIMS-IPSW > PDF link


Anderson, P. et al. (2001)

Locating watchtowers in terrains. Proc. 4th PIMS-GIMMC > PDF link