KY Huang Group

9. Ming-Shiu Lin, Tai-Ling Chao, Yu-Chi Chou, Yao Yi, Ci-ling Chen, Kuo-Yen Huang*, Sui-Yuan Chang*, Pan-Chyr Yang*. The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation. Journal of Biomedical Science. 2025 Jun 26;32(1):59.

8. Tong-Hong Wang #, Kuo-Yen Huang # (Co-first), Chin-Chuan Chen, Ya-Hsuan Chang, Hsuan-Yu Chen, Chuen Hsueh, Yi-Tsen Liu, Shuenn-Chen Yang, Pan-Chyr Yang*, Chi-Yuan Chen*. PM2.5 promotes lung cancer progression through activation of the AhR-TMPRSS2-IL18 pathway. EMBO Mol Med. 2023 Jun 7;15(6):e17014. 

7. Jia-You Fang #, Kuo-Yen Huang # (Co-first), Tong-Hong Wang#, Zih-Chan Lin, Chin-Chuan Chen, Sui-Yuan Chang, En-Li Chen, Tai-Ling Chao, Shuenn-Chen Yang, Pan-Chyr Yang*, Chi-Yuan Chen* Development of nanoparticles incorporated with quercetin and ACE2-membrane as a novel therapy for COVID-19. J Nanobiotechnology. 2024 Apr 12;22(1):169. 

6. Tong-Hong Wang, Yann-Lii Leu, Chin-Chuan Chen, Hsin-Jung Li, Shuenn-Chen Yang, Kuo-Yen Huang*, Chi-Yuan Chen* Psorachromene induces apoptosis and suppresses tumor growth in NSCLC cells harboring EGFR L858R/T790M/C797S. Phytother Res. 2022 May;36(5):2116-2126.

5. Kuo-Yen Huang, Ming-Shiu Lin, Ting-Chun Kuo, Ci-Ling Chen, Chung-Chih Lin, Yu-Chi Chou, Tai-Ling Chao, Yu-Hao Pang, Han-Chieh Kao, Rih-Sheng Huang, Steven Lin, Sui-Yuan Chang*, Pan-Chyr Yang*. Humanized COVID-19 decoy antibody effectively blocks viral entry and prevents SARS-CoV-2 infection. EMBO Mol Med 2021 6;13(1):e12828. 

4. Kuo-Yen Huang # (Co-first), Tong-Hong Wang #, Chin-Chuan Chen, Yann-Lii Leu, Hsin-Jung Li, Cai-Ling Jhong and Chi-Yuan Chen*. Growth Suppression in Lung Cancer Cells Harboring EGFR-C797S Mutation by Quercetin. Biomolecules. 2021 Sep; 11(9): 1271. 

3. Tong‐Hong Wang #, Chih‐Ching Wu #, Kuo‐Yen Huang # (Co-first), Yann‐Lii Leu, Shuenn‐Chen Yang, Ci‐Ling Chen and Chi‐Yuan Chen*. Integrated Omics Analysis of Non-Small-Cell Lung Cancer Cells Harboring the EGFR C797S Mutation Reveals the Potential of AXL as a Novel Therapeutic Target in TKI-Resistant Lung Cancer. Cancers (Basel). 2020 Dec 31;13(1):111. 

2. Kuo-Yen Huang, Shih-Han Kao, Wen-Lung Wang, Chi-Yuan Chen, Tzu-Hung Hsiao, Santosh B Salunke, Jeremy J W Chen, Kang-Yi Su, Shuenn-Chen Yang, Tse-Ming Hong*, Ching-Shih Chen*, Pan-Chyr Yang*. Small-molecule, T315, Promotes CBL-dependent Degradation of EGFR via Y1045 Autophosphorylation. Am J Respir Crit Care Med 2016 Apr 1;193(7):753-66. 

1. Li-Feng Hung #, Kuo-Yen Huang # (co-first), Deng-Ho Yang #, Deh-Ming Chang, Jenn-Haung Lai, Ling-Jun Ho*. Advanced glycation end products induce T cell apoptosis: Involvement of oxidative stress, caspase and the mitochondrial pathway. Mech Ageing Dev 2010;131(11-12):682-91.