Publications

Jeong, et al. (2025) Nature Communications (한빛사: https://buly.kr/4mcbrVz)

Liu, et al. (2024) Aging Cell 

Ryu and Hochstrasser (2021) Nucleic Acids Research (한빛사: https://han.gl/ySTOa)

Choi, et al. (2021) Experimental & Molecular Medicine

Ryu, et al. (2020) Nucleic Acids Research (한빛사: https://url.kr/TviWy8)

Ryu, et al. (2020) Experimental & Molecular Medicine

Ryu, et al. (2019) EMBO journal (한빛사: https://url.kr/bq9V6g)

Ryu, et al. (2018) Nature Communications (한빛사: https://url.kr/yDHhgZ)

Ryu, et al. (2016) Genes & Development (한빛사: https://url.kr/MAb4t9)

Ryu and Ahn (2014) BMC Biology

Ismail, T., Jeong, Y.G., Lee, H.K., Lee, H., Kim, Y., Lee, J.Y., Kim, S.H., Ryu, H.Y., Kwon, T.K., Park, T.J., Kwon, T., Khang, D., and Lee, H.S. (2025) In vivo analyses of embryotoxicity and teratogenicity of gold nanoparticles: Emphasis on the surface chemistry and toxicological responses. Ecotoxicology and Environmental Safety 304. (IF: 6.1)

Yang, B., Lee, H.K., Lee, H., Ryu, H.Y., Kim, H.T., and Lee, H.S. (2025) Mtx2 requirement for craniofacial morphogenesis with implications for mandibuloacral dysplasia. Biochemical and Biophysical Research Communications 784. (IF: 2.2)

Park, S., Liu, Y., Lim, S., Ryu, H.Y., and Ahn, S.H. (2025) Epigenetic regulation of intracellular branched-chain amino acid homeostasis maintains a normal lifespan. iScience 28, 112846 (IF: 4.1)

Jeong, D.W., Kim, S.Y., Jeoung, S.W., Zhao, D., Knight, J., Lam, T.T., Jin, J.H., Lee, H.S., Hochstrasser, H., and Ryu, H.Y. (2025) Auto-sumoylation of the yeast Ubc9 E2 SUMO-conjugating Enzyme Extends Cellular Lifespan. Nature Communications 16, 3735. (IF: 15.7) (한빛사: https://buly.kr/4mcbrVz)

Bae, J.E., Jang, S., Kim, J.B., Park, N.Y., Jo, D.S., Hyung, H., Kim, P., Kim, M.S., Ryu, H.Y., Lee, H.S., Lee, D.S., Baes, M., Ryoo, Z.Y., and Cho, D.H. (2025) HSD17B4 deficiency causes dysregulation of primary cilia and is alleviated by acetyl-CoA. Nature Communications (IF: 15.7)

Choi, D., Na, A.Y., Jeoung, S.W., Choi, Y.H., Park, N., Park, H.S., Kwon, H.K., Lee, H.S., Cho, D.H., Kim, D.H., and Ryu, H.Y. (2025) Histone H3 lysine 9 tri-methylation is associated with pterygium. BMC ophthalmology 25, 1. (IF: 1.7)

Hong, J., Lee, D., Hwang, A., Kim, T., Ryu, H.Y., and Choi, J. (2024) Rare disease genomics and precision medicine. Genomics & Informatics 22, 1.

Ryu, H.Y. (2024) Histone modification pathways suppressing cryptic transcription. Epigenomes 8, 42. (IF: 2.5)

Park, J.M., Choi, S., Choi, D.K., Lee, H.S., Cho, D.H., Choi, J., and Ryu, H.Y. (2024) Yeast Small Ubiquitin-Like Modifier (SUMO) Protease Ulp2 is Involved in RNA Splicing. Development & Reproduction 28, 47.

Liu, Y., Park, J.M., Lim, S., Duan, R., Lee, D.Y., Choi, D., Choi, D.K., Rhie, B.H., Cho, S.Y., Ryu, H.Y., and Ahn, S.H. (2024) Tho2-mediated escort of Nrd1 regulates the expression of aging-related genes. Aging Cell 23, 8. (IF: 8.0) (co-corresponding)

Kim, Y., Lee, H.K., Park, K.Y., Ismail, T., Lee, H., Ryu, H.Y., Cho, D.H., Kwon, T.K., Park, T.J., Kwon, T., and Lee, H.S. (2024) Actin depolymerizing factor destrin governs cell migration in neural development during Xenopus embryogenesis. Molecules and Cells 47, 6. (IF: 3.8)

Kim, J.B.,  Hyung, H., Bae, J.E., Jang, S., Park, N.Y., Jo, D.S., Kim, Y.H., Choi, D.K., Ryu, H.Y., Lee, H.S., Ryoo, Z.Y., and Cho, D.H. (2024) Increased ER stress by depletion of PDIA6 impairs primary ciliogenesis and enhances sensitivity to ferroptosis in kidney cells. BMB Reports 57, 10. (IF: 3.8)

Ismail, T., Lee, H.K., Lee, H., Kim, Y., Kim, E., Lee, J.Y., Kim, K.B., Ryu, H.Y., Cho, D.H., Kwon, T.K., Park, T.J., Kwon, T., and Lee, H.S. (2024) Early life exposure to perfluorooctanesulfonate (PFOS) impacts vital biological processes in Xenopus laevis: Integrated morphometric and transcriptomic analyses. Ecotoxicology and Environmental Safety 269, 115820. (IF: 6.8)

Chou, K.Y., Lee, J.Y., Kim, K.B., Kim, E., Lee, H.S., and Ryu, H.Y. (2023) Histone modification in Saccharomyces cerevisiae: A review of the current status. Computational and Structural Biotechnology Journal 21, 1843-1850. (IF: 7.271)

Ismail, T., Lee, H., Kim, Y., Ryu, H.Y., Cho, D.H., Ryoo, Z.Y., Lee, D.S., Kwon, T.K., Park, T.J., Kwon, T., and Lee, H.S. (2023) PCNB exposure during early embryogenic development induces developmental delay and teratogenicity by altering the gene expression in Xenopus laevis. Environmental Toxicology 38, 216-224. (IF: 4.109)

Ryu, H.Y. (2022) SUMO pathway is required for ribosome biogenesis. BMB Reports 55, 535-540. (IF: 5.041)

Bae, J.E., Kim, J.B., Jo, D.S., Park, N.Y., Kim, Y.H., Lee, H.J., Kim, S.H., Kim, S.H., Son, M., Kim, P., Ryu, H.Y., Lee, W.H., Ryoo, Z.Y., Lee, H.S., Jung, Y.K., and Cho, D.H. (2022) Carnitine Protects against MPP+-Induced Neurotoxicity and Inflammation by Promoting Primary Ciliogenesis in SH-SY5Y Cells. Cells 11, 2722. (IF: 7.666)

Jeoung, S.W., Park, H.S., Ryoo, Z.Y., Cho, D.H., Lee, H.S., and Ryu, H.Y. (2022) SUMOylation and major depressive disorder. International Journal of Molecular Sciences 23, 8023. (IF: 6.208)

Lim, S., Liu, Y., Rhie, B.H., Kim, J., Ryu, H.Y., and Ahn, S.H. (2022) Sus1 maintains a normal lifespan through regulation of TREX-2 complex-mediated mRNA export. Aging 14, 4990. (IF: 5.955) (co-corresponding)

Park, H.S., Lee, J., Lee, H.S., Ahn, S.H., and Ryu, H.Y. (2022) Nuclear mRNA Export and Aging. International Journal of Molecular Sciences 23, 5451. (IF: 6.208)
 

Choi, J., Ryoo, Z.Y., Cho, D.H., Lee, H.S., and Ryu, H.Y. (2021) Trans-tail regulation-mediated suppression of cryptic transcription. Experimental & Molecular Medicine 53, 1683-1688. (IF: 12.178)

Lee, H., Lee, N.Y., Kim, Y., Chai, H.S., Ismail, T., Ryu, H.Y., Cho, D.H., Ryoo, Z.Y., Lee, D.S., Kwon, T.K., Park, T.J., Kwon, T., and Lee, H.S. (2021) Physiological Functions of Thiol Peroxidases (Gpx1 and Prdx2) during Xenopus laevis Embryonic Development. Antioxidants 10, 1636. (IF: 7.675)

Choi, J.Y., Bae, J.E., Kim, J.B., Jo D.S., Park, N.Y., Kim, Y.H., Lee, H.J., Kim, S.H., Kim, S.H., Jeon, H.B., Na, H.N., Choii, H., Ryu, H.Y., Ryoo, Z.Y., Lee, H.S., and Cho, D.H. (2021) 2-IPMA ameliorates PM2.5-induced inflammation by promoting primary ciliogenesis in RPE cells. Molecules 26, 5409. (IF: 4.927)

Park, H.S, Kim, J., Ahn, S.H., and Ryu, H.Y. (2021) Epigenetic targeting of histone deacetylase in diagnostics and treatment of depression. International Journal of Molecular Sciences 22, 5398. (IF: 6.208)

Ryu, H.Y. and Hochstrasser, M. (2021) Histone sumoylation and chromatin dynamics.  Nucleic Acids Research 49, 6043-6052. (IF: 19.160) (co-corresponding) (한빛사: https://han.gl/ySTOa)

Ahn, H., Kim, S., Duan, R., Ryu, H.Y., and Ahn, S.H. (2021) The Spt7 subunit of the SAGA complex is required for the regulation of lifespan in both dividing and nondividing yeast cells. Mechanisms of Ageing and Development 196, 111480. (IF: 5.498) (co-corresponding) 

Ryu, H.Y. (2021) SUMO: a novel target for anti-coronavirus therapy. Pathogens and Global Health 115, 292-299. (IF: 3.735)

Ryu, H.Y. (2021) 끊이지 않는 코로나바이러스와의 전쟁. KSBMB TiBMB (https://url.vet/3fe38)
 

Ryu, H.Y. (2020) Advanced Technologies and Mechanisms for Yeast Evolutionary Engineering. Microbiology and Biotechnology Letters 48, 423-428. (IF: 0.36)

Lim, D., Cho, J.G., Yun E., Lee, A., Ryu, H.Y., Lee, Y.J., Yoon, S., Chang, W., Lee, M.S., Kwon, B.S., and Kim, J. (2020) MicroRNA 34a-AXL axis regulates vasculogenic mimicry formation in breast cancer cells. Genes 12, 9. (IF: 4.096)

Lee, H., Ismail, T., Kim, Y., Chae, S., Ryu, H.Y., Lee, D.S., Kwon, T.K., Park, T.J., Kwon, T., and Lee, H.S. (2020) Xenopus gpx3 Mediates Posterior Development by Regulating Cell Death during Embryogenesis. Antioxidants 9, 1265. (IF: 6.313)

Ryu, H.Y., Zhao, D., Li, J., Su, D., and Hochstrasser, M. (2020) Histone Sumoylation Promotes Set3 Histone-Deacetylase Complex-Mediated Transcriptional Regulation. Nucleic Acids Research 48, 12151-12168. (IF: 16.971) (co-corresponding) (한빛사: https://url.kr/TviWy8)

Luo, X., Song, R., Moreno, D.F., Ryu, H.Y., Hochstrasser, M., and Acar, M. (2020) Epigenetic mechanisms contribute to evolutionary adaptation of gene network activity under environmental selection. Cell Reports 33, 108306. (IF: 9.423) 

Ryu, H.Y., Ahn, S.H., and Hochstrasser, M. (2020) SUMO and cellular adaptive mechanisms. Experimental & Molecular Medicine 52, 931-939. (IF: 8.718) 

Duan, R., Ryu, H.Y., and Ahn, S.H. (2020) Symmetric dimethylation on histone H4R3 associates with histone deacetylation to maintain properly polarized cell growth. Research in Microbiology 171, 91-98. (IF: 3.992)

Ryu, H.Y., Su, D., Wilson, N.R., Zhao, D., Lopez-Giraldez, F., and Hochstrasser, M. (2019) The Ulp2 SUMO Protease Promotes Transcription Elongation through Regulation of Histone Sumoylation. EMBO Journal 38, e102003. (IF: 11.227) (한빛사: https://url.kr/bq9V6g)

Ryu, H.Y., Duan, R., and Ahn, S.H. (2019) Yeast symmetric arginine methyltransferase Hsl7 has a repressive role in transcription. Research in Microbiology 170, 222-229. (IF: 3.217) 

Ryu, H.Y., Lopez-Giraldez, F., Knight, J., Hwang, S.S., Renner, C., Kreft, S.G., and Hochstrasser, M. (2018) Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease. Nature Communications 9, 5417. (IF: 11.878) (한빛사: https://url.kr/yDHhgZ)

Ryu, H.Y. and Hochstrasser, M. (2017) Adaptive aneuploidy counters a dysregulated SUMO system. Cell Cycle 16, 383-385. (IF: 3.304) 

Ryu, H.Y., Wilson, N.R., Mehta, S., Hwang, S.S., and Hochstrasser, M. (2016) Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy. Genes & Development 30, 1881-1894. (IF: 9.413) (한빛사: https://url.kr/MAb4t9) This paper was recommended by Faculty of 1000 Biology. 

Ryu, H.Y. and Ahn, S.H. (2014) Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic rDNA condensation. BMC Biology 12, 75. (IF: 7.984) 

Ryu, H.Y., Rhie, B.H., and Ahn, S.H. (2014) Loss of the Set2 histone methyltransferase increases cellular lifespan in yeast cells. Biochemical and Biophysical Research Communications 446, 113-118. 5. (IF: 2.637)

Song, Y.H., Duan, R., Ryu, H.Y., and Ahn, S.H. (2014) The yeast ESCRT complexes are involved in the regulation of transcription elongation. Genes and Genomics 36, 335-343. (IF: 0.596) 

Duan, R.X., Rhie, B.H., Ryu, H.Y., and Ahn, S.H. (2013) The RNA polymerase II Rpb4/7 subcomplex regulates cellular lifespan through an mRNA decay process. Biochemical and Biophysical Research Communications 441, 266-270. (IF: 2.853) 

Rhie, B.H., Song, Y.H., Ryu, H.Y., and Ahn, S.H. (2013) Cellular aging is associated with increased ubiquitylation of histone H2B in yeast telomeric heterochromatin. Biochemical and Biophysical Research Communications 439, 570-575. (IF: 2.853)