Cheng-Lin Chan,† Yong-Ting Tsao,† († denotes equal contribution), Aira Shayne Paculba, Pei-Shan Lin, Zong-Nan Tsai, Hung-Hsuan Chiu, Risa Kunitake, Ming-Jia Chiu, Chun-Chi Yeh, Cheng-Chau Chiu, and Hsuan-Hung Liao*, Irradiation of Bifunctional Masked Ketone Pro-Aromatics Unveils Autoinductive Autocatalysis via Electron Donor–Acceptor (EDA) Complexes, Org. Lett. 2025, DOI: 10.1021/acs.orglett.5c02448 Link
Kuei-Chen Chang,† Hung-Hsuan Chiu,† († denotes equal contribution), Pin-Gong Huang, Shinje Miñoza, Wen-Hsuan Lee, Prem Kumar Keerthipati, Sasirome Racochote, Yi-Hua Lee, Chih-Ju Chou, Che-Ming Hsu, Che-Wei Chang, Darunee Soorukram, Cheng-chau Chiu, and Hsuan-Hung Liao*, Photoenolization of α,β-Unsaturated Esters Enables Enantioselective Contra-Thermodynamic Positional Isomerization to α‑Tertiary β,γ-Alkenyl Esters, J. Am. Chem. Soc. 2025, DOI: 10.1021/jacs.4c15732. Link
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Cheng-Lin Chan, Shao-Chi Lee, Pei-Shan Lin, Radyn Vanessa Phaz P. Tapales, Jia-Syuan Li, Chun-An Lai, Jyh-Tsung Lee, Chien-Hung Li, and Hsuan-Hung Liao*, FluoroFusion: NHC-Catalyzed Nucleophilic Aromatic Substitution Reaction Unveils Functional Perfluorinated Diarylmethanones, Org. Lett. 2024, 26, 11, 2338–2342. Link
Zong-Nan Tsai, Li-Yun Li, Aira Shayne Paculba, Shinje Miñoza, Yong-Ting Tsao, Hsuan-Hung Liao*, Pei-Shan Lin, Pro-aromatic Dihydroquinazolinones – From Multigram Synthesis to Reagents for Gram-scale Metallaphotoredox Reactions, Chem Asian J. 2024,19, e202301004. Link
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Shinje Miñoza, Ivy Librando, Hsuan-Hung Liao*, Ketone-derived pro-aromatic reagents for radical group transfer reactions and deconstructive functionalizations, Synlett. 2023, DOI: 10.1055/a-2197-1909. Link
Che-Ming Hsu, Heng-Bo Lin, Xin-Zhi Hou, Radyn Vanessa Phaz P. Tapales, Chen-Kuei Shih, Shinje Miñoza, Yu-Syuan Tsai, Zong-Nan Tsai, Cheng-Lin Chan, and Hsuan-Hung Liao*, Azetidines with All-Carbon Quaternary Centers: Merging Relay Catalysis with Strain Release Functionalization, J. Am. Chem. Soc. 2023, 145, 34, 19049–19059. Link
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Cheng-Lin Chan, Shao-Chi Lee, Hsuan-Hung Liao*, A protocol for the gram-scale synthesis of polyfluoroaryl sulfides via an SNAr step, STAR Protocols, 2023, 4, 102043. Link
Sheenagh G. Aiken,† Joseph M. Bateman,† Hsuan-Hung Liao,† Alexander Fawcett, Teerawut Bootwicha, Paolo Vincetti, Eddie L. Myers, Adam Noble & Varinder K. Aggarwal* , Iterative synthesis of 1,3-polyboronic esters with high stereocontrol and application to the synthesis of bahamaolide A, Nat. Chem. 2023, 15, 248–256. Link
†Contributed equally: Sheenagh G. Aiken, Joseph M. Bateman, Hsuan-Hung Liao.
Shinje Miñoza,† Wei-Cheng Ke,† Yin-Yin Yu,† Prem Kumar Keerthipati, Kuei-Chen Chang, Wei-Cheng Kao, Zong-Nan Tsai, and Hsuan-Hung Liao* , Direct Synthesis of Oxaspirolactones in Batch, Photoflow, and Silica Gel-Supported Solvent-free Conditions via Visible-Light Photo- and Heterogeneous Brønsted Acid Relay Catalysis, Green Chem., 2022, 24, 9157-9167. Link
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Hsuan-Hung Liao*, Shao-Chi Lee, Hsin Kao, Yu-Ling Hsu, Che-Ming Hsu, Yong-Ting Tsao, Shinje Miñoza, Li-Yun Li, Zong-Nan Tsai, Kuei-Chen Chang, Cheng-Ku Cheng, Cheng-Lin Chan, Yi-Sian Chien, Cheng-chau Chiu*, Synthesis of perfluoroaryl sulfides at electron-poor arenes via an SNAr step with an unexpected mechanism, Cell Rep. Phys. Sci. 2022, 3, 8, 101010. Link
Hsuan-Hung Liao*, Shinje Miñoza, Shao-Chi Lee, Magnus Rueping*, Aza-ortho-Quinone Methidesas Reactive Intermediates: Generation and Utilityin Contemporary Asymmetric Synthesis, Chem. Eur. J. 2022, e202201112. Link
Che-Ming Hsu†, Shao-Chi Lee†(†equal contribution), Hao-En Tsai, Yong-Ting Tsao, Cheng-Lin Chan, Shinje Miñoza, Zong-Nan Tsai, Li-Yun Li, and Hsuan-Hung Liao*, Desulfurative Ni-Catalyzed Reductive Cross-Coupling of Benzyl Mercaptans/Mercaptoacetates with Aryl Halides, J. Org. Chem. 2022, 87, 5, 3799-3803. Link
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蔡郁萱(Yu-Syuan Tsai) ; 謝承宇(Cheng-Yu Hsieh) ; 廖軒宏(Hsuan-Hung Liao) ; 王琢堅(Vincent C.-C. Wang), 簡介電化學在有機合成上的發展和應用 A Brief Overview of Organic Electrosynthesis, Chemistry, 2021, 79, 4, 327 - 338. Link
Shao-Chi Lee†, Li-Yun Li†, Zong-Nan Tsai† (†equal contribution), Yi-Hsin Lee, Yong-Ting Tsao, Pin-Gong Huang, Cheng-Ku Cheng, Heng-Bo Lin, Ting-Wei Chen, Chung-Hsin Yang, Cheng-Chau Chiu, and Hsuan-Hung Liao*, Aromatization as an Impetus to Harness Ketones for Metallaphotoredox-Catalyzed Benzoylation/Benzylation of (Hetero)arenes, Org. Lett. 2022, 24, 1, 85-89 . Link
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H.-H. Liao, C.-C. Hsiao, I. Atodiresei, and M. Rueping, Multiple hydrogen-bond activation in asymmetric brønsted acid catalysis , Chem.-Eur.J. , 2018 , 24 , 7718.
(DOI: 10.1002/chem.201800677)
A. Chatupheeraphat*, H.-H. Liao* (*equal contribution) , W. Srimontree, L. Guo, Y. Minenkov, A. Poater, L. Cavallo, M. Rueping, Ligand-controlled chemoselective nickel catalyzed Suzuki-Miyaura cross-couplings: Ester as cross-coupling partner for c(sp2)-c(sp3) bond formation , J. Am. Chem. Soc , 2018 , 140 , 3724.
(DOI: 10.1021/jacs.7b12865)
S.-C. Lee, H.-H. Liao, A. Chatupheeraphat, M. Rueping, Nickel-catalyzed C-S bond formation via decarbonylative thioetherification of esters, amides and intramolecular recombination fragment coupling of thioesters , Chem.-Eur. J. , 2018 , 24 , 3608.
(DOI: 10.1002/chem.201705842)
S.-C. Lee, L. Guo, H. Yue, H.-H. Liao, M. Rueping, Nickel-catalyzed decarbonylative silylation, borylation, and amination of arylamides via a deamidative reaction pathway , Synlett , 2017 , 28 , 2594. (DOI: 10.1055/s-0036-1591495)
A. Chatupheeraphat*, H.-H. Liao* (*equal contribution) , S.-C. Lee, M. Rueping, Nickel-Catalyzed C–CN Bond Formation via Decarbonylative Cyanation of Esters, Amides, and Intramolecular Recombination Fragment Coupling of Acyl Cyanides , Org. Lett , 2017 , 19 , 4255. (DOI: 10.1021/acs.orglett.7b01905)
W. Srimontree, A. Chatupheeraphat, H.-H. Liao, M. Rueping, Amide to Alkyne Interconversion via a Nickel/Copper-Catalyzed Deamidative Cross-Coupling of Aryl and Alkenyl Amides , Org. Lett. , 2017 ,19 , 3091 (DOI:10.1021/acs.orglett.7b01194)
H. Yue, L. Guo, H.-H. Liao, M. Rueping, Catalytic ester and amide to amine interconversion: Nickel-catalyzed decarbonylative amination of aryl and heteroaryl esters and amides , Angew. Chem. Int. Ed. ,2017 , 56 , 4282.
(DOI: 10.1002/anie.201611819)
A. Chatupheeraphat*, H.-H. Liao*, S. Mader* (*equal contribution) , M. Sako, H. Sasai, I. Atodiresei , and M. Rueping, Asymmetric Brønsted acid-catalyzed substitution of diaryl methanols with thiols and alcohols for the synthesis of chiral thioethers and ethers , Angew. Chem. Int. Ed. , 2016 , 55 , 4803.
(DOI: 10.1002/anie.201511179)
H.-H. Liao, A. Chatupheeraphat, C.-C. Hsiao, I. Atodiresei, M. Rueping, Asymmetric Brønsted acid catalyzed synthesis of triarylmethanes-construction of communesin and spiroindoline scaffolds ,Angew. Chem. Int. Ed. , 2015 , 54 , 15540.
(DOI: 10.1002/anie.201505981)
C.-C. Hsiao, S. Raja, H.-H. Liao, I. Atodiresei, M. Rueping, Ortho-quinone methides as reactive intermediates in asymmetric Brønsted acid catalyzed cycloadditions with unactivated alkenes by exclusive activation of the electrophile , Angew. Chem. Int. Ed. , 2015 , 54 , 5762.
(DOI: 10.1002/anie.201409850)
C.-C. Hsiao, H.-H. Liao, M. Rueping, Enantio- and diastereoselective access to distant stereocenters embedded in tetrahydroxanthenes: utilizing ortho-quinone methides as reactive intermediates in asymmetric Brønsted acid catalysis , Angew. Chem. Int. Ed. , 2014 , 53 , 13258.
(DOI: 10.1002/anie.201406587)
H.-H. Liao, C.-C. Hsiao, E. Sugiono, and M. Rueping, Shedding light on Brønsted acid catalysis - a photocyclization-reduction reaction for the asymmetric synthesis of tetrahydroquinolines from aminochalcones in batch and flow , Chem. Comm. , 2013 , 49 , 7953.
(DOI: 10.1039/C3CC43996H)
C.-C. Hsiao, H.-H. Liao, E. Sugiono, and M. Rueping, Shedding light on organocatalysis-light-assisted asymmetric ion-pair catalysis for the enantioselective hydrogenation of pyrylium Ions , Chem.-Eur. J ,2013 , 19 , 9775.
(DOI: 10.1002/chem.201300766)
H.-H. Liao, R.-S. Liu, Effects of haloniums on gold-catalyzed ring expansion of 1-oxiranyl-1-alkynylcyclopropanes , Chem. Commun. , 2011 , 47 , 1339.
(DOI: 10.1039/C0CC03309J)
C.-Y. Yang, M.-S. Lin, H.-H. Liao, and R.-S. Liu, Diversity of products in the gold-catalyzed cyclization of 1-epoxy-1-alkynylcyclopropanes by using 1-oxyallyl cations , Chem.-Eur. J. , 2010 , 16 , 2696.
(DOI: 10.1002/chem.200903419)
A. Das, H.-H. Liao, and R.-S. Liu, Platinum-catalyzed chemoselectively hydrative dimerization of 2-alkynyl-1-acetylbenzenes for one-pot facile synthesis of chrysene derivatives , J. Org. Chem. , 2007 , 72 , 9214.
(DOI: 10.1021/jo701580r)