Publications

61. Li X, Zhao Z, Ye H, Li D, Huang X, Lee JH, Liu R. CDO1 phosphorylation is required for IL-6-induced tumor cell proliferation through governing cysteine availability. Cell Commun Signal. 2025 Apr 23;23(1):194. doi: 10.1186/s12964-025-02189-w. PMID: 40269955 

60. Park SH, Seo JH, Kim MY, Yun HJ, Kang BK, Kim JH, Heo SV, Lee YH, Park HR, Choi MS, Lee JH. Enhanced Antitumor Activity of Korean Black Soybean Cultivar 'Soman' by Targeting STAT-Mediated Aerobic Glycolysis. Antioxidants (Basel). 2025 Feb 18;14(2):228. doi: 10.3390/antiox14020228. PMID: 40002413; PMCID: PMC11852074. 

59. Muneeswaran T, Bhatt T, Park SH, Maruthupandy M, Kim M, Mathur V, Lee JH, Kim MS, Cho WS. Polyethylene glycol used as a dispersant potentiates the toxicity of insecticides in mammalian cells rather than insects. Environ Int. 2025 Feb;196:109307. doi: 10.1016/j.envint.2025.109307. Epub 2025 Jan 27. PMID: 39914082. 

58. Park JW, Kang M, Kim G, Hyun SY, Shin J, Kim SY, Lee JH, Choi WS, Lee JH, Lee K, Kim SH, Cho WS, Kim HS. The impact of atmospheric ultrafine particulate matter on IgE-mediated type 1 hypersensitivity reaction. J Hazard Mater. 2025 Feb 15;484:136705. doi: 10.1016/j.jhazmat.2024.136705. Epub 2024 Nov 29. PMID: 39637818. 

57. Kim B, Park YY, Lee JH. CXCL10 promotes melanoma angiogenesis and tumor growth. Anim Cells Syst (Seoul). 2024 Sep 11;28(1):453-465. doi: 10.1080/19768354.2024.2402024. PMID: 39268223; PMCID: PMC11391877. 

56. Park SH, Ju JS, Woo H, Yun HJ, Lee SB, Kim SH, Győrffy B, Kim EJ, Kim H, Han HD, Eyun SI, Lee JH, Park YY. The m6A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism. Exp Mol Med. 2024 Jun;56(6):1373-1387. doi: 10.1038/s12276-024-01235-w. Epub 2024 Jun 3. PMID: 38825643; PMCID: PMC11263342. 

55. Park SH, Lee J, Yun HJ, Kim SH, Lee JH. Metformin Suppresses Both PD-L1 Expression in Cancer Cells and Cancer-Induced PD-1 Expression in Immune Cells to Promote Antitumor Immunity. Ann Lab Med. 2024 Mar 26. doi: 10.3343/alm.2023.0443. Epub ahead of print. PMID: 38529546.

54. Yun HJ, Li M, Guo D, Jeon SM, Park SH, Lim JS, Lee SB, Liu R, Du L, Kim SH, Shin TH, Eyun SI, Park YY, Lu Z, Lee JH. AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth. J Exp Clin Cancer Res. 2023 Dec 15;42(1):340. PMID: 38098117

53. Park SH, Kim G, Yang GE, Yun HJ, Shin TH, Kim ST, Lee K, Kim HS, Kim SH, Leem SH, Cho WS, Lee JH. Disruption of phosphofructokinase activity and aerobic glycolysis in human bronchial epithelial cells by atmospheric ultrafine particulate matter. J Hazard Mater. 2024 Feb 15;464:132966. 

52. Du L, Su Z, Wang S, Meng Y, Xiao F, Xu D, Li X, Qian X, Lee SB, Lee JH, Lu Z, Lyu J. EGFR-Induced and c-Src-Mediated CD47 Phosphorylation Inhibits TRIM21-Dependent Polyubiquitylation and Degradation of CD47 to Promote Tumor Immune Evasion. Adv Sci (Weinh). 2023 Aug 4:e2206380. PMID: 37541303

51. Hao Y, Ren T, Huang X, Li M, Lee JH, Chen Q, Liu R, Tang Q. Rapid phosphorylation of glucose-6-phosphate dehydrogenase by casein kinase 2 sustains redox homeostasis under ionizing radiation. Redox Biol. 2023 Sep;65:102810. PMID: 37478541

50. Lee JH. Phosphofructokinase 1 Platelet Isoform Enhances VEGF Expression in Part Through HIF-1α Up-regulation in Breast Cancer. Anticancer Res. 2023 Jan;43(1):75-84. PMID: 36585185

49. Lim JS, Shi Y, Park SH, Jeon SM, Zhang C, Park YY, Liu R, Li J, Cho WS, Du L, Lee JH. Mutual regulation between phosphofructokinase 1 platelet isoform and VEGF promotes glioblastoma tumor growth. Cell Death Dis. 2022 Nov 26;13(11):1002. PMID: 36435833

48. Wang S, Park SH, Lim JS, Park YY, Du L, Lee JH. Phosphofructokinase 1 platelet isoform induces Pd-L1 expression to promote glioblastoma immune evasion. Genes Genomics. 2022 Aug 2. PMID: 35917090

47. Zhu J, Cheng H, Wang L, Xu W, Wang J, Han Q, Lee JH, Du L, Lyu J. Discoidin domain receptor 1 promotes lung adenocarcinoma migration via the AKT/snail signaling axis. Mol Biol Rep. 2022 Aug;49(8):7275-7286. Epub 2022 May 13. PMID: 35562515

46. Jeon SM, Lim JS, Park SH, Kim HJ, Kim HR, Lee JH. Blockade of PD-L1/PD-1 signaling promotes osteo-/odontogenic differentiation through Ras activation. Int J Oral Sci. 2022 Apr 1;14(1):18. PMID: 35365595

45. Li J, Zhang T, Ren T, Liao X, Hao Y, Lim JS, Lee JH, Li M, Shao J, Liu R. Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy. Nat Commun. 2022 Mar 4;13(1):1172. PMID: 35246531

44. Xiao Y, Li J, Liao X, He Y, He T, Yang C, Jiang L, Jeon SM, Lee JH, Chen Y, Liu R, Chen Q. RIOX1-demethylated cGAS regulates ionizing radiation-elicited DNA repair. Bone Res. 2022 Feb 24;10(1):19. PMID: 35210392

43. Li J, Shao J, Zeng Z, He Y, Tang C, Park SH, Lee JH, Liu R. Mechanosensitive turnover of phosphoribosyl pyrophosphate synthetases regulates nucleotide metabolism. Cell Death Differ. 2022 Jan;29(1):206-217. Epub 2021 Aug 31. PMID: 34465890

42. Jeon SM, Lim JS, Park SH, Lee JH. Wnt signaling promotes tumor development in part through phosphofructokinase 1 platelet isoform upregulation. Oncol Rep. 2021 Nov;46(5):234. Epub 2021 Sep 13. PMID: 34515327

41. Liu R, Li J, Shao J, Lee JH, Qiu X, Xiao Y, Zhang B, Hao Y, Li M, Chen Q. Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair. Cell Metab. 2021 Oct 5;33(10):2076-2089.e9. Epub 2021 Aug 2. PMID: 34343500.

40. Liu R*, Lee JH* (* Co-first authors), Li J, Yu R, Tan L, Xia Y, Zheng Y, Bian XL, Lorenzi PL, Chen Q, Lu Z. Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets. Mol Cell. 2021 Jul 1;81(13):2722-2735.e9. Epub 2021 Jun 1. PMID: 34077757

39. Jeon SM, Lim JS, Kim HR, Lee JH. PFK activation is essential for the odontogenic differentiation of human dental pulp stem cells. Biochem Biophys Res Commun. 2021 Mar 12;544:52-59. Epub 2021 Jan 29. PMID: 33516882

38. Mun JY, Baek SW, Park WY, Kim WT, Kim SK, Roh YG, Jeong MS, Yang GE, Lee JH, Chung JW, Choi YH, Chu IS, Leem SH. E2F1 Promotes Progression of Bladder Cancer by Modulating RAD54L Involved in Homologous Recombination Repair. Int J Mol Sci. 2020 Nov 27;21(23):9025. PMID: 33261027

37. Du L*, Lee JH* (*Co-first authors), Jiang H, Wang C, Wang S, Zheng Z, Shao F, Xu D, Xia Y, Li J, Zheng Y, Qian X, Li X, Kim HR, Xing D, Liu P, Lu Z, Lyu J. β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion. J Exp Med. 2020 Nov 2;217(11):e20191115. PMID: 32860047

36. Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, Hung MC, Lu Z. The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature. 2020 Apr;580(7804):530-535. Epub 2020 Apr 8. PMID: 32322062

35. Lee JH#, Shao F# (# Co-Corresponding authors), Ling J, Lu S, Liu R, Du L, Chung JW, Koh SS, Leem SH, Shao J, Xing D, An Z, Lu Z. Phosphofructokinase 1 Platelet Isoform Promotes β-Catenin Transactivation for Tumor Development. Front Oncol. 2020 Mar 5;10:211. PMID: 32195176

34. Wang S, Yao F, Lu X, Li Q, Su Z, Lee JH, Wang C, Du L. Temozolomide promotes immune escape of GBM cells via upregulating PD-L1. Am J Cancer Res. 2019 Jun 1;9(6):1161-1171. PMID: 31285949

33. Xu D, Li X, Shao F, Lv G, Lv H, Lee JH, Qian X, Wang Z, Xia Y, Du L, Zheng Y, Wang H, Lyu J, Lu Z. The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62. Sci Adv. 2019 Apr 24;5(4):eaav4570. PMID: 31032410

32. Lee JH, Liu R, Li J, Wang Y, Tan L, Li XJ, Qian X, Zhang C, Xia Y, Xu D, Guo W, Ding Z, Du L, Zheng Y, Chen Q, Lorenzi PL, Mills GB, Jiang T, Lu Z. EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation. Mol Cell. 2018 Apr 19;70(2):197-210.e7. PMID: 29677490

31. Kim B, Lee JH, Jin WJ, Kim HH, Ha H, Lee ZH. JN-2, a C-X-C motif chemokine receptor 3 antagonist, ameliorates arthritis progression in an animal model. Eur J Pharmacol. 2018 Mar 15;823:1-10. Epub 2018 Feb 4. PMID: 29378189.

30. Wang Y, Guo YR, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee JH, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J, He J, Xing D, Tao YJ, Lu Z. KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase. Nature. 2017 Dec 14;552(7684):273-277. Epub 2017 Dec 6. PMID: 29211711

29. Qian X, Li X, Tan L, Lee JH, Xia Y, Cai Q, Zheng Y, Wang H, Lorenzi PL, Lu Z. Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress. Cancer Discov. 2018 Jan;8(1):94-107. Epub 2017 Oct 26. PMID: 29074724

28. Lee JH, Liu R, Li J, Zhang C, Wang Y, Cai Q, Qian X, Xia Y, Zheng Y, Piao Y, Chen Q, de Groot JF, Jiang T, Lu Z. Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis. Nat Commun. 2017 Oct 16;8(1):949. PMID: 29038421

27. Lee JH*, Kim B* (* Co-first authors), Jin WJ, Kim HH, Ha H, Lee ZH. Pathogenic roles of CXCL10 signaling through CXCR3 and TLR4 in macrophages and T cells: relevance for arthritis. Arthritis Res Ther. 2017 Jul 19;19(1):163. PMID: 28724396

26. Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee JH, Li W, Lyu J, Rao G, Zhang X, Qian CN, Rozen SG, Jiang T, Lu Z. Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. Mol Cell. 2017 Jun 1;66(5):684-697.e9. Epub 2017 May 25. PMID: 28552616

25. Xia Y, Yang W, Fa M, Li X, Wang Y, Jiang Y, Zheng Y, Lee JH, Li J, Lu Z. RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis. J Exp Med. 2017 Jun 5;214(6):1843-1855. Epub 2017 May 15. PMID: 28507061

24. Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z. Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Mol Cell. 2017 Mar 2;65(5):917-931.e6. Epub 2017 Feb 23. PMID: 28238651

23. Lee JH, Ji H, Lu Z. FAM129B activates Ras and promotes aerobic glycolysis. Cell Cycle. 2016 Jun 2;15(11):1391-2. Epub 2016 Apr 25. PMID: 27111472

22. Li X, Qian X, Peng LX, Jiang Y, Hawke DH, Zheng Y, Xia Y, Lee JH, Cote G, Wang H, Wang L, Qian CN, Lu Z. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Nat Cell Biol. 2016 May;18(5):561-71. Epub 2016 Apr 18. Erratum in: Nat Cell Biol. 2016 May 27;18(6):709. PMID: 27088854

21. Ji H, Lee JH* (* Co-fisrt authors), Wang Y, Pang Y, Zhang T, Xia Y, Zhong L, Lyu J, Lu Z. EGFR phosphorylates FAM129B to promote Ras activation. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):644-9. Epub 2015 Dec 31. PMID: 26721396

20. Zheng Y, Li X, Qian X, Wang Y, Lee JH, Xia Y, Hawke DH, Zhang G, Lyu J, Lu Z. Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation. Nat Cell Biol. 2015 Oct;17(10):1348-55 Epub 2015 Aug 17. PMID: 26280537

19. Lee JH, Kim B, Jin WJ, Kim JW, Kim HH, Ha H, Lee ZH. Trolox inhibits osteolytic bone metastasis of breast cancer through both PGE2-dependent and independent mechanisms. Biochem Pharmacol. 2014 Sep 1;91(1):51-60. Epub 2014 Jun 11. PMID: 24929117

18. Kim SD, Kim HN, Lee JH, Jin WJ, Hwang SJ, Kim HH, Ha H, Lee ZH. Trapidil, a platelet-derived growth factor antagonist, inhibits osteoclastogenesis by down-regulating NFATc1 and suppresses bone loss in mice. Biochem Pharmacol. 2013 Sep 15;86(6):782-90. Epub 2013 Aug 6. PMID: 23928189

17. Kim HN, Lee JH, Jin WJ, Lee ZH. α-Tocopheryl Succinate Inhibits Osteoclast Formation by Suppressing Receptor Activator of Nuclear Factor-kappaB Ligand (RANKL) Expression and Bone Resorption. J Bone Metab. 2012 Nov;19(2):111-20. Epub 2012 Nov 16. PMID: 24524041 

16. Park JS, Park MK, Oh HJ, Woo YJ, Lim MA, Lee JH, Ju JH, Jung YO, Lee ZH, Park SH, Kim HY, Cho ML, Min JK. Grape-seed proanthocyanidin extract as suppressors of bone destruction in inflammatory autoimmune arthritis. PLoS One. 2012;7(12):e51377.  Epub 2012 Dec 10. PMID: 23251512 

15. Kim HN, Lee JH, Jin WJ, Ko S, Jung K, Ha H, Lee ZH. MS-275, a benzamide histone deacetylase inhibitor, prevents osteoclastogenesis by down-regulating c-Fos expression and suppresses bone loss in mice. Eur J Pharmacol. 2012 Sep 15;691(1-3):69-76. Epub 2012 Jul 27. PMID: 22846626. 

14. Lee JH, Kim HN, Kim KO, Jin WJ, Lee S, Kim HH, Ha H, Lee ZH. CXCL10 promotes osteolytic bone metastasis by enhancing cancer outgrowth and osteoclastogenesis. Cancer Res. 2012 Jul 1;72(13):3175-86. PMID: 22562465 (Research highlight on BoneKEy Reports)

13. Kim HN, Lee JH, Bae SC, Ryoo HM, Kim HH, Ha H, Lee ZH. Histone deacetylase inhibitor MS-275 stimulates bone formation in part by enhancing Dhx36-mediated TNAP transcription. J Bone Miner Res. 2011 Sep;26(9):2161-73. PMID: 21590736

12. Ha H, Lee JH, Kim HN, Lee ZH. α-Tocotrienol inhibits osteoclastic bone resorption by suppressing RANKL expression and signaling and bone resorbing activity. Biochem Biophys Res Commun. 2011 Mar 25;406(4):546-51. PMID: 21352805

11. Son J, Lee JH, Kim HN, Ha H, Lee ZH. cAMP-response-element-binding protein positively regulates breast cancer metastasis and subsequent bone destruction. Biochem Biophys Res Commun. 2010 Jul 23;398(2):309-14. PMID: 20599715

10. Lee JH*, Jin H* (* Co-first authors), Shim HE, Kim HN, Ha H, Lee ZH. Epigallocatechin-3-gallate inhibits osteoclastogenesis by down-regulating c-Fos expression and suppressing the nuclear factor-kappaB signal. Mol Pharmacol. 2010 Jan;77(1):17-25. PMID: 19828731

9. Kim HN, Ha H, Lee JH, Jung K, Yang D, Woo KM, Lee ZH. Trichostatin A inhibits osteoclastogenesis and bone resorption by suppressing the induction of c-Fos by RANKL. Eur J Pharmacol. 2009 Nov 25;623(1-3):22-9. PMID: 19766111

8. Lee JH, Kim HN, Yang D, Jung K, Kim HM, Kim HH, Ha H, Lee ZH. Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling. J Biol Chem. 2009 May 15;284(20):13725-34. PMID: 19299513

7. Kwak HB, Sun HM, Ha H, Kim HN, Lee JH, Kim HH, Shin HI, Lee ZH. Tanshinone IIA suppresses inflammatory bone loss by inhibiting the synthesis of prostaglandin E2 in Osteoblasts. Eur J Pharmacol. 2008 Dec 28;601(1-3):30-7. PMID: 18973753

6. Kwak HB, Sun HM, Ha H, Lee JH, Kim HN, Lee ZH. AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the Akt and ERK signaling pathways. Mol Cells. 2008 Nov 30;26(5):436-42. PMID: 18695355

5. Kwak HB, Ha H, Kim HN, Lee JH, Kim HS, Lee S, Kim HM, Kim JY, Kim HH, Song YW, Lee ZH. Reciprocal cross-talk between RANKL and interferon-gamma-inducible protein 10 is responsible for bone-erosive experimental arthritis. Arthritis Rheum. 2008 May;58(5):1332-42. PMID: 18438854

4. Ha H, Lee JH, Kim HN, Kwak HB, Kim HM, Lee SE, Rhee JH, Kim HH, Lee ZH. Stimulation by TLR5 modulates osteoclast differentiation through STAT1/IFN-beta. J Immunol. 2008 Feb 1;180(3):1382-9. PMID: 18209032

3. Kwak HB, Yang D, Ha H, Lee JH, Kim HN, Woo ER, Lee S, Kim HH, Lee ZH. Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1. Exp Mol Med. 2006 Jun 30;38(3):256-64. PMID: 16819284

2. Ha H, Lee JH, Kim HN, Kim HM, Kwak HB, Lee S, Kim HH, Lee ZH. alpha-Lipoic acid inhibits inflammatory bone resorption by suppressing prostaglandin E2 synthesis. J Immunol. 2006 Jan 1;176(1):111-7. PMID: 16365401