Selected Publications

Imaging intracellular motion with dynamic micro-optical coherence tomography. Biomed. Opt. Express 11, 5, 2768–2778 (2020) 

Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies. Sci. Transl. Med. 11, 504, eaav3505 (2019). 

Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia. Opt. Lett. 42, 4, 867–870 (2017). 

Fluorescence and reflectance spectral imaging system for a murine mammary window chamber model. Biomed. Opt. Express 6, 8, 2887 (2015). 

Multi-modality imaging of a murine mammary window chamber for breast cancer research. Biotechniques 57, 1, 45–50 (2014). 

Tunable liquid-filled lens integrated with aspherical surface for spherical aberration compensation. Opt. Express 18, 10, 9945–54 (2010). 

Liquid tunable diffractive/refractive hybrid lens. Opt. Lett. 34, 18, 2793–5 (2009). 

Endomicroscopy

Longitudinal improvements in clinical and functional outcomes following initiation of elexacaftor/tezacaftor/ivacaftor in patients with cystic fibrosis. Heliyon. 10, 8, e29188 (2024)

COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging. Am. J. Respir. Cell Mol. Biol. 69, 5, 592–595 (2023)  

In vivo optical endomicroscopy: two decades of translational research towards next generation diagnosis of eosinophilic esophagitis. Transl. Med. Commun. 6, (2021). 

Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies. Sci. Transl. Med. 11, 504, eaav3505 (2019). 

Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia. Opt. Lett. 42, 4, 867–870 (2017). 

Preclinical, animal studies

Mucociliary transport deficiency and disease progression in Syrian hamsters with SARS-CoV-2 infection. JCI Insight 8, e163962 (2023).

Fluorescence and reflectance spectral imaging system for a murine mammary window chamber model. Biomed. Opt. Express 6, 8, 2887 (2015). 

Multi-modality imaging of a murine mammary window chamber for breast cancer research. Biotechniques 57, 1, 45–50 (2014). 

Studies on cell biology, cell types, and mutations in relation with pathophysiology

Transgenic ferret models define pulmonary ionocyte diversity and function. Nature 621, 857–867 (2023) 

STAT3 Mutation-Associated Airway Epithelial Defects as A Mechanism for Pulmonary Complications in Job Syndrome. J. Allergy Clin. Immunol. 152, 538–550 (2023). 

Evaluation of a novel CFTR potentiator in COPD ferrets with acquired CFTR dysfunction. Eur. Respir. J. 60, 2101581 (2022). 

A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Nat. Med. 26, 244–251 (2020). 

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature 560, 7718, 319 (2018). 

Studies on inflammatory responses

Neutrophil dysfunction in cystic fibrosis. J. Cyst. Fibros. 20, 1062–1071 (2021) 

Aspergillus fumigatus cell wall promotes apical airway epithelial recruitment of human neutrophils. Infect. Immun. 88, 2, e00813-19 (2019). 

Studies on mucociliary transport

Mucociliary transport deficiency and disease progression in Syrian hamsters with SARS-CoV-2 infection. JCI Insight 8, e163962 (2023).

Pulmonology

A glycopolymer improves viscoelasticity and mucociliary transport of abnormal cystic fibrosis mucus. JCI Insight 4, 8, (2019). 

Ophthalmology

Stromal Nerve Imaging and Tracking Using Micro-Optical Coherence Tomography. Transl. Vis. Sci. Technol. 9, 5, 6 (2020). 

Cardiology

Micro-Optical Coherence Tomography for Endothelial Cell Visualization in the Coronary Arteries. JACC Cardiovasc. Imaging 12, 9, 1878–1880 (2019). 

Cochlear

Micro-optical coherence tomography of the mammalian cochlea. Sci. Rep. 6, April, 33288 (2016) 

Gastroenterology

In vivo optical endomicroscopy: two decades of translational research towards next generation diagnosis of eosinophilic esophagitis. Transl. Med. Commun. 6, (2021).