Hyunji Lee's Lab @ Kyungsung University

25.

C. L. Chaudhary, K. Ghimire, K. Yadav, H. Kim, J.-W. Nam, J.-G. Jee, J.-A. Kim, B.-S. Jeong*, H. Lee*

Discovery of a Novel Cyclobutanol Scaffold With Anti-Inflammatory Activity and Its Modular Synthesis

Asian J. Org. Chem., 2026, 15, e70283

24.

S. Kim, M. J. Kim, J. Han, J. H. Kim, S. K. Lee, E. H. Koh, H. J. Yoo, H. Lee*, S. Kim*

A Triazole Bioisostere-Based Approach to Understanding Ceramide Amide Bond Conformation and Function

Chem. Asian J. 2025, 20, e00925

23.

D. Bae, P. Chaudhary, J.-A. Kim, H. Lee*, B.-S. Jeong*

A Concise and High-Yielding Synthesis of Dechlorotrichotoxin A

Asian J. Org. Chem., 2025, 14, e202400775

22.

H. Yoon, J. Jo, H. Hyun, G. Lee, S. Ma, J. Sohn, D. K. Sung, C. Y. Han, M. Kim, D. Hwang, H. Lee, Y. Shin, K. T. Oh*, C. Lim*

Extracellular vesicle as therapeutic agents in anti-aging: Mechanistic insights and future potential

 Journal of Controlled Release 2025, 383, 113796 

21.

E. W. Syahputra, H. Lee, H. Cho, H. J. Park, K.-S. Park*, D. Hwang*

PROTAC Delivery Strategies for Overcoming Physicochemical Properties and Physiological Barriers in Targeted Protein Degradation

Pharmaceutics 2025, 17

20.

H. Cho, H. Lee, D. Hwang*

Development of Novel Fluticasone/Salmeterol/Tiotropium-Loaded Dry Powder Inhaler and Bioequivalence Assessment to Commercial Products in Rats

Pharmaceutics 2025, 17

19.

Bae, D.; Nam, J.-W.; Park, H.; Chaudhary, P.; Kim, J.-A.; Lee, H.*; Jeong, B.-S.* 

Structure confirmation of dechlorotrichotoxin A through stereoselective total synthesis 

J. Nat. Prod., 2023, 86, 11, 2585-2591

18. 

Bae, D.; Chaudhary, P.; Been, J.-H.; Gautam, J.; Lee, J.; Shah, S.; Kim, E.; Lee, H.; Nam, T.-G.; Jeong, B.-S.; Kim, J.-A. 

Antitumor effect of (Z)-3-(quinolin-2-ylmethylene)-4,6-dimethyl-5- hydroxy-7-azaoxindole down-regulating the Gas6-Axl axis

Eur. J. Med. Chem., 2023, 251, 115274

17. 

Lee, H.*; Wu, C.*; Desormeaux, E. K.; Sarksian, R.; van der Donk, W. A.

Improved Production of Class I Lanthipeptides in Escherichia coli

Chem. Sci., 2023, 14 (10), 2537–2546

This article is part of the themed collection: 2023 Chemical Science HOT Article Collection

16. 

Ayikpoe, R. S.*; Shi, C.*; Battiste, A. J.*; Eslami, S. M.; Ramesh, S.; Simon, M. A.; Bothwell, I. R.; Lee, H.; Rice, A. J.; Ren, H.; Tian, Q.; Harris, L. A.; Sarksian, R.; Frerk, A. M.; Precord, T. W.; van der Donk, W. A.; Mitchell, D. A.; Zhao, H. 

A scalable platform to discover antimicrobials of ribosomal origin 

Nat. Commun., 2022, 13, 6135 

15. 

Hoy, M. J.; Park, E*; Lee, H.*; Lim, W. Y.*; Cole, D. C.; DeBouver, N. D.; Bobay, B. G.; Pierce, P. G.; Fox III, D.; Ciofani, M.; Juvvadi, P. R.; Steinbach, W.; Hong, J.; Heitman, J. 

Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus 

mBio, 2022, 13, e01049 

14. 

Lee, H.; van der Donk, W. A. 

Macrocyclization and backbone modification in RiPP biosynthesis. 

Annu. Rev. Biochem., 2022, 91, 269–294

13. 

Awasthi, B. P.; Lee, H.*; Jeong, B.-S.*

Synthesis of pyridoxine-derived dimethylpyridinols fused with aminooxazole, aminoimidazole, and aminopyrrole 

Molecules, 2022, 27, 2075 

12. 

Daniels, P. N.; Lee, H.; Splain, R. A.; Ting, C. P.; Zhu, L.; Zhao, X.; Moore, B. S.; van der Donk, W. A.

Discovery of a new biosynthetic pathway to aromatic amines using glycyl-tRNA as nitrogen donor A biosynthetic pathway to aromatic amines that uses glycyl-tRNA as nitrogen donor 

Nat. Chem., 2022, 14, 71–77

11. 

Kwak, S. H.; Stephenson, T. N.; Lee, H. E.; Ge, Y.; Lee, H.; Min, S. M.; Kim, J. H.; Kwon, D. Y.; Lee, Y. M.; Hong, J. 

Evaluation of manassantin A tetrahydrofuran core region analogues and cooperative therapeutic effects with EGFR inhibition 

J. Med. Chem., 2020, 63 (13), 6821–6833

10. 

Lee, S.; Lee, Y. M.; Lee, H.-J.; Jeon, H.; Lee, H.; Shin, D.; Kim, S.

Membrane fusion through the generation of triazole ceramide via click chemistry at the membrane surface 

Asian J. Org. Chem., 2019, 8 (9), 1713–1717

9. 

Lee, H.; Sylvester, K.; Derbyshire, E. R.; Hong, J. 

Synthesis and Analysis of Natural-Product-Like Macrocycles by Tandem Oxidation/Oxa-Conjugate Addition Reactions 

Chem.–Eur. J., 2019, 25 (26), 6500–6504

8. 

Lee, M.; Zhao, J.; Kwak, S.-H.; Cho, J.; Lee, M.; Gillespie, R. A.; Kwon, D.-Y.; Lee, H.; Park, H.-J.; Wu, Q.; Zhou, P.; Hong, J. 

Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay 

ACS Infect. Dis., 2019, 5 (4), 641–651

7. 

Gautam, J.; Banskota, S.; Lee, H.; Lee, Y. J.; Jeon, Y. H.; Kim, J. A.; Jeong, B. S. 

Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis 

Exp. Mol. Med., 2018, 50 (9), 1-14

6. 

Kim, B.; Ratnayake, R.; Lee, H.; Shi, G.; Zeller, S. L.; Li, C.; Luesch, H.; Hong, J. 

Synthesis and biological evaluation of largazole zinc-binding group analogs

Bioorg. Med. Chem., 2017, 25 (12), 3077–3086

5. 

Lee, H.; Lee, Y.-K.; Kim, D.-G.; Son, M.-S.; Nam, T.-g.; Jeong, B.-S. 

Tocopherol side chain synthesis via asymmetric organocatalytic transfer hydrogenation and convenient measurement of stereoselectivity

Tetrahedron Lett., 2014, 55 (43), 5895–5897

4. 

Lee, H.; Kim, D. G.; Banskota, S.; Lee, Y. K.; Nam, T. G.; Kim, J. A.; Jeong, B. S. 

Pyridoxine-derived bicyclic amido-, ureido-, and carbamato-pyridinols: synthesis and antiangiogenic activities

Org. Biomol. Chem., 2014, 12 (43), 8702–8710

3. 

Lee, H.; Banskota, S.; Kim, D. G.; Been, J. H.; Jin, Y. J.; Gautam, J.; Jang, H.; Nam, T. G.; Kim, J. A.; Jeong, B. S. 

Synthesis and antiangiogenic activity of 6-amido-2,4,5-trimethylpyridin-3-ols

 Bioorg. Med. Chem. Lett., 2014, 24 (14), 3131–3136

2. 

Kim, D. G.; Kang, Y.; Lee, H.; Lee, E. K.; Nam, T. G.; Kim, J. A.; Jeong, B. S. 

6-Amino-2,4,5-trimethylpyridin-3-ols: a new general synthetic route and antiangiogenic activity

Eur. J. Med. Chem., 2014, 78, 126–139

1.

Lee, H.-J.*; Lim, C.*; Hwang, S.; Jeong, B. S.; Kim, S.

Silver-mediated exo-selective tandem desilylative bromination/oxycyclization of silyl-protected alkynes: synthesis of 2-bromomethylene-tetrahydrofuran

Chem. Asian J. 2011, 6, 1943–1947