A potential novel personalized treatment for head and neck squamous cell carcinoma.
Patients with HNSCC may preserve their lymph nodes after treatment which prevents them from experiencing future immune complexities.
The patients will be able to receive immune checkpoint blockade therapy after the initial tumor removal surgery.
The design enhances quality of life after treatment.
With the major component being the patient's own lymph node, the design is relatively simple and easy to perform.
The decellularization process was optimized and can be used in other studies.
The decellularized lymph node was designed to mimic the native lymph node which can assist future study of head and neck cancer metastasis.
The decellularized lymph node can be used to study the effects of drugs, vaccines, or therapies on the lymphatic system.