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The expression of G2/M gene is repressed by the binding of DREAM to the CHR promoter during G0/G1 cell-cycle phase.
In early S phase, MMB binds to the CHR.
MMB recruits FOXM1 which initiate transcription.
In G2, M phase, B-MYB is degraded and the G2/M gene expression is maximized.
3 most common sequences:
-TTTGAA (CCNB2)
-TTTAAA
-TTCGAA (BUB1)
BUB1:
-Regulates spindle assembly checkpoint
-Kinase (STK) activity
-Chromosome alignment and segregation
CCNB2:
-Regulation of cell cycle
-CDK1 activation
-Mitotic progression
Idasanutlin treatment to study CHR-dependent gene repression
Main Questions
Main Questions
What are the consequences of CHR inactivation?
2. How does the inactivation of CHR affect mRNA and protein expression of G2/M genes?
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