Publications

Peer-reviewed journal articles

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1. 1. D. J. Hellenbrand, J. S. Lee, E. J. Mickelson, M. C. Baer, E. L. Ott, N. R. Martinson, M. R. Celeen, K. H. Hilger B. E. Neilsena, A. N. Jacobs, R. R. Mishra, S. A. Hurley, W. L. Murphy, A. S. Hanna. Mineral coated microparticles delivering interleukin-4, interleukin-10, and interleukin-13 reduce inflammation and improve function after spinal cord injury in a rat. Experimental Neurology, 2025; 386: 115179. 🔗

   2. G. Fontana, B. Nemke, Y. Lu, C. Chamberlain, J. S. Lee, J. Choe, H. Jiao, M. Nelson, M. Amitrano, W. J. Li, M. Markel, W. L. Murphy. Local delivery of TGF-β1-mRNA supports chondrogenesis and decreases fibrosis in osteochondral defects. Bioactive Materials 2025; 45: 509-519. 🔗

   3. M. B. Parlato, J. S. Lee, D. G. Belair, G. Fontana, E. Leiferman, R. Hanna, C. Chamberlain, E. A. Ranheim, W. L. Murphy, M. A. Halanski. Subperiosteal delivery of transforming growth factor beta 1 and human growth hormone from mineralized PCL films. Journal of Biomedical Materials Research Part A 2024; 112(9): 1578-1593. 🔗 

   4. J. Choe, H. M. Brinkman, J. S. Lee, W. L. Murphy. Optimized biomimetic minerals maintain activity of mRNA complexes after long term storage. Acta Biomaterialia 2024; 174: 428-436. 🔗

   5. D. J. Hellenbrand, C. M. Quinn, Z. J. Piper, R. T. Elder, R. R. Mishra, T. L. Marti, P. M. Omuro, R. M. Roddik, J. S. Lee, W. L. Murphy, A. S. Hanna. The secondary injury cascade after spinal cord injury: an analysis of local cytokine/chemokine regulation. Neural Regeneration Research 2024; 19(6): 1308-1317. 🔗

   6. J. S. Lee, P. Guo, K. Klett, M. Hall, K. Sinha, S. Ravuri, J. Huard, W. L. Murphy. VEGF-attenuated platelet-rich plasma improves therapeutic effect on cartilage repair. Biomaterials Science 2022; 10(9): 2172-2181. 🔗

   7. M. Orth, T. Fritz, J. Stutz, C. Scheuer, B. Ganse, Y. Bullinger, J. S. Lee, W. L. Murphy, M. W. Laschke, M. D. Menger, T. Pohlemann. Local application of mineral-coated microparticles loaded with VEGF and BMP-2 induces the healing of murine atrophic non-unions. Frontiers in Bioengineering and Biotechnology 2022; 9: 809397. 🔗

   8. D. G. Belair, J. S. Lee, A. V. Kellner, J. Huard, W. L. Murphy. Receptor mimicking TGF-β1 binding peptide for targeting TGF-β1 signaling. Biomaterials Science 2021; 9(3): 645-652. 🔗

   9. D. J. Hellenbrand, C. L. Haldeman, J. S. Lee, A. G. Gableman, E. K. Dai, S. D. Ortman, J. C. Gotchy, K. K. Miller, A. M. Doucas, N. C. Nowak, W. L. Murphy, A. S. Hanna. Functional recovery after peripheral nerve injury via sustained growth factor delivery from mineral-coated microparticles. Neural Regeneration Research 2021; 16(5): 871-877. 🔗

   10. G. Fontana, H. L. Martin, J. S. Lee, P. Hematti, W. L. Murphy. Mineral-coated microparticles enhance mRNA-based transfection of human bone marrow cells. Molecular Therapy: Nucleic Acids 2019; 18: 455-464. 🔗

   11. J. S. Lee*, S. W. Bae*, W. L. Murphy. Dynamic, bioresponsive hydrogels via changes in DNA aptamer conformation. Macromolecular Bioscience 2019; 19(2): 1800353. (* Equally contributed to this work) 🔗

   12. G. Fontana, J. Gershlak, M. Adamski, J. S. Lee, S. Matsumoto, H. D. Le, B. Binder, J. Wirth, G. Gaudette, W. L. Murphy. Biofunctionalized plants as diverse biomaterials for human cell culture. Advanced Healthcare Materials 2017; 6(8): 1601225. 🔗

   13. J. S. Lee, X. Yu, A. J. W. Johnson, W. L. Murphy. Mineral binding peptides with enhanced binding stability in serum. Biomaterials Science 2017; 5(4): 663-668. 🔗

   14. E. Aktas, C. S. Chamberlain, E. E. Saether, S. E. Duenwald-Kuehl, J. Kondratko-Mittnacht, M. Stitgen, J. S. Lee, A. E. Clements, W. L. Murphy, R. Vanderby. Immune modulation with primed mesenchymal stem cells delivered via biodegradable scaffold to repair an Achilles tendon segmental defect. Journal of Orthopaedic Research 2017; 35(2): 269-280. 🔗

   15. S. J. Polak, J. S. Lee, W. L. Murphy, S. Tadier, L. Gremillard, I. V. Lightcap, A. J. W. Johnson. Microstructural control of modular peptide release from microporous biphasic calcium phosphate. Materials Science and Engineering C 2017; 72: 268-277. 🔗

   16. A. S. Hanna, D. L. Thompson, D. J. Hellenbrand, J. S. Lee, C. J. Madura, M. G. Wesley, N. J. Dillon, T. Sharma, C. J. Enright, W. L. Murphy. Sustained release of neurotrophin-3 via calcium phosphate-coated sutures promotes axonal regeneration after spinal cord injury. Journal of Neuroscience Research 2016; 94(7): 645-652. 🔗

   17. C. S. Chamberlain, J. S. Lee, E. M. Leiferman, N. X. Maassen, G. S. Baer, R. Vanderby, W. L. Murphy. Effects of BMP-12-releasing sutures on Achilles tendon healing. Tissue Engineering, Part A 2015: 21(5-6): 916-927. 🔗

   18. S. R. Caliari, E. A. Gonnerman, W. K. Grier, D. W. Weisgerber, J. M. Banks, A. J. Alsop, J. S. Lee, R. C. Bailey, B. A. C. Harley. Collagen scaffold arrays for combinatorial screening of biophysical and biochemical regulators of cell behavior. Advanced Healthcare Materials 2015; 4(1): 59-64. 🔗

   19. D. Suarez-Gonzalez, J. S. Lee, A. Diggs, Y. Lu, B. Nemke, M. D. Markel, S. J. Hollister, W. L. Murphy. Controlled multiple growth factor delivery from bone tissue engineering scaffolds via designed affinity. Tissue Engineering, Part A 2014; 20(15-16): 2077-2087. 🔗

   20. J. S. Lee*, S. H. Brounts*, S. Weinberg, S. K. Lan Levengood, E. L. Smith, W. L. Murphy. High affinity binding of an engineered, modular peptide to bone tissue. Molecular Pharmaceutics 2013; 10(5): 2086-2090. (* Equally contributed to this work) 🔗

   21. J. S. Lee, W. L. Murphy. Functionalizing calcium phosphate biomaterials with antibacterial silver particles. Advanced Materials 2013; 25(8): 1173-1179. 🔗

   22. Lu, J. S. Lee, B. Nemke, B. K. Graf, K. Royalty, R. Illgen, R. Vanderby, M. D. Markel, W. L. Murphy. Coating with a modular bone morphogenetic peptide promotes healing of a bone-implant gap in an ovine model. PLoS One 2012; 7(11): e50378. 🔗

   23. J. S. Lee*, D. Suarez-Gonzalez*, S. K. Lan Levengood, R. Vanderby, W. L. Murphy. Mineral coatings modulate β-TCP stability and enable growth factor binding and release. Acta Biomaterialia 2012; 8(3): 1117-1124. (* Equally contributed to this work) 🔗

   24. J. S. Lee, D. Suarez-Gonzalez, W. L. Murphy. Mineral coatings for temporally controlled delivery of multiple proteins. Advanced Materials 2011; 23(37): 4279-4284. (Featured on Frontispiece) 🔗

   25. Y. Lu, J. S. Lee, B. Nemke, G. Baer, B. K. Graf, W. L. Murphy, M. D. Markel. Histologic evaluation of suture material loaded with basic fibroblast growth factor (bFGF) on acute rotator cuff repair in ovine model. Current Orthopaedic Practice 2011; 22(5): 425-431. 🔗

   26. D. J. Gary, H. Lee, R. Sharma, J. S. Lee, Y. Kim, Z. Y. Cui, D. Jia, V. D. Bowman, P. R. Chipman, L. Wan, Y. Zou, G. Mao, K. Park, B. S. Herbert, S. F. Konieczny, Y. Y. Won. Influence of nano-carrier architecture on in vitro siRNA delivery performance and in vivo biodistribution: polyplexes vs. micelleplexes. ACS Nano 2011; 5(5): 3493-3505. 🔗

   27. J. S. Lee, A. J. W. Johnson, W. L. Murphy. A modular, hydroxyapatite-binding version of vascular endothelial growth factor. Advanced Materials 2010; 22(48): 5494-5498. (Featured on Inside Cover) 🔗 

   28. J. S. Lee, Y. Lu, G. S. Baer, M. D. Markel, W. L. Murphy. Controllable protein delivery from coated surgical sutures. Journal of Materials Chemistry 2010: 20(40): 8894-8903. 🔗

   29. J. S. Lee, J. S. Lee, W. L. Murphy. Modular peptides promote human mesenchymal stem cell differentiation on biomaterial surfaces. Acta Biomaterialia 2010; 6(1): 21-28. 🔗 

   30. J. S. Lee, J. S. Lee, A. J. W. Johnson, W. L. Murphy. Modular peptide growth factors for substrate-mediated stem cell differentiation. Angewandte Chemie International Edition 2009; 48(34): 6266-6269. 🔗 

   31. J. S. Lee, S. J. Hwang, D. J. Kim, S. C. Kim, D. S. Lee. Formation of poly(ethylene glycol)-poly(ɛ-caprolactone) nanoparticle via nanoprecipitation. Macromolecular Research 2009; 17(2): 72-78. 🔗

   32. R. Sharma, J. S. Lee, R. C. Bettencourt, C. Xiao, S. F. Konieczny, Y. Y. Won. Effects of the incorporation of a hydrophobic middle block into a PEG-polycation diblock copolymer on the physicochemical and cell interaction properties of the polymer-DNA complexes. Biomacromolecules 2008; 9(11): 3294-3307. 🔗 

   33. J. S. Lee, H. K. Lee, S. C. Kim. Intrinsic viscosity and unperturbed dimension of poly(dl-lactic acid) solution. Macromolecular Research 2008; 16(7): 631-636. 🔗

   34. D. Zhu, M. A. Haiderkker, J. S. Lee, Y. Y. Won, J. C. M. Lee. Application of molecular rotors to the determination of the molecular weight-dependence of viscosity in polymer melts. Macromolecules 2007; 40(21): 7730-7732. 🔗

   35. W. S. Shim, J. S. Lee, D. S. Lee. pH-Induced micellization of biodegradable block copolymers containing sulfamethazine. Macromolecular Research 2005; 13(4): 344-351. 🔗

   36. M. S. Kim, W. S. Shim, R. R. Pal, J. S. Lee, S. W. Kim, D. S. Lee. pH-Induced micellization of sulfamethazine-coupled MPEG-PCLA block copolymer. Macromolecular Research 2005; 13(4): 352-355. 🔗

   37. J. S. Lee, S. H. Kim, Y. J. Kim, T. Akaike, S. C. Kim. Hepatocyte adhesion on poly[N-p-vinylbenzyl-4-O-β-galactopyranosyl-d-glucoamide]-coated poly(l-lactic acid) surface. Biomacromolecules 2005; 6(4): 1906-1911. 🔗

   38. J. S. Lee, H. K. Lee, S. C. Kim. Thermodynamic parameters in poly(lactic acid) solutions in dialkyl phthalate. Polymer 2004; 45(13): 4491-4498. 🔗

   39. J. S. Lee, H. K. Lee, J. Y. Kim, S. Hyon, S. C. Kim. Thermally induced phase separation in poly(lactic acid)/dialkyl phthalate systems. Journal of Applied Polymer Science 2003; 88(9): 2224-2232. 🔗

   40. K. J. Baik, J. Y. Kim, J. S. Lee, H. K. Lee, S. C. Kim. Morphology of membranes formed from polysulfone/polyethersulfone/N-methyl-2-pyrrolidone/water system by immersion precipitation. Korea Polymer Journal 2001; 9(5): 285-291. 🔗

Book chapters

1. J. S. Lee, R. T. Hill, A. Chilkoti, W. L. Murphy, “Surface Patterning” in Biomaterials Science: An Introduction to Materials in Medicine, 4th Edition, Elsevier, 2020.

2. T. W. Franklin-Ford, D. Suarez-Gonzalez, J. S. Lee, W. L. Murphy, “Biomimetic Hydroxyapatite Materials for Therapeutic Delivery” in Hydroxyapatite Coatings for Biomedical Applications, S. Zhang, Ed., in Advances in Materials Science and Engineering, CRC Press, 2013.

Patents

1. W. L. Murphy, G. Fontana, A. Khalil, J. S. Lee. Delivery of biologics via mineral crystals for regenerative medicine applications. Patent application filed. (US2023/0035942A1)

2. A. B. Clements, J. S. Lee, M. Ostrowski. Methods for treating or preventing inflammatory events. Patent application filed. (WO2022/051247A1) 

3. M. Ostrowski, A. B. Clements, J. S. Lee. Compositions and methods for vaccine delivery. Patent application filed. (WO2022/031594A1)

4. J. S. Lee, A. Clements. Inorganic coatings for the sustained release of bioactive compounds. Patent application filed. (WO2021/167957A1)

5. W. L. Murphy, S. K. Lan Levengood, S. H. Brounts, J. S. Lee. Modular, bioactive peptides for binding native bone and improving bone graft osteoinductivity. Patent application filed. (US2014/0235542)

6. C. S. Chamberlain, J. S. Lee, B. K. Graf, G. S. Baer, R. Vanderby, W. L. Murphy. Selection of platelet rich plasma components via mineral binding. Patent application filed. (US2014/0141047)

7. W. L. Murphy, G. A. Hudalla, J. T. Koepsel, J. S. Lee, S. Levengood. Proteoglycan-binding peptides that modulate stem cell behavior. Patent application filed. (US2011/0269231)

8. J. S. Lee, M. D. Markel, B. K. Graf, G. Baer, Y. Lu, W. L. Murphy. Biologically active sutures for regenerative medicine. Granted. (US 9,636,109)

9. W. L. Murphy, J. S. Lee, M. D. Markel, B. K. Graf. Methods of decorating hydroxyapatite biomaterials with modular, biologically active molecules. Granted. (US 8,846,860)

10. W. L. Murphy, M. D. Markel, B. K. Graf, Y. Lu, J. S. Lee. Tissue regeneration system. Granted (US 8,778,869)

11. W. L. Murphy, J. S. Lee, M. D. Markel, B. K. Graf. Decorating hydroxyapatite biomaterials with modular, biologically active molecules. Granted. (US 8,420,774)