ACE LAB

Animal Cell Engineering Lab

Department of Biological Sciences, KAISTProf. Gyun Min Lee

Welcome to Animal Cell Engineering Lab!

For the production of recombinant proteins, Chinese hamster ovary (CHO) cells have been the most popular hosts in industry since the first product, human tPA, was approved for marketing in the mid 1980's. As of 2002, more than 50 recombinant proteins produced from CHO cells are approved for marketing. Our research group focus on the research and development of therapeutic protein production using recombinant CHO cells. The topics range from molecular biology to bioprocess engineering.

  1. “Small Molecule Epigenetic Modulators for Enhancing Recombinant Protein Expression in CHO Cell Cultures”, D. Kim, C. Yoon, and G. M. Lee, Biotechnol. Bioeng. (2022).

  2. “Improving the Secretory Capacity of CHO Producer Cells: the Effect of Controlled Blimp1 Expression, a Master Transcription Factor for Plasma Cells”, S. H. Kim, M. Baek, S. Park, S. Shin, J. S. Lee, G. M. Lee, Metabolic Eng. (2022).

  3. “Factors Affecting the Quality of Therapeutic Proteins in Recombinant Chinese Hamster Ovary Cell Culture”, T. K. Ha, D. Kim, C. L. Kim, L. M. Grav, and G. M. Lee, Biotechnol. Adv. (2021).