Publications

Zafar MA*, Behera J*, Machado CNH*, Zhong Y, Li X, Joshi S, Fazaa YE, Camacho V, Georgiev P, Kurmi K, Haigis MC, Chatila T, Charbonnier LM. Glutamine-dependent biosynthetic pathways fuel autoreactive T and B cells in Foxp3 deficiency-mediated disease. JCI Insight 2026. August 5:2025.11.04.686569. doi: 10.1101/2025.11.04.686569. Impact Factor: 7.19.
Behera J, Rai H, Tyagi SC, Voor MJ, Tyagi N. Exercise Preconditioning Improves Mitochondrial Biogenesis and Bone Formation through Mitigating lncRNA-Pvt1 Dependent Tfam Hypermethylation in Hind-Limb Suspended Mice. Nature Communications (NCOMMS-24-18095B; Revision submitted). Impact Factor: 17.69.
Behera J, Tyagi SC, Voor MJ, Tyagi N, Myer D. Commd4 deficiency in macrophages induces bone loss via gut microbial dysbiosis-dependent expansion of intestinal Th17 cells. Nat Immunol. 2024(NImmunol-24-18095C; revision submitted). Impact Factor: 31.25.
Zafar M, Behera J, Machado CH, Zhong Y, Li X, Joshi S, Fazaa YE, Camacho V, Georgiev P, Kurmi K, Haigis M, and Charbonnier LM. Glutamine-Dependent Biosynthetic Pathways Fuel Autoreactive T and B Cells in Foxp3 Deficiency-Mediated Autoimmunity. J. Exp. Med. 2025 (under review). ImpactFactor:18.25.
Behera J, Ison J, Voor MJ, Tyagi N. Probiotics Stimulate Bone Formation in Obese Mice via Histone Methylations. Theranostics. 2021Jul25;11(17): 8605-8623.doi:10.7150/thno.63749. Impact Factor:12.5.
Behera J, Kumar A, Tyagi SC, Voor MJ, Tyagi N. Exosomal lncRNA-H19 promotes osteogenesisandangiogenesisthroughmediatingAngpt1/Tie2-NO signaling in CBS-heterozygous mice. Theranostics 2021.doi:10.7150/thno.58410. Impact Factor:12.5.
Behera J, Ison J, Tyagi SC, Robson D, Voor MJ, Tyagi N. Exercise-linked skeletal irisin ameliorates diabetes-associated osteoporosis by inhibiting oxidative damage-dependent miR-218-FNDC5/pyroptosis axis. Diabetes. 2022 Jul 8: db210573. doi: 10.2337/db21-0573. Impact Factor:10.23.
Chilton P, Smita G, Behera J, Barve S. Age-associated temporal decline in butyrate-producing bacteria plays a key pathogenic role in the onset and progression of neuropathology and memory deficits in 3xTg-AD mice. Gut Microbes. 2024 August 12: gm23123. Accepted.Impact Factor:12.23.
ZhangH-Ge, Sundaram K, Mu J, KumarA, BeheraJ, LeiC, SriwastvaMK, XuF, Dryden GW, Zhang L, Chen S, Yan J, Zhang X, Park JW, Merchant ML, Tyagi N,Teng Y. Oral administration of plant exosome-like nanoparticles inhibits brain inflammation by targeting microglial cells and gut A.muciniphila in obese mice. Theranostics. 2022 Jan 1;12(3):1220-1246. doi: 10.7150/thno.65427.ImpactFactor:12.5.
Behera J, Kelly KE, Voor MJ, Metreveli N, Tyagi SC, Tyagi N. Hydrogen Sulfide Promotes Bone Homeostasis by Balancing Inflammatory Cytokine Signaling in CBS-Deficient Mice through an Epigenetic Mechanism. Scientific Report.2018Oct15;8:15226.doi:10.1038/s41598-018-33149. Impact Factor:5.37.
Behera J, Pitchiah KM, Ireen FA, Govindan S, Ramasamy MS. miRNA-15IL-10Rα Axis Promotes Kabasura Kudineer Induced Immunomodulation by Suppressing Oxidative Stress. J Ethnopharmacol. 2023 Apr 6:305:116032. Impact factor 5.16.
Behera J, Tyagi SC, Tyagi N, Voor MJ. Mechanisms of Autophagy and Mitophagy In Skeletal Development, Diseases and Therapeutics. LifeSci.2022Jul15;301:120595. doi:10.1016/j.lfs.2022.120595. Impact Factor:5.03.
BeheraJ, TyagiN. Exosomes: mediators of bone diseases, protection, and therapeutic potential. Oncoscience. 2018 Jun 23;5(5-6):181-195. doi: 10.18632/oncoscience.421. Impact Factor:5.75.
BeheraJ,GeorgeAK,VoorMJ,Tyagi SC,TyagiN.Hydrogen sulfide epigenetically mitigates bone loss through OPG/RANKL regulation during hyperhomocysteinemia in mice.Bone.2018Sep;114:90-108. doi: 10.1016/j.bone.2018.06.009.ImpactFactor:5.39.
Behera J, Kelly KE,Tyagi N. Hydrogen sulfide prevents ethanol-induced ZO-1 CpG promoter hypermethylation-dependent vascular permeability via miR-218/DNMT3a axis. J Cell Physiol. 2021Oct;236(10):6852-6867. doi:10.1002/jcp.30382. Impact Factor: 6.38.
BeheraJ, Ison J, RaiH, Tyagi N. Allyl Sulfide Promotes Osteoblast Differentiation and Bone density via reducing mitochondrial DNA release mediated Kdm6b/H3K27me3 epigenetic mechanism. Biochem Biophys Res Commun. 2021 Mar 5;543:87-94. doi: 10.1016/j.bbrc.2021.01.016. ImpactFactor:3.57.
BeheraJ, JessicaIson, Tyagi SC,TyagiN.The role of gut microbiota in bone homeostasis. Bone.2020Jun;135:115317. Impact Factor:5.39.
Behera J, Tyagi SC, Tyagi N. Hydrogen Sulfide for Building Better Bones.Bone.2019Jul;124:33-39. Impact Factor:5.39.
Behera J, Bala J, Nuru M, Tyagi SC, Tyagi N. Homocysteine as a Pathological Biomarker for Bone Disease. J Cell Physiology. 2017 Oct;232(10):2704-2709. doi: 10.1002/jcp.25693. Impact Factor:6.38.
Geore AK, Behera J, Homme RP, Tyagi N, Tyagi SC, Singh M. Rebuilding Microbiome for Mitigating Traumatic Brain Injury: Importance of Restructuring the Gut-Microbiome-Brain Axis. Molecular Neurobiology 2021 Mar 27:1-14.doi:10.1007/s12035-021-02357-2). Impact Factor:5.60.
Behera J, Ison J, Tyagi MN, Voor MJ. Diabetic Covid-19 severity: Impaired glucose tolerance and pathologic bone loss. Biochem Biophys Res Commun-21-243; 2022 Jul 25;11(17):8605-8623. doi:10.7150/thno.63749.Impact Factor: 3.57.
Behera J, Tyagi SC,Tyagi N. Hyperhomocysteinemia-induced endothelial progenitor cells dysfunction through hypermethylation of CBS promoter. Biochem Biophys Res Commun. 2019 Feb 26;510(1):135-141.doi:10.1016/j.bbrc.2019.01.066. Impact Factor: 3.57.
Behera J, Govindan S, Ramasamy MS. Nitric oxide promotes cell-matrix adhesion of endothelial progenitor cells under hypoxia condition viaI TGA5 CpG promoter demethylation. Biochem Biophys Res Commun (Accepted, December,2022). Impact factor: 3.57.
Rajendran S, Sundaresan L, Venkatachalam G, Rajendran K, Behera J, Chatterjee S. Temporaldynamics of nitricoxide wave in early vasculogenesis. VascMed. 2021Sep 27:1358863X211035445. doi:10.1177/1358863X211035445. Impact Factor:3.23.
NagarajanS, Raj RK, Saravanakumar V, Balaguru UM, BeheraJ, RajendranVK, ShathyaY, AliBM, Sumantran V, Chatterjee S. Mechanical perturbations trigger endothelial nitric oxide synthase activity in human red blood cells. Scientific Report. 2016 Jun 27;6:26935. doi: 10.1038/srep26935. Impact Factor: 4.37.
Behera J, Nagarajan S, Saran U, Kumar R, Keshri GK, Suryakumar G, Chatterjee S. Nitric oxiderestores peripheral blood mononuclear cell adhesion against hypoxia via NO-cGMP signaling. CellBiochemFunct.2020Apr;38(3):319-329.Impact Factor:3.68.
Majumder A, Singh M, Behera J, Theilen NT, George AK, Tyagi N, Metreveli N, Tyagi SC. Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury. Am J Physiol Cell Physiol. 2018 Aug15.doi:10.1152/ajpcell.00147.2018.Impact Factor:5.28.
Yuankun Zhai, Behera J, Voor MJ, Kumar A, Tyagi SC, Tyagi N Hydrogen Sulfide attenuates homocysteine induced osteoblast dysfunction by inhibiting mitochondrial toxicity. J Cell Physiology.2019Aug;234(10):18602-18614.doi:10.1002/jcp.28498.ImpactFactor:6.38.
Mondal NK, Behera J, Kelly KE, George AK, Tyagi PK, Tyagi N. Tetrahydrocurcumin epigeneticallymitigates mitochondrial dysfunction in brain vasculature during ischemic stroke. Neurochem Int.2019 Jan;122:120-138. doi: 10.1016/j.neuint.2018.11.015. Epub 2018 Nov 22. Impact Factor: 4.29.
Majumder A, Singh M, George AK,BeheraJ, Tyagi N, Tyagi SC.Hydrogen sulfide improves postischemic neoangiogenesis in the hind limb of cystathionine-β-synthase mutant mice via PPAR-γ/VEGF axis. Physiological Report. 2018 Sep;6(17): e13858. doi: 10.14814/phy2.13858. Impact Factor: 2.26.
George AK*, Behera J*, Kelly KE, Mondal NK, Richardson KP, Tyagi N. Exercise Mitigates Alcohol Induced Endoplasmic Reticulum Stress Mediated Cognitive Impairment through ATF6-Herp Signaling. Scientific Report. 2018 Mar 26;8(1):5158. doi: 10.1038/s41598-018-23568-z. Impact Factor: 4.37.
Mondal NK, Behera J, Kelly KE, George AK, Tyagi PK, Tyagi N. Tetrahydrocurcumin epigeneticallymitigates mitochondrial dysfunction in brain vasculature during ischemic stroke. Neurochem Int.2019 Jan;122:120-138. doi: 10.1016/j.neuint.2018.11.015. Epub 2018 Nov 22. Impact Factor: 4.29.
Majumder A, Behera J, Jeremic N, Tyagi SC. Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy. J Cell Biochem. 2017 Aug;118(8):2108-2117. doi: 10.1002/jcb.25841.ImpactFactor: 4.52.
Vacek JC, Behera J, George AK, Kamat PK, Kalani A, Tyagi N. Tetrahydro curcumin ameliorates homocysteine-mediated mitochondrial remodeling in brain endothelial cells. J Cell Physiology. 2018 Apr; 233(4): 3080-3092.doi:10.1002/jcp.26145. Impact Factor: 6.38.
Gajalakshmi P, Priya MK, Pradeep T, Behera J, Muthumani K, Madhuwanti S, Saran U, Chatterjee S. Breast cancer drugs dampen vascular functions by interfering with nitric oxide signaling in endothelium. Toxicol Appl Pharmacol. 2013Jun1; 269 (2):121-31. doi:10.1016/j.taap.2013.03.011. Impact Factor: 4.50.
George AK, Behera J, Kelly KE, Zhai Y, Tyagi N. Hydrogen sulfide, endoplasmic reticulum stress and alcohol mediated neurotoxicity. Brain Res Bull. 2017Apr;130:251-256. doi:10.1016/j.brainresbull.2017.02.002. Impact Factor: 4.07.

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Publications

Behera J, Rai H, Tyagi SC, Voor MJ, Tyagi N. Exercise Preconditioning Improves Mitochondrial Biogenesis and Bone Formation through Mitigating lncRNA-Pvt1 Dependent Tfam Hypermethylation in Hind-Limb Suspended Mice. Nature Communications (NCOMMS-24-18095B; Revision submitted). Impact Factor: 17.69.

Behera J, Tyagi SC, Voor MJ, Tyagi N, Myer D. Commd4 deficiency in macrophages induces bone loss via gut microbial dysbiosis-dependent expansion of intestinal Th17 cells. Nat Immunol. 2024(NImmunol-24-18095C; revision submitted). Impact Factor: 31.25.

Zafar M, Behera J, Machado CH, Zhong Y, Li X, Joshi S, Fazaa YE, Camacho V, Georgiev P, Kurmi K, Haigis M, and Charbonnier LM. Glutamine-Dependent Biosynthetic Pathways Fuel Autoreactive T and B Cells in Foxp3 Deficiency-Mediated Autoimmunity. J. Exp. Med. 2025 (under review). ImpactFactor:18.25.

Behera J, Ison J, Voor MJ, Tyagi N. Probiotics Stimulate Bone Formation in Obese Mice via Histone Methylations. Theranostics. 2021Jul25;11(17): 8605-8623.doi:10.7150/thno.63749. Impact Factor:12.5.

Behera J, Kumar A, Tyagi SC, Voor MJ, Tyagi N. Exosomal lncRNA-H19 promotes osteogenesisandangiogenesisthroughmediatingAngpt1/Tie2-NO signaling in CBS-heterozygous mice. Theranostics 2021.doi:10.7150/thno.58410. Impact Factor:12.5.

Behera J, Ison J, Tyagi SC, Robson D, Voor MJ, Tyagi N. Exercise-linked skeletal irisin ameliorates diabetes-associated osteoporosis by inhibiting oxidative damage-dependent miR-218-FNDC5/pyroptosis axis. Diabetes. 2022 Jul 8: db210573. doi: 10.2337/db21-0573. Impact Factor:10.23.

Chilton P, Smita G, Behera J, Barve S. Age-associated temporal decline in butyrate-producing bacteria plays a key pathogenic role in the onset and progression of neuropathology and memory deficits in 3xTg-AD mice. Gut Microbes. 2024 August 12: gm23123. Accepted.Impact Factor:12.23.

Behera J, Kelly KE, Voor MJ, Metreveli N, Tyagi SC, Tyagi N. Hydrogen Sulfide Promotes Bone Homeostasis by Balancing Inflammatory Cytokine Signaling in CBS-Deficient Mice through an Epigenetic Mechanism. Scientific Report.2018Oct15;8:15226.doi:10.1038/s41598-018-33149. Impact Factor:5.37.

Behera J, Pitchiah KM, Ireen FA, Govindan S, Ramasamy MS. miRNA-15IL-10Rα Axis Promotes Kabasura Kudineer Induced Immunomodulation by Suppressing Oxidative Stress. J Ethnopharmacol. 2023 Apr 6:305:116032. Impact factor 5.16.

Behera J, Tyagi SC, Tyagi N, Voor MJ. Mechanisms of Autophagy and Mitophagy In Skeletal Development, Diseases and Therapeutics. LifeSci.2022Jul15;301:120595. doi:10.1016/j.lfs.2022.120595. Impact Factor:5.03.

BeheraJ, TyagiN. Exosomes: mediators of bone diseases, protection, and therapeutic potential. Oncoscience. 2018 Jun 23;5(5-6):181-195. doi: 10.18632/oncoscience.421. Impact Factor:5.75.

BeheraJ,GeorgeAK,VoorMJ,Tyagi SC,TyagiN.Hydrogen sulfide epigenetically mitigates bone loss through OPG/RANKL regulation during hyperhomocysteinemia in mice.Bone.2018Sep;114:90-108. doi: 10.1016/j.bone.2018.06.009.ImpactFactor:5.39.

Behera J, Kelly KE,Tyagi N. Hydrogen sulfide prevents ethanol-induced ZO-1 CpG promoter hypermethylation-dependent vascular permeability via miR-218/DNMT3a axis. J Cell Physiol. 2021Oct;236(10):6852-6867. doi:10.1002/jcp.30382. Impact Factor: 6.38.

BeheraJ, Ison J, RaiH, Tyagi N. Allyl Sulfide Promotes Osteoblast Differentiation and Bone density via reducing mitochondrial DNA release mediated Kdm6b/H3K27me3 epigenetic mechanism. Biochem Biophys Res Commun. 2021 Mar 5;543:87-94. doi: 10.1016/j.bbrc.2021.01.016. ImpactFactor:3.57.

BeheraJ, JessicaIson, Tyagi SC,TyagiN.The role of gut microbiota in bone homeostasis. Bone.2020Jun;135:115317. Impact Factor:5.39.

Behera J, Tyagi SC, Tyagi N. Hydrogen Sulfide for Building Better Bones.Bone.2019Jul;124:33-39. Impact Factor:5.39.

Behera J, Bala J, Nuru M, Tyagi SC, Tyagi N. Homocysteine as a Pathological Biomarker for Bone Disease. J Cell Physiology. 2017 Oct;232(10):2704-2709. doi: 10.1002/jcp.25693. Impact Factor:6.38.

Geore AK, Behera J, Homme RP, Tyagi N, Tyagi SC, Singh M. Rebuilding Microbiome for Mitigating Traumatic Brain Injury: Importance of Restructuring the Gut-Microbiome-Brain Axis. Molecular Neurobiology 2021 Mar 27:1-14.doi:10.1007/s12035-021-02357-2). Impact Factor:5.60.

Behera J, Ison J, Tyagi MN, Voor MJ. Diabetic Covid-19 severity: Impaired glucose tolerance and pathologic bone loss. Biochem Biophys Res Commun-21-243; 2022 Jul 25;11(17):8605-8623. doi:10.7150/thno.63749.Impact Factor: 3.57.

Behera J, Tyagi SC,Tyagi N. Hyperhomocysteinemia-induced endothelial progenitor cells dysfunction through hypermethylation of CBS promoter. Biochem Biophys Res Commun. 2019 Feb 26;510(1):135-141.doi:10.1016/j.bbrc.2019.01.066. Impact Factor: 3.57.

Behera J, Govindan S, Ramasamy MS. Nitric oxide promotes cell-matrix adhesion of endothelial progenitor cells under hypoxia condition viaI TGA5 CpG promoter demethylation. Biochem Biophys Res Commun (Accepted, December,2022). Impact factor: 3.57.

Rajendran S, Sundaresan L, Venkatachalam G, Rajendran K, Behera J, Chatterjee S. Temporaldynamics of nitricoxide wave in early vasculogenesis. VascMed. 2021Sep 27:1358863X211035445. doi:10.1177/1358863X211035445. Impact Factor:3.23.

Behera J, Nagarajan S, Saran U, Kumar R, Keshri GK, Suryakumar G, Chatterjee S. Nitric oxiderestores peripheral blood mononuclear cell adhesion against hypoxia via NO-cGMP signaling. CellBiochemFunct.2020Apr;38(3):319-329.Impact Factor:3.68.

Yuankun Zhai, Behera J, Voor MJ, Kumar A, Tyagi SC, Tyagi N Hydrogen Sulfide attenuates homocysteine induced osteoblast dysfunction by inhibiting mitochondrial toxicity. J Cell Physiology.2019Aug;234(10):18602-18614.doi:10.1002/jcp.28498.ImpactFactor:6.38.

Mondal NK, Behera J, Kelly KE, George AK, Tyagi PK, Tyagi N. Tetrahydrocurcumin epigeneticallymitigates mitochondrial dysfunction in brain vasculature during ischemic stroke. Neurochem Int.2019 Jan;122:120-138. doi: 10.1016/j.neuint.2018.11.015. Epub 2018 Nov 22. Impact Factor: 4.29.

Majumder A, Singh M, George AK,BeheraJ, Tyagi N, Tyagi SC.Hydrogen sulfide improves postischemic neoangiogenesis in the hind limb of cystathionine-β-synthase mutant mice via PPAR-γ/VEGF axis. Physiological Report. 2018 Sep;6(17): e13858. doi: 10.14814/phy2.13858. Impact Factor: 2.26.

George AK*, Behera J*, Kelly KE, Mondal NK, Richardson KP, Tyagi N. Exercise Mitigates Alcohol Induced Endoplasmic Reticulum Stress Mediated Cognitive Impairment through ATF6-Herp Signaling. Scientific Report. 2018 Mar 26;8(1):5158. doi: 10.1038/s41598-018-23568-z. Impact Factor: 4.37.

Mondal NK, Behera J, Kelly KE, George AK, Tyagi PK, Tyagi N. Tetrahydrocurcumin epigeneticallymitigates mitochondrial dysfunction in brain vasculature during ischemic stroke. Neurochem Int.2019 Jan;122:120-138. doi: 10.1016/j.neuint.2018.11.015. Epub 2018 Nov 22. Impact Factor: 4.29.

Majumder A, Behera J, Jeremic N, Tyagi SC. Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy. J Cell Biochem. 2017 Aug;118(8):2108-2117. doi: 10.1002/jcb.25841.ImpactFactor: 4.52.

Vacek JC, Behera J, George AK, Kamat PK, Kalani A, Tyagi N. Tetrahydro curcumin ameliorates homocysteine-mediated mitochondrial remodeling in brain endothelial cells. J Cell Physiology. 2018 Apr; 233(4): 3080-3092.doi:10.1002/jcp.26145. Impact Factor: 6.38.

George AK, Behera J, Kelly KE, Zhai Y, Tyagi N. Hydrogen sulfide, endoplasmic reticulum stress and alcohol mediated neurotoxicity. Brain Res Bull. 2017Apr;130:251-256. doi:10.1016/j.brainresbull.2017.02.002. Impact Factor: 4.07.

George AK, Behera J, Kelly KE, Mondal NK, Richardson KP, Tyagi N. Exercise Mitigates Alcohol Induced Endoplasmic Reticulum Stress Mediated Cognitive Impairment through ATF6-Herp Signaling. Scientific Report. 2018 Mar 26;8(1):5158. doi: 10.1038/s41598-018-23568-z. Impact Factor: 4.37.