ACE LAB
Animal Cell Engineering Lab
Department of Biological Sciences, KAISTProf. Gyun Min Lee
Welcome to Animal Cell Engineering Lab!
For the production of recombinant proteins, Chinese hamster ovary (CHO) cells have been the most popular hosts in industry since the first product, human tPA, was approved for marketing in the mid 1980's. As of 2002, more than 50 recombinant proteins produced from CHO cells are approved for marketing. Our research group focus on the research and development of therapeutic protein production using recombinant CHO cells. The topics range from molecular biology to bioprocess engineering.
“SiMPl-GS: Advancing Cell Line Development via Synthetic Selection Marker for Next-Generation Biopharmaceutical Production”, C. Yoon, E. J. Lee, D. Kim, S. Joung, Y. Kim, H. Jung, Y. G. Kim, G. M. Lee, Adv. Sci. (2024).
“Genome-Wide CRISPR/Cas9 Screening Unveils a Novel Target ATF7IP-SETDB1 Complex for Enhancing Difficult-to-Express Protein Production”, S. H. Kim, J. Park, S. Shin, S. Shin, D. Chun, Y. G. Kim, J. Yoo, W. K. You, J. S. Lee, G. M. Lee, ACS Synth. Biol. (2024).
“Genome-Wide CRISPR/Cas9 Knockout Screening to Mitigate Cell Growth Inhibition Induced by Histone Deacetylase Inhibitors in Recombinant CHO Cells”, D. Kim, S. H. Kim, C. Yoon, G. M. Lee, Biotechnol. Bioeng. (2023).