Embedded Files
Small (2018)
Theranostics (2017)
Mol Ther (2014)
Peer-reviewed Papers:
Peer-reviewed Papers:
Heo S, Ryu Y, Kim S, Lee CK, Bae J, Jo SM, LeeJJ. Development of an EGFR-Targeted Adenoviral E4orf4 Protein Nanoparticle for Cancer Therapy. Biotechnol. Bioprocess Eng. 2026 In press.
Ryu DH, You DH, Jung MK, Lee JS, Park S, Hong CA, Ryu Y, Lee JJ, Jo SM. Anticancer Strategy Based on Glucose Oxidase-induced Oxidative Stress. KSBB Journal. 2025 Sep 30; 40(3): 229-241.
Bae J, Ryu Y, Choi J, Jeong MS, Lee CK, Hong CA, Ji S, Heo S, Kim S, Jo SM, Lee JJ. Exploring Multivalency-driven Sensitivity Modulation for Optimization and Fine-Tuning of Avidity-based Biosensors. Biosens. Bioelectron. 2025 Mar 1;271:116989.
Heo S, Baek J, Bae J, Seo BA, Kim S, Jeong S, Kim S, Ryu Y, Lee JJ. Protein Ligation-assisted Reconstitution of Split HRP Fragments for Facile Production of HRP-fusion Proteins in E.coli. ChemBioChem. 2023 Jun 1;24(11):e202200700.
Kim S, Hong EH, Lee CK, Ryu Y, Jeong H, Heo S, Lee JJ, Ko HJ. Amelioration of DSS-induced Acute Colitis in Mice by Recombinant Monomeric Human Interleukin-22. Immune Netw. 2022 Jun;22(3):e26.
Kwon J, Cho H, Kim S, Ryu Y, Lee JJ. A Combination Strategy of Solubility Enhancers for Effective Production of Soluble and Bioactive Human Enterokinase. J Biotechnol. 2021 Nov;340:57-63.
Song Y, Jeong H, Kim SR, Ryu Y, Baek J, Kwon J, Cho H, Kim KN, Lee JJ. Dissecting the Impact of Target Binding Kinetics of Protein Binders on Tumor Localization. iScience. 2021 Feb;24(2):102104.
Sohn YK, Son S, Choi Y, Hwang DE, Seo HD, Lee JJ, Kim HS. Effective inhibition of C3a-mediated pro-inflammatory response by a human C3a-specific protein binder. Biotechnol. Bioeng. 2020 Jun;117(6):1904-1908 .
Ryu Y, Hong CA, Song Y, Beak J, Seo BA, Lee JJ, Kim HS. Modular Protein-DNA Hybrid Nanostructures as a Drug Delivery Platform. Nanoscale. 2020 Feb 27;12(8):4975-4981.
Ryu Y, Kang JA, Kim D, Kim SR, Kim S, Park SJ, Kwon SH, Kim KN, Lee DE, Lee JJ, Kim HS. Programed assembly of nucleoprotein nanoparticles using DNA and zinc fingers for targeted protein delivery. Small. 2018 Dec;14(52):e1802618. (Inside cover)
Seo BA, Cho T, Lee DZ, Lee JJ, Lee B, Kim SW, Shin HS, Kang MG. LARGE, an intellectual disability-associated protein, regulates AMPA-type glutamate receptor trafficking and memory. Proc Natl Acad Sci USA. 2018 Jul 3;115(27):7111-7116.
Kim TY, Seo HD, Lee JJ, Kang JA, Kim WS, Kim HM, Song HY, Park JM, Lee DE, Kim HS. A dimeric form of a small-sized protein binder exhibits enhanced anti-tumor activity through prolonged blood circulation. J Control Release. 2018 Jun 10;279:282-291.
Kim JW, Lee JJ, Choi JS, Kim HS. Electrostatically assembled dendrimer complex with a high-affinity protein binder for targeted gene delivery. Int J Pharm. 2018 Jun 10;544(1): 39-45.
Pyo A, Yun M, Kim HS, Kim TY, Lee JJ, Kim JY, Lee S, Kwon SY, Bom HS, Kim HS, Kim DY, Min JJ. (64)Cu-Labeled Repebody Molecules for Imaging of Epidermal Growth Factor Receptor Expressing Tumors. J Nucl Med. 2018 Feb;59(2):340-346.
Mushtaq S, Rho JK, Kang JA, Lee JJ, Kim JY, Nam YR, Yun SJ, Lee GH, Park SH, Lee DE, Kim HS. Radiolabeling and preliminary biodistribution study of (99m)Tc-labeled antibody-mimetic scaffold protein repebody for initial clearance properties. Bioorg Med Chem Lett. 2017 Nov 15;27(22):5060-5064.
Yun M, Kim DY, Lee JJ, Kim HS, Kim HS, Pyo A, Ryu Y, Kim TY, Zheng JH, Yoo SW, Hyun H, Oh G, Jeong J, Moon M, Min JH, Kwon SY, Kim JY, Chung E, Hong Y, Lee W, Kim HS, Min JJ. A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors. Theranostics. 2017 Sep;7(10):2620-2633. (Back cover)
Lee JJ, Kang JA, Ryu Y, Han SS, Nam YR, Rho JK, Choi DS, Kang SW, Lee DE, Kim HS. Genetically engineered and self-assembled oncolytic protein nanoparticles for targeted cancer therapy. Biomaterials. 2017 Mar;120:22-31.
Seo HD, Lee JJ, Kim YJ, Hantschel O, Lee SG, Kim HS. Alkaline phosphatase-fused repebody as a new format of immuno-reagent for an immunoassay. Anal Chim Acta. 2017 Jan 15;950:184-191.
Hwang DE, Choi JM, Yang CS, Lee JJ, Heu W, Jo EK, Kim HS. Effective suppression of C5a-induced proinflammatory response using anti-human C5a repebody. Biochem Biophys Res Commun. 2016 Sep 2;477(4):1072-7.
Kim HY, Lee JJ, Kim N, Heo WD, Kim HS. Tracking protein-protein interaction and localization in living cells using a high-affinity molecular binder. Biochem Biophys Res Commun. 2016 Feb 19;470(4):857-63.
Lee JJ, Choi HJ, Yun M, Kang Y, Jung JE, Ryu Y, Kim TY, Cha YJ, Cho HS, Min JJ, Chung CW, Kim HS. Enzymatic prenylation and oxime ligation for the synthesis of stable and homogeneous protein-drug conjugates for targeted therapy. Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12020-4. (Hot paper)
Jo SM, Lee JJ, Heu W, Kim HS. Nanotentacle-structured magnetic particles for efficient capture of circulating tumor cells. Small. 2015 Apr 24;11(16):1975-82.
Ryu Y, Jin Z, Lee JJ, Noh SH, Shin TH, Jo SM, Choi J, Park H, Cheon J, Kim HS. Size-controlled construction of magnetic nanoparticle clusters using DNA-binding zinc finger protein. Angew Chem Int Ed Engl. 2015 Jan 12;54(3):923-6.
Ryou JH, Park K, Lee JJ, Kim D, Kim HS. Soluble expression of human glycoprotein Ibα in Escherichia coli through replacement of the N-terminal capping domain. Protein Expr Purif. 2014 Sep;101:21-7.
Heu W, Choi JM, Lee JJ, Jeong S, Kim HS. Protein binder for affinity purification of human immunoglobulin antibodies. Anal Chem. 2014 Jun 17;86(12):6019-25.
Lee Y, Lee JJ, Kim S, Lee SC, Han J, Heu W, Park K, Kim HJ, Cheong HK, Kim D, Kim HS, Lee KW. Dissecting the critical factors for thermodynamic stability of modular proteins using molecular modeling approach. PLoS One. 2014 May 21;9(5):e98243.
Lee JJ, Kim HJ, Yang CS, Kyeong HH, Choi JM, Hwang DE, Yuk JM, Park K, Kim YJ, Lee SG, Kim D, Jo EK, Cheong HK, Kim HS. A high-affinity protein binder that blocks the IL-6/STAT3 signaling pathway effectively suppresses non-small cell lung cancer. Mol Ther. 2014 Jul;22(7):1254-65. (Front cover)
Lee SC, Park K, Han J, Lee JJ, Kim HJ, Hong S, Heu W, Kim YJ, Ha JS, Lee SG, Cheong HK, Jeon YH, Kim D, Kim HS. Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering. Proc Natl Acad Sci USA. 2012 Feb 28;109(9):3299-304.
Registered Patents:
Registered Patents:
Human enterokinase fusion protein with improved expression level and solubility and a preparing method thereof (10-2643064, KR)
Streptactin conjugated quantum dot and process for preparing the same (10-0172929, KR)
Water-Soluble Polypeptides Comprised of Repeat Modules, Method for Preparing the Same and Method for A Target-Specific Polypeptide and Analysis of Biological Activity Thereof (9,441,017, US)
Repebody-Protein toxin Conjugate, Preparation Methods and Use Thereof (10-1751501, KR)
Repebody Against Immunoglobulin G and Uses Thereof (10-1654890, KR)
Novel polypeptide binding with human complement component 5a and Uses Thereof (10-1624702, KR)
Novel Polypeptides Binding with red fluorescent protein (10-1624703, KR)
Novel Polypeptide Binding with Ectodomain of Human Epidermal Growth Factor Receptor (10-1587622, KR)
Method for Improving Repebody Containing Repeat Module (10-1572219, KR)
Novel Polypeptides Binding with Interleukin-6 and Uses Thereof (10-1517196, KR)
Novel polypeptide binding with interleukin-6 (10-1356075, KR)
Novel MD-2 binding polypeptide and the use thereof (10-1255682, KR)
Internalin-fused soluble Leucin-Rich Repeat (LRR) family proteins and method for preparing the same (10-1219628, KR)
Novel polypeptide selective binding with mouse immunoglobulin G or rabbit immunoglobulin G and uses thereof (10-1818152, KR)
A Novel Modified Ornithine Decarboxylase Protein and a Use thereof (6239108, JP)
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