Laboratory of Cell Signaling Networks
CSN Laboratory
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Research Concept
Our research objective is to comprehensively analyze intricate signaling networks within the various cell types of the oral & maxillofacial region. To achieve this, we have developed and applied innovative single-cell-based approaches tailored to a wide range of biological scenarios, with a particular focus on host-microbe interactions. The novel insights garnered from our research serve as a critical foundation for the advancement of therapeutic strategies targeting a diverse diseases in medicine and dentistry.
The primary methodologies employed in the CSN lab are as follows:
Optical approaches: These enable the real-time monitoring of dynamic changes in cell signaling activities through the use of ultra-fast and highly sensitive fluorescent biosensors.
NGS-based multiomics approaches: These methods uncover complex alterations in the genome, transcriptome, and proteome, collectively referred to as the 'regulome.' Additionally, they facilitate the integration of data across different levels, shedding light on the 'interactome' involving various cell types, including the oral microbiome.
Research Facilities
illumina Nextseq (SNU core facility)
Bulk and single cell sequencing
illumina Miseq (SNU Dent core facility)
Microbiome/metagenomic sequencing
Dell Server
NGS data Analysis
ZEISS LSM 800 (SNU core facility)
High resolution imaging
BioTek CYTATION5
Timelaps live cell imaging
Micro CT (SNU core facility)
High resolution 3D hard tissue image
News
Aug 11 Dr. Seo-Young Lee has become a part of our lab as a new postdoctoral researcher! Anticipating the significant contributions she will make, we look forward to the positive impact she will bring to our team.
Aug 11 Eun Joong Kweon, our new PhD graduate student, joined our lab. She graduated her Master's degree in SNU College of Natural Science. Let's make great discoveries together!
June 10 Welcome Youn Ha Baek and Seung Oh Lee! They joined our lab for their summer internship. We will support their first step in research!
Mar 24 We are thrilled to announce that our latest paper on MDM2-Targeting PROTAC has been published in Advanced Science (Link). Congratulation to Sol Jeong for her exceptional dedication! We extend our sincere gratitude to all collaborators for making this achievement possible. Additionally, our paper has been selected for for Editor's Choice (Link) - don't miss the chance to explore our exciting contributions to this field!
Recent Publications
Sol Jeong*#, Jae-Kook Cha*, Wasim Ahmed*, Jaewan Kim#, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun-Ju An#, Seung Chan An, Jaemin Lee, Jimin Choi, Sun-Young Kim, Jun-Seok Lee, Soonchul Lee#, Junwon Choi#, Jin Man Kim#. Development of MDM2-targeting PROTAC for Advancing Bone Regeneration. Advanced Science, 2025. (*co-first, #co-corresponding)
SY Park*, D Kim*, JW Jung, HJ An, J Lee, Y Park, D Lee, S Lee#, JM Kim#*. Targeting class A GPCRs for hard tissue regeneration. Biomaterials, 2023 (*co-first, #co-corresponding)
JW Jung, SY Park, EJ Seo, IH Jang, Y Park, D Lee, D Kim*, JM Kim*. Functional expression of oxytocin receptors in pulp-dentin complex. Biomaterials, 2023 (*co-corresponding)
JM Kim*, Y Jo, JW Jung, K Park*, A mechanogenetic role of actomyosin complex in branching morphogenesis of epithelial organs. Development 148 (6), 2021 (*co-corresponding)
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