Programme
Day 1: 30 Nov 2023
Chairs: Paulo Oliveira/Michelangelo Campanella/Boris Turk
Registration 8:30 - 9:15 (Lisbon Time)
9:30 - 10:00
Official Opening
President of the Local Organizing Committee, University of Coimbra
President CNC-UC, Director of CIBB, University of Coimbra
Vice-Rector for Research, University of Coimbra
10:45 - 11:15
---- FLAD-sponsored talk ----
Invited Talk 1.1 - Mitochondria and the epigenome: how do we get there, what are the outcomes
Janine Santos
NIH U.S.A.
Coffee Break 11:15 - 11:45
11:45 - 12:15
Invited Talk 1.2 - Mitochondrial interactions: touch me, don't touch me; just be sweet
Nuno Raimundo
Multidisciplinary Institute of Ageing, U. Coimbra, PORTUGAL &
Penn State College of Medicine, U.S.A.
12:15 - 12:30
Short Talk 1.1 - Role of mitochondrial heteroplasmy and quality control mechanisms in the regulation of epigenetic traits of ageing.
Richard Boulton-McDonald
Queen Mary University of London, UK
12:30 - 13:15 Flash Talks 1 (5 min each, no discussion)
FP1. Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia.
Christos Chinopoulos Semmelweis University, Budapest, HUNGARY
FP2. Extracellular purines imbalance in severe obesity and the impact of bariatric surgery.
Bruna Moraes Isidoro Universidade Federal de Ciências da Saúde de Porto Alegre, BRAZIL
FP3. Sex-Specific Impact of Maternal Obesity and Gestational Exercise on Offspring's Cardiac Health: Insights into Mitochondrial Function and NO Signaling.
Mariana S. Diniz University of Coimbra, PORTUGAL
FP4. Unraveling Heterogeneity of Cellular Redox Responses During Metabolic Priming.
Sónia A. Pinho University of Coimbra, PORTUGAL.
FP5. A genome wide screening to identify mediators of cellular senescence induced by loss of the mitochondrial fission protein Fis1.
Ludovica Zambello University of Padua, ITALY
FP6. Biological evaluation of novel dually-targeted metalloconjugates containing a PSMA inhibitor and a TPP group for prostate cancer theranostics.
Margarida Sobral University of Coimbra, PORTUGAL
Lunch, Poster Viewing, Sponsor Talk 13:15 - 14:45
Sponsor Talk: Analysis of Rates of Bioenergetic Metabolic Pathways in Different Cell Compartments. Enrico Tatti, Biolog Inc.
14:45 - 15:15
Invited Talk 1.3- Carbon monoxide promotes mitochondrial homeostasis in astrocytes and microglia: mitophagy, mitochondrial biogenesis and mitochondrial metabolism
Helena Vieira
FCT, Lisboa, PORTUGAL
15:15 - 15:30
Short Talk 1.2 - Senescence impairs C2C12 myoblast differentiation.
José P. Castelão-Baptista
University of Oviedo, SPAIN; University of Coimbra, PORTUGAL
15:30 - 15:45
Short Talk 1.3- Hierarchical S-adenosylmethionine dependency in mitochondria in heart and skeletal muscle.
Anastasia Rumyantseva
Karolinska Institutet, Stockholm, SWEDEN
Coffee Break & Poster Viewing 16:15 - 17:15
17:15 - 17:45
Invited Talk 1.4 - The role of mitochondria in the Gut-Brain axis in Parkinson´s disease
Sandra Cardoso
CNC-CIBB, U. Coimbra, PORTUGAL
17:45 - 18:00
Short Talk 1.4- Mitochondrial fitness sustains healthy muscle aging
David Sebastian
University of Barcelona, SPAIN
Day 2: 1 Dec 2023
Chairs: Ildiko Szabo/Jiri Neuzil/Shazib Pervaiz
9:00 - 9:30
Invited Talk 2.1 - The Nucleus-Mitochondria Crosstalk is What Matters: Cytochrome c as a Moonlighting Protein
Irene Diaz Moreno
University of Seville, SPAIN
9:30 - 10:00
Invited Talk 2.2 - Hallmarks of cancer: new dimensions in calcium signaling
Natalia Prevarskaya
University of Lille, FRANCE
10:00 - 10:15
Short Talk 2.1 - The adaptor protein Miro1 modulates horizontal transfer of mitochondria in cancer
Zuzana Nahácka
Czech Academy of Sciences, Prague, CZECH REPUBLIC
Coffee Break 10:15 - 10:45
10:45 - 11:15
Invited Talk 2.3 - A novel mTORC2-AKT-ROS axis triggers mitophagy-mediated execution of mutant KRAS expressing cancer cells
Shazib Pervaiz
National University of Singapore, SINGAPORE
11:15 - 11:30
Short Talk 2.2 - Mitochondrial adaptations in thermogenic tissues during cancer cachexia and upon different ambient temperatures
Andrea Irazoki
University of Copenhagen, DENMARK
11:30 - 11:45
Short Talk 2.3 - Targeting mitophagy to maximize the immunostimulatory effects of radiation therapy in ER+ breast cancer.
Emma Guilbaud
Weill Cornell Medical College, New York, USA
11:45 - 12:30 Flash Talks 2 (5 min each, no discussion)
FP7. Acquisition of respiration-competent mitochondria is necessary for glioblastoma formation.
Renata Zobalová Czech Academy of Sciences, Prague, CZECH REPUBLIC
FP8. How does the natural compound 7α-acetoxy-6β-hydroxyroyleanone (Roy) modulates glioblastoma cells autophagy?
Mariana Magalhães University of Coimbra, PORTUGAL
FP9. Kv1.3 potassium channel of myeloid cells controls tumor growth in vivo.
Tatiana Varanita University of Padova, ITALY
FP10. Impact of fatty acids on astrocytic bioenergetics.
Marina Garcia-Macia Universidad de Salamanca, SPAIN
FP11. Culture Shock! Investigating the Impact of Physiological Tumour-Like Conditions on Cultured Cancer Cells.
Georgina Gardner Brock University, Ontario, CANADA
FP12. Miro1 role in intra- and inter-cellular mitochondrial movement in tumour microenvironment.
Jaromír Novák Czech Academy of Sciences, Prague, CZECH REPUBLIC
Lunch, Poster Viewing, Sponsor Talk 12:30 - 14:00
14:00 - 14:45
Keynote Talk II - Mitochondrial rheostat that predisposes to cancer
Aleksandra Filipovska
University of Western Australia, AUSTRALIA
Social Programme: Visit to the University of Coimbra 15:00 (Optional)
Meeting Dinner with "Fado de Coimbra" 19:30 (Optional, Extra)
University of Coimbra
Fado de Coimbra
Day 3: 2 Dec 2023
Chairs: Catherine Brenner, Boris Zhivotovsky
9:00 - 9:30
Invited Talk 3.1 - Mitochondrial stress responses dictate nuclear softening and tissue remodeling
Alexandra Trifunovic
University of Cologne, GERMANY
9:30 - 10:00
Invited Talk 3.2 - AIF-CHCHD4 dependent metabolic plasticity in pediatric cancer
Catherine Brenner
CNRS/Gustave Roussy/Université Paris- Saclay, FRANCE
10:00 - 10:15
Short Talk 3.1 - Alternative pathway of aspartate synthesis sustains tumor growth
Jakub Rohlena
Czech Academy of Sciences, Prague, CZECH REPUBLIC
10:15 - 10:30
Short Talk 3.2 - Revealing of metabolic alterations in primary fibroblasts of patients with Neurodegeneration with Brain Iron Accumulation - subtype MPAN
Mariusz R. Wieckowski
Nencki Institute of Experimental Biology PAS, Warsaw, POLAND
10:30 - 11:15 Flash Talks 3 (5 min each, no discussion)
FP13. Mitochondria : new actor in cell-to-cell communication.
Stéphanie Herkenne University of Liège, BELGIUM
FP14. Functional autophagy is required for the formation of mitochondrial contact sites that aid in the progression of breast cancer.
Brindha Kannan Queen Mary University of London, UK
FP15. Exploration of the role of mitochondria in reactive oxygen species generation under moderate hypoxia at the hippocampal CA3 area.
João L. Alves University of Coimbra, PORTUGAL
FP16. Miro1 regulates the migratory properties and metastatic potential of B16 melanoma cells.
Gabriela L. Oliveira Czech Academy of Sciences, Prague, CZECH REPUBLIC ; University of Coimbra, PORTUGAL
FP17. Metabolism: novel frontier for a multi-targeted approach in Neuroblastoma.
Daniela Dias-Pedroso CNRS/Gustave Roussy/Université Paris- Saclay, FRANCE
FP18. A gut miRNA targets cardiolipin synthase and affects mitochondrial function: relevance for Parkinson’s disease.
Ana Raquel Esteves University of Coimbra, PORTUGAL
Coffee Break 11:15 - 11:45
11:45 - 12:15
Invited Talk 3.3 - Mitochondrial control of cardiac fate and function
Timothy Wai
CNRS/Institut Pasteur, Paris, FRANCE
12:15 - 12:45
Invited Talk 3.4 - Oxygen-sensitive Regulation of Mitochondrial Mass and its implication in the von Hippel-Lindau Syndrome
Susanne Schlisio
Karolinska Institutet, Stockholm, SWEDEN
12:45 - 13:00
Short Talk 3.3 - Peptides as a targeting strategy to eradicate Pancreatic Ductal Adenocarcinoma (PDAC)
Sofia Parrasia
University of Padova, ITALY
13:00- 13:15
Short Talk 3.4 - Pharmacological evaluation of compounds inhibiting the mitochondrial protein complex AIF/CHCHD4
Hong-Toan Lai
CNRS/Gustave Roussy/Université Paris- Saclay, FRANCE
Lunch, Poster Viewing, Sponsor Talk 13:15 - 14:45
14:45 - 15:15
Invited Talk 3.5: Mechanisms of ferroptosis in cardiac diseases: the role of mitochondria
Sabzali Javadov
San Juan, U.S.A.
15:15 - 15:30
Short Talk 3.5 - AntiOxCIN6 potentiates cisplatin anticancer therapy by lowering mitochondrial metabolism while upregulating energetic glycolytic dependence
José Teixeira
University of Coimbra, PORTUGAL
15:30 - 15:45
Short Talk 3.6 - The endoplasmic reticulum (ER)-mitochondria communication in schizophrenia
Ana Catarina Pereira
University of Coimbra, PORTUGAL
Coffee Break 15:45 - 16:15
16:15 - 17:00
---- Elsevier-sponsored talk ----
Keynote Talk III - Mitochondrial turnover in neurodegeneration and ageing
Nektarios Tavernarakis
University of Crete, GREECE
17:00 - 17:30
Closing session & Awards for Best Oral and Poster presentations*
*3 Short Talks and 6 Poster presentations will be selected to receive the Best Oral Presentation and Best Poster Presentation Awards.