Publications

Moreno TM, Brown ME, Kumsta C. Hyperactivation of mTORC1 by an endogenous raga-1 gain-of-function mutation does not reduce lifespan in C. elegans. MicroPubl Biol. 2025 Apr 25;2025:10.17912/micropub.bio-logy.001520. doi: 10.17912/micropub.biology.001520. eCollection 2025. PMID: 40385374 Article Link 

Moreno TM, Nieto-Torres JL, Kumsta C. Monitoring Autophagy in Human Aging: Key Cell Models and Insights. Front Biosci (Landmark Ed). 2025 Mar 20;30(3):27091. doi: 10.31083/FBL27091. PMID: 40152379 Review. Article Link 

Brown ME, Hernandez-Urbina DA, Kumsta C. Low Humidity enhances thermotolerance in Caenorhabditis elegans. MicroPubl Biol. 2024 Nov 23;2024:10.17912/micropub.biology.001404. doi: 10.17912/micropub.biology.001404. eCollection 2024. PMID: 39650082 Article Link

Lim SHY, Hansen M, Kumsta C. Molecular Mechanisms of Autophagy Decline During Aging. Cells 2024, 13, 1364. Article Link 

Sun LH, Lange CM, Hansen M, Kumsta C. Neuronal waste management: new roles for autophagy genes in the extrusion of protein aggregates and in longevity. Autophagy. 2024 Mar 6:1-3. doi: 10.1080/15548627.2024.2322 420. PMID: 38411179 Article Link 

Yang Y, Arnold ML, Lange CM, Sun LH, Broussalian M, Doroodian S, Ebata H, Choy EH, Poon K, Moreno TM, Singh A, Driscoll M, Kumsta C*, Hansen M*. Autophagy protein ATG-16.2 and its WD40 domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans neurons. Nature Aging. 2024 Feb;4(2):198-212. doi: 10.1038/s43587-023-00548-1. PMID: 38177330  *Co-Corresponding Authors Article Link
 

Chamoli M, Rane A, Foulger A, Chinta SJ, Shahmirzadi AA, Kumsta C, Nambiar DK, Hall D, Holcom A, Angeli S, Schmidt M, Pitteri S, Hansen M, Lithgow GJ, Andersen JK. A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan. Nature Aging. 2023 Dec;3(12):1529-1543. doi: 10.1038/s43587-023-00524-9. PMID: 37957360 

Lim C-Y, Lin H-T, Kumsta C, Lu T-C, Wang F-Y, Kang Y-H, Hansen M, Ching T-T, Hsu A-L. SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity. Autophagy. 2022 May 3;1-17. doi:10.1080/15548627.2022.2068267. Online ahead of print. PMID: 35503435

Moreno TM, Lange CM, and Kumsta C. Transcriptional regulation of autophagy in aging. Current Opinion in Physiology. 2022, ISSN: 2468-8673, vol. 29. p.100591.2022

Pre-Print

Singh A, Kaduskar B, Reddy KC, Kumsta C, Bier E, Hansen M, Chalasani SH. Conserved neuropeptidergic regulation of intestinal integrity in invertebrate models of aging. bioRxiv 2022.02.24.481867; doi: https://doi.org/10.1101/2022.02.24.481867

Klionsky DJ, (…), Kumsta C, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751

Aragonès G, Dasuri K, Olukorede O, Francisco SG, Renneburg C, Kumsta C, Hansen M, Kageyama S, Komatsu M, Rowan S, Volkin J, Workman M, Yang W, Daza P, Ruano D, Dominguez-Martín H, Rodríguez-Navarro JA, Du XL, Brownlee MA, Bejarano A, Taylor A. Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability. Aging Cell 2020 Nov 4:e13257. doi: 10.1111/acel.13257. Epub 2020 Nov 4. PMID: 33146912

Chang JT, Hansen M, and Kumsta C. Assessing tissue-specific autophagic flux in adult Caenorhabditis elegans. Methods Mol Biol 2020, 187-200, doi:10.1007/978-1-0716-0592-9_17. PMID: 32410036

Aparicio R, Hansen M, Walker DW, Kumsta C. The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner. Autophagy. 2020 Apr;16(4):772-774. doi: 10.1080/15548627.2020.1725404. Epub 2020 Feb 10. PMID: 32041473

Kumsta C*, Chang JT, Lee R, Tan EP, Yang Y, Choy E, Hansen M*. The autophagy receptor p62/SQSTM1/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy” Nature Commun. 2019 Dec 11;10(1):5648. doi: 10.1038/s41467-019-13540-4. PMID: 31827090 * Co-corresponding authors

Kumsta C and Hansen M. Getting under the skin: Cuticle damage elicits systemic autophagy response in C. elegans. J Cell Biol. 2019 Dec 2;218(12):3885-3887. doi: 10.1083/jcb.201911020. Epub 2019 Nov 13. PMID: 31723005

Zhou B, Kreuzer J, Kumsta C, Wu L, Kamer KJ, Cedillo L, Zhang Y, Li S, Kacergis MC, Webster CM, Fejes-Toth G, Naray-Fejes-Toth A, Das S, Hansen M, Haas W, Soukas AA. Mitochondrial permeability uncouples elevated autophagy and lifespan extension. Cell. 2019 Apr 4;177(2):299-314.e16. doi: 10.1016/j.cell.2019.02.013. Epub 2019 Mar 28. PMID: 30929899

Lubas M, Harder LM, Kumsta C, Tiessen I, Hansen M, Andersen JS, Lund AH, Frankel LB. eIF5A is required for autophagy by mediating ATG3 translation. EMBO Rep. 2018 Jun;19(6). Pii: e46072. Doi: 10.15252/embr.201846072. PMID: 29712776

Chang JT, Kumsta C, Hellman AB, Adams LM, Hansen M. Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging. Elife. 2017 Jul 4;6. Pii: e18459. Doi: 10.7554/eLife.18459. PMID: 28675140

Kumsta C, Chang JT, Schmalz J, Hansen M. Hormetic heat stress induces autophagy via HSF-1 to improve survival and proteostasis in
C. elegans. Nature Commun. 2017 Feb 15;8:14337. Doi: 10.1038/ncomms14337. PMID: 28198373

Kumsta C, Hansen M. Hormetic heat shock and HSF-1 overexpression improve C. elegans survival and proteostasis by inducing autophagy. Autophagy. 2017 Mar 23:1-2. Doi: 10.1080/15548627.2017.1299313. PMID: 28333578

Gelino S, Chang JT, Kumsta C, She X, Davis A, Nyugen C, Panowski S, Hansen M. Intestinal Autophagy Improves Healthspan and Longevity in C. elegans During Dietary Restriction. PLOS Genetics. 2016 Aug 16;12(8):e1006271. Doi: 10.1371/journal.pgen.1006271. eCollection 2016 Aug. PMID: 27529578

McQuary PR, Liao CY, Chang JT, Kumsta C, She X, Davis A, Chu CC, Gelino S, Gomez-Amaro RL, Petrascheck M, Brill LM, Ladiges WC, Kennedy BK, Hansen M. C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension. Cell Reports. 2016 Mar 8;14(9):2059-67. Doi: 10.1016/j.celrep.2016.02.012. PMID: 26923601

Zhang H, Chang JT, Guo B, Hansen M, Jia K, Kovács AL, Kumsta C, Lapierre LR, Legouis R, Lin L, Lu Q, Meléndez A, O’Rourke EJ, Sato K, Sato M, Wang X, Wu F. Guidelines for monitoring autophagy in Caenorhabditis elegans. Autophagy. 2015; 11(1):9-27. Doi: 10.1080/15548627.2014.1003478. PMID: 25569839

Lapierre LR*, Kumsta C*, Sandri M, Ballabio A, Hansen M. Transcriptional and epigenetic regulation of autophagy in aging. Autophagy. 2015;11(6):867-80. Doi: 10.1080/15548627.2015.1034410. PMID: 25836756 * Co-first authors

Kumsta C, Ching T-T, Nishimura M, Davis AE, Gelino S, Catan HH, Yu X, Chu C-C, Ong B, Panowski SH, Baird N, Bodmer R, Hsu A-L, Hansen M. Integrin-linked kinase modulates longevity and thermotolerance in C. elegans through neuronal control of HSF-1. Aging Cell. 2014 Jun;13(3):419-30. Doi: 10.1111/acel.12189. PMID: 24314125

Nishimura N, Kumsta C, Kaushik G, Diop SB, Ding Y, Bisharat-Kernizan J, Catan HH, Cammarato A, Ross RS, Engler AJ, Bodmer R, Hansen M, Ocorr K. A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging. Aging Cell. 2014 Jun;13(3):431-40. Doi: 10.1111/acel.12193. PMID: 24400780

Kumsta C and Hansen M. C. elegans rrf-1 Mutations Maintain RNAi Efficiency in the Soma in Addition to the Germline. PLOS One. 2012; 7(5):e35428. Doi: 10.1371/journal.pone.0035428. PMID: 22574120

Kumsta C, Thamsen M, Jakob U. Effects of Oxidative Stress on Behavior, Physiology, and the Redox Thiol Proteome of Caenorhabditis elegans. Antioxid Redox Signal. 2011 Mar 15;14(6):1023-37. Doi: 10.1089/ars.2010.3203. PMID: 20649472

Thamsen M, Kumsta C, Li F, Jakob U. Is Overoxidation of Peroxiredoxin Physiologically Significant? Antioxid Redox Signal. 2011 Feb 15;14(4):725-30. Doi: 10.1089/ars.2010.3717. PMID: 20964547

Kumsta C and Jakob U. Redox-regulated Chaperones. Biochemistry. 2009 Jun 9;48(22):4666-76. Doi: 10.1021/bi9003556. Review. PMID: 19368357

Ilbert M, Kumsta C, Jakob U. Cellular Responses to Oxidative Stress. In: Oxidative Folding of Peptides and Proteins. Editors: Johannes Buchner, Luis Moroder, published by Royal Society of Chemistry, 2009, p.158-178