I’m a Biochemist with a strong biophysical background and I'm trained as a computational and structural biologist - although my academic background has a strong biomedical and biomolecular focus. My main research interests lie at the intersection of Biochemistry, Biophysics, and Bioinformatics, with a particular focus on:
Proteins and antibodies structure, folding and interactions.
Computational modeling and molecular dynamics (MD) simulations of proteins.
From October 2020 to December 2023 I pursued a Bachelor's in Biotechnologies at Sapienza University. The Bachelor's path had a strong focus on biomolecular, medical and pharmaceutical disciplines, but personal interests led me to further explore chemistry by following several elective courses from the Chemistry department.
From March to December 2023 I carried out my wet-lab B.Sc. experimental thesis internship in Francesca Cutruzzolà's group at the Department of Biochemical Sciences "Alessandro Rossi Fanelli" of Sapienza University of Rome, under the supervision of Sharon Spizzichino.
The project focused on expressing, purifying and characterising recombinant human enzymes - Thymidylate synthase (TYMS) and Serine Hydroxymethyltransferase (SHMT) - of the folate cycle involved in cancer mechanisms, and on probing their interaction with nucleic acids to investigate their DNA/RNA-binding and riboregulation properties.
Since October 2023, I have been enrolled in the Master’s program in Biochemistry at Sapienza University, with a strong focus on Structural Biology, Computational Biology, and Biophysics. I gained hands-on experience in Structural Biology during an Erasmus+ Traineeship at the Institute of Biotechnology of the Czech Academy of Sciences, and in Computational Biology during my collaboration with the Structural Bioinformatics Group and my MSc thesis internship. As for Biophysics, I had the opportunity to explore it further by taking several elective courses from the Physics of Biosystems Master's program at Sapienza.
During my Erasmus+ stay in Prague at the BIOCEV research center, I worked in the Structure and Function of Biomolecules lab under Jan Dohnálek. My project focused on purifying, characterizing, and crystallizing the SmNuc1 nuclease from Stenotrophomonas maltophilia, and trying to “trap” intermediate ligand-bound conformations by quickly soaking crystals in c-di-GMP solutions.
Since October 2024, I’ve been collaborating with Alessandro Paiardini’s Structural Bioinformatics Group at Sapienza University, working alongside PhD student Sara Giordani. The project involves phylogenetic and structural analysis of inner mitochondrial membrane transporters in the SLC25A family, as well as molecular dynamics (MD) simulations of the human enzyme DOPA decarboxylase. Find out more about the project on my GitHub profile!
Since June 2024, I’ve also been doing my training and MSc thesis work in Computational Biophysics at IIT’s Center for Life Nano- & Neuro-Science, under the supervision of Edoardo Milanetti.
Since february 2025, I collaborate with the haematology department of Tor Vergata Hospital as data manager.
Since June 2024, I have been training in computational biophysics at the Center for Life Nano- & Neuro-Science of the Italian Institute of Technology (IIT) under the supervision of Edoardo Milanetti.
Since October 2024, I have been carrying out my dry-lab M.Sc. thesis research at IIT. The project focuses on developing a theoretical protocol to improve the scoring of native-like antibody-antigen docking poses using symmetric and asymmetric radially distributed statistical potentials.
You can find out more about the training project on my GitHub profile here, and about the Master's thesis project here!
P.S. If you spot any mistakes, inaccuracies, missing attributions, or anything else that needs correcting in what I’ve written, please feel free to reach out to me via email.