Research outputs
* = Corresponding author; # = Equal authorship
Published:
Kumar, K.*, Kumar, S., Goswami, A., & Moholkar, V. S. (2024). Advancing sustainable biofuel production: A computational insight into microbial systems for isopropanol synthesis and beyond. Process Safety and Environmental Protection. https://doi.org/10.1016/j.psep.2024.06.024
Karan Kumar*, Shraddha M. Jadhav, & Vijayanand S. Moholkar (2024). Acetone-Butanol-Ethanol (ABE) fermentation with Clostridial Co-cultures for Enhanced Biobutanol Production. Process Safety and Environmental Protection, 185, 277-285. https://doi.org/10.1016/j.psep.2024.03.027
Karan Kumar, Lepakshi Barbora, and Vijayanand S. Moholkar (2024). Genomic insights into clostridia in bioenergy production: Comparison of metabolic capabilities and evolutionary relationships. Biotechnology and Bioengineering, 121, 1298–1313. https://doi.org/10.1002/bit.28610
Karan Kumar, Pallavi Patro, Unnati Raut, Varsha Yadav, Lepakshi Barbora, and Vijayanand S. Moholkar* (2023). Elucidating the molecular mechanism of ultrasound-enhanced lipase-catalyzed biodiesel synthesis: a computational study. Biomass Conversion and Biorefinery, 1-12. https://doi.org/10.1007/s13399-023-04742-4
Neha Singh#, Karan Kumar#, Arun Goyal, and Vijayanand S. Moholkar* (2022). Ultrasound-assisted biodiesel synthesis by in–situ transesterification of microalgal biomass: Optimization and kinetic analysis. Algal Research, 61, 102582. https://doi.org/10.1016/j.algal.2021.102582
Karan Kumar, Kuldeep Roy, and Vijayanand S. Moholkar* (2021). Mechanistic investigations in sonoenzymatic synthesis of n-butyl levulinate. Process Biochemistry, 111, 147-158. https://doi.org/10.1016/j.procbio.2021.09.005
Ritesh Malani, Karan Kumar#, Sachin B Umriwad#, Arun Goyal, and Vijyanand Suryakant Moholkar* (2019). Ultrasound-assisted enzymatic biodiesel production using blended feedstock of non–edible oils: Kinetic analysis. Energy Conversion and Management, 188, 142-150. https://doi.org/10.1016/j.enconman.2019.03.052
Preprints:
Avinash Anand, Karan Kumar*, Kaustubh Chandrakant Khaire, Kuldeep Roy, and Vijayanand S. Moholkar (2023). Ultrasound-Assisted Hydrolysis of Food Waste using Glucoamylase: Statistical Optimization and Mechanistic Analysis with Molecular Simulations. bioRxiv 2023.12.14.571620; https://doi.org/10.1101/2023.12.14.571620
Karan Kumar*, Azeeza Siddiqa. MD, Pragati, Priti Chandane, Mahima Kori, A Shivram, Saanya Yadav, Lepakshi Barbora, and Vijayanand S. Moholkar, (2022). Computational investigations in inhibition of alcohol/aldehyde dehydrogenase in lignocellulosic hydrolysates. bioRxiv 2022.11.19.517192; https://doi.org/10.1101/2022.11.19.517192
Karan Kumar, Lepakshi Barbora, Vijayanand S. Moholkar* (2022). Comparative genomic analysis and constraint-based analysis of genome-scale metabolic models of the genus Clostridia. Authorea, November 16, 2022. https://doi.org/10.22541/au.166858569.91782041/v1
Karan Kumar, Pallavi Patro, Unnati Raut, et al., (2022). Ultrasonic enhancement of lipase-catalyzed reactions: Mechanistic investigation using molecular docking analysis. Authorea, October 31, 2022; https://doi.org/10.22541/au.166722851.12958171/v1
Caroline Vilas Boas de Melo, Maruf Ahmed Bhuiyan, Winfred Nyoroka Gatua, Stephen Kanyerezi, Leonard Uzairue, Priscilla Abechi, Karan Kumar, et al. (2020). Transcriptomic dysregulations associated with SARS-CoV-2 infection in human nasopharyngeal and peripheral blood mononuclear cells. bioRxiv 2020.09.09.289850; https://doi.org/10.1101/2020.09.09.289850
In preparation
Karan Kumar, Lepakshi Barbora, and Vijayanand S. Moholkar, "Unravelling the genomic differences between solventogenic species Clostridium acetobutylicum ATCC 824 and Clostridium pasteurianum ATCC 6013"
Karan Kumar, Lepakshi Barbora, and Vijayanand S. Moholkar, "Biochemical and Systems Biological comparison of acetone-butanol-ethanol (ABE) fermentation in solventogenic species C. acetobutylicum and C. pasteurianum"
Karan Kumar, Lepakshi Barbora, and Vijayanand S. Moholkar, "Deciphering the physiological underpinning of solventogenesis in Clostridia using genome-scale metabolic models"
Shyamali Sarma, Karan Kumar, Vikash Kumar Dubey, and Vijayanand S. Moholkar, "Optimization of Medium for Waste Glycerol Fermentation for Biohydrogen Production"
Books/book chapters
* = Corresponding author; # = Equal authorship
Published:
Kumar, K., Anand, A., Moholkar, V.S.* (2024). Molecular Hydrogen (H2) Metabolism in Microbes: A Special Focus on Biohydrogen Production. In: Soccol, C.R., Brar, S.K., Permaul, K., Pakshirajan, K., de Carvalho, J.C. (eds) Biohydrogen - Advances and Processes. Biofuel and Biorefinery Technologies, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-031-49818-3_2
Anand, A., Kumar, K., Moholkar, V.S.* (2024). Various Routes for Hydrogen Production and Its Utilization for Sustainable Economy. In: Soccol, C.R., Brar, S.K., Permaul, K., Pakshirajan, K., de Carvalho, J.C. (eds) Biohydrogen - Advances and Processes. Biofuel and Biorefinery Technologies, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-031-49818-3_20
Shraddha M. Jadhav & Karan Kumar* (2024). Biomarker Analysis for Alzheimer's Disease. In: Bhattacharya, K., Bhattacharjee, A.(eds) Computational and Experimental Studies in Alzheimer's Disease, Chapman and Hall/CRC Press. https://doi.org/10.1201/9781003412069-5
Karan Kumar* and Vijayanand S. Moholkar (2023). Mechanistic Aspects of Enhanced Kinetics in Sonoenzymatic Processes Using Three Simultaneous Approaches. In: Moholkar, V.S., Mohanty, K., Goud, V.V. (eds) Sustainable Energy Generation and Storage. NERC 2022. Springer, Singapore. https://doi.org/10.1007/978-981-99-2088-4_5
Karan Kumar*, Heena Shah, and Vijayanand S. Moholkar (2022). Genetic Algorithm for Optimization of Fermentation Processes of Various Enzyme Productions. In Optimization of Sustainable Enzymes Production, pp. 121-144. Chapman and Hall/CRC Press. https://doi.org/10.1201/9781003292333-6
Karan Kumar, Anveshika Manoj, and Kausar Mahmood Ansari* (2019). A Review on Food Additives Toxicity (khaady yojakon kee vishaaktata par ek sameeksha). Vishvigyan Sandesh, CSIR-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India vol. 30, pp. 11-14, 2018-19, ISBN: 0972-1746.
Proof-submitted (In-press)
Karan Kumar, Kaustubh C. Khaire, Kuldeep Roy, and Vijayanand S. Moholkar*, Applications of Microbial Fermentation Technique for the Synthesis of Bioalcohols from Different Agrobiomass. In: Chakraborty, S., Nayak, J., & Banerjee, S., (eds.) Agricultural Biomass for the Synthesis of Value-Added Materials (Accepted)
Karan Kumar*, Piyal Mondal, Shraddha M. Jadhav, and Vijayanand S. Moholkar, Application of Enzymatic Technique for the Synthesis of Bio-degradable Polymers from Different Agrobiomass. In: Chakraborty, S., Nayak, J., & Banerjee, S., (eds.) Agricultural Biomass for the Synthesis of Value-Added Materials (Accepted)
Karan Kumar*, Shrivatsa Hegde, Ramyakrishna A.R, Anweshan, and Vijayanand S. Moholkar*, Application of Microbial Technique for the Synthesis of Organic Acid from Different Agrobiomass. In: Chakraborty, S., Nayak, J., & Banerjee, S., (eds.) Agricultural Biomass for the Synthesis of Value-Added Materials (Accepted)
Anjli Tanwar, Disha Mukherjee, Karan Kumar*, and Vijayanand S. Moholkar*, Application of Microbial Fermentation Technique for the Synthesis of Fermentable Sugars from Different Agrobiomass. In: Chakraborty, S., Nayak, J., & Banerjee, S., (eds.) Agricultural Biomass for the Synthesis of Value-Added Materials (Accepted)
Shraddha M. Jadhav, Poulami Mukherjee, Karan Kumar*, and Vijayanand S. Moholkar*, Application of Enzymatic Technique for the Synthesis of Bio-alcohols From Different Agrobiomass. In: Chakraborty, S., Nayak, J., & Banerjee, S., (eds.) Agricultural Biomass for the Synthesis of Value-Added Materials (Accepted)
Presentations/Talks
* = Corresponding author; # = Equal authorship
Invited Talks/Lectures
Keynote Speaker on the topic entitled, "Recent advances in Clostridial co-culture techniques to mitigate global energy crisis by enhanced biofuel production", at 3rd International Webinar on Biofuel & Biomass 2022 at Singapore City, Singapore, organized by Conference Mind, December 08-09, 2022. (Best Keynote Speaker Award)
Karan Kumar* and Vijayanand S. Moholkar, "Deciphering the physiological underpinning of solventogenesis in Clostridia using genome-scale metabolic models" short invited talk at 16th International Conference on the Genetics, Physiology, and Synthetic Biology of Solvent- and Acid-Forming Clostridia (Clostridia XVI), held at INSA in Toulouse, France (September 14 - 17, 2022).
Invited Speaker on the topic entitled, “In-silico approach to enhance the production of alcoholic biofuels in solventogenic Clostridia: Recent progress in the reconstruction of genome-scale metabolic models” at 2nd International Webinar on Biofuel & Biomass 2022 organized by Conference Mind, scheduled during January 24-25, 2022. (Best Young Scientist Award)
Invited as guest speaker for the event on career guidance cum expert lecture on the topic “Application of Computational Biology and Bioinformatics in Biofuel Production Technologies”, at Seminar Hall, Faculty of Life Sciences, Mandsaur University, Mandsaur, Madhya Pradesh on January 1st, 2022.
Presentations (Oral/Poster)
Karan Kumar* and Vijayanand S. Moholkar, "Unravelling the genomic differences between solventogenic species Clostridium acetobutylicum ATCC 824 and Clostridium pasteurianum ATCC 6013", Oral presentation at upcoming VII- International Conference on Sustainable Energy and Environmental Challenges (VI-SEEC), at Indian Institute of Technology - BHU, Varanasi, Uttar Pradesh, India (December 16-18, 2022). (Best Paper Award)
Avinash Anand*, Karan Kumar, Kaustubh Chandrakant Khaire and Vijayanand Suryakant Moholkar, "Enzymatic saccharification of food waste for biohydrogen production: A response surface based optimization and molecular simulation approach", Poster presentation at International Conference on Biotechnology for Sustainable Bioresources and Bioeconomy (BSBB-2022), Indian Institute of Technology, Guwahati, India. (December 7-11, 2022)
Karan Kumar* and Vijayanand S. Moholkar, "Computational investigations in inhibition of alcohol/ aldehyde dehydrogenase (AAD) in lignocellulosic hydrolysates" poster presentation at 30th Conference on Intelligent Systems for Molecular Biology (ISMB 2022) held at Monona Terrace Convention Center, Madison, Wisconsin, United States (July 10 - 14, 2022).
Karan Kumar* and Vijayanand S. Moholkar, "Mechanistic aspects of enhanced kinetics in sonoenzymatic processes using three simultaneous approaches", Oral presentation at North-East Research Conclave 2022 (NERC 2022) held at Indian Institute of Technology Guwahati, Assam, India (May 20-22, 2022). (Springer Best Paper Award)
Karan Kumar* "Investigation and Enhancing the production of alcoholic biofuels using Systems Metabolic Engineering Approach", Three Minute Thesis Presentation (3MTT) at Research & Industrial Conclave Integration 2022 (RIC 2022), organized by Students' Academic Board in collaboration with IIT Guwahati Research Park at Indian Institute of Technology Guwahati, Assam, India (January 20-23, 2022).
Pragati*, Karan Kumar, and Vijayanand S. Moholkar, "Potent process inhibitors affecting the key enzyme adhE2 for butanol production in alcohologenesis in Clostridium acetobutylicum", Oral presentation at Research & Industrial Conclave Integration 2022, organized by Students' Academic Board in collaboration with IIT Guwahati Research Park at Indian Institute of Technology Guwahati, Assam, India (January 20-23, 2022). (Best Oral Presentation Award)
Karan Kumar* and Vijayanand S. Moholkar, "Reconstruction and constraint-based analysis of genome-scale metabolic models: In-silico approach to enhance the production of biofuels in solventogenic Clostridia", Oral presentation at Research & Industrial Conclave Integration 2022, organized by Students' Academic Board in collaboration with IIT Guwahati Research Park at Indian Institute of Technology Guwahati, Assam, India (January 20-23, 2022).
Karan Kumar* and Vijayanand S. Moholkar, "Theoretical studies to understand the inhibition mechanism of alcohol/aldehyde dehydrogenase due to inhibitors present in hydrolysates from lignocellulosic biomass", Oral presentation at VI- International Conference on Sustainable Energy and Environmental Challenges (VI-SEEC), Lucknow, Uttar Pradesh, India (December 27-29, 2021).
Karan Kumar* and Vijayanand S. Moholkar. "Comparative genomic analysis and constraint-based analysis of available genome-scale metabolic models of the solventogenic clostridia", contributory talk (oral presentation) at International Conference on Biotechnology for Resources Efficiency, Energy, Environment, Chemicals and Health (BREEECH-2021), CSIR- Indian Institute of Petroleum, Dehradun, Uttarakhand, India (December 1-4, 2021). (Best Oral Presentation Award)
Karan Kumar* and Vijayanand S. Moholkar. "Unravelling the mechanistic aspects of sono-enzymatic esterification via dual approach of experiments and computational analysis", e-poster presentation at ESS-AOSS-JSS 1st Joint Sonochemistry Conference (online) (November 8-10, 2021).
Karan Kumar* and Vijayanand S. Moholkar, "Applications of Machine Learning in Systems Metabolic Engineering Strategies for Enhanced Biofuel Production", e-poster presentation in Second Edition of Virtual International Conference on Natural Products and Synthetic Biology (ICNSB-2020), Vellore Institute of Technology, Vellore and Society of Chemical and Synthetic Biology (virtual conference, abstract published).
Karan Kumar* and Vijayanand S. Moholkar, "Systems Metabolic Engineering Strategies to Enhance Production of Biofuels: A mini-review", oral presentation in the 2nd International Conference on Bioprocess for Sustainable Environment and Energy (ICBSEE-2020), March 05-07, 2020. ICBSEE-20-39, page no.: 86, (ISBN: 818553107) (abstract published).
Ritesh Malani, Karan Kumar*, Sachin B Umriwad, Arun Goyal, and Vijyanand Suryakant Moholkar, "Ultrasound-assisted enzymatic biodiesel production using a blended feedstock of non–edible oils: Kinetic analysis", oral presentation Fourth Asia-Oceania Sonochemical Society Conference (AOSS-4), Nanjing University, Nanjing, China, September 19 – 21, 2019.
Karan Kumar*, Darpan Raghav, and Rathinasamy Krishnan, "Recent advances in carbon-based nanostructured materials (CBNs) and their biomedical applications," in First International Conference on Energy and Environment: Global Challenges (ICEE-2018), Department of Chemical Engineering, National Institute of Technology Calicut, Kerala, India (abstract published).
Addressed Seminar on the topic "To Identify the Molecular Targets of Small Molecules Using Drug Affinity Responsive Target Stability (DARTS) " at School of Biotechnology, National Institute of Technology Calicut, Kerala, India on March 15, 2018.