Publications 成果發表

2022

• P. H. Chen, H. K. Lai, Y. C. Yeh, K. W. Chang, M. C. Hou, and W. C. Kuo*. En-face polarization-sensitive optical coherence tomography to characterize early-stage esophageal cancer and determine tumor margin, Biomed. Opt. Express, 13(9), 4773-4786, 2022.

• YS Fu, PR Chen, CC Yeh, JY Pan, WC Kuo*, KW Tseng*, Human Umbilical Mesenchymal Stem Cell Xenografts Repair UV-Induced Photokeratitis in a Rat Model. Biomedicines, 10(5), 1125, 2022.

• EYH Huang, MC Kao, CK Ting, WJS Huang, YT Yeh, HH Ke, WC Kuo*, Needle-Probe Optical Coherence Tomography for Real-Time Visualization of Veress Peritoneal Needle Placement in a Porcine Model: A New Safety Concept for Pneumoperitoneum Establishment in Laparoscopic Surgery. Biomedicines 10 (2), 485, 2022.

• Hao-Yu Tsai, Henkie Isahwan Ahmad Mulyadi Lai, Zhang-Yuan Chen, Tai-Chi Lin, Winnie Khor, Wen-Chuan Kuo, Jia-Pu Syu, Ping-Hsing Tsai, Yi-Ping Yang, Yueh Chien, Shih-Jen Chen, De-Kuang Hwang, Shih-Hwa Chiou, Shih-Jie Chou, Inhibition of DUSP6 Activates Autophagy and Rescues the Retinal Pigment Epithelium in Sodium Iodate-Induced Retinal Degeneration Models In Vivo and In Vitro. Biomedicines 10 (1), 159, 2022.

• PY Lai, TY Shih, CH Chang*, WC Kuo*, Applications of Multi-Contrast Optical Coherence Tomography in Assessment of Dysplastic Nevi to Malignant Melanoma. Frontiers in Physics, 146, 2022.

2021

• W. -C. Kuo*, M. -C. Kao, C. -K. Ting and W. -N. Teng. Optical coherence tomography needle probe in neuraxial block application. Accept to be published in IEEE Journal of Selected Topics in Quantum Electronics, doi: 10.1109/JSTQE.2020.3042076, 2021. (Impact factor: 4.917)

• Lai P-Y, Shih T-Y, Chang Y-H, Chou Y-S, Wu T-H, Su Y-Y, Chang C-H*, Kuo W-C*, In vivo Longitudinal Tracking of Lymphangiogenesis and Angiogenesis in Cutaneous Melanoma Mouse Model Using Multifunctional Optical Coherence Tomography, JID Innovations 2021, doi: https://doi.org/10.1016/j.xjidi.2021.100010.

• Wei-Nung Teng, Meng-ChunKao, Chien-Kun Ting, and Wen-Chuan Kuo*. Fibre-needle Swept-source Optical Coherence Tomography for the Real-time Visualization of the Fascia Plane Block Procedure in a Swine Model. Anesth Analg. 2020 Nov 30. doi: 10.1213/ANE.0000000000005288. Epub ahead of print. PMID: 33264115. (Impact factor: 4.305)

2020

• Pei-Yu Lai, Chung-Hsing Chang, Hong-Ren Su, and Wen-Chuan Kuo*. Lymphatic vessel segmentation in optical coherence tomography by added U-Net-based CNN for artifacts minimization, Biomedical Optics Express, 2020, 11, No. 5, 2679-2693, 2020. (Impact factor: 4.23)

• Ping-Hsien Chen, Hung-Yi Lee, Yi-Fen Chen, Yi-Chen Yeh, Kuo-Wei Chang, Ming-Chih Hou and Wen-Chuan Kuo*. Detection of Oral Dysplastic and Early Cancerous Lesions by Polarization-Sensitive Optical Coherence Tomography. Cancers 12, 2376, 1-18, 2020. (Impact factor: 6.102)

• P. H. Chen, Y. J. Chen, Y. J. Chen, Y. F. Chen, Y. C. Yeh, K. W. Chang, M. C. Hou, and W. C. Kuo*. Quantification of microvascular change for diagnosing early digestive squamous cell carcinoma by optical coherence tomography. Biomedical Optics Express, 2020. 11(3): p. 1244-1256. (Impact factor: 4.23)

2019

• Tulsi Anna, Mr. Sandeep Chakraborty, Chia-Yi Cheng, Vishal Srivastava, Arthur Chiou, and Wen-Chuan Kuo*, “Elucidation of microstructural changes in leaves during senescence using spectral domain optical coherence tomography,” Scientific Reports 9, 1167, 2019. (Impact factor: 3.998)

2018

• Jia-Pu Shu, Waradee Buddhakosai, Shih-Jen Chen, Chang-Chih Ke, Shih-Hwa Chiou, Wen-Chuan Kuo*, Supercontinuum source-based multi-contrast optical coherence tomography, Biomed. Opt. Express, 9(12), 6132-6144, 2018.

• Ai-Ho Liao, Ho-Chiao Chuang, Bo-Ya Chang, Wen-Chuan Kuo, Chih-Hung Wang, Hong-Wei Gao, and Chien-Ping Chiang, Combining microbubble contrast agent with pulsed-laser irradiation for transdermal drug delivery, Pharmaceutics 10, 175, 1-14, 2018.

• Mung-Chung Kao, Adrian Pegoraro, David M. Kingston, Albert Stolow, Wen-Chuan Kuo, Patrick H.J. Mercier, Ankur Gogoi1, Fu-Jen Kao and Andrew Ridsdale, “Direct mineralogical imaging of economic ore and rock samples with multi-modal non-linear optical microscopy,” Scientific Reports 8, 16917, 2018.

• Meng-Chun Kao, Yu-Te Wu, Mei-Young Tsou, Wen-Chuan Kuo*, Chien-Kun Ting*, “Intelligent Epidural Needle Placement using Fiber-Probe Optical Coherence Tomography in a Piglet Model,” Biomed. Opt. Express, 9 (8), 3711-3724, 2018.

• Wen‐Chuan Kuo*, Yue‐Ming Kuo, Jia‐Pu Syu, Han‐Lin Wang, Chi‐Ming Lai, Jia‐Wei Chen, Yu‐Chun Lo, and You‐Yin Chen*, “The use of intensity‐based Doppler variance method for single vessel response to functional neurovascular activation,” J. Biophotonics, e201800017, 2018.

• Ping-Hisen Chen, Chien-Hsien Wu, Yi-Fen Chen, Yi-Chen Yeh, Bo-Han Lin, Kuo-Wei Chang, Pei-Yu Lai, Ming-Chih Hou, Ching-Liang Lu, and Wen-Chuan Kuo*, "Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis Stages,” Biomed. Opt. Express 9(4), 1461-1476, 2018.

• T. Anna*, S. Chakraborty, A. Karmenyan, A. Chiou, W. C Kuo*, “En-face tomographic imaging of scattering objects using single broadband light emitting diode based full-field optical coherence microscopy,” Sovremennye tehnologii v medicine 10(1), 27, 2018.

2017

• Wen-Chuan Kuo, Meng-Chun Kao, Mei-Yung Tsou, Chien-Kun Ting. In vivo images of the epidural space with two and three-dimensional optical coherence tomography in a porcine model. PLoS One 2017; 12(2):0172149 (14 pages).

• Tulsi Anna, Ting-Wei Chang, Chih-Ming Lai, Arthur Chiou, and Wen-Chuan Kuo*, A Feasibility Study of Broad-Band White Light Emitting Diode (WLED) based Full-Field Optical Coherence Microscopy (FF-OCM) using Derivative-based Algorithm, IEEE photonics Journal 2017; 9(2):3900513.

2016

• Michael G. Sowa, Wen-Chuan Kuo, Alex C-T. Ko, David G. Armstrong. Review of near-infrared methods for wound assessment. J. Biomed Opt. 2016; 21(9):091304 (17 pages).

• W. C. Kuo, Y. M. Kuo, and S. Y. Wen*. Quantitative and rapid estimations of human sub-surface skin mass using ultra-high-resolution spectral domain optical coherence tomography. Journal of Biophotonics 2016; 9(4):343–350.

2015

• Wen-Chuan Kuo, Meng-Chun Kao, Kuang-Yi Chang, Wei-Nung Teng, Mei-Yung Tsou, Yin Chang, Chien-Kun Ting. Fiber-needle Swept-source Optical Coherence Tomography System for the Identification of the Epidural Space in Piglets. Anesthesiology 2015; 122(3):585-94. (Impact factor: 5.555; Rank: 8.07%)

• Meng-Chum Kao, Che-Yen Kung, Chun-Li Lin, and Wen-Chuan Kuo*. Simultaneous measurement of multiple scattering coefficient and scattering anisotropy factor for quantitative assessment of dental tissue. Journal of Medical Imaging and Health Informatics 2015; 5(8):1859-1863.

• Chih-Chia Huang*, Po-Yang Chang, Chien-Liang Liu, Jia-Pu Xu, and Wen-Chuan Kuo*. New insight on optical Fe3O4 nanoclusters promising for near infrared theranostic applications. Nanoscale 2015; 7(29):12689-12697. (Impact factor: 7.76; Rank: 7.93%)

• Meng-Chum Kao, Chun-Li Lin, Che-Yen Kung, Y. F. Huang, and Wen-Chuan Kuo*. Miniature endoscopic optical coherence tomography for calculus detection. Appl. Opt. 2015; 54(24):7419-7423.

2014

• Chun-Li Lin, Wen-Chuan Kuo, Yen-Hsiang Chang, Jin-Jie Yu, Yun-Chu Lin. Examination of ceramic/enamel interfacial debonding using acoustic emission and optical coherence tomography. Dental Materials 2014; 30:910-916. (Impact factor: 4.039; Rank: 7.14%)

• Hermann Lin, Meng-Chun Kao, Chih-Ming Lai, Jyun-Cin Huang, and Wen-Chuan Kuo*. All fiber optics circular-state swept source polarization-sensitive optical coherence tomography. Journal of Biomedical Optics 2014; 19(2):021110 (9 pages).

• Fang-Tsu Liao, Po-Nien Yang, Cheng-Yi Chang, Shou-Yuan Guo, Ming-Tsan Su, and Wen-Chuan Kuo*. Necessity of angiotensin-converting enzyme-related gene for cardiac functions and longevity of Drosophila melanogaster assessed by optical coherence tomography. Journal of Biomedical Optics 2014; 19(1):011014.

• Wen-Chuan Kuo, Book chapter, The Current Trends of Optics and Photonics, Topics in Applied Physics/Optical Coherence Tomography for Quantitative Diagnosis in Cardiovascular Disease, 2014 Springer. (978-94-017-9392-6)

2013

• C. L. Lin, W. C. Kuo, J. J. Yu, and S. F. Huang. Examination of ceramic restorative material interfacial debonding using acoustic emission and optical coherence tomography. DENTAL MATERIALS 2013; 29(4): 382-388.

• Shou-Yuan Guo, Fang-Tsu Liao, Ming-Tsan Su, Cheng-Yi Chang,Hong-Ren Su, Jyun-Cin Huang, and Wen-Chuan Kuo*. Semi-automatic and rapid quantification of heartbeat parameters in Drosophila by using OCT imaging. JOURNAL OF BIOMEDICAL OPTICS 2013; 18(2):026004-1~026004-8.

• Wen-Chuan Kuo, Chih-Ming Lai, Yi-Shiang Huang, Cheng-Yi Chang. Balanced detection for spectral domain optical coherence tomography. Optics Express 2013; 21(16):19280-19291.

• Wen-Chuan Kuo, Yu-Ki Bao, and Chih-Ming Lai. Simultaneous measurement of refractive index and thickness of transparent material by dual-beam confocal microscopy. Measurement Science and Technology 2013; 24:075003 (5 pages) .

2012

• Wen-Chuan Kuo, Yune-Shee Lai, Chih-Ming Lai, and Yi-Shiang Huang. Balanced-Detection Spectral Domain OCT with a Multi-line Single Camera for SNR Enhancement. APPLIED OPTICS 2012; 51(24):5936-5940.

2010

• M. H. Liu, W. C. Kuo, H. C. Wei, C. C. Tsai, C. J. Yu, B. J. Liang, and Chien Chou. Cell parameter measurement of a twisted nematic liquid crystal device using interferometric polarimeter under normal incidence. OPTICS EXPRESS 2010; 18(9):8795-8766 .

• Wen-Chuan Kuo*, Shey-Chien Lin, and Chung-Yu Chuang. Birefringence measurement in polarization sensitive optical coherence tomography using differential-envelope detection method. REVIEW OF SCIENTIFIC INSTRUMENTS 2010; 81:053705-1~053705-6.

• W.-C. Kuo, C.-Y. Chuang, M.-Y. Chou, W.-H. Huang and S.-T. Cheng. Phase detection with sub-nanometer sensitivity using polarization quadrature encoding method in optical coherence tomography. Progress in Electromagnetics Research-PIER 2010; 104:297-311.

• W. C. Kuo. Optical Coherence Tomography: Introduction of Basics and Progress. 光學工程 2010; 112:35-42 (DI).

• W. C. Kuo. Polarization-Sensitive Optical Coherence Tomography in Cardiology, Advances in Lasers and Electro Optics, Ch. 31, Vedran Kordic, Eds., IN-TECH, Vienna, Austria 2010. (978-953-307-088-9)

2009

• Wen-Chuan Kuo, Fu-Jay Juang, Hong-Ren Su, and Mei-Li Hsieh. Non-destructive nano-scale profile measurement on two-dimensional photonic crystal structure using differential confocal microscopy. JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B 2009; 27(4):1805-1808.

• W. C. Kuo, C. H. Chan, C. H. Chou, and JC-H Cheng. Swept source optical coherence tomography for radiation-enhanced hepatocellular carcinoma cell invasion imaging. PHYSICS IN MEDICINE AND BIOLOGY 2009; 54(13):4289-4297.

• Wen-Chuan Kuo, Wei-Chien Lin, Shey-Chien Lin, and Chih-Ming Lai. Analog-based detection method in optical low-coherence reflectometer for measurement of retardation and fast-axis orientation. JOURNAL OF ELECTROMAGNETIC WAVES AND APPLICATIONS 2009; 23(5):523-533.

• Jeou-Jong Shyu, Che-Hung Chan, Ming-Wei Hsiung, Po-Nien Yang, Huei-Wen Chen, and Wen-Chuan Kuo. Diagnosis of articular cartilage damage by polarization-sensitive optical coherence tomography and the extracted optical properties. Progress in Electromagnetics Research-PIER 2009; 91:365-376.

• 郭文娟. 光學同調斷層攝影術(optical coherence tomography)的原理與應用. 科技發展政策報導(行政院國家科學委員會科學技術資料中心出版) 2009; 6 (OI).

2008

• Wen-Chuan Kuo*, Ming-Wei Hsiung, Jeou-Jong Shyu, Nai-Kuan Chou, and Po-Nien Yang. Assessment of arterial characteristics in human atherosclerosis by extracting optical properties from polarization-sensitive optical coherence tomography. OPTICS EXPRESS 2008; 16(11):8117-8125.

• Huan-Jang Huang, Tsung-Yu Hsieh, Li-Dek Chou, Wen-Chuan Kuo, and Chien Chou. Analog differential-phase detection in optical coherence reflectometer. OPTICS EXPRESS 2008; 16(17):12847-12858.

2007

• Wen-Chuan Kuo, Nai-Kuan Chou, Chien Chou, Chih-Ming Lai, Huan-Jang Huang, and Jeou-Jong Shyu. Polarization-Sensitive Optical Coherence Tomography for Imaging Human Atherosclerosis. APPLIED OPTICS 2007; 46(13):2520-2527.

• Wen-Chuan Kuo, Ming-Wei Hsiung, and Po-Nien Yang. Extracting quantitative optical properties of human vessel from PS-OCT images. Journal of Medical and Biological Engineering 2007; 27(4):191-197.

2006

• 郭文娟. 非侵入式生醫斷層影像簡介. 物理雙月刊 2006; 28(4):698-703 (DI).

• Chien Chou, Hsieh-Ting Wu, Yen-Chen Huang, Yi-Ling Chen, and Wen-Chuan Kuo. Characteristics of a paired surface plasma waves biosensor. OPTICS EXPRESS 2006; 14:4307-4315.

2005

• Wen-Chuan Kuo, Huan-Jang Huang, Chih-Ming Lai, Gwo-Jen Jan, Chien Chou. Polarization sensitive optical coherence tomography using only linearly polarized light. OPTICAL AND QUANTUM ELECTRONICS 2005; 37:1213–1223.

• Wen-Chuan Kuo, Yi-Sheng Liao, Gwo-Jen Jan, Hui-Kang Teng, Chien Chou. Simultaneous Measurement of Phase Retardation and Fast Axis Angle of a Phase Retardation Plate. JAPANESE JOURNAL OF APPLIED PHYSICS 2005; 44(2):1095-1100.

2004

• Chien Chou, W. C. Kuo, T. S. Hsieh, H. K. Teng. A phase sensitive optical rotation measurement in a scattered chiral medium using a Zeeman laser. OPTICS COMMUNICATIONS 2004; 230:259-266.

2003

• C. Chou, W. C. Kuo, C. Y. Han. Circular Polarized Optical Heterodyne Interferometer on Optical Activity Measurement of a Quartz Crystal. APPLIED OPTICS 2003; 42(25):5096-5100.

• W. C. Kuo, C. Chou, H. T. Wu. Optical heterodyne surface plasmon resonance biosensor, 28(15). OPTICS LETTERS 2003; 28(15):1329-1331.

專利權

• 台灣：申請/證書號

1.偵測與分析消化道黏膜之方法及系統 106116102

2.取得分類歸納邊界之方法及其應用之自動辨識方法與系統 105113957

3.平衡偵測光譜域光學同調斷層掃描系統 I 465686

• 美國：申請/證書號

1. Method of obtaining a classification line and automatic recognition method and system using the same 15/204,478

2. Optical tomography method & device, US20070236699A1

3. Optical image guided probe device, USA invention patent submitted, 2020/01/09.

4. Method and system for detecting and analyzing mucosa of digestive tract US18/32999

非專屬技術授權

1. Low coherence interference imaging technology

2. long range swept source optical coherence tomography for full eye imaging

3. High resolution spectral domain optical coherence tomography for retinal imaging