2024

• Co-infecting Phages Impede Each Other’s Entry into the Cell

Nguyen, T.V.P., Wu, Y., Yao, T, Trinh, J.T., Zeng, L., Chemla, Y.R., and Golding, I.

Current Biology 34, 1-14 (2024) 

• Structural Basis for the Attachment of an RNA Virus to Tight-adherence Pili 

Wang, Y., Theodore, M., Xing, Z., Narsaria, U., Yu, Z., Zeng, L., and Zhang, J. 

Science Advances 10, eadl4450 (2024)

• Removal of Pseudomonas Type IV Pili by a Small RNA Virus

Thongchol, J.#, Yu, Z.#, Harb, L., Lin, Y., Koch, M., Theodore, M., Narsaria, U., Shaevitz, J., Gitai, Z., Wu, Y., Zhang, J.*, and Zeng, L.*

Science 384, eadl0635 (2024) #, co-first author. *, co-corresponding author.

News press. 

Research Highlight in Nature Reivews Microbiology: Phages get snappy.

• Structural Basis of Acinetobacter Type IV Pili Targeting by an RNA Virus

Meng, R. #, Xing, Z. #, Chang, J. #, Yu, Z., Thongchol, J., Xiao, W., Wang, Y., Chamakura, K., Zeng, Z., Wang, F., Young, R., Zeng, L., and Zhang, J.

Nature Communications 15, 2746 (2024) #, co-first author.

2023

• Trypanosome RNA helicase KREH2 differentially controls non-canonical editing and putative repressive structure via a novel proposed ‘bifunctional’ gRNA in mRNA A6

Meehan, J., McDermott, S., Ivens, A., Goodall, Z., Chen, Z., Yu, Z., Woo, J., Rodshagen, T., McCleskey, L., Sechrist, R., Stuart, K.,  Zeng, L., Rouskin, S., Savill, N., Schnaufer, A., Zhang, X., and Cruz-Reyes, J. 

Nucleic Acids Research doi.org/10.1093/nar/gkad453 (2023) 

2022

• Cells with Stochastically Increased Methyltransferase to Restriction Endonuclease Ratios Provide an Entry for Bacteriophage into Protected Cell Population

Kirillov, A., Morozova, N., Polinovskaya, V., Smirnov, S., Khodorkovskii, M., Zeng, L., Ispolatov, I., and Severinov, K.

Nucleic Acids Research doi.org/10.1093/nar/gkac1124 (2022) 

• Contributions of F-specific Subunits to the F Plasmid-Encoded Type IV Secretion System and F pilus

Kishida, K., Khara, P., Harb, L., Bosserman, R., Mamun, A., Li, Y., Zeng, L., Hu, B., and Christie, P.J.

Molecular Microbiology doi: 10.1111/mmi.14908 (2022) 

• New Insights into the Structure and Assembly of Bacteriophage P1

Gonzales, M., Piya, D., Koehler, B., Zhang, K., Yu, Z., Zeng, L., and Gill, J.

Viruses 2022, 14, 678 (2022) 

2021

• Interactions Between Viral Regulatory Proteins Ensure an MOI-Independent Probability of Lysogeny during Infection by Bacteriophage P1

Zhang, K., Pankratz, K., Duong, H., Theodore, M., Guan, J, Jiang, A., Lin, Y. and Zeng, L.

mBio 12(5): e01013-21 (2021) 

• Type IV Secretion Systems: Advances in Structure, Function, and Activation

Costa, T.R.D., Harb, L., Khara, P., Zeng, L., Hu, B., and Christie, P.J.

Molecular Microbiology 115(3), 436-452 (2021) 

• From bench to keyboard and back again: a brief history of lambda phage modeling

Cortes, M., Lin, Y., Zeng, L.*, and Balázsi, G.*

Annual Review of Biophysics 50, 117-134 (2021). * co-corresponding author. 

2020

• ssRNA Phage Penetration Triggers Detachment of the F-pilus

Harb, L., Chamakura, K., Khara, P., Christie, P.J., Young, R., and Zeng, L.

PNAS 117(41), 25751-25758 (2020) 

       Research Highlight

• Emerging Heterogeneous Compartments by Viruses in Single Bacterial Cells

Trinh, J.T., Shao, Q., Guan J., and Zeng, L.

Nature Communications 11, 3813 (2020) 

• Phage-Phage Interactions

Trinh, J.T. and Zeng, L.

In the book “Biocommunication of Phages”, Springer 2020.

• Bacteriophage P1 does not Show Spatial Preference when Infecting Escherichia coli

Zhang, K., Young, R. and Zeng, L.

Virology 542, 1-7 (2020) 

2019

• Structure Regulates Phage Lysis-Lysogeny Decisions

Trinh, J.T. and Zeng, L.

Trends in Microbiology 27(1), 3-4 (2019) 

• The Role of Side Tail Fibers during the Infection Cycle of Phage Lambda

Guan, J., Ibarra, D., and Zeng, L.

Virology 527, 57-63 (2019) 

• BREX System of Escherichia coli Distinguishes Self from Non-Self by Methylation of a Specific DNA Site

• Gordeeva, J., Morozova, N., Sierro, N., Isaev, A., Tsvetkova, K., Matlashov, M., Ivanov, N., Zeng, L., and Severinov, K.

Nucleic Acids Research 47(1), 253-265 (2019) 

• High-resolution Studies of Lysis-lysogeny Decision Making in Bacteriophage Lambda

Shao, Q., Trinh, J.T., and Zeng, L.

Journal of Biological Chemistry 294(10), 3343-3349 (2019)

2018

• Coupling of DNA Replication and Negative Feedback Controls Gene Expression for Cell-fate Decisions

Shao, Q., Cortes, M., Trinh, J.T., Guan, J., Balázsi, G., and Zeng, L.

iScience 6, 1-12 (2018) 

• Towards Single-cell Single-molecule Pull-down

Wang, X., Park, S., Zeng, L., Jain, A., and Ha, T.

Biophysical Journal 115(2), 283-288 (2018) 

• Fluorescent Nanodiamond-bacteriophage Conjugates Maintain Host Specificity

Trinh, J.T., Alkahtani, M.A., Rampersaud, I., Rampersaud, A., Scully, M., Young, R.F., Hemmer, P., and Zeng, L.

Biotechnology and Bioengineering 115, 1427-1436 (2018) 

2017

•  Late-arriving Signals Contribute Less to Cell Fate Decisions

Cortes, M., Trinh, J.T., Zeng, L., and Balázsi, G.

Biophysical Journal 113(9), 2110-2120 (2017) 

• Virus Interactions: Competition or Cooperation?

Trinh, J.T. and Zeng, L.

Future Microbiology 12(7), 561-564 (2017) 

• Visualization of Phage DNA Degradation by a Type I CRISPR-Cas System at the Single-cell Level

Guan, J., Shi, X., Burgos, R., and Zeng, L.

Quantitative Biology 5(1), 67-75 (2017) 

• Cell Fate Decisions Emerge as Phages Cooperate or Compete inside their Host

Trinh, J.T., Székely, T., Shao, Q., Balázsi, G., and Zeng, L.

Nature Communications 8, 14341 (2017) 

       Research Highlight

2016

• Lysis-lysogeny Coexistence: Prophage Integration during Lytic Development

Shao, Q., Trinh, J.T., McIntosh, C.S., Christenson, B., Balázsi, G., and Zeng, L.

Microbiologyopen 6(1) (2016) 

• The Global Reciprocal Reprogramming between Mycobacteriophage SWU1 and Mycobacterium Reveals the Molecular Strategy of Subversion and Promotion of Phage Infection

Fan, X., Duan, X., Huang Q., Zhou, M., Wang, H., Zeng, L., Young, R., and Xie, J.

Frontiers in Microbiology 7, 41 (2016)

2015

• Phage DNA Dynamics in Cells with Different Fates

Shao, Q., Hawkins, A., and Zeng, L.

Biophysical Journal 108, 2048-2060 (2015) 

• Genomic and Proteomic Analyses of Mycobacteriophage SWU1 Isolated from China Soil

Fan, X., Yan, J., Xie, L., Zeng, L., Young, R., and Xie, J.

Gene 561, 45-53 (2015) PMID: 25701596. 

Prior to 2012 

• Following Cell-fate in E. coli after Infection by Phage Lambda

Zeng, L.* and Golding, I.

Journal of Visualized Experiments 56, e3363, DOI: 10.3791/3363 (2011) *Corresponding author 

• Single-virus Tracking Reveals a Spatial Receptor-Dependent Search Mechanism

Rothenberg, E., Sepulveda, L.A., Skinner, S.O., Zeng, L., Selvin, P.R., and Golding, I.

Biophysical Journal 100, 2875-2882 (2011) 

• Decision Making at a Subcellular Level Determines the Outcome of Bacteriophage Infection

Zeng, L., Skinner, S.O., Sippy, J., Feiss, M., and Golding, I.

Cell 141(4), 682-691 (2010)

Nature Research Highlights: Cell biology: Viral Vote

• Wake Response of a Finite-sized Particle in a Turbulent Channel Flow

Zeng, L., Balachandar, S., Najjar, F., and Fischer, P.

International Journal of Multiphase Flows 36, 406-422 (2010)

• Forces on a Finite-sized Particle Located Close to a Wall in a Linear Shear Flow

Zeng, L., Najjar, F., Balachandar, S., and Fischer, P.

Physics of Fluids 21, 033302 (2009)

• Interactions of a Stationary Finite-sized Particle with Wall Turbulence

Zeng, L., Balachandar, S., Fischer, P., and Najjar, F.

Journal of Fluid Mechanics 594, 271-305 (2008)

• Wall-induced Forces on a Rigid Sphere at Finite Re

Zeng, L., Balachandar, S., and Fischer, P.

Journal of Fluid Mechanics 536, 1-25 (2005)