Research

Our research is focused on the effects of carbon monoxide (CO) on health, using a multidisciplinary approach. Combining physiological studies with neuroimaging, cell biology and developmental biology, our aim is to determine the impact low-dose CO has on health across the lifespan. 

Human physiology and neuroscience. We use very low-dose CO exposures to test its impact on cerebral blood flow, neuronal function (MRI, EEG), behaviour and physiological parameters in healthy human volunteers. The custom-made exposure system allows parallel measurements using EEG, transcranial Doppler ultrasound, end-tidal gases, respiratory rate, pulse and blood pressure measurements, saturation, psychological testing and exercise testing.  

Developmental biology. We use an avian model organism to identify the impact of CO exposure on development. Our exposure system is custom-built, and affords multiple exposure levels within an incubator, and can also be used for cell biology work. Several techniques are used in concert with the exposure system, including uCT to identify morphological changes in the brain and heart. 

Cell biology. We use human cell lines to probe pathways and mechanisms that are affected by CO exposure. For exposure of the cells, we use the same exposure system as for our developmental biology work. Our cell biology research is supported by the well-equipped laboratories within the Biomolecular Sciences Research Centre in the City Campus. 

We would not be able to do this without the generous support of our funders.