Precision Research in host Immunity & Systems Microbiology
PRISM Laboratory
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Research Concept
Our research objective is to comprehensively analyze intricate signaling networks within the various cell types of the oral & maxillofacial region. To achieve this, we have developed and applied innovative single-cell-based approaches tailored to a wide range of biological scenarios, with a particular focus on host-microbe interactions. The novel insights garnered from our research serve as a critical foundation for the advancement of therapeutic strategies targeting a diverse diseases in medicine and dentistry.
The primary methodologies employed in the CSN lab are as follows:
Optical approaches: These enable the real-time monitoring of dynamic changes in cell signaling activities through the use of ultra-fast and highly sensitive fluorescent biosensors.
NGS-based multiomics approaches: These methods uncover complex alterations in the genome, transcriptome, and proteome, collectively referred to as the 'regulome.' Additionally, they facilitate the integration of data across different levels, shedding light on the 'interactome' involving various cell types, including the oral microbiome.
Research Facilities
illumina Nextseq (SNU core facility)
Bulk and single cell sequencing
illumina Miseq (SNU Dent core facility)
Microbiome/metagenomic sequencing
Dell Server
NGS data Analysis
ZEISS LSM 800 (SNU core facility)
High resolution imaging
BioTek CYTATION5
Timelaps live cell imaging
Micro CT (SNU core facility)
High resolution 3D hard tissue image
News
March 2 Yongwon Oh, Doyeon An, and Hye Bin Im are new prospective graduate students in our lab. Please welcome them!
Jan 30 We are thrilled to announce that our latest paper on Integrative analysis of Orofacial Diseases by Byeong Soo Eom has been accepted in Nature Communications.
Jan 5 Junheon Yu joined our lab for his winter internship! Let's support his first journey as a researcher.
Recent Publications
K Nam*, BS Eom*, JY Kim, MG Lee, JM Lee, K Lee, JK Cha, JM Kim#, S Lee#, SJ Kim#, Integrative genomic analysis of 21 orofacial diseases identifies novel risk loci and shared genetic architecture with systemic diseases. Nature Communications, 2026 (Accepted)
Sol Jeong*, Jae-Kook Cha*, Wasim Ahmed*, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun-Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun-Young Kim, Jun-Seok Lee, Soonchul Lee#, Junwon Choi#, Jin Man Kim#. Development of MDM2-targeting PROTAC for Advancing Bone Regeneration. Advanced Science, 2025. (*co-first, #co-corresponding)
SY Park*, D Kim*, JW Jung, HJ An, J Lee, Y Park, D Lee, S Lee#, JM Kim#*. Targeting class A GPCRs for hard tissue regeneration. Biomaterials, 2023 (*co-first, #co-corresponding)
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