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RESEARCH QUESTIONS UNDER INVESTIGATION
RESEARCH QUESTIONS UNDER INVESTIGATION
Our group is deeply invested in the development of optical imaging technology and spatially-resolved sensing. We work at the frontiers of optical science, nanophotonics, and laser physics to create next-generation imaging technologies that benefit the biomedical field. The overarching research questions driving our investigations include:
How can we extract structural and functional information from scattering media, like biological tissues, with better performance than current state-of-the-art methods?
How can the various degrees of freedom of light be used to our advantage in encoding and decoding imaging information?
To what extent do various biological materials respond differently to the different degrees of freedom of light? How can we leverage that knowledge to enhance pathology assessment?
How can the novel imaging platforms innovated in our lab interface seamlessly with clinically relevant in vitro models?
Research Project 1: Advance Optical Imaging Performance with Quantum Mimicry
Research Project 1: Advance Optical Imaging Performance with Quantum Mimicry
This project involves the application of advanced techniques in pulse shaping, polarization control, and wavefront shaping to generate mode-entangled light sources. As suggested by the name, we utilize these mode-entangled light sources for quantum mimicry.
Our objective is to develop a robust imaging tool that offers quantum advantages while overcoming limitations of low photon flux inherent in genuine quantum light sources that are based on spontaneous parametric down conversion (SPDC). We are currently focusing on integrating such quantum advantages into a label-free depth-resolved imaging technology known as optical coherence tomography (OCT).
Research Project 2: Enhancing Optical Phenotyping Capabilities with Structured Light
Research Project 2: Enhancing Optical Phenotyping Capabilities with Structured Light
The dynamic behavior of cells within living systems can only be accurately studied and understood by using non-invasive techniques that avoid undesirable perturbations to their native environment. We use the term optical phenotyping to describe the use of optical methods to extract information about the dynamic and oftentimes adaptive behavior of living systems at the microscopic, cellular level.
In this project, our group is investigating how various forms of structured light could be used to advance dynamic contrast imaging of live cells.
Research Project 3: Developing Metaoptics for Compact Bio-Analysis
Research Project 3: Developing Metaoptics for Compact Bio-Analysis
The advent of metaoptics, man-made nanophotonic devices that are typically sub-wavelength thin, has made it possible to miniaturize bulky optical systems into much more compact designs involving fewer components. One of the focuses of this project is to explore the use of metasurfaces to build compact structured light imaging systems. At the same time, we are designing novel forms of metasurfaces to augment our optical phenotyping research.
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