Respiratory syncytial virus (RSV) is a respiratory virus that affects the lungs and its bronchioles. It is one of the common causes of a childhood illness which infects most children by age of two years. RSV also infects adults. Severe RSV infections include pneumonia and bronchitis. The growing disease rate is one of the key factors which boosts the market growth. According to the data published by the Cleveland Clinic, approximately 57,000 children under 5 years need hospital care due to RSV in the U.S. each year. In addition, nearly 177,000 adults are hospitalized for RSV each year.
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Older adults age over 65 years are at higher risk for RSV. In addition, adults with chronic lung or heart disease and adults with weak immune system also pose high risk for severe RSV. The share of population aged 65 and above increased to 9% in 2019 from 6% in 1990 globally, according to the World Population Ageing 2019: Highlights report published by the United Nations.
The report also highlighted that this proportion is expected to increase to further 16% by the year 2050. The growing older population is expected to be favourable patient base for RSV analysing their risk rate. Thus, the increasing older population is expected to support the market growth over the forecast period. Likewise, the increasing new born population also provide favourable environment for market growth. As per the research paper published by the National Institute of Allergy and Infectious Diseases (NIH), almost all children become infected with RSV by the age of 2 years, with around 75,000 to 125,000 of them hospitalized yearly in the U.S.
Strong product pipeline for RSV is also expected to support the growth of the market. For instance, in February 2021, GlaxoSmithKline plc started Phase III clinical program for studying the safety, immunogenicity, persistence, and reactogenicity RSV candidate vaccine for older adults.
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Growth Influencers:
Increasing Disease Burden
The rising disease prevalence of RSV is a key factor boosting the market growth. According to the data published by Centers for Disease Control and Prevention (CDC), RSV leads to about 2.1 million outpatients visits among children below 5 years in the U.S. yearly. In addition, according to the data published by Oxford Vaccine Group, around 30, 000 babies and children below 5 years of age are anticipated to be hospitalized yearly in the UK due to RSV. The increasing disease rate of RSV globally, has led to an increase in demand for effective therapies.
Advent of Targeted Therapies:
Currently, new antiviral therapies for respiratory syncytial virus are in development. New long-acting monoclonal antibodies for RSV have demonstrated promising results in initial clinical trials. In addition, several market players are engaged in developing therapies for RSV. For instance, Novavax’s ResVax – RSV F Vaccine is in Phase III. In addition, in September 2019, Janssen Pharmaceuticals announced the receival of Breakthrough Therapy Designation by the U.S. Food and Drug Administration (FDA) for its investigational prophylactic vaccine developed for prevention of RSV-mediated lower respiratory disease in older adults aged 60 and above. Conclusively, the emerging number of therapies are expected to support the market growth in coming years.
High Cost of Disease Management:
The cost associated with management of RSV is high which is expected to hinder market growth. For instance, the cost of palivizumab is about USD 6000. In addition, according to an article published by Journal of Perinatalogy in August 2016, the average cost of RSV hospitalizations ranged from USD 8334 among full term infants to USD 39,354 among the preterm infants. Furthermore, the cost of technology required for developing RSV therapies is high. This factor may further hamper the growth of global RSV market.
Inaccessibility Of Diagnostic Facilities:
Lack of adequate diagnostic facilities for RSV in developing and under developed economies specifically in the Middle East and African region may hamper market growth. In addition, limited awareness among parents in rural areas about diagnosis of RSV may further hamper the market growth.
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Segments Overview:
The global RSV market is bifurcated into drug type, dosage form, treatment type, and distribution channel.
By Drug Type
Ribavirin
Synagis
Virazole
Palivizumab
Riba Tab
Others
Synagis accounted for largest share of more than 32% in the global market based on drug type. Synagis is a drug to prevent severe respiratory syncytial virus in children and infants who are at high risk. Further, Virazole is expected to be the fastest growing market segment over the forecast period.
By Dosage Form
Oral
Injectable
Inhaler
Others
The injectable dosage form segment holds for largest market share in the global RSV market. In addition, oral segment is expected to be the fastest growing segment during the assessment period.
By Treatment Type
Immune prophylaxis
Supportive care
Antiviral Medications
The antiviral medication section is expected to be the fastest growing segment over the forecast period. The increasing hospitalization rate due to RSV due to the growing disease prevalence is expected to support the segment growth.
By Distribution Channel
Hospital pharmacies
Drug Stores
Retail pharmacies
Clinics
The hospital pharmacies segment holds the highest market share in the global market based on distribution channel. Hospital pharmacies are preferred distribution channel owing to the easy accessibility of all types of medications.
Regional Overview:
On regional basis, the global respiratory syncytial virus market is segmented into North America, Europe, Asia Pacific, Middle East & Africa, and South America.
North America holds major share of more than 37% in the global RSV market, followed by Europe. The market growth in North America is majorly due to increasing incidence of RSV and growing infant population. Further, the market growth in the European region is majorly attributed to growing disease prevalence coupled with funding provided by the government.
Competitive Landscape:
Key players in the global RSV market include AbbVie, Inc., AstraZeneca PLC, Atea Pharmaceuticals, Bausch Health Companies Inc., Celltrion Inc., Enanta Pharmaceuticals, Inc, F. Hoffmann-La Roche AG, Gilead Sciences, Inc., GlaxoSmithKline PLC, Johnson & Johnson’s, mAbxience, Medivir AB, Merck Co., Inc., Pfizer Inc., ReViral Ltd., Sanofi and Teva Pharmaceutical Industries Ltd.
Companies operating in the global RSV market are involved in strategic partnerships, mergers and acquisitions, and new product development. For instance, in March 2021, ReViral Ltd and LianBio entered into partnership and license agreement for developing and commercializing Sisunatovir in China.
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Report also includes following pointers:
COVID-19 Impact Analysis:
As Covid-19 is a respiratory disease like RSV, few companies such as GENETWORx Labs are producing RSV diagnostic kits with combination to coronavirus testing. Apart from this, the negative impact of Covid-19 was noted on manufacturing units in the starting phase of the Pandemic owing to travel ban and temporary shutdown of manufacturing units. Further, Covid-19 is expected to impact RSV vaccines in the clinical trial phase, it is anticipated that the trials may get extended, or other changes can be made to the studies’ protocol.
Epidemiology and Patient Population for 8 MM (US, EU5 {Germany, France, Italy, Spain, UK}, Japan, China)
o Assumptions and Rationale
o Total Incident Cases of Respiratory Syncytial Virus
o Case-Specific Incidence of Respiratory Syncytial Virus
o Age-Specific Incidence of Respiratory Syncytial Virus
o Incident of Respiratory Syncytial Virus by Extremities (%)
• Treatment and Management of Respiratory Syncytial Virus
• Unmet Needs
• Marketed Drugs
o Synagis (Palivizumab): MedImmune/Abbott Laboratories Inc.
– Product Description
– Regulatory Milestones
– Clinical Development
– Ongoing Current Pipeline Activity
– Safety and efficacy
– Product Profile
o Virazole (Ribavirin): ICN Pharmaceuticals
– Product Description
– Regulatory Milestones
– Clinical Development
– Ongoing Current Pipeline Activity
– Safety and efficacy
– Product Profile
• Emerging Drugs
o EDP 938: Enanta Pharmaceuticals
– Product Description
– Other Development Activities
– Clinical Development
– Clinical Trials Information
– Safety and Efficacy
– Product Profile
o Nirsevimab: AstraZeneca
– Product Description
– Other Development Activities
– Clinical Development
– Clinical Trials Information
– Safety and Efficacy
– Product Profile
o MEDI8897: MedImmune LLC
– Product Description
– Other Development Activities
– Clinical Development
– Clinical Trials Information
– Safety and Efficacy
– Product Profile
o JNJ-53718678: Janssen Sciences Ireland UC
– Product Description
– Other Development Activities
– Clinical Development
– Clinical Trials Information
– Safety and Efficacy
– Product Profile
• Target population and RSV vaccine
o Maternal
o Infants
o Children
o Elderly
• RSV Vaccines in Pipeline
The global RSV market report offers insights on the below pointers:
• Market Penetration: Report provides comprehensive data on the market offered by the key players
• Market Development: The report provides detailed information about emerging markets and examines penetration across mature segments of the markets
• Market Diversification: The report offers in-depth information about untapped geographies, recent developments, and investments
• Competitive Landscape Assessment: Mergers & acquisitions, certifications, product launches, collaborations in the market have been provided in this research report. In addition, the report also emphasizes on the SWOT analysis of the leading players.
• Product Development & Innovation: Report provides intelligent insights on future technologies, R&D activities, and breakthrough product developments
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The global RSV market report answers questions such as:
• What is the market size and forecast of the Global RSV Market?
• What are the inhibiting factors and impact of COVID-19 on the Global RSV Market during the assessment period?
• Which are the products/segments/areas/channels to invest in over the assessment period in the Global RSV Market?
• What are the technology trends and regulatory scenarios in the Global RSV Market?
• What is the market share of the leading players in the Global RSV Market?
• What strategies are considered favorable for entering the Global RSV Market?
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